Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

GLIA

Volumn 58, Issue 14, 2010, Pages 1766-1774

  Jänen, Sven B ^a   Chaachouay, Hassan ^a   Richter Landsberg, Christiane ^a  

^a UNIVERSITY OF OLDENBURG   (Germany)

Author keywords

Glial cells; Heat shock proteins; Macroautophagy; Rapamycin; Ubiquitin

Indexed keywords

3 METHYLADENINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; HEAT SHOCK PROTEIN 25; PROTEASOME INHIBITOR; RAPAMYCIN;

AGGRESOME; ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOPHAGY; CELL METABOLISM; CELL STRESS; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOSKELETON; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; UBIQUITINATION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; AUTOPHAGY; CELL AGGREGATION; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; CYTOSKELETON; INCLUSION BODIES; LEUPEPTINS; NEURODEGENERATIVE DISEASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, WISTAR;

EID: 78349276861     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.21047     Document Type: Article

References (45)

1. Bauer NG, Richter-Landsberg C. 2006. The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress. J Mol Neurosci 29: 153-168.
2. Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, et al. 2006. Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet 15: 433-442.
3. Boland B, Nixon RA. 2006. Neuronal macroautophagy: From development to degeneration. Mol Aspects Med 27(5-6): 503-519.
4. Bolhuis S, Richter-Landsberg C. 2010. Effect of proteasome inhibition by MG-132 on HSP27 oligomerization, phosphorylation, and aggresome formation in the OLN-93 oligodendroglia cell line. J Neurochem 10.111/j, 1471-4159.2010.06600.x.
5. Chin SS, Goldman JE. 1996. Glial inclusions in CNS degenerative diseases. J Neuropathol Exp Neurol 55: 499-508.
6. Ciechanover A, Brundin P. 2003. The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg. Neuron 40: 427-446.
7. Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, Yin XM. 2007. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 171: 513-524.
8. Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H. 2003. Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci USA 100: 721-726.
9. Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. 2009. Life and death partners: Apoptosis, autophagy and the cross-talk between them. Cell Death Differ 16: 966-975.
10. Forman MS, Trojanowski JQ, Lee VM. 2004. Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 10: 1055-1063.
11. Garcia-Mata R, Bebok Z, Sorscher EJ, Sztul ES. 1999. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J Cell Biol 146: 1239-1254.
12. Goldbaum O, Richter-Landsberg C. 2004. Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture. J Neurosci 24: 5748-5757.
13. Goldbaum O, Riedel M, Stahnke T, Richter-Landsberg C. 2009. The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition. Glia 57: 1566-1577.
14. Goldbaum O, Vollmer G, Richter-Landsberg C. 2006. Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes. Glia 53: 891-901.
15. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889.
16. Jellinger KA. 2009. Recent advances in our understanding of neurodegeneration. J Neural Transm 116: 1111-1162.
17. Johnston JA, Ward CL, Kopito RR. 1998. Aggresomes: A cellular response to misfolded proteins. J Cell Biol 143: 1883-1898.
18. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
19. Keller JN, Gee J, Ding Q. 2002. The proteasome in brainaging. Ageing Res Rev 1: 279-293.
20. Kiselyov K, Jennigs JJJr, Rbaibi Y, Chu CT. 2007. Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy 3: 259-262.
21. Klionsky DJ. 2007. Autophagy: From phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8: 931-937.
22. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, et al. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
23. Kopito RR. 2000. Aggresomes, inclusion bodies and proteinaggregation. Trends Cell Biol 10: 524-530.
24. Lee DH, Goldberg AL. 1998. Proteasome inhibitors cause induction of heat shock proteins and trehalose, which together confer thermotolerance in Saccharomyces cerevisiae. Mol Cell Biol 18: 30-38.
25. Levine B, Klionsky DJ. 2004. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477.
26. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. 2007. Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752.
27. Martinez-Vicente M, Cuervo AM. 2007. Autophagy and neurodegeneration: When the cleaning crew goes on strike. Lancet Neurol 6: 352-361.
28. Miller DW, Cookson MR, Dickson DW. 2004. Glial cell inclusions and the pathogenesis of neurodegenerative diseases. Neuron Glia Biol 1: 13-21.
29. Mizushima N, Yoshimori T. 2007. How to interpret LC3 immunoblotting. Autophagy 3: 542-545.
30. Muchowski PJ, Wacker JL. 2005. Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci 6: 11-22.
31. Neuhoff V, Philipp K, Zimmer HG, Mesecke S. 1979. A simple, versatile, sensitive and volume-independent method for quantitative protein determination which is independent of other external influences. Hoppe Seylers Z Physiol Chem 360: 1657-1670.
32. Nixon RA. 2006. Autophagy in neurodegenerative disease: Friend, foe or turncoat? Trends Neurosci 29: 528-535.
33. Noda T, Fujita N, Yoshimori T. 2009. The late stages of autophagy: how does the end begin? Cell Death Differ 16: 984-990.
34. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, et al. 2007. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447: 859-863.
35. Quinlan RA, Brenner M, Goldman JE, Messing A. 2007. GFAP and its role in Alexander disease. Exp Cell Res 313: 2077-2087.
36. Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC. 2006. Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet 15: 1209-1216.
37. Richter-Landsberg C, Bauer NG. 2004. Tau-inclusion body formation in oligodendroglia: The role of stress proteins and proteasome inhibition. Int J Dev Neurosci 22: 443-451.
38. Richter-Landsberg C, Vollgraf U. 1998. Mode of cell injury and death after hydrogenperoxide exposure in cultured oligodendroglia cells. Exp Cell Res 244: 218-229.
39. Riedel M, Goldbaum O, Schwarz L, Schmitt S, Richter-Landsberg C. 2010. 17-AAG induces cytoplasmic α-synuclein aggregate clearance by induction of autophagy. Plos One 5: e8753.
40. Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. 2007. Potential therapeutic applications of autophagy. Nat Rev Drug Discov 6: 304-312.
41. Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. 2009. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ 16: 46-56.
42. Sherman MY, Goldberg AL. 2001. Cellular defenses against unfolded proteins: A cellbiologist thinks about neurodegenerative diseases. Neuron 29: 15-32.
43. Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE. 2008. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet 17: 1540-1555.
44. Taylor JP, Tanaka F, Robitschek J, Sandoval CM, Taye A, Markovic-Plese S, Fischbeck KH. 2003. Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Hum Mol Genet 12: 749-757.
45. Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC. 2006. Aggregate-prone proteins are cleared from the cytosol by autophagy: Therapeutic implications. Curr Top Dev Biol 76: 89-101.