Iron Deficiency Anemia: Problems in Diagnosis and Prevention at the Population Level

Hematology/Oncology Clinics of North America

Volumn 30, Issue 2, 2016, Pages 309-325

  Pasricha, Sant Rayn ^a   Drakesmith, Hal ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Anemia; Children; Hepcidin; Infection; Iron; Malaria; Public health

Indexed keywords

ANTHELMINTIC AGENT;

ANTIMICROBIAL THERAPY; DELAYED CORD CLAMPING; DEWORMING; DIARRHEA; DIET SUPPLEMENTATION; EVIDENCE BASED MEDICINE; HOOKWORM INFECTION; HUMAN; INFECTION RISK; IRON DEFICIENCY ANEMIA; IRON THERAPY; MALARIA; MALARIA CONTROL; MEASUREMENT; NONHUMAN; OBSTETRIC PROCEDURE; PREVALENCE; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; ANEMIA, IRON-DEFICIENCY; FEMALE; HEALTH; MALE; PREGNANCY;

ANEMIA, IRON-DEFICIENCY; FEMALE; GLOBAL HEALTH; HUMANS; MALE; PREGNANCY; PREVALENCE;

EID: 84963641794     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2015.11.003     Document Type: Review

References (78)

1. Stevens G.A., Finucane M.M., De-Regil L.M., et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health 2013, 1(1):e16-e25.
2. World Health Organization The global prevalence of anaemia in 2011 2015, World Health Organization, Geneva (Switzerland).
3. Kassebaum N.J., Jasrasaria R., Naghavi M., et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 2013, 123(5):615-624.
4. Pasricha S.R. Anemia: a comprehensive global estimate. Blood 2014, 123(5):611-612.
5. World Health Organization Essential nutrition actions: improving maternal, newborn, infant and young child health and nutrition 2013, World Health Organization, Geneva (Switzerland).
6. Pasricha S.R., Drakesmith H., Black J., et al. Control of iron deficiency anemia in low and middle-income countries. Blood 2013, 121(14):2607-2617.
7. De-Regil L.M., Suchdev P.S., Vist G.E., et al. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database Syst Rev 2011, (9). CD008959.
8. Allen L., de Benoist B., Dary O., et al. Guidelines on food fortification with micronutrients 2006, World Health Organization; Food and Agricultural Organization of the United Nations, Geneva (Switzerland).
9. Garcia-Casal M.N., Layrisse M. Iron fortification of flours in Venezuela. Nutr Rev 2002, 60(7 Pt 2):S26-S29.
10. Jones E., Pasricha S.R., Allen A., et al. Hepcidin is suppressed by erythropoiesis in hemoglobin E beta-thalassemia and beta-thalassemia trait. Blood 2015, 125(5):873-880.
11. McDonald S.J., Middleton P. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev 2008, (2). CD004074.
12. Andersson O., Lindquist B., Lindgren M., et al. Effect of delayed cord clamping on neurodevelopment at 4 years of age: a randomized clinical trial. JAMA Pediatr 2015, 169(7):631-638.
13. World Health Organization Optimal timing of cord clamping for the prevention of iron deficiency anaemia in infants 2014, e-Library of Evidence for Nutrition Actions (eLENA), Accessed June 1, 2015. Available at:. http://www.who.int/elena/titles/cord_clamping/en/Geneva.
14. Cercamondi C.I., Egli I.M., Ahouandjinou E., et al. Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. Am J Clin Nutr 2010, 92(6):1385-1392.
15. Doherty C.P., Cox S.E., Fulford A.J., et al. Iron incorporation and post-malaria anaemia. PLoS One 2008, 3(5):e2133.
16. Atkinson S.H., Armitage A.E., Khandwala S., et al. Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children. Blood 2014, 123(21):3221-3229.
17. Frosch A.E., Ondigo B.N., Ayodo G.A., et al. Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. Am J Clin Nutr 2014, 100(3):968-973.
18. Meremikwu M.M., Donegan S., Sinclair D., et al. Intermittent preventive treatment for malaria in children living in areas with seasonal transmission. Cochrane Database Syst Rev 2012, (2). CD003756.
19. Pasricha S.R., Caruana S.R., Phuc T.Q., et al. Anemia, iron deficiency, meat consumption, and hookworm infection in women of reproductive age in northwest Vietnam. Am J Trop Med Hyg 2008, 78(3):375-381.
20. Gulani A., Nagpal J., Osmond C., et al. Effect of administration of intestinal anthelmintic drugs on haemoglobin: systematic review of randomised controlled trials. BMJ 2007, 334(7603):1095.
21. Adish A.A., Esrey S.A., Gyorkos T.W., et al. Effect of consumption of food cooked in iron pots on iron status and growth of young children: a randomised trial. Lancet 1999, 353(9154):712-716.
22. Charles C.V., Dewey C.E., Daniell W.E., et al. Iron-deficiency anaemia in rural Cambodia: community trial of a novel iron supplementation technique. Eur J Public Health 2011, 21(1):43-48.
23. Haider B.A., Olofin I., Wang M., et al. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 2013, 346:f3443.
24. Pena-Rosas J.P., De-Regil L.M., Dowswell T., et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev 2012, (12). CD004736.
25. Christian P., Stewart C.P., LeClerq S.C., et al. Antenatal and postnatal iron supplementation and childhood mortality in rural Nepal: a prospective follow-up in a randomized, controlled community trial. Am J Epidemiol 2009, 170(9):1127-1136.
26. Zeng L., Dibley M.J., Cheng Y., et al. Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial. BMJ 2008, 337:a2001.
27. Christian P., Murray-Kolb L.E., Khatry S.K., et al. Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal. JAMA 2010, 304(24):2716-2723.
28. Parsons A.G., Zhou S.J., Spurrier N.J., et al. Effect of iron supplementation during pregnancy on the behaviour of children at early school age: long-term follow-up of a randomised controlled trial. Br J Nutr 2008, 99(5):1133-1139.
29. Pasricha S.R., Low M., Thompson J., et al. Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis. J Nutr 2014, 144(6):906-914.
30. Verdon F., Burnand B., Stubi C.L., et al. Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. BMJ 2003, 326(7399):1124.
31. Pasricha S.-R., Hayes E., Kalumba K., et al. Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-analysis of randomised controlled trials. Lancet Glob Health 2013, 1(2):e77-e86.
32. Sachdev H., Gera T., Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr 2005, 8(2):117-132.
33. Wang B., Zhan S., Gong T., et al. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database Syst Rev 2013, (6). CD001444.
34. Murray-Kolb L.E., Khatry S.K., Katz J., et al. Preschool micronutrient supplementation effects on intellectual and motor function in school-aged Nepalese children. Arch Pediatr Adolesc Med 2012, 166(5):404-410.
35. Pongcharoen T., DiGirolamo A.M., Ramakrishnan U., et al. Long-term effects of iron and zinc supplementation during infancy on cognitive function at 9 y of age in northeast Thai children: a follow-up study. Am J Clin Nutr 2011, 93(3):636-643.
36. Murray-Kolb L. Iron supplementation in early life and child health. Lancet Glob Health 2013, 1(2):e56-e57.
37. Low M., Farrell A., Biggs B.A., et al. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials. CMAJ 2013, 185(17):E791-E802.
38. Calis J.C., Phiri K.S., Faragher E.B., et al. Severe anemia in Malawian children. N Engl J Med 2008, 358(9):888-899.
39. Menendez C., Kahigwa E., Hirt R., et al. Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 1997, 350(9081):844-850.
40. Drakesmith H., Prentice A.M. Hepcidin and the iron-infection axis. Science 2012, 338(6108):768-772.
41. Murray M.J., Murray A.B., Murray M.B., et al. The adverse effect of iron repletion on the course of certain infections. Br Med J 1978, 2(6145):1113-1115.
42. Prentice A.M., Verhoef H., Cerami C. Iron fortification and malaria risk in children. JAMA 2013, 310(9):914-915.
43. Nemeth E., Valore E.V., Territo M., et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101(7):2461-2463.
44. Armitage A.E., Eddowes L.A., Gileadi U., et al. Hepcidin regulation by innate immune and infectious stimuli. Blood 2011, 118(15):4129-4139.
45. Darton T.C., Blohmke C.J., Giannoulatou E., et al. Rapidly escalating hepcidin and associated serum iron starvation are features of the acute response to typhoid infection in humans. PLoS Negl Trop Dis 2015, 9(9):e0004029.
46. Armitage A.E., Stacey A.R., Giannoulatou E., et al. Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections. Proc Natl Acad Sci U S A 2014, 111(33):12187-12192.
47. Sazawal S., Black R.E., Ramsan M., et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006, 367(9505):133-143.
48. Tielsch J.M., Khatry S.K., Stoltzfus R.J., et al. Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. Lancet 2006, 367(9505):144-152.
49. Pasricha S.R., Atkinson S.H., Armitage A.E., et al. Expression of the iron hormone hepcidin distinguishes different types of anemia in African children. Sci Transl Med 2014, 6(235):235re233.
50. Vanderelst D., Speybroeck N. An adjusted bed net coverage indicator with estimations for 23 African countries. Malar J 2013, 12:457.
51. Zlotkin S., Newton S., Aimone A.M., et al. Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trial. JAMA 2013, 310(9):938-947.
52. Soofi S., Cousens S., Iqbal S.P., et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet 2013, 382(9886):29-40.
53. Yousafzai A.K., Rasheed M.A., Rizvi A., et al. Effect of integrated responsive stimulation and nutrition interventions in the Lady Health Worker programme in Pakistan on child development, growth, and health outcomes: a cluster-randomised factorial effectiveness trial. Lancet 2014, 384(9950):1282-1293.
54. Jonker F.A., Calis J.C., van Hensbroek M.B., et al. Iron status predicts malaria risk in Malawian preschool children. PLoS One 2012, 7(8):e42670.
55. Gwamaka M., Kurtis J.D., Sorensen B.E., et al. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis 2012, 54(8):1137-1144.
56. Hershko C., Gordeuk V.R., Thuma P.E., et al. The antimalarial effect of iron chelators: studies in animal models and in humans with mild falciparum malaria. J Inorg Biochem 1992, 47(3-4):267-277.
57. Clark M.A., Goheen M.M., Fulford A., et al. Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. Nat Commun 2014, 5:4446.
58. Hershko C. Mechanism of iron toxicity. Food Nutr Bull 2007, 28(4 Suppl):S500-S509.
59. Brittenham G.M., Andersson M., Egli I., et al. Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: a randomized study. Am J Clin Nutr 2014, 100(3):813-820.
60. Zimmermann M.B., Chassard C., Rohner F., et al. The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire. Am J Clin Nutr 2010, 92(6):1406-1415.
61. Jaeggi T., Kortman G.A., Moretti D., et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2015, 64(5):731-742.
62. Dostal A., Baumgartner J., Riesen N., et al. Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African children. Br J Nutr 2014, 112(4):547-556.
63. Pasricha S.R., Flecknoe-Brown S.C., Allen K.J., et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med J Aust 2010, 193(9):525-532.
64. Toblli J.E., Cao G., Olivieri L., et al. Comparative study of gastrointestinal tract and liver toxicity of ferrous sulfate, iron amino chelate and iron polymaltose complex in normal rats. Pharmacology 2008, 82(2):127-137.
65. Litovitz T., Manoguerra A. Comparison of pediatric poisoning hazards: an analysis of 3.8 million exposure incidents. A report from the American Association of Poison Control Centers. Pediatrics 1992, 89(6 Pt 1):999-1006.
66. White K.C. Anemia is a poor predictor of iron deficiency among toddlers in the United States: for heme the bell tolls. Pediatrics 2005, 115(2):315-320.
67. Mei Z., Cogswell M.E., Parvanta I., et al. Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials. J Nutr 2005, 135(8):1974-1980.
68. Raiten D.J., Ashour F.A., Ross A.C., et al. Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr 2015, 145(5):1039S-1108S.
69. Garcia-Casal M.N., Peña-Rosas J.P., Pasricha S.-R. Rethinking ferritin cutoffs for iron deficiency and overload. Lancet Haematol 2014, 1(2):e92-e94.
70. Pasricha S.R., Rooney P., Schneider H. Soluble transferrin receptor and depth of bone marrow suppression following high dose chemotherapy. Support Care Cancer 2009, 17(7):847-850.
71. Pasricha S.R., Frazer D.M., Bowden D.K., et al. Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with beta-thalassemia major: a longitudinal study. Blood 2013, 122(1):124-133.
72. Suominen P., Punnonen K., Rajamaki A., et al. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 1998, 92(8):2934-2939.
73. World Health Organization, Centers for Disease Control and Prevention Assessing the iron status of populations: including literature reviews. Report of a Joint World Health Organization/Centers for Disease Control and Prevention technical consultation on the assessment of iron status at the population level, Geneva, Switzerland, 6-8 April 2004 2007, World Health Organization/Centers for Disease Control and Prevention, Geneva (Switzerland).
74. Ganz T. Systemic iron homeostasis. Physiol Rev 2013, 93(4):1721-1741.
75. Kautz L., Jung G., Valore E.V., et al. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet 2014, 46(7):678-684.
76. Choi H.S., Song S.H., Lee J.H., et al. Serum hepcidin levels and iron parameters in children with iron deficiency. Korean J Hematol 2012, 47(4):286-292.
77. Pasricha S.R., McQuilten Z., Westerman M., et al. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 2011, 96(8):1099-1105.
78. Pereira D.I., Bruggraber S.F., Faria N., et al. Nanoparticulate iron (III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans. Nanomedicine 2014, 10(8):1877-1886.