Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse

GLIA

Volumn 60, Issue 6, 2012, Pages 948-964

  Alfonso Loeches, Silvia ^a   Pascual, Maria ^a   Gómez Pinedo, Ulises ^b   Pascual Lucas, Maya ^a   Renau Piqueras, Jaime ^c   Guerri, Consuelo ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Demyelination; Ethanol intake; Live imaging; Myelin proteins; Neuronal damage; TLR4 receptors

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ALCOHOL; CASPASE 3; CHONDROITIN SULFATE; MYELIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEOLIPID PROTEIN; TOLL LIKE RECEPTOR 4;

ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CORPUS CALLOSUM; DOWN REGULATION; ELECTRON MICROSCOPE; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; MYELIN SHEATH; MYELINATION; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN STRUCTURE; WHITE MATTER; WILD TYPE;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ALCOHOLISM; ANIMALS; ANTIGENS; CASPASE 3; CELL DEATH; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; GENE EXPRESSION REGULATION; INDOLES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MYELIN PROTEINS; MYELIN SHEATH; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; ORGANIC CHEMICALS; PROTEOGLYCANS; TOLL-LIKE RECEPTOR 4;

EID: 84859702166     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22327     Document Type: Article

References (53)

1. Akira S, Takeda K. 2004. Functions of toll-like receptors: Lessons from KO mice. C R Biol 327: 581-589.
2. Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I, Guerri C. 2010. Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J Neurosci 30: 8285-8295.
3. Back SA, Tuohy TM, Chen H, Wallingford N, Craig A, Struve J, Luo NL, Banine F, Liu Y, Chang A, Trapp BD, Bebo BFJr, Rao MS, Sherman LS. 2005. Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med 11: 966-972.
4. Blanco AM, Valles SL, Pascual M, Guerri C. 2005. Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. JImmunol 175: 6893-6899.
5. Caldwell LC, Schweinsburg AD, Nagel BJ, Barlett VC, Brown SA, Tapert SF. 2005. Gender and adolescent alcohol use disorders on BOLD (blood oxygen level dependent) response to spatial working memory. Alcohol Alcohol 40: 194-200.
6. Casella GT, Bunge MB, Wood PM. 2004. Improved immunocytochemical identification of neural, endothelial, and inflammatory cell types in paraffin-embedded injured adult rat spinal cord. J Neurosci Methods 139: 1-11.
7. Chang A, Nishiyama A, Peterson J, Prineas J, Trapp BD. 2000. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 20: 6404-6412.
8. Damjanac M, Rioux Bilan A, Barrier L, Pontcharraud R, Anne C, Hugon J, Page G. 2007. Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Brain Res 1128: 40-49.
9. de la Monte SM. 1988. Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch Neurol 45: 990-992.
10. Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL. 2009. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol 10: 958-964.
11. Felts PA, Woolston AM, Fernando HB, Asquith S, Gregson NA, Mizzi OJ, Smith KJ. 2005. Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide. Brain 128(Part 7): 1649-1666.
12. Fernandez-Lizarbe S, Pascual M, Guerri C. 2009. Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol 183: 4733-4744.
13. Girolamo F, Ferrara G, Strippoli M, Rizzi M, Errede M, Trojano M, Perris R, Roncali L, Svelto M, Mennini T, Virgintino D. 2011. Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis. Neurobiol Dis 43: 678-689.
14. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. 2010. Mechanisms underlying inflammation in neurodegeneration. Cell 140: 918-934.
15. Greer JM, Lees MB. 2002. Myelin proteolipid protein-The first 50 years. Int J Biochem Cell Biol 34: 211-215.
16. Harper C, Matsumoto I. 2005. Ethanol and brain damage. Curr Opin Pharmacol 5: 73-78.
17. Irving EA, Bentley DL, Parsons AA. 2001. Assessment of white matter injury following prolonged focal cerebral ischaemia in the rat. Acta Neuropathol 102: 627-635.
18. Kadhim H, De Prez C, Gazagnes MD, Sebire G. 2003. In situ cytokine immune responses in acute disseminated encephalomyelitis: Insights into pathophysiologic mechanisms. Hum Pathol 34: 293-297.
19. Kang SH, Fukaya M, Yang JK, Rothstein JD, Bergles DE. 2010. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 68: 668-681.
20. Kril JJ, Halliday GM, Svoboda MD, Cartwright H. 1997. The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79: 983-998.
21. Ledeen RW, Chakraborty G. 1998. Cytokines, signal transduction, and inflammatory demyelination: Review and hypothesis. Neurochem Res 23: 277-289.
22. Lee SR, Tsuji K, Lee SR, Lo EH. 2004. Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J Neurosci 24: 671-678.
23. Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T. 2002. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22: 2478-2486.
24. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA. 2000. Gene expression in human alcoholism: Microarray analysis of frontal cortex. Alcohol Clin Exp Res 24: 1873-1882.
25. Lewohl JM, Wixey J, Harper CG, Dodd PR. 2005. Expression of MBP, PLP, MAG, CNP, and GFAP in the human alcoholic brain. Alcohol Clin Exp Res 29: 1698-1705.
26. Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, Mayfield RD. 2006. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31: 1574-1582.
27. Marta M, Meier UC, Lobell A. 2009. Regulation of autoimmune encephalomyelitis by toll-like receptors. Autoimmun Rev 8: 506-509.
28. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA. 2002. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81: 802-813.
29. Nishiyama A, Komitova M, Suzuki R, Zhu X. 2009. Polydendrocytes (NG2 cells): Multifunctional cells with lineage plasticity. Nat Rev Neurosci 10: 9-22.
30. Nyati KK, Prasad KN, Verma A, Singh AK, Rizwan A, Sinha S, Paliwal VK, Pradhan S. 2010. Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barre syndrome in Northern Indian population. J Neuroimmunol 218: 116-119.
31. Okamoto H, Miki T, Lee KY, Yokoyama T, Kuma H, Wang ZY, Gu H, Li HP, Matsumoto Y, Irawan S, Bedi KS, Nakamura Y, Takeuchi Y. 2006. Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption. Neurosci Lett 406: 76-80.
32. Ooigawa H, Nawashiro H, Fukui S, Otani N, Osumi A, Toyooka T, Shima K. 2006. The fate of Nissl-stained dark neurons followingtraumatic brain injury in rats: Difference between neocortex and hippocampus regarding survival rate. Acta Neuropathol 112: 471-481.
33. Pascual M, Balino P, Alfonso-Loeches S, Aragon CM, Guerri C. 2011. Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage. Brain Behav Immun 25( Suppl 1): S80-S91.
34. Paula-Barbosa MM, Tavares MA. 1985. Long term alcohol consumption induces microtubular changes in the adult rat cerebellar cortex. Brain Res 339: 195-199.
35. Peterson LK, Fujinami RS. 2007. Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. J Neuroimmunol 184: 37-44.
36. Pfefferbaum A, Adalsteinsson E, Sullivan EV. 2006a. Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism. Neurobiol Aging 27: 994-1009.
37. Pfefferbaum A, Adalsteinsson E, Sullivan EV. 2006b. Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women. Biol Psychiatry 59: 364-372.
38. Pfefferbaum A, Rosenbloom M, Deshmukh A, Sullivan E. 2001. Sex differences in the effects of alcohol on brain structure. Am J Psychiatry 158: 188-197.
39. Pfefferbaum A, Rosenbloom MJ, Fama R, Sassoon SA, Sullivan EV. 2010. Transcallosal white matter degradation detected with quantitative fiber tracking in alcoholic men and women: Selective relations to dissociable functions. Alcohol Clin Exp Res 34: 1201-1211.
40. Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT. 2008. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation 5: 10.
41. Reed MG, Howard CV. 1998. Surface-weighted star volume: Concept and estimation. J Microsc 190(Part 3): 350-356.
42. Romero AM, Esteban-Pretel G, Marin MP, Ponsoda X, Ballestin R, Canales JJ, Renau-Piqueras J. 2010. Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary culture. Toxicol Sci 118: 602-612.
43. Schmued LC, Hopkins KJ. 2000. Fluoro-Jade B: A high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874: 123-130.
44. Schroder K, Tschopp J. 2010. The inflammasomes. Cell 140: 821-832.
45. Schulte T, Muller-Oehring EM, Pfefferbaum A, Sullivan EV. 2010. Neurocircuitry of emotion and cognition in alcoholism: Contributions from white matter fiber tractography. Dialogues Clin Neurosci 12: 554-560.
46. Schweinsburg BC, Alhassoon OM, Taylor MJ, Gonzalez R, Videen JS, Brown GG, Patterson TL, Grant I. 2003. Effects of alcoholism and gender on brain metabolism. Am J Psychiatry 160: 1180-1183.
47. Shi SR, Cote RJ, Taylor CR. 2001. Antigen retrieval techniques: Current perspectives. J Histochem Cytochem 49: 931-937.
48. Skundric DS, Dai R, Zakarian VL, Zhou W. 2008. Autoimmune-induced preferential depletion of myelin-associated glycoprotein (MAG) is genetically regulated in relapsing EAE (B6 x SJL) F1 mice. Mol Neurodegener 3: 7.
49. Sloane JA, Batt C, Ma Y, Harris ZM, Trapp B, Vartanian T. 2010. Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci USA 107: 11555-11560.
50. Valles SL, Blanco AM, Pascual M, Guerri C. 2004. Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol 14: 365-371.
51. Wang JJ, Durazzo TC, Gazdzinski S, Yeh PH, Mon A, Meyerhoff DJ. 2009. MRSI and DTI: A multimodal approach for improved detection of white matter abnormalities in alcohol and nicotine dependence. NMR Biomed 22: 516-522.
52. Wang L, Andersson S, Warner M, Gustafsson JA. 2001. Morphological abnormalities in the brains of estrogen receptor beta knockout mice. Proc Natl Acad Sci USA 98: 2792-2796.
53. Wu YJ, Tang YF, Xiao ZC, Bao ZM, He BP. 2008. NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression. Mol Neurodegener 3: 18.