Transfer of myelin-reactive Th17 cells impairs endogenous remyelination in the central nervous system of cuprizone-fed mice

Journal of Neuroscience

Volumn 35, Issue 22, 2015, Pages 8626-8639

  Baxi, Emily G ^a   DeBruin, Joseph ^a   Tosi, Dominique M ^a   Grishkan, Inna V ^a   Smith, Matthew D ^a   Kirby, Leslie A ^a   Strasburger, Hayley J ^a   Fairchild, Amanda N ^a   Calabresi, Peter A ^a   Gocke, Anne R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axons; Cuprizone; Demyelination; Inflammation; Multiple sclerosis; Oligodendrocyte precursor cells

Indexed keywords

CUPRIZONE; GAMMA INTERFERON; INTERLEUKIN 17; MYELIN; CD45 ANTIGEN; FREUND ADJUVANT; MONOAMINE OXIDASE INHIBITOR; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); MYELIN PROTEIN; PEPTIDE FRAGMENT;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; MONOCYTE; MONONUCLEAR CELL; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; REMYELINIZATION; TH1 CELL; TH17 CELL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL POLARITY; CENTRAL NERVOUS SYSTEM; CHEMICALLY INDUCED; DEMYELINATING DISEASES; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; MYELIN SHEATH; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; REGENERATION; TIME; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD45; CELL POLARITY; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CUPRIZONE; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; FREUND'S ADJUVANT; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MONOAMINE OXIDASE INHIBITORS; MONOCYTES; MYELIN PROTEINS; MYELIN SHEATH; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NEUTROPHIL INFILTRATION; PEPTIDE FRAGMENTS; REGENERATION; TH17 CELLS; TIME FACTORS;

EID: 84930459853     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3817-14.2015     Document Type: Article

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