Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain

Neuropathology and Applied Neurobiology

Volumn 22, Issue 3, 1996, Pages 199-206

  Targett, M P ^a   Sussman, J ^b   Scolding, N ^b   O'Leary, M T ^a   Compston, D A S ^b   Blakemore, W F ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Dept of Clin Veterinary Medicine ^*  (United Kingdom)

Author keywords

Demyelination; Human glial cells; Multiple sclerosis; Oligodendrocyte; Remyelination; Transplantation

Indexed keywords

ETHIDIUM BROMIDE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; DEMYELINATION; FEMALE; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MALE; MEDICAL ETHICS; MULTIPLE SCLEROSIS; MYELIN SHEATH; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; SPINAL CORD; STEM CELL; WHITE MATTER;

EID: 0029970104     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.1996.tb00895.x     Document Type: Article

References (35)

1. Archer DR, Levén S, Duncan ID. Myelination by cryopreserved xenografts and allografls in the myelin-deficient rat. Expt Neurol 1994; 125: 268-77
2. Armstrong RC, Dorn HH, Kufta CV, Friedman E, Dubois-Dalcq ME. Pre-oligodendrocytes from adult human CNS. J Neurosci 1992; 12: 1358-47
3. Bansal R, Warrington AE, Gard AL, Ranscht B, Pfeiffer SE. Multiple and novel specificities of monoclonal antibodies 01, 04, and R-mAb used in the analysis of oligodendrocyte development. J Neurosci Res 1989; 24: 548-57
4. Blakemore WF. Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone. J Neurol Sci 1973; 20: 73-83
5. Blakemore WF. Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerve. Nature 1977; 266: 68-9
6. Blakemore WF, Crang AJ. Intensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system. Dev Neurosci 1988; 10: 1-10
7. Blakemore WF, Crang AJ. Transplantation of glial cells into areas of demyelination in the adult rat spinal cord. In Neural Transplantation: a Practical Approach. Eds S Dunnett, A Bjorklund. Oxford: Oxford University Press, 1992: 105-22
8. Blakemore WF, Crang AJ, Franklin RJM, Tang K, Ryder S. Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS. Glia 1995; 13: 79-91
9. Bottenstein JE, Sato GH. Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Nat Acad Sci USA 1979; 76: 514-7
10. Carroll WM, Jennings AR. Early recruitment of oligodendrocyte precursors in CNS demyelination. Brain 1994; 117: 563-78
11. Crang AJ, Franklin RJM, Blakemore WF et al. The differentiation of glial cell progenitor populations following transplantation into non-repairing CNS glial lesions in adult animals. J Neuroimmunol 1992; 40: 243-54
12. Duncan ID, Hammang JP, Jackson KF, Wood PM, Bunge RP, Langford L. Transplantation of oligodendrocytes, and Schwann cells into the spinal cord of the myelin deficient rat. J Neurocytol 1988; 17: 351-60
13. Duncan ID, Paino C, Archer DR, Wood PM. Functional capacities of transplanted cell-sorted adult oligodendrocytes. Dev Neurosci 1992; 14: 114-22
14. ffrench-Constant C, Raff MC. Proliferating bipotential glial progenitor cells in adult optic nerve. Nature 1986; 319: 499-502
15. Franklin RJM, Crang AJ, Blakemore WF. The role of astrocytes in the remyelination of glial-free areas of demyelination. In Neural Regeneration, Ed FJ Seil. New York: Raven Press, 1993: 125-33
16. Godfraind C, Friedrich VL, Holmes KV, Dubois-Dalcq M. In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice. J Cell Biol 1989; 109:2405-16
17. Groves AK, Barnett SC, Franklin RJM et al. Repair of demyelinated lesions by transplantation of purified O-2 A progenitor cells. Nature 1993; 362: 453-5
18. Gumpel M. Raumann N, Raoul M. Jacque C. Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brain. Neurosci Lett 1983; 37: 307-11
19. Gumpel M, Lachapelle F, Gansmuller A, Baulac M. Baron-Van Evercooren A, Baumann N. Transplantation of human embryonic oligodendrocytes into shiverer brain. Annal NY Acad Sci 1987; 495: 71-85
20. Levi ADO, Bunge RP. Studies of myelin formation after transplantation of human Schwann cells into the severe combined immunodeficient mouse. Exp Neurol 1994; 130: 41-52
21. Levi ADO, Guénard V, Aebischer P, Bunge RP. The functional characteristics of Schwann cells cultured from human peripheral nerve after transplantation into a gap within the rat sciatic nerve. J Neurosci 1994; 14: 1309-19
22. Ludwin SK. The perineuronal satellite oligodendrocyte. Acta Neuropath 1979; 47: 49-53
23. Ludwin SK. An autoradiographic study of cellular proliferation in remyelination of the central nervous system. Am J Pathol 1979; 65: 683-96
24. Ludwin SK, Bakker DA. Can oligodendrocytes attached to myelin proliferate. J Neurosci 1988; 8: 1239-44
25. Ludwin SK, Szuchet S. Myelination by mature ovine oligodendrocytes in vivo and in vitro: evidence that different steps in the myelination process are independently controlled. Glia 1993; 8: 219-51
26. Rosenbluth J, Hasegawa M, Shirasuki N, Rosen CL, Liu Z. Myelin formation following transplantation of normal fetal glia into myelin deficient rat spinal cord. J Neurocytol 1990; 19: 718-50
27. Scolding NJ, Rayner PJ, Sussman J, Shaw C, Compston DAS. A proliferative adult human oligodendrocyte progenitor. NeuroReport 1995; 6: 441-45
28. Szuchet S. Polak PE, Yim SH. Mature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes. Dev Neurosci: 1896; 8: 208-21
29. Targett MP, Blakemore WF. The use of xenografting to evaluate the remyelinating potenial of glial cell cultures. Eye 1994; 8: 238-44
30. Targett MP, Sussman J, Compston DAS, Blakemore WF. The repair of areas of demyelination by the transplantation of adult rat glial cells. Neuropathol Appl Neurobiol 1995; 21: 155
31. Warrington AE, Barbarese E, Pfeiffer SE. Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts. J Neurosci Res 1993: 34: 113
32. Whittemore SR, Sanon HR, Wood PM. Concurrent isolation and characterization of oligodendrocytes, microglia and astrocytes from adult human spinal cord. Int J Dev Neurosci 1993; 11: 755-64
33. Wolswijk G, Noble M. Identification of an adult-specific glial progenitor cell. Development 1989; 105: 587-400
34. Wood PM, Bunge RP. The origin of remyelinating cells in the adult central nervous system-the role of the mature oligodendrocyte. Glia 1991; 4: 225-32
35. Wood PM, Mora J. Source of remyelinating oligodendrocytes. Adv Neurol 1993; 59: 113-23