The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis

Journal of Molecular Medicine

Volumn 94, Issue 7, 2016, Pages 771-785

  Ji, Quanbo ^a   Xu, Xiaojie ^b   Zhang, Qiang ^a,c   Kang, Lei ^d   Xu, Yameng ^e   Zhang, Ke ^f   Li, Ling ^b   Liang, Yingchun ^b   Hong, Tian ^b   Ye, Qinong ^b   Wang, Yan ^a  

^a Chinese Peoples Liberation Army General Hospital   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^d PEKING UNIVERSITY FIRST HOSPITAL   (China)

^e XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

ADAMTS 5; AP 1; IL 1 ; miR 30a; Osteoarthritis

Indexed keywords

AGGRECANASE 2; INTERLEUKIN 1BETA; MICRORNA; MICRORNA 30A; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; ADAMTS5 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; MIRN30 MICRORNA, HUMAN; STRESS ACTIVATED PROTEIN KINASE;

3' UNTRANSLATED REGION; AGED; ARTICLE; BIOINFORMATICS; CARTILAGE CELL; CARTILAGE MATRIX; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE BINDING SITE; OSTEOARTHRITIS; PATHOGENESIS; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ARTICULAR CARTILAGE; BINDING SITE; BIOLOGY; CHONDROCYTE; GENE EXPRESSION REGULATION; GENETICS; KNEE; KNEE OSTEOARTHRITIS; KNEE REPLACEMENT; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; PRIMARY CELL CULTURE;

3' UNTRANSLATED REGIONS; ADAMTS5 PROTEIN; AGED; ARTHROPLASTY, REPLACEMENT, KNEE; BASE SEQUENCE; BINDING SITES; CARTILAGE, ARTICULAR; CHONDROCYTES; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KNEE JOINT; MALE; MICRORNAS; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84962821190     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1418-z     Document Type: Article

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