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Volumn 17, Issue 3, 2016, Pages

TFE3 alleviates hepatic steatosis through autophagy-induced lipophagy and PGC1α-mediated fatty acid β-oxidation

Author keywords

Autophagy; Hepatic steatosis; PGC1 ; TFE3; oxidation

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E3; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; PPARGC1A PROTEIN, HUMAN; TFE3 PROTEIN, HUMAN;

EID: 84962563171     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17030387     Document Type: Article
Times cited : (46)

References (33)
  • 1
    • 84954338945 scopus 로고    scopus 로고
    • Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation
    • [CrossRef] [PubMed]
    • Brunt, E.M. Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation. Int. J. Mol. Sci. 2015, 17, 97[CrossRef] [PubMed]
    • (2015) Int. J. Mol. Sci , vol.17 , pp. 97
    • Brunt, E.M.1
  • 2
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Choi, S.S.; Diehl, A.M. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr. Opin. Lipidol. 2008, 19, 295–300[CrossRef] [PubMed]
    • (2008) Curr. Opin. Lipidol , vol.19 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 4
    • 66949165559 scopus 로고    scopus 로고
    • Autophagy in disease: A double-edged sword with therapeutic potential
    • [CrossRef] [PubMed]
    • Martinet, W.; Agostinis, P.; Vanhoecke, B.; Dewaele, M.; de Meyer, G.R. Autophagy in disease: A double-edged sword with therapeutic potential. Clin. Sci. 2009, 116, 697–712[CrossRef] [PubMed]
    • (2009) Clin. Sci , vol.116 , pp. 697-712
    • Martinet, W.1    Agostinis, P.2    Vanhoecke, B.3    Dewaele, M.4    De Meyer, G.R.5
  • 5
    • 79954475565 scopus 로고    scopus 로고
    • Autophagy in nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Amir, M.; Czaja, M.J. Autophagy in nonalcoholic steatohepatitis. Expert Rev. Gastroenterol. Hepatol. 2011, 5, 159–166[CrossRef] [PubMed]
    • (2011) Expert Rev. Gastroenterol. Hepatol , vol.5 , pp. 159-166
    • Amir, M.1    Czaja, M.J.2
  • 6
    • 84866122688 scopus 로고    scopus 로고
    • Autophagy modulation as a potential therapeutic target for diverse diseases
    • [CrossRef] [PubMed]
    • Rubinsztein, D.C.; Codogno, P.; Levine, B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov. 2012, 11, 709–30[CrossRef] [PubMed]
    • (2012) Nat. Rev. Drug Discov , vol.11 , pp. 709-730
    • Rubinsztein, D.C.1    Codogno, P.2    Levine, B.3
  • 7
    • 84873660610 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • [CrossRef] [PubMed]
    • Choi, A.M.; Ryter, S.W.; Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 2013, 368, 1845–1846[CrossRef] [PubMed]
    • (2013) N. Engl. J. Med , vol.368 , pp. 1845-1846
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 9
    • 77955789211 scopus 로고    scopus 로고
    • Altered lipid content inhibits autophagic vesicular fusion
    • [CrossRef] [PubMed]
    • Koga, H.; Kaushik, S.; Cuervo, A.M. Altered lipid content inhibits autophagic vesicular fusion. FASEB J. 2010, 24, 3052–3065[CrossRef] [PubMed]
    • (2010) FASEB J , vol.24 , pp. 3052-3065
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 10
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • [CrossRef] [PubMed]
    • Yang, L.; Li, P.; Fu, S.; Calay, E.S.; Hotamisligil, G.S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010, 11, 467–478[CrossRef] [PubMed]
    • (2010) Cell Metab , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 11
    • 80052617116 scopus 로고    scopus 로고
    • Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression
    • [CrossRef] [PubMed]
    • Inami, Y.; Yamashina, S.; Izumi, K.; Ueno, T.; Tanida, I.; Ikejima, K.; Watanabe, S. Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression. Biochem. Biophys. Res. Commun. 2011, 412, 618–625[CrossRef] [PubMed]
    • (2011) Biochem. Biophys. Res. Commun , vol.412 , pp. 618-625
    • Inami, Y.1    Yamashina, S.2    Izumi, K.3    Ueno, T.4    Tanida, I.5    Ikejima, K.6    Watanabe, S.7
  • 12
    • 46249115957 scopus 로고    scopus 로고
    • Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation
    • [CrossRef] [PubMed]
    • Harada, M.; Hanada, S.; Toivola, D.M.; Ghori, N.; Omary, M.B. Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology 2008, 47, 2026–2035[CrossRef] [PubMed]
    • (2008) Hepatology , vol.47 , pp. 2026-2035
    • Harada, M.1    Hanada, S.2    Toivola, D.M.3    Ghori, N.4    Omary, M.B.5
  • 13
    • 84876287362 scopus 로고    scopus 로고
    • Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice
    • [CrossRef] [PubMed]
    • Lin, C.W.; Zhang, H.; Li, M.; Xiong, X.; Chen, X.; Chen, X.; Dong, X.C.; Yin, X.M. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J. Hepatol. 2013, 58, 993–999[CrossRef] [PubMed]
    • (2013) J. Hepatol , vol.58 , pp. 993-999
    • Lin, C.W.1    Zhang, H.2    Li, M.3    Xiong, X.4    Chen, X.5    Chen, X.6    Dong, X.C.7    Yin, X.M.8
  • 14
    • 84952927680 scopus 로고    scopus 로고
    • Protective role of autophagy in methionine-choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice
    • [CrossRef] [PubMed]
    • Chen, R.; Wang, Q.; Song, S.; Liu, F.; He, B.; Gao, X. Protective role of autophagy in methionine-choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice. Eur. J. Pharmacol. 2016, 770, 126–133[CrossRef] [PubMed]
    • (2016) Eur. J. Pharmacol , vol.770 , pp. 126-133
    • Chen, R.1    Wang, Q.2    Song, S.3    Liu, F.4    He, B.5    Gao, X.6
  • 16
    • 84893055506 scopus 로고    scopus 로고
    • The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
    • ra9[CrossRef] [PubMed]
    • Martina, J.A.; Diab, H.I.; Lishu, L.; Jeong, A.L.; Patange, S.; Raben, N.; Puertollano, R. The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci. Signal. 2014, 7, ra9[CrossRef] [PubMed]
    • (2014) Sci. Signal , pp. 7
    • Martina, J.A.1    Diab, H.I.2    Lishu, L.3    Jeong, A.L.4    Patange, S.5    Raben, N.6    Puertollano, R.7
  • 17
    • 84978144234 scopus 로고    scopus 로고
    • Role of chaperone-mediated autophagy in metabolism
    • [CrossRef] [PubMed]
    • Tasset, I.; Cuervo, A.M. Role of chaperone-mediated autophagy in metabolism. FEBS J. 2016[CrossRef] [PubMed]
    • (2016) FEBS J
    • Tasset, I.1    Cuervo, A.M.2
  • 18
    • 3242888703 scopus 로고    scopus 로고
    • LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
    • [CrossRef] [PubMed]
    • Kabeya, Y.; Mizushima, N.; Yamamoto, A.; Oshitani-Okamoto, S.; Ohsumi, Y.; Yoshimori, T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J. Cell Sci. 2004, 117, 2805–2812[CrossRef] [PubMed]
    • (2004) J. Cell Sci , vol.117 , pp. 2805-2812
    • Kabeya, Y.1    Mizushima, N.2    Yamamoto, A.3    Oshitani-Okamoto, S.4    Ohsumi, Y.5    Yoshimori, T.6
  • 20
    • 84907881796 scopus 로고    scopus 로고
    • Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Fukuo, Y.; Yamashina, S.; Sonoue, H.; Arakawa, A.; Nakadera, E.; Aoyama, T.; Uchiyama, A.; Kon, K.; Ikejima, K.; Watanabe, S. Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease. Hepatol. Res. 2014, 44, 1026–1036[CrossRef] [PubMed]
    • (2014) Hepatol. Res , vol.44 , pp. 1026-1036
    • Fukuo, Y.1    Yamashina, S.2    Sonoue, H.3    Arakawa, A.4    Nakadera, E.5    Aoyama, T.6    Uchiyama, A.7    Kon, K.8    Ikejima, K.9    Watanabe, S.10
  • 21
    • 84921475513 scopus 로고    scopus 로고
    • Autophagy and non-alcoholic fatty liver disease
    • Lavallard, V.J.; Gual, P. Autophagy and non-alcoholic fatty liver disease. BioMed Res. Int. 2014, 2014, 120179
    • (2014) Biomed Res. Int
    • Lavallard, V.J.1    Gual, P.2
  • 22
    • 84903314885 scopus 로고    scopus 로고
    • Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
    • [CrossRef] [PubMed]
    • Martina, J.A.; Diab, H.I.; Li, H.; Puertollano, R. Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis. Cell. Mol. Life Sci. 2014, 71, 2483–2497[CrossRef] [PubMed]
    • (2014) Cell. Mol. Life Sci , vol.71 , pp. 2483-2497
    • Martina, J.A.1    Diab, H.I.2    Li, H.3    Puertollano, R.4
  • 23
    • 83555176010 scopus 로고    scopus 로고
    • Lipotoxicity in NASH
    • [CrossRef] [PubMed]
    • Fuchs, M.; Sanyal, A.J. Lipotoxicity in NASH. J. Hepatol. 2012, 56, 291–293[CrossRef] [PubMed]
    • (2012) J. Hepatol , vol.56 , pp. 291-293
    • Fuchs, M.1    Sanyal, A.J.2
  • 25
    • 84900404551 scopus 로고    scopus 로고
    • Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells
    • [CrossRef] [PubMed]
    • Yin, J.; Luo, Y.; Deng, H.; Qin, S.; Tang, W.; Zeng, L.; Zhou, B. Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells. J. Ethnopharmacol. 2014, 154, 229–239[CrossRef] [PubMed]
    • (2014) J. Ethnopharmacol , vol.154 , pp. 229-239
    • Yin, J.1    Luo, Y.2    Deng, H.3    Qin, S.4    Tang, W.5    Zeng, L.6    Zhou, B.7
  • 26
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • [CrossRef] [PubMed]
    • Finck, B.N.; Kelly, D.P. PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease. J. Clin. Investig. 2006, 116, 615–622[CrossRef] [PubMed]
    • (2006) J. Clin. Investig , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 27
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic. Biol. Med. 2012, 52, 59–69[CrossRef] [PubMed]
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 28
    • 46749125376 scopus 로고    scopus 로고
    • Transcriptional control of mitochondrial biogenesis: The central role of PGC-1α
    • [CrossRef] [PubMed]
    • Ventura-Clapier, R.; Garnier, A.; Veksler, V. Transcriptional control of mitochondrial biogenesis: The central role of PGC-1α. Cardiovasc. Res. 2008, 79, 208–217[CrossRef] [PubMed]
    • (2008) Cardiovasc. Res , vol.79 , pp. 208-217
    • Ventura-Clapier, R.1    Garnier, A.2    Veksler, V.3
  • 29
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • [CrossRef] [PubMed]
    • Scarpulla, R.C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim. Biophys. Acta Mol. Cell Res. 2011, 1813, 1269–1278[CrossRef] [PubMed]
    • (2011) Biochim. Biophys. Acta Mol. Cell Res , vol.1813 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 32
    • 0031724470 scopus 로고    scopus 로고
    • Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo
    • [CrossRef] [PubMed]
    • Aksan, I.; Goding, C.R. Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol. Cell. Biol. 1998, 18, 6930–6938[CrossRef] [PubMed]
    • (1998) Mol. Cell. Biol , vol.18 , pp. 6930-6938
    • Aksan, I.1    Goding, C.R.2


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