Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice

Journal of Neuroimmunology

Volumn 92, Issue 1-2, 1998, Pages 38-49

  Hiremath, M M ^a   Saito, Y ^a   Knapp, G W ^a   Ting, J P Y ^a,b   Suzuki, K ^a   Matsushima, G K ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Astrocytes; Brain; Central nervous system (CNS); Immunology; Microglia macrophage

Indexed keywords

CUPRIZONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEMYELINATION; MACROPHAGE; MALE; MICROGLIA; MICROSCOPY; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ASTROCYTES; BODY WEIGHT; BRAIN; CELL COUNT; CHELATING AGENTS; COPPER; CORPUS CALLOSUM; CUPRIZONE; DEMYELINATING DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; MYELIN SHEATH; TIME FACTORS;

EID: 0032440093     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00168-4     Document Type: Article

References (42)

1. Bakker D.A., Ludwin S.K. Blood-brain barrier permeability during cuprizone-induced demyelination: implication for the pathogenesis of immune-mediated demyelinating diseases. J. Neurol. Sci. 78:1987;125-137.
2. Blakemore W.F. Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice. J. Neurocytol. 1:1972;413-426.
3. Blakemore W.F. Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone. J. Neurol. Sci. 20:1973;63-72.
4. Blakemore W.F. Remyelination of the superior cerebellar peduncle in old mice following demyelination induced by cuprizone. J. Neurol. Sci. 22:1974;121-126.
5. Bruck W. The role of macrophages in demyelination. Brain Pathol. 7:1997;741-752.
6. Bunge M.B., Bunge R.P., Ris H. Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord. J. Biophys. Biochem. Cytol. 10:1961;67-94.
7. Cammer W., Zhang H. Atypical localization of the oligodendrocytic isoform (PI) of glutathione-S-transferase in astrocytes during cuprizone intoxication. J. Neurosci. Res. 36:1993;183-190.
8. Elsworth S., Howell J.M. Variation in the response of mice to cuprizone. Res. Vet. Sci. 14:1973;385-387.
9. Fujita N., Ishiguro H., Sato S., Kurihara T., Kuwano R., Sakimura K., Takahashi Y., Miyatake T. Induction of myelin-associated glycoprotein mRNA in experimental remyelination. Brain Res. 513:1990;152-155.
10. Gledhill R.F., Harrison B.M., McDonald W.I. Demyelination and remyelination following acute spinal cord compression. Exp. Neurol. 38:1973;472-487.
11. Harrison B.M., McDonald W.I., Ochoa J. Remyelination in the central diphtheria toxin lesion. J. Neurol. Sci. 17:1972;293-302.
12. Hickey W.G., Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 239:1988;290-292.
13. Hirano A., Levine S., Zimmerman H.M. Remyelination in the central nervous system after cyanide intoxication. J. Neuropathol. Exp. Neurol. 28:1968;234-245.
14. Komoly S., Jeyasingham M., Pratt O., Lantos P. Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination. J. Neurol. Sci. 79:1987;141-148.
15. Kondo A., Nakano T., Suzuki K. Blood-brain barrier permeability in twitcher and cuprizone-intoxicated mice. Dev. Brain Res. 425:1987;186-190.
16. Lampert P.W. Demyelination and remyelination in experimental allergic encephalomyelitis. J. Neuropathol. Exp. Neurol. 24:1965;371-385.
17. Lampert P.W. Electron microscopic studies on ordinary and hyperacute experimental allergic encephalomyelitis. Acta Neuropathol. 9:1967;99-126.
18. Li H., Newcombe J., Groome N., Cuzner M.L. Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques. Neuropathol. Appl. Neurobiol. 19:1993;214-223.
19. Ludwin S.K. Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity. Lab. Invest. 39:1978;597-612.
20. Ludwin S.K. Pathology of demyelination and remyelination. Adv. Neurol. 31:1981;123-168.
21. Martin R., McFarland H.F., McFarlin D.E. Immunological aspects of demyelinating disease. Annu. Rev. Immunol. 10:1992;153-187.
22. Matsushima G.K., Taniike T., Glimcher L.H., Grusby M.J., Frelinger J.A., Suzuki K., Ting J.P.-Y. Absence of MHC class II molecules reduces CNS demyelination, microglia/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Cell. 78:1994;645-656.
23. Mattiace L.A., Davies P., Dickson D.W. Detection of HLA-DR on microglia in post-mortem human brain is a function of clinical and technical factors. Am. J. Pathol. 136:1990;1101-1104.
24. McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. 38:1988;1285-1291.
25. McGeer P.L., Itagaki S., McGeer E.G. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 76:1988;550-557.
26. Ohno M., Higashi Y., Suzuki K. Microglial cell response to neuronal degeneration in the brain of brindled mouse. Dev. Brain Res. 67:1992;37-45.
27. Perlmutter L.S., Scott S.A., Barron E., Chui H.C. Ia-positive microglia in human brain: association with Alzheimer lesions. J. Neurosci. Res. 33:1992;549-558.
28. Prineas J., Raine C.S., Wisniewski H. An ultrastructural study of experimental demyelination and remyelination: Part 3. Chronic experimental allergic encephalomyelitis in the central nervous system. Lab. Invest. 21:1969;472-483.
29. Raine C.S. Multiple sclerosis: immune system molecule expression in the central nervous system. J. Neuropathol. Exp. Neurol. 53:1994;328-337.
30. Sidman, R.L., Angervine, J.B., Pierce, E.T., 1971. Atlas of the Mouse Brain and Spinal Cord. Commonwealth Fund Book. Harvard Univ. Press, Cambridge, MA, p. 38.
31. 3. J. Comp. Neurol. 116:1961;349-367.
32. Styren S.D., Civin W.H., Rogers J. Molecular, cellular and pathological characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp. Neurol. 110:1990;93-104.
33. Suzuki K. Giant hepatic mitochondria: production in mice fed with cuprizone. Science. 163:1969;81-82.
34. Suzuki K., Kikkawa Y. Status spongiosus of CNS and hepatic changes induced by cuprizone (Bis-cyclohexanone oxalyldihydrazone). Am. J. Pathol. 54:1969;307-325.
35. Ting J.P.-Y., Shigekawa B., Linthicum D.S., Weiner L.P., Frelinger J.A. Expression and synthesis of murine immune response associated (Ia) antigens by brain cells. Proc. Natl. Acad. Sci. USA. 78:1981;3170-3174.
36. Tomimoto H., Akiguchi I., Akiyama H., Kimura J., Yanagihara T. T-cell infiltration and expression of Ia antigen by macrophages and microglia in a heterogeneous group in leukoencephalopathy. Am. J. Pathol. 143:1993;579-586.
37. Traugott U., Reinherz E., Raine C. Multiple sclerosis: distribution of T-cell subsets within active chronic lesions. Science. 219:1983;308-310.
38. Walshe J.M. Copper: not too little, not too much, but just right. J. R. Coll. Phys. London. 29:1995;280-283.
39. Wisniewski H., Raine C.R. An ultrastructural study of experimental demyelination and remyelination: Part 5. Central and peripheral nervous system lesions caused by diphtheria toxin. Lab. Invest. 25:1971;73-80.
40. Yajima K., Suzuki K. Demyelination and remyelination in the rat CNS following ethidium bromide injection. Lab. Invest. 41:1979;385-392.
41. Zamvil S.S., Steinman L. The T-lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:1990;579-621.
42. Zlotkin S.H., Atkinson S., Lockitch G. Trace elements in nutrition for premature infants. Clin. Perinatol. 22:1995;223-240.