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Volumn 54, Issue 5, 2017, Pages 3219-3229

Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study

Author keywords

Cuprizone; Demyelination; Multiple sclerosis; Olig1; Remyelination; Resveratrol

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ADENOSINE TRIPHOSPHATE; CUPRIZONE; CYTOCHROME C OXIDASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN ALPHA; MYELIN; MYELIN BASIC PROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 1; RESVERATROL; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; STILBENE DERIVATIVE;

EID: 84962808791     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-9891-5     Document Type: Article
Times cited : (101)

References (57)
  • 1
    • 84892567726 scopus 로고    scopus 로고
    • Promoting remyelination in multiple sclerosis-recent advances
    • PID: 24242317
    • Münzel EJ, Williams A (2013) Promoting remyelination in multiple sclerosis-recent advances. Drugs 73:2017–2029. doi:10.1007/s40265-013-0146-8
    • (2013) Drugs , vol.73 , pp. 2017-2029
    • Münzel, E.J.1    Williams, A.2
  • 2
    • 19944413626 scopus 로고    scopus 로고
    • bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS
    • COI: 1:CAS:528:DC%2BD2cXhtVOjsLrN, PID: 15604411
    • Arnett HA, Fancy SPJ, Alberta JA et al (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306:2111–2115. doi:10.1126/science.1103709
    • (2004) Science , vol.306 , pp. 2111-2115
    • Arnett, H.A.1    Fancy, S.P.J.2    Alberta, J.A.3
  • 3
    • 0027153235 scopus 로고
    • Oligodendrocyte injury is an early event in lesions of multiple sclerosis
    • COI: 1:STN:280:DyaK3szltl2hsg%3D%3D, PID: 8350635
    • Rodriguez M, Scheithauer BW, Forbes G, Kelly PJ (1993) Oligodendrocyte injury is an early event in lesions of multiple sclerosis. Mayo Clin Proc 68:627–636. doi:10.1016/S0025-6196(12)60597-7
    • (1993) Mayo Clin Proc , vol.68 , pp. 627-636
    • Rodriguez, M.1    Scheithauer, B.W.2    Forbes, G.3    Kelly, P.J.4
  • 4
    • 33947535936 scopus 로고    scopus 로고
    • Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis
    • COI: 1:CAS:528:DC%2BD2sXls12rs70%3D, PID: 17388953
    • Rodriguez M (2007) Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis. Brain Pathol 17:219–229. doi:10.1111/j.1750-3639.2007.00065.x
    • (2007) Brain Pathol , vol.17 , pp. 219-229
    • Rodriguez, M.1
  • 5
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • PID: 11796850
    • Chang A, Tourtellotte WW, Rudick R, Trapp BD (2002) Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 346:165–173. doi:10.1056/NEJMoa010994
    • (2002) N Engl J Med , vol.346 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 6
    • 0030785547 scopus 로고    scopus 로고
    • Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord
    • COI: 1:STN:280:DyaK1c%2FjsF2qtA%3D%3D, PID: 9370229
    • Keirstead HS, Blakemore WF (1997) Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord. J Neuropathol Exp Neurol 56:1191–201
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 1191-1201
    • Keirstead, H.S.1    Blakemore, W.F.2
  • 7
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: from biology to therapy
    • COI: 1:CAS:528:DC%2BD1cXht1GrtrfJ, PID: 18931697
    • Franklin RJM, Ffrench-Constant C (2008) Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 9:839–855. doi:10.1038/nrn2480
    • (2008) Nat Rev Neurosci , vol.9 , pp. 839-855
    • Franklin, R.J.M.1    Ffrench-Constant, C.2
  • 8
    • 0034281366 scopus 로고    scopus 로고
    • NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
    • COI: 1:CAS:528:DC%2BD3cXmsVyhurc%3D, PID: 10964946
    • Chang A, Nishiyama A, Peterson J et al (2000) NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 20:6404–6412
    • (2000) J Neurosci , vol.20 , pp. 6404-6412
    • Chang, A.1    Nishiyama, A.2    Peterson, J.3
  • 9
    • 84872020822 scopus 로고    scopus 로고
    • Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2
    • COI: 1:CAS:528:DC%2BC38Xhs12itbzL, PID: 23165259
    • Meijer DH, Kane MF, Mehta S et al (2012) Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci 13:819–31. doi:10.1038/nrn3386
    • (2012) Nat Rev Neurosci , vol.13 , pp. 819-831
    • Meijer, D.H.1    Kane, M.F.2    Mehta, S.3
  • 10
    • 84885190381 scopus 로고    scopus 로고
    • Cuprizone-induced demyelination as a tool to study remyelination and axonal protection
    • COI: 1:CAS:528:DC%2BC3sXhsV2nur3J, PID: 23666824
    • Zendedel A, Beyer C, Kipp M (2013) Cuprizone-induced demyelination as a tool to study remyelination and axonal protection. J Mol Neurosci 51:567–572. doi:10.1007/s12031-013-0026-4
    • (2013) J Mol Neurosci , vol.51 , pp. 567-572
    • Zendedel, A.1    Beyer, C.2    Kipp, M.3
  • 11
    • 0018234553 scopus 로고
    • Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity
    • COI: 1:CAS:528:DyaE1MXitVCgsg%3D%3D, PID: 739762
    • Ludwin SK (1978) Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity. Lab Invest 39:597–612
    • (1978) Lab Invest , vol.39 , pp. 597-612
    • Ludwin, S.K.1
  • 12
    • 84908670613 scopus 로고    scopus 로고
    • Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis
    • COI: 1:CAS:528:DC%2BC2cXhslyrtL%2FL, PID: 25445182
    • Praet J, Guglielmetti C, Berneman Z et al (2014) Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis. Neurosci Biobehav Rev 47:485–505. doi:10.1016/j.neubiorev.2014.10.004
    • (2014) Neurosci Biobehav Rev , vol.47 , pp. 485-505
    • Praet, J.1    Guglielmetti, C.2    Berneman, Z.3
  • 13
    • 0015820697 scopus 로고
    • Enzymic activities and sodium, potassium and copper concentrations in mouse brain and liver after cuprizone treatment in vivo
    • COI: 1:CAS:528:DyaE2cXptFOltg%3D%3D, PID: 4357499
    • Venturini G (1973) Enzymic activities and sodium, potassium and copper concentrations in mouse brain and liver after cuprizone treatment in vivo. J Neurochem 21:1147–1151. doi:10.1111/j.1471-4159.1973.tb07569.x
    • (1973) J Neurochem , vol.21 , pp. 1147-1151
    • Venturini, G.1
  • 14
    • 69549105728 scopus 로고    scopus 로고
    • Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum
    • COI: 1:CAS:528:DC%2BD1MXhtVGju77O, PID: 19259754
    • Groebe A, Clarner T, Baumgartner W et al (2009) Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum. Cerebellum 8:163–174. doi:10.1007/s12311-009-0099-3
    • (2009) Cerebellum , vol.8 , pp. 163-174
    • Groebe, A.1    Clarner, T.2    Baumgartner, W.3
  • 15
    • 0032440093 scopus 로고    scopus 로고
    • Microglial/macrophage accumulation during cuprizone-induced demyelination in C57Bl/6 mice
    • COI: 1:CAS:528:DyaK1cXnvVWisrg%3D, PID: 9916878
    • Hiremath MMM, Saito Y, Knapp GWW et al (1998) Microglial/macrophage accumulation during cuprizone-induced demyelination in C57Bl/6 mice. J Neuroimmunol 92:38–49. doi:10.1016/S0165-5728(98)00168-4
    • (1998) J Neuroimmunol , vol.92 , pp. 38-49
    • Hiremath, M.M.M.1    Saito, Y.2    Knapp, G.W.W.3
  • 16
    • 84862684427 scopus 로고    scopus 로고
    • Mitochondrial sirtuins—a new therapeutic target for repair and protection in multiple sclerosis
    • COI: 1:STN:280:DC%2BC38jis12isA%3D%3D, PID: 22708600
    • Rice CM, Sun M, Kemp K et al (2012) Mitochondrial sirtuins—a new therapeutic target for repair and protection in multiple sclerosis. Eur J Neurosci 35:1887–1893. doi:10.1111/j.1460-9568.2012.08150.x
    • (2012) Eur J Neurosci , vol.35 , pp. 1887-1893
    • Rice, C.M.1    Sun, M.2    Kemp, K.3
  • 17
    • 79953291261 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
    • COI: 1:CAS:528:DC%2BC3MXls1Omtbk%3D, PID: 21446022
    • Campbell GR, Ziabreva I, Reeve AK et al (2011) Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol 69:481–492. doi:10.1002/ana.22109
    • (2011) Ann Neurol , vol.69 , pp. 481-492
    • Campbell, G.R.1    Ziabreva, I.2    Reeve, A.K.3
  • 18
    • 33744819999 scopus 로고    scopus 로고
    • Antioxidants in multiple sclerosis: do they have a role in therapy?
    • COI: 1:CAS:528:DC%2BD28XnvVyktb4%3D, PID: 16734496
    • Carlson NG, Rose JW (2006) Antioxidants in multiple sclerosis: do they have a role in therapy? CNS Drugs 20:433–441. doi:10.2165/00023210-200620060-00001
    • (2006) CNS Drugs , vol.20 , pp. 433-441
    • Carlson, N.G.1    Rose, J.W.2
  • 19
    • 81155123332 scopus 로고    scopus 로고
    • Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries
    • COI: 1:CAS:528:DC%2BC3MXhs12nt7zF
    • Cuzzola F, Ciurleo R, Giacoppo S et al (2011) Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries. CNS Neurol Disord Drug Targets 10:849–62
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 849-862
    • Cuzzola, F.1    Ciurleo, R.2    Giacoppo, S.3
  • 20
    • 78650482951 scopus 로고    scopus 로고
    • Oral resveratrol reduces neuronal damage in a model of multiple sclerosis
    • Shindler K, Ventura E, Dutt M (2010) Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neurol 30:328–339. doi:10.1097/WNO.0b013e3181f7f833.Oral
    • (2010) J Neurol , vol.30 , pp. 328-339
    • Shindler, K.1    Ventura, E.2    Dutt, M.3
  • 21
    • 84865851734 scopus 로고    scopus 로고
    • Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis
    • Fonseca-Kelly Z, Nassrallah M, Uribe J, et al (2012) Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front Neurol 1–9. doi:10.3389/fneur.2012.00084
    • (2012) Front Neurol , pp. 1-9
    • Fonseca-Kelly, Z.1    Nassrallah, M.2    Uribe, J.3
  • 22
    • 33746878256 scopus 로고    scopus 로고
    • Implications of protease M/neurosin in myelination during experimental demyelination and remyelination
    • COI: 1:CAS:528:DC%2BD28XotV2mtbs%3D, PID: 16890353
    • Bando Y, Ito S, Nagai Y et al (2006) Implications of protease M/neurosin in myelination during experimental demyelination and remyelination. Neurosci Lett 405:175–180. doi:10.1016/j.neulet.2006.06.030
    • (2006) Neurosci Lett , vol.405 , pp. 175-180
    • Bando, Y.1    Ito, S.2    Nagai, Y.3
  • 23
    • 84893171836 scopus 로고    scopus 로고
    • Measuring motor coordination in mice
    • Deacon RMJ (2013) Measuring motor coordination in mice. J Vis Exp e2609. doi:10.3791/2609
    • (2013) J Vis Exp , vol.e2609
    • Deacon, R.M.J.1
  • 24
    • 79957670752 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage
    • COI: 1:CAS:528:DC%2BC3MXntVyjtLY%3D, PID: 21555210
    • Yoshikawa K, Palumbo S, Toscano CD, Bosetti F (2011) Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage. Prostaglandins Leukot Essent Fatty Acids 85:43–52. doi:10.1016/j.plefa.2011.04.022
    • (2011) Prostaglandins Leukot Essent Fatty Acids , vol.85 , pp. 43-52
    • Yoshikawa, K.1    Palumbo, S.2    Toscano, C.D.3    Bosetti, F.4
  • 25
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation. In: Methods Enzym
    • Buege JA, Aust SD (1974) Microsomal lipid peroxidation. In: Methods Enzym. pp 302–310
    • (1974) pp 302–310
    • Buege, J.A.1    Aust, S.D.2
  • 26
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues
    • COI: 1:CAS:528:DyaF1MXktVSlt7k%3D, PID: 4388022
    • Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502–522. doi:10.1016/0003-2697(69)90064-5
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 27
    • 6344289360 scopus 로고    scopus 로고
    • Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging
    • COI: 1:CAS:528:DC%2BD2cXhtVaqt7nO, PID: 15271654
    • Navarro A, Boveris A (2004) Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging. Am J Physiol Regul Integr Comp Physiol 287:R1244–R1249. doi:10.1152/ajpregu.00226.2004
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287 , pp. R1244-R1249
    • Navarro, A.1    Boveris, A.2
  • 28
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
    • COI: 1:CAS:528:DyaE2MXhtlGm, PID: 4215654
    • Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469–474. doi:10.1111/j.1432-1033.1974.tb03714.x
    • (1974) Eur J Biochem , vol.47 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 29
    • 0033984710 scopus 로고    scopus 로고
    • The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles
    • COI: 1:CAS:528:DC%2BD3cXhtlCiuro%3D, PID: 10682852
    • Paradies G, Petrosillo G, Pistolese M, Ruggiero FM (2000) The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett 466:323–326. doi:10.1016/S0014-5793(00)01082-6
    • (2000) FEBS Lett , vol.466 , pp. 323-326
    • Paradies, G.1    Petrosillo, G.2    Pistolese, M.3    Ruggiero, F.M.4
  • 30
    • 71849104860 scopus 로고
    • Protein measurement with the folin phenol reagent, J Biol Chem
    • Lowry OH, Rosebrough NJ, Farr L, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem
    • (1951) Randall RJ
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, L.3
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method
    • COI: 1:CAS:528:DC%2BD38XhtFelt7s%3D, PID: 11846609
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods 25:402–8. doi:10.1006/meth.2001.1262
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 84906316516 scopus 로고    scopus 로고
    • Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
    • PID: 24659953
    • Gudi V, Gingele S, Skripuletz T, Stangel M (2014) Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned. Front Cell Neurosci 8:73. doi:10.3389/fncel.2014.00073
    • (2014) Front Cell Neurosci , vol.8 , pp. 73
    • Gudi, V.1    Gingele, S.2    Skripuletz, T.3    Stangel, M.4
  • 33
    • 54849431986 scopus 로고    scopus 로고
    • Differential changes in axonal conduction following CNS demyelination in two mouse models
    • PID: 18973589
    • Bando Y, Takakusaki K, Ito S et al (2008) Differential changes in axonal conduction following CNS demyelination in two mouse models. Eur J Neurosci 28:1731–1742. doi:10.1111/j.1460-9568.2008.06474.x
    • (2008) Eur J Neurosci , vol.28 , pp. 1731-1742
    • Bando, Y.1    Takakusaki, K.2    Ito, S.3
  • 34
    • 77952886177 scopus 로고    scopus 로고
    • The multiple roles of myelin protein genes during the development of the oligodendrocyte
    • PID: 20017732
    • Fulton D, Paez PM, Campagnoni AT (2010) The multiple roles of myelin protein genes during the development of the oligodendrocyte. ASN Neuro 2:e00027. doi:10.1042/AN20090051
    • (2010) ASN Neuro , vol.2
    • Fulton, D.1    Paez, P.M.2    Campagnoni, A.T.3
  • 35
    • 77949873025 scopus 로고    scopus 로고
    • Myelination and the trophic support of long axons
    • COI: 1:CAS:528:DC%2BC3cXivFKntr4%3D, PID: 20216548
    • Nave K-A (2010) Myelination and the trophic support of long axons. Nat Rev Neurosci 11:275–283. doi:10.1038/nrn2797
    • (2010) Nat Rev Neurosci , vol.11 , pp. 275-283
    • Nave, K.-A.1
  • 36
    • 38149031549 scopus 로고    scopus 로고
    • Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination
    • COI: 1:STN:280:DC%2BD1c%2FksV2qtg%3D%3D, PID: 17961136
    • Lindner M, Heine S, Haastert K et al (2008) Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination. Neuropathol Appl Neurobiol 34:105–114. doi:10.1111/j.1365-2990.2007.00879.x
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 105-114
    • Lindner, M.1    Heine, S.2    Haastert, K.3
  • 37
    • 84930459853 scopus 로고    scopus 로고
    • Transfer of myelin-reactive Th17 cells impairs endogenous remyelination in the central nervous system of cuprizone-fed mice
    • COI: 1:CAS:528:DC%2BC2MXhtVGhur%2FE, PID: 26041928
    • Baxi EG, DeBruin J, Tosi DM et al (2015) Transfer of myelin-reactive Th17 cells impairs endogenous remyelination in the central nervous system of cuprizone-fed mice. J Neurosci 35:8626–8639. doi:10.1523/JNEUROSCI.3817-14.2015
    • (2015) J Neurosci , vol.35 , pp. 8626-8639
    • Baxi, E.G.1    DeBruin, J.2    Tosi, D.M.3
  • 38
    • 18544386562 scopus 로고    scopus 로고
    • Increased Aβ peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer’ s disease
    • COI: 1:CAS:528:DC%2BD38XmtlSksro%3D, PID: 12220172
    • Roher AE, Weiss N, Kokjohn TA et al (2002) Increased Aβ peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer’ s disease. Biochemistry 41:11080–11090. doi:10.1021/bi026173d
    • (2002) Biochemistry , vol.41 , pp. 11080-11090
    • Roher, A.E.1    Weiss, N.2    Kokjohn, T.A.3
  • 39
    • 84945177024 scopus 로고    scopus 로고
    • Aggregation of MBP in chronic demyelination
    • COI: 1:CAS:528:DC%2BC2MXhtF2ltr7I, PID: 26273684
    • Frid K, Einstein O, Friedman-Levi Y et al (2015) Aggregation of MBP in chronic demyelination. Ann Clin Transl Neurol 2:711–721. doi:10.1002/acn3.207
    • (2015) Ann Clin Transl Neurol , vol.2 , pp. 711-721
    • Frid, K.1    Einstein, O.2    Friedman-Levi, Y.3
  • 40
    • 67651115860 scopus 로고    scopus 로고
    • Regional differences between grey and white matter in cuprizone induced demyelination
    • COI: 1:CAS:528:DC%2BD1MXptVCjsr0%3D, PID: 19524552
    • Gudi V, Moharregh-Khiabani D, Skripuletz T et al (2009) Regional differences between grey and white matter in cuprizone induced demyelination. Brain Res 1283:127–138. doi:10.1016/j.brainres.2009.06.005
    • (2009) Brain Res , vol.1283 , pp. 127-138
    • Gudi, V.1    Moharregh-Khiabani, D.2    Skripuletz, T.3
  • 41
    • 0029970104 scopus 로고    scopus 로고
    • Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain
    • COI: 1:STN:280:DyaK28zps12iug%3D%3D, PID: 8804021
    • Targett MP, Sussman J, Scolding N et al (1996) Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain. Neuropathol Appl Neurobiol 22:199–206
    • (1996) Neuropathol Appl Neurobiol , vol.22 , pp. 199-206
    • Targett, M.P.1    Sussman, J.2    Scolding, N.3
  • 42
    • 84878527176 scopus 로고    scopus 로고
    • Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models
    • COI: 1:CAS:528:DC%2BC3sXoslWjur0%3D, PID: 23595275
    • Boyd A, Zhang H, Williams A (2013) Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta Neuropathol 125:841–859. doi:10.1007/s00401-013-1112-y
    • (2013) Acta Neuropathol , vol.125 , pp. 841-859
    • Boyd, A.1    Zhang, H.2    Williams, A.3
  • 43
    • 84924463269 scopus 로고    scopus 로고
    • Olig1 function is required for oligodendrocyte differentiation in the mouse brain
    • COI: 1:CAS:528:DC%2BC2MXhtVCktLrF, PID: 25762682
    • Dai J, Bercury KK, Ahrendsen JT, Macklin WB (2015) Olig1 function is required for oligodendrocyte differentiation in the mouse brain. J Neurosci 35:4386–4402. doi:10.1523/JNEUROSCI.4962-14.2015
    • (2015) J Neurosci , vol.35 , pp. 4386-4402
    • Dai, J.1    Bercury, K.K.2    Ahrendsen, J.T.3    Macklin, W.B.4
  • 44
    • 84905053623 scopus 로고    scopus 로고
    • Oligodendrogenesis in the normal and pathological central nervous system
    • El Waly B, Macchi M, Cayre M, Durbec P (2014) Oligodendrogenesis in the normal and pathological central nervous system. Front Neurosci 8:1–22. doi:10.3389/fnins.2014.00145
    • (2014) Front Neurosci , vol.8 , pp. 1-22
    • El Waly, B.1    Macchi, M.2    Cayre, M.3    Durbec, P.4
  • 45
    • 78649364642 scopus 로고    scopus 로고
    • Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes
    • PID: 20665559
    • Ziabreva I, Campbell G, Rist J et al (2010) Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes. Glia 58:1827–1837. doi:10.1002/glia.21052
    • (2010) Glia , vol.58 , pp. 1827-1837
    • Ziabreva, I.1    Campbell, G.2    Rist, J.3
  • 46
    • 84886798197 scopus 로고    scopus 로고
    • Proenergetic effects of resveratrol in the murine neuronal cell line neuro2a
    • COI: 1:CAS:528:DC%2BC3sXht1Cgs73F, PID: 23934760
    • Nguyen NTQ, Ooi L, Piller SC, Münch G (2013) Proenergetic effects of resveratrol in the murine neuronal cell line neuro2a. Mol Nutr Food Res 57:1901–1907. doi:10.1002/mnfr.201300145
    • (2013) Mol Nutr Food Res , vol.57 , pp. 1901-1907
    • Nguyen, N.T.Q.1    Ooi, L.2    Piller, S.C.3    Münch, G.4
  • 47
    • 67650091375 scopus 로고    scopus 로고
    • Resveratrol induces mitochondrial biogenesis in endothelial cells
    • COI: 1:CAS:528:DC%2BD1MXovVKisL0%3D
    • Csiszar A, Labinskyy N, Pinto JT et al (2009) Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Hear Circ Physiol 297:H13–H20. doi:10.1152/ajpheart.00368.2009
    • (2009) Am J Physiol Hear Circ Physiol , vol.297 , pp. H13-H20
    • Csiszar, A.1    Labinskyy, N.2    Pinto, J.T.3
  • 48
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • COI: 1:CAS:528:DC%2BC38XmsVCit7w%3D, PID: 22560220
    • Price NL, Gomes AP, Ling AJY et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15:675–690. doi:10.1016/j.cmet.2012.04.003
    • (2012) Cell Metab , vol.15 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.Y.3
  • 49
    • 84884753706 scopus 로고    scopus 로고
    • Nuclear factor kappa B (NF-KappaB) in multiple sclerosis pathology
    • COI: 1:CAS:528:DC%2BC3sXhtlyrs7%2FP, PID: 24007818
    • Mc Guire C, Prinz M, Beyaert R, van Loo G (2013) Nuclear factor kappa B (NF-KappaB) in multiple sclerosis pathology. Trends Mol Med 19:604–613. doi:10.1016/j.molmed.2013.08.001
    • (2013) Trends Mol Med , vol.19 , pp. 604-613
    • Mc Guire, C.1    Prinz, M.2    Beyaert, R.3    van Loo, G.4
  • 50
    • 84940068942 scopus 로고    scopus 로고
    • The effect of melatonin on behavioral, molecular, and histopathological changes in cuprizone model of demyelination
    • Vakilzadeh G, Khodagholi F, Ghadiri T et al (2015) The effect of melatonin on behavioral, molecular, and histopathological changes in cuprizone model of demyelination. Mol Neurobiol. doi:10.1007/s12035-015-9404-y
    • (2015) Mol Neurobiol
    • Vakilzadeh, G.1    Khodagholi, F.2    Ghadiri, T.3
  • 51
    • 33846675520 scopus 로고    scopus 로고
    • NF-kappa B as a therapeutic target in neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BD2sXlt12rtA%3D%3D, PID: 17227229
    • Camandola S, Mattson MP (2007) NF-kappa B as a therapeutic target in neurodegenerative diseases. Expert Opin Ther Targets 11:123–132. doi:10.1517/14728222.11.2.123
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 123-132
    • Camandola, S.1    Mattson, M.P.2
  • 52
    • 79953672493 scopus 로고    scopus 로고
    • IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-KappaB in the central nervous system
    • PID: 21310728
    • Raasch J, Zeller N, Van Loo G et al (2011) IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-KappaB in the central nervous system. Brain 134:1184–1198. doi:10.1093/brain/awq359
    • (2011) Brain , vol.134 , pp. 1184-1198
    • Raasch, J.1    Zeller, N.2    Van Loo, G.3
  • 53
    • 81955164222 scopus 로고    scopus 로고
    • Characterisation of microglia during de- and remyelination: can they create a repair promoting environment?
    • PID: 21971527
    • Voß EV, Škuljec J, Gudi V et al (2012) Characterisation of microglia during de- and remyelination: can they create a repair promoting environment? Neurobiol Dis 45:519–528. doi:10.1016/j.nbd.2011.09.008
    • (2012) Neurobiol Dis , vol.45 , pp. 519-528
    • Voß, E.V.1    Škuljec, J.2    Gudi, V.3
  • 54
    • 36348975230 scopus 로고    scopus 로고
    • Resveratrol (trans-3,5,4′-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor
    • COI: 1:CAS:528:DC%2BD2sXhsVagsr7F, PID: 17872969
    • Singh NP, Hegde VL, Hofseth LJ et al (2007) Resveratrol (trans-3,5,4′-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor. Mol Pharmacol 72:1508–1521. doi:10.1124/mol.107.038984.compounds
    • (2007) Mol Pharmacol , vol.72 , pp. 1508-1521
    • Singh, N.P.1    Hegde, V.L.2    Hofseth, L.J.3
  • 55
    • 77957851846 scopus 로고    scopus 로고
    • Beneficial effects of minocycline on cuprizone induced cortical demyelination
    • COI: 1:CAS:528:DC%2BC3cXntlGnu7o%3D, PID: 20544279
    • Skripuletz T, Miller E, Moharregh-Khiabani D et al (2010) Beneficial effects of minocycline on cuprizone induced cortical demyelination. Neurochem Res 35:1422–1433. doi:10.1007/s11064-010-0202-7
    • (2010) Neurochem Res , vol.35 , pp. 1422-1433
    • Skripuletz, T.1    Miller, E.2    Moharregh-Khiabani, D.3
  • 56
    • 77953452925 scopus 로고    scopus 로고
    • Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination
    • COI: 1:CAS:528:DC%2BD1MXht1KmsrjK
    • Hibbits N, Pannu R, Wu TJ, Armstrong RC (2009) Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination. ASN Neuro 1:153–164. doi:10.1042/AN20090032
    • (2009) ASN Neuro , vol.1 , pp. 153-164
    • Hibbits, N.1    Pannu, R.2    Wu, T.J.3    Armstrong, R.C.4
  • 57
    • 84892542773 scopus 로고    scopus 로고
    • The effects of resveratrol on chronic constriction injury of sciatic nerve in rats
    • COI: 1:CAS:528:DC%2BC2cXhvVWrtLk%3D, PID: 24394911
    • Bagriyanik HA, Ersoy N, Cetinkaya C et al (2014) The effects of resveratrol on chronic constriction injury of sciatic nerve in rats. Neurosci Lett 561:123–127. doi:10.1016/j.neulet.2013.12.056
    • (2014) Neurosci Lett , vol.561 , pp. 123-127
    • Bagriyanik, H.A.1    Ersoy, N.2    Cetinkaya, C.3


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