Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo

Molecular and Cellular Biology

Volumn 18, Issue 12, 1998, Pages 6930-6938

  Aksan, I ^a   Goding, C R ^a  

^a MARIE CURIE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; MONOPHENOL MONOOXYGENASE; TRANSCRIPTION FACTOR;

ARTICLE; DNA FLANKING REGION; DNA SEQUENCE; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MELANOCYTE; MICROPHTHALMIA; NONHUMAN; PIGMENT CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN STRUCTURE;

TESTUDINES;

EID: 0031724470     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.12.6930     Document Type: Article

References (44)

1. Baldwin, C. T., N. R. Lipsky, C. F. Hoth, T. Cohen, W. Mamuya, and A. Milunsky. 1994. Mutations in PAX3 associated with Waardenburg syndrome type I. Hum. Mutat. 3:205-211.
2. Baynash, A. G., K. Hosoda, A. Giaid, J. A. Richardson, N. Emoto, R. E. Hammer, and M. Yanagisawa. 1994. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 79:1277-1285.
3. Bentley, N. J., T. Eisen, and C. R. Goding. 1994. Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol. Cell. Biol. 14:7996-8006.
4. Bertolotto, C., R. Buscà, P. Abbe, K. Bille, E. Aberdam, J.-P. Ortonne, and R. Ballotti. 1998. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia. Mol. Cell. Biol. 18:694-702.
5. Bertolotto, C., K. Bille, J.-P. Ortonne, and R. Ballotti. 1996. Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product. J. Cell. Sci. 134:747-755.
6. Butt, J., J. Greenberg, I. Winship, S. Sellars, P. Beighton, and R. Ramesar. 1994. A splice junction mutation in PAX3 causes Waardenburg syndrome in a South African family. Hum. Mol. Genet. 3:197-198.
7. Crouch, D. H., F. Fisher, W. Clark, P. S. Jayaraman, C. R. Goding, and D. A. Gillespie. 1993. Gene-regulatory properties of Myc helix-loop-helix/leucine zipper mutants: Max-dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity. Oncogene 8:1849-1855.
8. Duttlinger, R., K. Manova, G. Berrozpe, T. Y. Chu, V. DeLeon, I. Timokhina, R. S. Chaganti, A. D. Zelenetz, R. F. Bachvarova, and P. Besmer. 1995. The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc. Natl. Acad. Sci. USA 92:3754-3758.
9. Ferré-D'Amaré, A. R., P. Pognonec, R. G. Roeder, and S. K. Burley. 1994. Structure and function of the b/HLH/Z domain of USF. EMBO J. 13:180-189.
10. Fisher, F., D. H. Crouch, P. S. Jayaraman, W. Clark, D. A. Gillespie, and C. R. Goding. 1993. Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo. EMBO J. 12:5075-5082.
11. Fisher, F., and C. R. Goding. 1992. Single amino acid substitutions alter helix-loop-helix protein specificity for bases flanking the core CANNTG motif. EMBO J. 11:4103-4109.
12. Galaktionov, K., X. Chen, and D. Beach. 1996. CDC25 cell-cycle phosphatase as a target of c-myc. Nature 382:511-517.
13. Galibert, M.-D., L. Boucontet, C. R. Goding, and T. Meo. 1997. Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor. J. Immunol. 159:6167-6183.
14. Ganss, R., G. Schutz, and F. Beermann. 1994. The mouse tyrosinase gene. Promoter modulation by positive and negative regulatory elements. J. Biol. Chem. 269:29808-29816.
15. Gardner, J. M., Y. Nakatsu, Y. Gondo, S. Lee, M. F. Lyon, R. A. King, and M. H. Brilliant. 1992. The mouse pink-eyed dilution gene: association with human Prader-Willi and Angelman syndromes. Science 257:1121-1124.
16. Goding, C. R., and J. Mellor. Unpublished observations.
17. Guthrie, C., and G. R. Fink. 1991. Methods in enzymology, vol. 194. Guide to yeast genetics and molecular biology. Academic Press, New York, N.Y.
18. Hemesath, T. J., E. R. Price, C. Takemoto, T. Badalian, and D. E. Fisher. 1998. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391:298-301.
19. Hemesath, T. J., E. Steingrimsson, G. McGill, M. J. Hansen, J. Vaught, C. A. Hodgkinson, H. Arnheiter, N. G. Copeland, N. A. Jenkins, and D. E. Fisher. 1994. Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev. 8:2770-2780.
20. Hirst, K., F. Fisher, P. C. McAndrew, and C. R. Goding. 1994. The transcription factor, the Cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal. EMBO J. 13:5410-5420.
21. Hodgkinson, C. A., K. J. Moore, A. Nakayama, E. Steingrimsson, N. G. Copeland, N. A. Jenkins, and H. Arnheiter. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74:395-404.
22. Hosoda, K., R. E. Hammer, J. A. Richardson, A. G. Baynash, J. C. Cheung, A. Giaid, and M. Yanagisawa. 1994. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 79:1267-1276.
23. Jayaraman, P. S., K. Hirst, and C. R. Goding. 1994. The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulation. EMBO J. 13:2192-2199.
24. Lee, S. T., R. D. Nicholls, M. T. Jong, K. Fukai, and R. A. Spritz. 1995. Organization and sequence of the human P gene and identification of a new family of transport proteins. Genomics 26:354-363.
25. Lowings, P., U. Yavuzer, and C. R. Goding. 1992. Positive and negative elements regulate a melanocyte-specific promoter. Mol. Cell. Biol. 12:3653-3662.
26. Moore, K. J. 1995. Insight into the microphthalmia gene. Trends Genet. 11:442-448.
27. Nakayama, A., M. T. Nguyen, C. C. Chen, K. Opdecamp, C. A. Hodgkinson, and H. Amheiter. 1998. Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently. Mech. Dev. 70:155-166.
28. Nocka, K., S. Majumder, B. Chabot, P. Ray, M. Cervone, A. Bernstein, and P. Besmer. 1989. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice. Genes Dev. 3:816-826.
29. O'Hare, P., and C. R. Goding. 1988. Herpes simplex virus regulatory elements and the irnmimoglobulin octamer domain bind a common factor and are both targets for virion transactivation. Cell 52:435-445.
30. Opdecamp, K., A. Nakayama, M. T. Nguyen, C. A. Hodgkinson, W. J. Pavan, and H. Arnheiter. 1997. Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development 124:2377-2386.
31. Pingault, V., N. Bondurand, K. Kuhlbrodt, D. E. Goerich, M.-O. Préhu, A. Puliti, B. Herbarth, I. Hermans-Borgmeyer, E. Legius, G. Matthijs, J. Amiel. S. Lyonnet, I. Ceccherini, G. Romeo, J. Clayton-Smith, A. P. Read, M. Wegner, and M. Goossens. 1998. SOX mutations in patients with Waardenburgs-Hirschprung disease. Nat. Genet. 18:171-173.
32. Puffenberger, E. G., K. Hosoda, S. S. Washington, K. Nakao, D. deWit, M. Yanagisawa, and A. Chakravart. 1994. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 79:1257-1266.
33. Sato, S., K. Roberts, G. Gambino, A. Cook, T. Kouzarides, and C. R. Goding. 1997. CBP/p300 as a co-factor for the microphthalmia transcription factor. Oncogene 14:3083-3092.
34. Silvers, W. K. 1979. The coat colors of mice. Springer-Verlag, New York, N.Y.
35. Solomon, D. L., B. Amati, and H. Land. 1993. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21: 5372-5376.
36. Southard-Smith, E. M., L. Kos, and W. Pavan. 1998. Sox10 mutation disrupts neural crest development in Dom Hirschprung mouse model. Nat. Genet. 18:60-64.
37. Steingrímsson, E., K. J. Moore, M. L. Lamoreaux, A. R. Ferré-D'Amaré, S. K. Burley, D. C. Sanders Zimring, L. C. Skow, C. A. Hodgkinson, H. Arnheiter, N. G. Copeland, and N. A. Jenkins. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nat. Genet. 8:256-263.
38. Tachibana, M., K. Takeda, Y. Nobukuni, K. Urabe, J. E. Long, K. A. Meyers, S. A. Aaronson, and T. Miki. 1996. Ectopic expression of MITF, a gene for Waardenhurgs syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. Nat. Genet. 14:50-54.
39. Tassabehji, M., V. E. Newton, and A. P. Read. 1994. Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. Nat. Genet. 8:251-255.
40. Tsujimura, T., E. Morii, M. Nozaki, K. Hashimoto, Y. Moriyama, K. Takebayashi, T. Kondo, Y. Kanakura, and Y. Kitamura. 1996. Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice. Blood 88:1225-1233.
41. Turque, N., F. Denhez, P. Martin, N. Planque, M. Bailly, A. Begue, D. Stehelin, and S. Saule. 1996. Characterization of a new melanocyte-specific gene (QNR-71) expressed in v-myc transformed quail neuroretina. EMBO J. 15:3338-3350.
42. Yasumoto, K.-I., K. Yokoyama, K. Shibata, Y. Tomita, and S. Shibahara. 1994. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol. Cell. Biol. 14:8058-8070.
43. Yasumoto, K.-I., K. Yokayama, K. Takahashi, Y. Tomita, and S. Shibahara. 1997. Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes. J. Biol. Chem. 272:503-509.
44. Yavuzer, U., E. Keenan, P. Lowings, J. Vachtenhein, G. Currie, and C. R. Goding. 1995. The microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription. Oncogene 10:123-134.