Cytokines as biochemical markers for knee osteoarthritis

World Journal of Orthopedics

Volumn 6, Issue 1, 2015, Pages 95-105

  Mabey, Thomas ^a   Honsawek, Sittisak ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Biomarker; Cytokines; Interleukin; Knee osteoarthritis

Indexed keywords

EID: 84921501774     PISSN: None     EISSN: 22185836     Source Type: Journal    
DOI: 10.5312/wjo.v6.i1.95     Document Type: Article

References (88)

1. Salihu HM, Bonnema SM, Alio AP. Obesity: What is an elderly population growing into? Maturitas 2009; 63: 7-12 [PMID: 19328637 DOI: 10.1016/j.maturitas.2009.02.010]
2. Organisation WH, Aging UNIo. Global Health and Aging. Available from: URL: http://www.who.int/ageing/publications/global_health.pdf, 2011
3. Kellgren JH, LawrencE JS. Rheumatism in miners. II. X-ray study. Br J Ind Med 1952; 9: 197-207 [PMID: 14944740]
4. Christgau S, Garnero P, Fledelius C, Moniz C, Ensig M, Gineyts E, Rosenquist C, Qvist P. Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 2001; 29: 209-215 [PMID: 11557363]
5. Kumm J, Tamm A, Lintrop M, Tamm A. Diagnostic and prognostic value of bone biomarkers in progressive knee osteoarthritis: a 6-year follow-up study in middle-aged subjects. Osteoarthritis Cartilage 2013; 21: 815-822 [PMID: 23523608 DOI: 10.1016/j.joca.2013.03.008]
6. Verma P, Dalal K. Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: a novel diagnostic and prognostic biomarker. J Orthop Res 2013; 31: 999-1006 [PMID: 23423905 DOI: 10.1002/jor.22324]
7. Bay-Jensen AC, Liu Q, Byrjalsen I, Li Y, Wang J, Pedersen C, Leeming DJ, Dam EB, Zheng Q, Qvist P, Karsdal MA. Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis. Clin Biochem 2011; 44: 423-429 [PMID: 21223960 DOI: 10.1016/j.clinbiochem.2011.01.001]
8. Pelletier JP, Raynauld JP, Caron J, Mineau F, Abram F, Dorais M, Haraoui B, Choquette D, Martel-Pelletier J. Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis. Ann Rheum Dis 2010; 69: 2095-2101 [PMID: 20570834 DOI: 10.1136/ard.2009.122002]
9. Swearingen CA, Carpenter JW, Siegel R, Brittain IJ, Dotzlaf J, Durham TB, Toth JL, Laska DA, Marimuthu J, Liu C, Brown DP, Carter QL, Wiley MR, Duffin KL, Mitchell PG, Thirunavukkarasu K. Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine. Osteoarthritis Cartilage 2010; 18: 1150-1158 [PMID: 20633682 DOI: 10.1016/j.joca.2010.06.011]
10. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 2011; 7: 33-42 [PMID: 21119608 DOI: 10.1038/nrrheum.2010.196]
11. Hart PH, Ahern MJ, Smith MD, Finlay-Jones JJ. Comparison of the suppressive effects of interleukin-10 and interleukin-4 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis. Immunology 1995; 84: 536-542 [PMID: 7790026]
12. Jovanovic D, Pelletier JP, Alaaeddine N, Mineau F, Geng C, Ranger P, Martel-Pelletier J. Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts. Osteoarthritis Cartilage 1998; 6: 40-49 [PMID: 9616438 DOI: 10.1053/joca.1997.0091]
13. Shingu M, Miyauchi S, Nagai Y, Yasutake C, Horie K. The role of IL-4 and IL-6 in IL-1-dependent cartilage matrix degradation. Br J Rheumatol 1995; 34: 101-106 [PMID: 7704454]
14. Vannier E, Miller LC, Dinarello CA. Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc Natl Acad Sci USA 1992; 89: 4076-4080 [PMID: 1533284]
15. van de Loo FA, Joosten LA, van Lent PL, Arntz OJ, van den Berg WB. Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum 1995; 38: 164-172 [PMID: 7848306]
16. Brown RA, Weiss JB. Neovascularisation and its role in the osteoarthritic process. Ann Rheum Dis 1988; 47: 881-885 [PMID: 2462856]
17. Fransès RE, McWilliams DF, Mapp PI, Walsh DA. Osteochondral angiogenesis and increased protease inhibitor expression in OA. Osteoarthritis Cartilage 2010; 18: 563-571 [PMID: 20060952 DOI: 10.1016/j.joca.2009.11.015]
18. Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol 2012; 8: 390-398 [PMID: 22641138 DOI: 10.1038/nrrheum.2012.80]
19. Ludin A, Sela JJ, Schroeder A, Samuni Y, Nitzan DW, Amir G. Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice. Osteoarthritis Cartilage 2013; 21: 491-497 [PMID: 23257244 DOI: 10.1016/j.joca.2012.12.003]
20. Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, Malfait AM. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci USA 2012; 109: 20602-20607 [PMID: 23185004 DOI: 10.1073/pnas.1209294110]
21. Chauffier K, Laiguillon MC, Bougault C, Gosset M, Priam S, Salvat C, Mladenovic Z, Nourissat G, Jacques C, Houard X, Berenbaum F, Sellam J. Induction of the chemokine IL-8/Kc by the articular cartilage: possible influence on osteoarthritis. Joint Bone Spine 2012; 79: 604-609 [PMID: 22342065 DOI: 10.1016/j.jbspin.2011.12.013]
22. Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, Heinegård D, Jordan JM, Kepler TB, Lane NE, Saxne T, Tyree B, Kraus VB. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis Cartilage 2006; 14: 723-727 [PMID: 16733093 DOI: 10.1016/j.joca.2006.04.001]
23. Kraus VB. Osteoarthritis year 2010 in review: biochemical markers. Osteoarthritis Cartilage 2011; 19: 346-353 [PMID: 21320614 DOI: 10.1016/j.joca.2011.02.002]
24. Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, Loeuille D, Kivitz AJ, Silver D, Appleton BE. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebocontrolled study. Arthritis Rheum 2009; 61: 344-352 [PMID: 19248129 DOI: 10.1002/art.24096]
25. Grunke M, Schulze-Koops H. Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade. Ann Rheum Dis England 2006; 555-556
26. Byun S, Sinskey YL, Lu YC, Ort T, Kavalkovich K, Sivakumar P, Hunziker EB, Frank EH, Grodzinsky AJ. Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury. Arch Biochem Biophys 2013; 532: 15-22 [PMID: 23333631 DOI: 10.1016/j.abb.2012.12.020]
27. Schulze-Tanzil G, Zreiqat H, Sabat R, Kohl B, Halder A, Müller RD, John T. Interleukin-10 and articular cartilage: experimental therapeutical approaches in cartilage disorders. Curr Gene Ther 2009; 9: 306-315 [PMID: 19534651]
28. Berger A, Hartrick C, Edelsberg J, Sadosky A, Oster G. Direct and indirect economic costs among private-sector employees with osteoarthritis. J Occup Environ Med 2011; 53: 1228-1235 [PMID: 22015547 DOI: 10.1097/JOM.0b013e3182337620]
29. Losina E, Daigle ME, Suter LG, Hunter DJ, Solomon DH, Walensky RP, Jordan JM, Burbine SA, Paltiel AD, Katz JN. Disease-modifying drugs for knee osteoarthritis: can they be cost-effective? Osteoarthritis Cartilage 2013; 21: 655-667 [PMID: 23380251 DOI: 10.1016/j.joca.2013.01.016]
30. Ruiz D, Koenig L, Dall TM, Gallo P, Narzikul A, Parvizi J, Tongue J. The direct and indirect costs to society of treatment for end-stage knee osteoarthritis. J Bone Joint Surg Am 2013; 95: 1473-1480 [PMID: 23965697 DOI: 10.2106/jbjs.l.01488]
31. Stöve J, Huch K, Günther KP, Scharf HP. Interleukin-1beta induces different gene expression of stromelysin, aggrecan and tumor-necrosis-factor-stimulated gene 6 in human osteoarthritic chondrocytes in vitro. Pathobiology 2000; 68: 144-149 [PMID: 11174072]
32. Chadjichristos C, Ghayor C, Kypriotou M, Martin G, Renard E, Ala-Kokko L, Suske G, de Crombrugghe B, Pujol JP, Galéra P. Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes. J Biol Chem 2003; 278: 39762-39772 [PMID: 12888570 DOI: 10.1074/jbc.M303541200]
33. E X, Cao Y, Meng H, Qi Y, Du G, Xu J, Bi Z. Dendritic cells of synovium in experimental model of osteoarthritis of rabbits. Cell Physiol Biochem 2012; 30: 23-32 [PMID: 22759953 DOI: 10.1159/000339046]
34. Hammacher A, Ward LD, Weinstock J, Treutlein H, Yasukawa K, Simpson RJ. Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding. Protein Sci 1994; 3: 2280-2293 [PMID: 7538847 DOI: 10.1002/pro.5560031213]
35. Schlaak JF, Schwarting A, Knolle P, Meyerzum Büschenfelde KH, Mayet W. Effects of Th1 and Th2 cytokines on cytokine production and ICAM-1 expression on synovial fibroblasts. Ann Rheum Dis 1995; 54: 560-565 [PMID: 7668899]
36. Guerne PA, Carson DA, Lotz M. IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol 1990; 144: 499-505 [PMID: 2104896]
37. Bender S, Haubeck HD, Van de Leur E, Dufhues G, Schiel X, Lauwerijns J, Greiling H, Heinrich PC. Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes. FEBS Lett 1990; 263: 321-324 [PMID: 2335234]
38. Porée B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann DJ, Malléin-Gerin F, Pujol JP, Boumediene K, Galéra P. Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. J Biol Chem 2008; 283: 4850-4865 [PMID: 18065760 DOI: 10.1074/jbc.M706387200]
39. Huebner JL, Kraus VB. Assessment of the utility of biomarkers of osteoarthritis in the guinea. Osteoarthritis Cartilage 2006; 14: 923-930 [DOI: 10.1016/j.joca.2006.03.007]
40. Maccoux LJ, Salway F, Day PJ, Clements DN. Expression profiling of select cytokines in canine osteoarthritis tissues. Vet Immunol Immunopathol 2007; 118: 59-67 [PMID: 17524496 DOI: 10.1016/j.vetimm.2007.04.006]
41. Ley C, Ekman S, Elmén A, Nilsson G, Eloranta ML. Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology. J Vet Med A Physiol Pathol Clin Med 2007; 54: 346-351 [PMID: 17718806 DOI: 10.1111/j.1439-0442.2007.00956.x]
42. Rubenhagen R, Schuttrumpf JP, Sturmer KM, Frosch KH. Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis. Acta Orthopaedica 2012; 83: 59-64 [DOI: 10.3109/17453674.2011.645195]
43. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988; 15: 1833-1840 [PMID: 3068365]
44. Stannus OP, Jones G, Quinn SJ, Cicuttini FM, Dore D, Ding C. The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. Arthritis Res Ther 2010; 12: R95 [PMID: 20482813 DOI: 10.1186/ar3022]
45. Shimura Y, Kurosawa H, Sugawara Y, Tsuchiya M, Sawa M, Kaneko H, Futami I, Liu L, Sadatsuki R, Hada S, Iwase Y, Kaneko K, Ishijima M. The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study. Osteoarthritis Cartilage 2013; 21: 1179-1184 [PMID: 23973128 DOI: 10.1016/j.joca.2013.05.014]
46. Penninx BWJH, Abbas H, Ambrosius W, Nicklas BJ, Davis C, Messier SP, Pahor M. Inflammatory markers and physical function among older adults with knee osteoarthritis. J Rheum 2004; 31: 2027-2031
47. Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, Spector TD. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum 2009; 60: 2037-2045 [PMID: 19565477 DOI: 10.1002/art.24598]
48. Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J, Ding C. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 2010; 18: 1441-1447 [DOI: 10.1016/j.joca.2010.08.016]
49. Doss F, Menard J, Hauschild M, Kreutzer HJ, Mittlmeier T, Müller-Steinhardt M, Müller B. Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells. Scand J Rheumatol 2007; 36: 136-139 [PMID: 17476620 DOI: 10.1080/03009740701250785]
50. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, Prolo P, Wong ML, Licinio J, Gold PW, Hermida RC, Mastorakos G, Chrousos GP. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 1999; 84: 2603-2607 [PMID: 10443646]
51. Pejovic S, Basta M, Vgontzas AN, Kritikou I, Shaffer ML, Tsaoussoglou M, Stiffler D, Stefanakis Z, Bixler EO, Chrousos GP. Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance. Am J Physiol Endocrinol Metab 2013; 305: E890-E896 [PMID: 23941878 DOI: 10.1152/ajpendo.00301.2013]
52. Haack M, Kraus T, Schuld A, Dalal M, Koethe D, Pollmächer T. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures. Psychoneuroendocrinology 2002; 27: 921-931 [PMID: 12383453]
53. Mosley B, Urdal DL, Prickett KS, Larsen A, Cosman D, Conlon PJ, Gillis S, Dower SK. The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem 1987; 262: 2941-2944 [PMID: 2950091]
54. Lotz M, Terkeltaub R, Villiger PM. Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes. J Immunol 1992; 148: 466-473 [PMID: 1729366]
55. Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E, Kubota M, Liu L, Xu Z, Futami I, Yusup A, Miyahara K, Xu S, Kaneko K, Kurosawa H. Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop 2011; 35: 831-838 [PMID: 20517696 DOI: 10.1007/s00264-010-1045-1]
56. Riyazi N, Slagboom E, de Craen AJ, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TW, Kloppenburg M. Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation. Arthritis Rheum 2005; 52: 1443-1450 [PMID: 15880595 DOI: 10.1002/art.21014]
57. Botha-Scheepers S, Watt I, Slagboom E, de Craen AJ, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TW, Kloppenburg M. Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis. Ann Rheum Dis 2008; 67: 1165-1169 [PMID: 18029383 DOI: 10.1136/ard.2007.084657]
58. Bowles RD, Mata BA, Bell RD, Mwangi TK, Huebner JL, Kraus VB, Setton LA. In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis. Arthritis Rheumatol 2014; 66: 637-646 [PMID: 24574224 DOI: 10.1002/art.38279]
59. Vincent HK, Percival SS, Conrad BP, Seay AN, Montero C, Vincent KR. Hyaluronic Acid (HA) Viscosupplementation on Synovial Fluid Inflammation in Knee Osteoarthritis: A Pilot Study. Open Orthop J 2013; 7: 378-384 [PMID: 24093052 DOI: 10.2174/1874325001307010378]
60. Aggarwal BB, Gupta SC, Sung B. Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol 2013; 169: 1672-1692 [PMID: 23425071 DOI: 10.1111/bph.12131]
61. Penninx BW, Abbas H, Ambrosius W, Nicklas BJ, Davis C, Messier SP, Pahor M. Inflammatory markers and physical function among older adults with knee osteoarthritis. J Rheumatol 2004; 31: 2027-2031 [PMID: 15468370]
62. Kammermann JR, Kincaid SA, Rumph PF, Baird DK, Visco DM. Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage. Osteoarthritis Cartilage 1996; 4: 23-34 [PMID: 8731393]
63. Pantsulaia I, Kalichman L, Kobyliansky E. Association between radiographic hand osteoarthritis and RANKL, OPG and inflammatory markers. Osteoarthritis Cartilage 2010; 18: 1448-1453 [DOI: 10.1016/j.joca.2010.06.009]
64. Ling SM, Patel DD, Garnero P, Zhan M, Vaduganathan M, Muller D, Taub D, Bathon JM, Hochberg M, Abernethy DR, Metter EJ, Ferrucci L. Serum protein signatures detect early radiographic osteoarthritis. Osteoarthritis Cartilage 2009; 17: 43-48 [PMID: 18571442 DOI: 10.1016/j.joca.2008.05.004]
65. Sun JM, Sun LZ, Liu J, Su BH, Shi L. Serum interleukin-15 levels are associated with severity of pain in patients with knee osteoarthritis. Dis Markers 2013; 35: 203-206 [PMID: 24167367 DOI: 10.1155/2013/176278]
66. Wang Y, Xu D, Long L, Deng X, Tao R, Huang G. Correlation between plasma, synovial fluid and articular cartilage Interleukin-18 with radiographic severity in 33 patients with osteoarthritis of the knee. Clin Exp Med 2014; 14: 297-304 [PMID: 23958877 DOI: 10.1007/s10238-013-0251-8]
67. Ritchlin C, Haas-Smith SA. Expression of interleukin 10 mRNA and protein by synovial fibroblastoid cells. J Rheumatol 2001; 28: 698-705 [PMID: 11327238]
68. Miossec P, Briolay J, Dechanet J, Wijdenes J, Martinez-Valdez H, Banchereau J. Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis. Arthritis Rheum 1992; 35: 874-883 [PMID: 1642654]
69. Alaaeddine N, Olee T, Hashimoto S, Creighton-Achermann L, Lotz M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 2001; 44: 1633-1643 [PMID: 11465714 DOI: 10.1002/1529-0131(200107)44]
70. Alaaeddine N, Di Battista JA, Pelletier JP, Kiansa K, Cloutier JM, Martel-Pelletier J. Differential effects of IL-8, LIF (proinflammatory) and IL-11 (anti-inflammatory) on TNF-alphainduced PGE(2)release and on signalling pathways in human OA synovial fibroblasts. Cytokine 1999; 11: 1020-1030 [PMID: 10623427 DOI: 10.1006/cyto.1999.0505]
71. Ashraf S, Mapp PI, Walsh DA. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum 2011; 63: 2700-2710 [PMID: 21538326 DOI: 10.1002/art.30422]
72. Honorati MC, Neri S, Cattini L, Facchini A. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage 2006; 14: 345-352 [PMID: 16311048 DOI: 10.1016/j.joca.2005.10.004]
73. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999; 5: 623-628 [PMID: 10371499 DOI: 10.1038/9467]
74. Honorati MC, Cattini L, Facchini A. IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes. Osteoarthritis Cartilage 2004; 12: 683-691 [PMID: 15325633 DOI: 10.1016/j.joca.2004.05.009]
75. Nagashima M, Yoshino S, Ishiwata T, Asano G. Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis. J Rheumatol 1995; 22: 1624-1630 [PMID: 8523334]
76. Saetan N, Honsawek S, Tanavalee A, Yuktanandana P, Meknavin S, Ngarmukos S, Tanpowpong T, Parkpian V. Relationship of plasma and synovial fluid vascular endothelial growth factor with radiographic severity in primary knee osteoarthritis. Int Orthop 2014; 38: 1099-1104 [PMID: 24297611 DOI: 10.1007/s00264-013-2192-y]
77. Pierzchala AW, Kusz DJ, Hajduk G. CXCL8 and CCL5 expression in synovial fluid and blood serum in patients with osteoarthritis of the knee. Arch Immunol Ther Exp (Warsz) 2011; 59: 151-155 [PMID: 21336628 DOI: 10.1007/s00005-011-0115-4]
78. Altman RD, Gold GE. Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage 2007; 15 Suppl A: A1-56 [PMID: 17320422 DOI: 10.1016/j.joca.2006.11.009]
79. McInnes IB, al-Mughales J, Field M, Leung BP, Huang FP, Dixon R, Sturrock RD, Wilkinson PC, Liew FY. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996; 2: 175-182 [PMID: 8574962]
80. Pavkova Goldbergova M, Pavek N, Lipkova J, Jarkovsky J, Stouracova M, Gatterova J, Vasku A, Soucek M, Nemec P. Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA? Biomarkers 2012; 17: 655-662 [PMID: 22998011 DOI: 10.3109/1354750x.2012.719036]
81. Chen J, Feigenbaum L, Awasthi P, Butcher DO, Anver MR, Golubeva YG, Bamford R, Zhang X, St Claire MB, Thomas CJ, Discepolo V, Jabri B, Waldmann TA. Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Ra. Proc Natl Acad Sci USA 2013; 110: 13534-13539 [PMID: 23904478 DOI: 10.1073/pnas.1312911110]
82. Kuczynski S, Winiarska H, Abramczyk M, Szczawinska K, Wierusz-Wysocka B, Dworacka M. IL-15 is elevated in serum patients with type 1 diabetes mellitus. Diabetes Res Clin Pract 2005; 69: 231-236 [PMID: 16098919 DOI: 10.1016/j.diabres.2005.02.007]
83. Saetan N, Honsawek S, Tanavalee A, Tantavisut S, Yuktanandana P, Parkpian V. Association of plasma and synovial fluid interferon-γ inducible protein-10 with radiographic severity in knee osteoarthritis. Clin Biochem 2011; 44: 1218-1222 [PMID: 21819974 DOI: 10.1016/j.clinbiochem.2011.07.010]
84. Vangsness CT, Burke WS, Narvy SJ, MacPhee RD, Fedenko AN. Human knee synovial fluid cytokines correlated with grade of knee osteoarthritis--a pilot study. Bull NYU Hosp Jt Dis 2011; 69: 122-127 [PMID: 22035391]
85. Orita S, Koshi T, Mitsuka T, Miyagi M, Inoue G, Arai G, Ishikawa T, Hanaoka E, Yamashita K, Yamashita M, Eguchi Y, Toyone T, Takahashi K, Ohtori S. Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet Disord 2011; 12: 144 [PMID: 21714933 DOI: 10.1186/1471-2474-12-144]
86. Kokebie R, Aggarwal R, Lidder S, Hakimiyan AA, Rueger DC, Block JA, Chubinskaya S. The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors. Arthritis Res Ther 2011; 13: R50 [PMID: 21435227 DOI: 10.1186/ar3293]
87. Santos ML, Gomes WF, Pereira DS, Oliveira DM, Dias JM, Ferrioli E, Pereira LS. Muscle strength, muscle balance, physical function and plasma interleukin-6 (IL-6) levels in elderly women with knee osteoarthritis (OA). Arch Gerontol Geriatr 2011; 52: 322-326 [PMID: 20627334 DOI: 10.1016/j.archger.2010.05.009]
88. Scanzello CR, Umoh E, Pessler F, Diaz-Torne C, Miles T, Dicarlo E, Potter HG, Mandl L, Marx R, Rodeo S, Goldring SR, Crow MK. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage 2009; 17: 1040-1048 [PMID: 19289234 DOI: 10.1016/j.joca.2009.02.011]