Autophagy constitutes a protective mechanism against ethanol toxicity in mouse astrocytes and neurons

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Pla, Antoni ^a   Pascual, Maria ^a   Guerri, Consuelo ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AUTOPHAGY PROTEIN 12; BECLIN 1; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PEPTIDES AND PROTEINS; PROTEIN CTSB; PROTEIN LC3 II; PROTEIN ULK1; UNCLASSIFIED DRUG; MTOR PROTEIN, MOUSE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOPHAGY; AUTOPHAGY LYSOSOME PATHWAY; CELL COUNT; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FETUS; IN VITRO STUDY; LYSOSOME; MALE; MOUSE; NERVE CELL; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIMARY CELL CULTURE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ASTROCYTES; AUTOPHAGY; BRAIN; CELLS, CULTURED; DOWN-REGULATION; ETHANOL; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; NECROSIS; NEURONS; SIGNAL TRANSDUCTION; SIROLIMUS; TOLL-LIKE RECEPTOR 4; TOR SERINE-THREONINE KINASES;

EID: 84963541664     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0153097     Document Type: Article

References (48)

1. Nikoletopoulou V, Papandreou ME, Tavernarakis N (2015) Autophagy in the physiology and pathology of the central nervous system. Cell Death Differ 22: 398-407. cdd2014204 [pii] doi: 10.1038/cdd.2014. 204 PMID: 25526091
2. Xilouri M, Stefanis L (2010) Autophagy in the central nervous system: Implications for neurodegenerative disorders. CNS Neurol Disord Drug Targets 9: 701-719. BSP/CDTCNSND/E-Pub/00079 [pii]. PMID: 20942791
3. Levine B, Mizushima N, Virgin HW (2011) Autophagy in immunity and inflammation. Nature 469: 323-335. nature09782 [pii] doi: 10.1038/nature09782 PMID: 21248839
4. Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90: 313-323. S0300-9084(07)00228-3 [pii] doi: 10.1016/j. biochi.2007.08.014 PMID: 17928127
5. Pla A, Pascual M, Renau-Piqueras J, Guerri C (2014) TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain. Cell Death Dis 5: E1066. cddis201446 [pii] doi: 10.1038/cddis.2014.46 PMID: 24556681
6. Hayes DM, Deeny MA, Shaner CA, Nixon K (2013) Determining the threshold for alcohol-induced brain damage: New evidence with gliosis markers. Alcohol Clin Exp Res 37: 425-434. doi: 10.1111/j.1530-0277.2012.01955.x PMID: 23347220
7. Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I, Guerri C (2010) Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J Neurosci 30: 8285-8295. 30/24/8285 [pii] doi: 10.1523/JNEUROSCI.0976-10.2010 PMID: 20554880
8. Alfonso-Loeches S, Pascual M, Gomez-Pinedo U, Pascual-Lucas M, Renau-Piqueras J, Guerri C (2012) Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse. Glia 60: 948-964. doi: 10.1002/glia.22327 PMID: 22431236
9. Kramer S, Wang-Rosenke Y, Scholl V, Binder E, Loof T, Khadzhynov D et al. (2008) Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat. Am J Physiol Renal Physiol 294: F440-F449. 00379.2007 [pii] doi: 10.1152/ajprenal.00379.2007 PMID: 18094032
10. von Haefen C, Sifringer M, Menk M, Spies CD (2011) Ethanol enhances susceptibility to apoptotic cell death via down-regulation of autophagy-related proteins. Alcohol Clin Exp Res 35: 1381-1391. doi: 10.1111/j.1530-0277.2011.01473.x PMID: 21410490
11. Wu D, Wang X, Zhou R, Yang L, Cederbaum AI (2012) Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy. Free Radic Biol Med 53: 1346-1357. S0891-5849(12)00400-5 [pii] doi: 10.1016/j.freeradbiomed.2012.07.005 PMID: 22819980
12. Luo J (2014) Autophagy and ethanol neurotoxicity. Autophagy 10: 2099-2108. doi: 10.4161/15548627.2014.981916 PMID: 25484085
13. Pascual-Lucas M, Fernandez-Lizarbe S, Montesinos J, Guerri C (2014) LPS or ethanol triggers clathrin-and rafts/caveolae-dependent endocytosis of TLR4 in cortical astrocytes. J Neurochem 129: 448-462. doi: 10.1111/jnc.12639 PMID: 24345077
14. Janen SB, Chaachouay H, Richter-Landsberg C (2010) Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes. Glia 58: 1766-1774. doi: 10.1002/glia.21047 PMID: 20645412
15. Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA (2014) WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell 55: 238-252. S1097-2765(14)00444-4 [pii] doi: 10.1016/j.molcel.2014.05.021 PMID: 24954904
16. Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H et al. (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282: 24131-24145. M702824200 [pii] doi: 10.1074/jbc.M702824200 PMID: 17580304
17. Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3: 542-545. 4600 [pii]. PMID: 17611390
18. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo AA et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222. doi: 10.1080/15548627.2015.1100356 PMID: 26799652
19. Eskelinen EL (2005) Maturation of autophagic vacuoles in Mammalian cells. Autophagy 1: 1-10. 1270 [pii]. PMID: 16874026
20. Ramachandran N, Munteanu I, Wang P, Aubourg P, Rilstone JJ, Israelian N et al. (2009) VMA21 deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification. Cell 137: 235-246. S0092-8674(09)00155-X [pii] doi: 10.1016/j.cell.2009.01.054 PMID: 19379691
21. Vidal-Donet JM, Carcel-Trullols J, Casanova B, Aguado C, Knecht E (2013) Alterations in ROS activity and lysosomal pH account for distinct patterns of macroautophagy in LINCL and JNCL fibroblasts. PLoS One 8: E55526. doi: 10.1371/journal.pone.0055526 PONE-D-12-26637 [pii]. PMID: 23408996
22. Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248. S009286740401150X [pii] doi: 10.1016/j.cell.2004.11.046 PMID: 15680329
23. Wang X, Michaelis EK (2010) Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2:12. doi: 10.3389/fnagi.2010.00012 PMID: 20552050
24. Buchanan MM, Hutchinson M, Watkins LR, Yin H (2010) Toll-like receptor 4 in CNS pathologies. J Neurochem 114: 13-27. JNC6736 [pii] doi: 10.1111/j.1471-4159.2010.06736.x PMID: 20402965
25. Okun E, Griffioen KJ, Mattson MP (2011) Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci 34: 269-281. S0166-2236(11)00021-X [pii] doi: 10.1016/j.tins.2011.02.005 PMID: 21419501
26. Blanco AM, Valles SL, Pascual M, Guerri C (2005) Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J Immunol 175: 6893-6899. 175/10/6893 [pii]. PMID: 16272348
27. Fernandez-Lizarbe S, Pascual M, Guerri C (2009) Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol 183: 4733-4744. jimmunol.0803590 [pii] doi: 10.4049/jimmunol.0803590 PMID: 19752239
28. Donohue TM Jr (2009) Autophagy and ethanol-induced liver injury. World J Gastroenterol 15: 1178-1185. PMID: 19291817
29. Rautou PE, Mansouri A, Lebrec D, Durand F, Valla D, Moreau R (2010) Autophagy in liver diseases. J Hepatol 53: 1123-1134. S0168-8278(10)00693-8 [pii] doi: 10.1016/j.jhep.2010.07.006 PMID: 20810185
30. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y et al. (2012) Autophagy is a protective response to ethanol neurotoxicity. Autophagy 8: 1577-1589. 21376 [pii] doi: 10.4161/auto.21376 PMID: 22874567
31. Ding WX, Li M, Chen X, Ni HM, Lin CW, GaoWet al. (2010) Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 139: 1740-1752. S0016-5085(10)01104-2 [pii] doi: 10.1053/j.gastro.2010.07.041 PMID: 20659474
32. Eid N, Ito Y, Otsuki Y (2015) Ethanol-induced hepatic autophagy: Friend or foe? World J Hepatol 7: 1154-1156. doi: 10.4254/wjh.v7.i9.1154 PMID: 26019731
33. Kaur J, Debnath J (2015) Autophagy at the crossroads of catabolism and anabolism. Nat Rev Mol Cell Biol 16: 461-472. nrm4024 [pii] doi: 10.1038/nrm4024 PMID: 26177004
34. Zhang J, Cao R, Cai T, Aschner M, Zhao F, Yao T et al. (2013) The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration. Neurotox Res. doi: 10.1007/s12640-013-9392-5
35. Mazan-Mamczarz K, Peroutka RJ, Steinhardt JJ, Gidoni M, Zhang Y, Lehrmann E et al. (2015) Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma. Cell Commun Signal 13:15. s12964-015-0091-0 [pii] doi: 10.1186/s12964-015-0091-0 PMID: 25849580
36. Ding WX, Li M, Yin XM (2011) Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets. Autophagy 7: 248-249. 14347 [pii]. PMID: 21150309
37. Delgado MA, Elmaoued RA, Davis AS, Kyei G, Deretic V (2008) Toll-like receptors control autophagy. EMBO J 27: 1110-1121. emboj200831 [pii] doi: 10.1038/emboj.2008.31 PMID: 18337753
38. Shi CS, Kehrl JH (2010) Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1. Autophagy 6: 986-987. 13288 [pii] doi: 10.4161/auto.6.7.13288 PMID: 20798608
39. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT (2007) Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27: 135-144. S1074-7613(07)00336-6 [pii] doi: 10.1016/j.immuni.2007.05.022 PMID: 17658277
40. Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40: 280-293. S1097-2765(10)00751-3 [pii] doi: 10.1016/j.molcel.2010.09.023 PMID: 20965422
41. Galluzzi L, Vicencio JM, Kepp O, Tasdemir E, Maiuri MC, Kroemer G (2008) To die or not to die: That is the autophagic question. Curr Mol Med 8: 78-91. PMID: 18336289
42. Lindqvist LM, Vaux DL (2014) BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy 10: 1474-1475. 29639 [pii] doi: 10.4161/auto.29639 PMID: 24991825
43. Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA et al. (2015) Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death Differ 22: 433-444. cdd2014151 [pii] doi: 10.1038/cdd.2014.151 PMID: 25257175
44. Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC (2014) Autophagy defends pancreatic beta cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest 124: 3489-3500. 71981 [pii] doi: 10.1172/JCI71981 PMID: 25036708
45. Frake RA, Ricketts T, Menzies FM, Rubinsztein DC (2015) Autophagy and neurodegeneration. J Clin Invest 125: 65-74. 73944 [pii] doi: 10.1172/JCI73944 PMID: 25654552
46. Giordano S, Darley-Usmar V, Zhang J (2014) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol 2: 82-90. doi: 10.1016/j.redox.2013.12.013 S2213-2317 (13)00101-8 [pii]. PMID: 24494187
47. Barres BA, Barde Y (2000) Neuronal and glial cell biology. Curr Opin Neurobiol 10: 642-648. S0959438800001343 [pii]. PMID: 11084327
48. Tydlacka S, Wang CE, Wang X, Li S, Li XJ (2008) Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J Neurosci 28: 13285-13295. 28/49/13285 [pii] doi: 10.1523/JNEUROSCI.4393-08.2008 PMID: 19052220