Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits

Blood

Volumn 92, Issue 8, 1998, Pages 2934-2939

  Suominen, Pauli ^a   Punnonen, Kari ^b   Rajamäki, Allan ^b   Irjala, Kerttu ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; FERROUS SULFATE; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; DIET SUPPLEMENTATION; ERYTHROPOIESIS; FEMALE; HUMAN; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; PREVENTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; TREATMENT OUTCOME;

EID: 0032532635     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.8.2934.420k07_2934_2939     Document Type: Article

References (48)

1. Dallman PR, Siimes MA, Stekel A: Iron deficiency in infancy and childhood. Am J Clin Nutr 33:86, 1980
2. Expert Scientific Working Group: Summary of a report on assessment of the iron nutritional status of the United States population. Am J Clin Nutr 42:1318, 1985
3. Dallman PR, Yip R: Changing characteristics of childhood anemia (special article). J Pediatr 114:161, 1989
4. Hallberg L, Hulten L, Lindstedt G, Lundberg P-A, Mark A, Purens J, Svanberg B, Swolin B: Prevalence of iron deficiency in Swedish adolescents. Pediatr Res 34:680, 1993
5. Hallberg L, Bengtsson C, Lapidus L, Lindstedt G, Lundberg P-A, Hulten L: Screening for iron deficiency: An analysis based on bonemarrow examinations and serum ferritin determinations in a population sample of women. Br J Haematol 85:787, 1993
6. Holyoake TL, Stott DJ, McKay PJ, Hendry A, MacDonald JB, Lucie NP: Use of plasma ferritin concentration to diagnose iron deficiency in elderly patients. J Clin Pathol 46:857, 1993
7. Withold W, Neumayer C, Beyrau R, Heins M, Schauseil S, Rick W: Efficacy of transferrin determination in human sera in the diagnosis of iron deficiency. Eur J Clin Chem Clin Biochem 32:19, 1994
8. Bruner A, Joffe A, Duggan A, Casella J, Brandt J: Randomised study of cognitive effects of iron supplementation in non-anemic iron-deficient adolescent girls. Lancet 348:992, 1996
9. Bonkovsky H, Ponka P, Bacon B, Drysdale J, Grace N, Tavill A: An update on iron metabolism: Summary of the Fifth International Conference on Disorders of Iron Metabolism. Hepatology 24:718, 1996
10. Cook JD, Finch CA: Assessing iron status of a population. Am J Clin Nutr 32:2115, 1979
11. Cook JD: Clinical evaluation of iron deficiency. Semin Hematol 19:6, 1982
12. Hastka J, Lasserre J-J, Schwarzbeck A, Reiter A, Hehlmann R: Laboratory tests of iron status: Correlation or common sense? Clin Chem 42:718, 1996
13. Brittenham GM: Disorders of iron metabolism: Iron deficiency and iron overload, in Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE (eds): Hematology, Basic Principles and Practice (ed 2). New York, NY, Churchill Livingstone, 1995, p 492
14. Skikne BS, Flowers CH, Cook JD: Serum transferrin receptor: A quantitative measure of tissue iron deficiency. Blood 75:1870, 1990
15. Baynes RD: Refining the assessment of body iron status (editorial). Am J Clin Nutr 64:793, 1996
16. Punnonen K, Irjala K, Rajamäki A: Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89:1052, 1997
17. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD: Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 119:385, 1992
18. Punnonen K, Irjala K, Rajamäki A: Iron deficiency anemia is associated with high serum levels of transferrin receptor. Clin Chem 40:774, 1994
19. Suominen P, Punnonen K, Rajamäki A, Irjala K: The evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients. Clin Chem 43:1641, 1997
20. Flowers CH, Skikne BS, Covell AM, Cook JD: The clinical measurement of serum transferrin receptor. J Lab Clin Med 114:368, 1989
21. Sohlberg HE: Approved recommendation (1986) on the theory of reference values. Part 1. The concept of reference values. J Clin Chem Clin Biochem 25:337, 1987
22. National Committee for Clinical Laboratory Standards: How to define and determine reference intervals in the clinical laboratory; Approved guideline. National Committee for Clinical Laboratory Standards Document C28-A 15:15, 1995
23. Garby L, Irnell L, Werner I: Iron deficiency in women of fertile age in a Swedish community. Acta Med Scand 185:113, 1969
24. van Zeben D, Bieger R, van Wermeskerken RKA, Castel A, Hermans J: Evaluation of microcytosis using serum ferritin and red blood cell distribution width. Eur J Haematol 44:105, 1990
25. Baynes RD: Assessment of iron status (review). Clin Biochem 29:209, 1996
26. Huebers HA, Finch CA: The physiology of transferrin and transferrin receptors. Physiol Rev 67:520, 1987
27. Kairisto V, Poola A: Software for illustrative presentation of basic clinical characteristics of laboratory tests - GraphROC for Windows. Scand J Clin Lab Invest Suppl 222:43, 1995
28. Guyatt GH, Oxman AD, Mahmoud A, Willan A, McIlroy W: Laboratory diagnosis of iron deficiency anemia: An overview. J Gen Intern Med 7:145, 1992
29. Cook JD, Lynch SR: The liabilities of iron deficiency (review). Blood 68:803, 1986
30. Lee RG: Iron deficiency and iron-deficiency anemia, in Lee RG, Bithell TC, Foerster J, Athens JW, Lukens JN (eds): Wintrobe's Clinical Hematology, (vol 1, ed 9). Philadelphia, PA, Lea & Febiger, 1993, p 808
31. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA: Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 75:102, 1990
32. Cook JD, Lipschitz DA, Laughton EMM, Finch CA: Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 27:681, 1974
33. Looker AC, Gunter EW, Cook JD, Green R, Harris JW: Comparing serum ferritin values from different population surveys. Vital Health Stat 2 111:1, 1991
34. Vicente C, Porto G, de Sousa M: Method for establishing serum ferritin reference values depending on sex and age. Clin Med 116:779, 1990
35. Wheby MS: Effect of iron therapy on serum ferritin levels in iron-deficiency anemia. Blood 56:138, 1980
36. Simmons WK, Cook JD, Bingham KC, Thomas M, Jackson J, Jackson M, Ahluwalia N, Kahn SG, Patterson AW: Evaluation of a gastric delivery system for iron supplementation in pregnancy. Am J Clin Nutr 58:622, 1993
37. Cavill I, Jacobs A, Worwood, M: Diagnostic methods for iron status (review). Ann Clin Biochem 23:168, 1986
38. Blake DR, Waterworth RF, Bacon PA: Assessment of iron stores in inflammation by assays of serum ferritin concentrations. BMJ 283:1147, 1981
39. Burns ER, Goldberg NS, Lawrence C, Wenz B: Clinical utility of serum tests for iron deficiency in hospitalized patients. Am J Clin Pathol 93:240, 1990
40. Coenen JLLM, van Dieijen-Visser MP, van Pelt J, van Deursen CTBM, Fickers MMF, van Wersch JWJ, Brombacher PJ: Measurement of serum ferritin used to predict concentrations of iron in bone marrow in anemia of chronic disease. Clin Chem 37:560, 1991
41. Witte DL, Angstadt DS, Davis SH, Schrantz RD: Predicting bone marrow iron stores in anemic patients in a community hospital using ferritin and erythrocyte sedimentation rate. Am J Clin Pathol 90:85, 1988
42. Kurer SB, Seifert B, Michel B, Ruegg R, Fehr J: Prediction of iron deficiency in chronic inflammatory rheumatic disease anemia. Br J Haematol 91:820, 1995
43. Porter DR, Sturrock RD, Capell HA: The use of serum ferritin estimation in the investigation of anemia in patients with rheumatoid arthritis. Clin Exp Rheumatol 12:179, 1994
44. Konijn AM, Hershko C: Ferritin synthesis in inflammation. Br J Haematol 37:7, 1977
45. Cooper MJ, Zlotkin SH: Day-to-day variation of transferrin receptor and ferritin in healthy men and women. Am J Clin Nutr 64:738, 1996
46. Cook JD, Skikne BS, Baynes RD: Serum transferrin receptor. Annu Rev Med 44:63, 1993
47. Tietz NW, Rinker AD, Morrison SR: When is a serum iron really a serum iron? The status of serum iron measurements. Clin Chem 40:546, 1994
48. Borel MJ, Smith SM, Derr J, Beard JL: Day-to-day variation in iron-status indices in healthy men and women. Am J Clin Nutr 54:729, 1991