메뉴 건너뛰기




Volumn 22, Issue 2, 2016, Pages 91-105

Treatment of nonalcoholic fatty liver disease: Where do we stand? an overview

Author keywords

Insulin sensitizers; liver protectors; Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis; Ursodeoxycholic acid; Vitamin E

Indexed keywords

ACARBOSE; ALPHA TOCOPHEROL; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTHOCYANIN; ANTIFIBROTIC AGENT; ANTILIPEMIC AGENT; ELAFIBRANOR; FOLIC ACID; ICOSAPENTAENOIC ACID ETHYL ESTER; INSULIN SENSITIZING AGENT; LIVER PROTECTIVE AGENT; METRELEPTIN; OBETICHOLIC ACID; PIOGLITAZONE; PRADIGASTAT; PROBIOTIC AGENT; QUERCETIN; RESVERATROL; ROFLUMILAST; S ADENOSYLMETHIONINE; TETRAHYDROLIPSTATIN; URSODEOXYCHOLIC ACID; VITAMIN D; 2-(2,6-DIMETHYL-4-(3-(4-(METHYLTHIO)PHENYL)-3-OXO-1-PROPENYL)PHENOXYL)-2-METHYLPROPANOIC ACID; ANTIDIABETIC AGENT; CHALCONE DERIVATIVE; CHENODEOXYCHOLIC ACID; PROPIONIC ACID DERIVATIVE;

EID: 84962346000     PISSN: 13193767     EISSN: 19984049     Source Type: Journal    
DOI: 10.4103/1319-3767.178527     Document Type: Article
Times cited : (32)

References (135)
  • 1
    • 78650774076 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground
    • Chitturi S, Wong VW, Farrell G. Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground. J Gastroenterol Hepatol 2011; 26(Suppl 1): 163-72
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 163-172
    • Chitturi, S.1    Wong, V.W.2    Farrell, G.3
  • 3
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Söderberg C, Stå l P, Askling J, Glaumann H, Lindberg G, Marmur J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 2010; 51: 595-602
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Söderberg, C.1    Stå, L.P.2    Askling, J.3    Glaumann, H.4    Lindberg, G.5    Marmur, J.6
  • 4
    • 58849132440 scopus 로고    scopus 로고
    • Clinical features and outcomes of cirrhosis due to non-Alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
    • Yatsuji S, Hashimoto E, Tobari M, Taniai M, Tokushige K, Shiratori K. Clinical features and outcomes of cirrhosis due to non-Alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C. J Gastroenterol Hepatol 2009; 24: 248-54
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 248-254
    • Yatsuji, S.1    Hashimoto, E.2    Tobari, M.3    Taniai, M.4    Tokushige, K.5    Shiratori, K.6
  • 6
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-Alcoholic fatty liver disease (NAFLD): A systematic review and meta-Analysis of randomised trials
    • Musso G, Cassader M, Rosina F, Gambino R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-Alcoholic fatty liver disease (NAFLD): A systematic review and meta-Analysis of randomised trials. Diabetologia 2012; 55: 885-904
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 7
    • 84861901590 scopus 로고    scopus 로고
    • The diagnosis and management of non-Alcoholic fatty liver disease: Practice guideline by the American association for the study of liver diseases, American college of gastroenterology, and the American gastroenterological association
    • American Association for the Study of Liver Diseases; American College of Gastroenterology; American Gastroenterological Association
    • Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al.; American Association for the Study of Liver Diseases; American College of Gastroenterology; American Gastroenterological Association. The diagnosis and management of non-Alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 2012; 107: 811-26
    • (2012) Am J Gastroenterol , vol.107 , pp. 811-826
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6
  • 8
    • 84911375849 scopus 로고    scopus 로고
    • Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial
    • Babio N, Toledo E, Estruch R, Ros E, Martínez-González MA, Castañer O, et al. Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ 2014; 186: E649-57
    • (2014) CMAJ , vol.186 , pp. E649-E657
    • Babio, N.1    Toledo, E.2    Estruch, R.3    Ros, E.4    Martínez-González, M.A.5    Castañer, O.6
  • 9
    • 43549088340 scopus 로고    scopus 로고
    • Effect of a dietary-induced weight loss on liver enzymes in obese subjects
    • Gasteyger C, Larsen TM, Vercruysse F, Astrup A. Effect of a dietary-induced weight loss on liver enzymes in obese subjects. Am J Clin Nutr 2008; 87: 1141-7
    • (2008) Am J Clin Nutr , vol.87 , pp. 1141-1147
    • Gasteyger, C.1    Larsen, T.M.2    Vercruysse, F.3    Astrup, A.4
  • 10
    • 78149283488 scopus 로고    scopus 로고
    • Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes
    • Fatty Liver Subgroup of the Look AHEAD Research Group
    • Lazo M, Solga SF, Horska A, Bonekamp S, Diehl AM, Brancati FL, et al.; Fatty Liver Subgroup of the Look AHEAD Research Group. Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care 2010; 33: 2156-63
    • (2010) Diabetes Care , vol.33 , pp. 2156-2163
    • Lazo, M.1    Solga, S.F.2    Horska, A.3    Bonekamp, S.4    Diehl, A.M.5    Brancati, F.L.6
  • 11
    • 77950359230 scopus 로고    scopus 로고
    • Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes
    • Look AHEAD Adipose Research Group
    • Albu JB, Heilbronn LK, Kelley DE, Smith SR, Azuma K, Berk ES, et al.; Look AHEAD Adipose Research Group. Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes. Diabetes 2010; 59: 627-33
    • (2010) Diabetes , vol.59 , pp. 627-633
    • Albu, J.B.1    Heilbronn, L.K.2    Kelley, D.E.3    Smith, S.R.4    Azuma, K.5    Berk, E.S.6
  • 12
    • 33646483917 scopus 로고    scopus 로고
    • A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease
    • Zelber-Sagi S, Kessler A, Brazowsky E, Webb M, Lurie Y, Santo M, et al. A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2006; 4: 639-44
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 639-644
    • Zelber-Sagi, S.1    Kessler, A.2    Brazowsky, E.3    Webb, M.4    Lurie, Y.5    Santo, M.6
  • 13
    • 58949102847 scopus 로고    scopus 로고
    • Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial
    • Harrison SA, Fecht W, Brunt EM, Neuschwander-Tetri BA. Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial. Hepatology 2009; 49: 80-6
    • (2009) Hepatology , vol.49 , pp. 80-86
    • Harrison, S.A.1    Fecht, W.2    Brunt, E.M.3    Neuschwander-Tetri, B.A.4
  • 14
    • 77952118055 scopus 로고    scopus 로고
    • European Medicine Agency. Available from. [Last accessed on 2015 Apr 19]
    • European Medicine Agency. Xenical 120 mg Summary of Product Characteristics. Available from: http: //www.ema.europa.eu/docs/en GB/document library/EPAR - Product Information/human/000154/WC500058428.pdf. [Last accessed on 2015 Apr 19]
    • Xenical 120 Mg Summary of Product Characteristics
  • 15
    • 84874597977 scopus 로고    scopus 로고
    • Bariatric surgery as potential treatment for nonalcoholic fatty liver disease A future treatment by choice or by chance?
    • Hafeez S, Ahmed MH. Bariatric surgery as potential treatment for nonalcoholic fatty liver disease: A future treatment by choice or by chance?. J Obes 2013; 2013: 839275
    • (2013) J Obes , vol.2013 , pp. 839275
    • Hafeez, S.1    Ahmed, M.H.2
  • 17
    • 57149101692 scopus 로고    scopus 로고
    • Effect of bariatric surgery on nonalcoholic fatty liver disease Systematic review and meta-Analysis
    • Mummadi RR, Kasturi KS, Chennareddygari S, Sood GK. Effect of bariatric surgery on nonalcoholic fatty liver disease: Systematic review and meta-Analysis. Clin Gastroenterol Hepatol 2008; 6: 1396-402
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1396-1402
    • Mummadi, R.R.1    Kasturi, K.S.2    Chennareddygari, S.3    Sood, G.K.4
  • 19
    • 84919706677 scopus 로고    scopus 로고
    • Bariatric surgery and non-Alcoholic fatty liver disease: Current and potential future treatments
    • Sasaki A, Nitta H, Otsuka K, Umemura A, Baba S, Obuchi T, et al. Bariatric surgery and non-Alcoholic fatty liver disease: Current and potential future treatments. Front Endocrinol (Lausanne) 2014; 5: 164
    • (2014) Front Endocrinol (Lausanne , vol.5 , pp. 164
    • Sasaki, A.1    Nitta, H.2    Otsuka, K.3    Umemura, A.4    Baba, S.5    Obuchi, T.6
  • 22
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus Vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E, Gentilcore E, Manini R, Natale S, Vanni E, Villanova N, et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005; 100: 1082-90
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3    Natale, S.4    Vanni, E.5    Villanova, N.6
  • 23
    • 79955446251 scopus 로고    scopus 로고
    • Effect of Vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial. JAMA 2011; 305: 1659-68
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5    Rosenthal, P.6
  • 25
    • 0141996322 scopus 로고    scopus 로고
    • Effect of pioglitazone on biochemical indices of non-Alcoholic fatty liver disease in upper body obesity
    • Shadid S, Jensen MD. Effect of pioglitazone on biochemical indices of non-Alcoholic fatty liver disease in upper body obesity. Clin Gastroenterol Hepatol 2003; 1: 384-7
    • (2003) Clin Gastroenterol Hepatol , vol.1 , pp. 384-387
    • Shadid, S.1    Jensen, M.D.2
  • 26
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal GP, Thomas JA, Kaye PV, Lawson A, Ryder SD, Spendlove I, et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008; 135: 1176-84
    • (2008) Gastroenterology , vol.135 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3    Lawson, A.4    Ryder, S.D.5    Spendlove, I.6
  • 28
    • 80055042241 scopus 로고    scopus 로고
    • The role of thiazolidinediones in non-Alcoholic steatohepatitis -A systematic review andmeta analysis
    • Mahady SE, Webster AC, Walker S, Sanyal A, George J. The role of thiazolidinediones in non-Alcoholic steatohepatitis -A systematic review andmeta analysis. J Hepatol 2011; 55: 1383-90
    • (2011) J Hepatol , vol.55 , pp. 1383-1390
    • Mahady, S.E.1    Webster, A.C.2    Walker, S.3    Sanyal, A.4    George, J.5
  • 29
    • 78650971903 scopus 로고    scopus 로고
    • Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: The St Francis Heart Study randomized clinical trial
    • Foster T, Budoff MJ, Saab S, Ahmadi N, Gordon C, Guerci AD. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: The St Francis Heart Study randomized clinical trial. Am J Gastroenterol 2011; 106: 71-7
    • (2011) Am J Gastroenterol , vol.106 , pp. 71-77
    • Foster, T.1    Budoff, M.J.2    Saab, S.3    Ahmadi, N.4    Gordon, C.5    Guerci, A.D.6
  • 31
    • 4243359801 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of NASH
    • Horlander J, Kwo P. Atorvastatin for the treatment of NASH. Hepatology 1997; 26: 544A
    • (1997) Hepatology , vol.26 , pp. 544A
    • Horlander, J.1    Kwo, P.2
  • 32
    • 0347917155 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis
    • Kiyici M, Gulten M, Gurel S, Nak SG, Dolar E, Savci G, et al. Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis. Can J Gastroenterol 2003; 17: 713-8
    • (2003) Can J Gastroenterol , vol.17 , pp. 713-718
    • Kiyici, M.1    Gulten, M.2    Gurel, S.3    Nak, S.G.4    Dolar, E.5    Savci, G.6
  • 33
    • 78651473467 scopus 로고    scopus 로고
    • Efficacy of long-Term ezetimibe therapy in patients with nonalcoholic fatty liver disease
    • Park H, Shima T, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, et al. Efficacy of long-Term ezetimibe therapy in patients with nonalcoholic fatty liver disease. J Gastroenterol 2011; 46: 101-7
    • (2011) J Gastroenterol , vol.46 , pp. 101-107
    • Park, H.1    Shima, T.2    Yamaguchi, K.3    Mitsuyoshi, H.4    Minami, M.5    Yasui, K.6
  • 34
    • 84925339397 scopus 로고    scopus 로고
    • Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial
    • San Diego Integrated NAFLD Research Consortium (SINC).
    • Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, et al.; San Diego Integrated NAFLD Research Consortium (SINC Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial) Hepatology 2015 61 239-50
    • (2015) Hepatology , vol.61 , pp. 239-250
    • Loomba, R.1    Sirlin, C.B.2    Ang, B.3    Bettencourt, R.4    Jain, R.5    Salotti, J.6
  • 35
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
    • Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study. J Pediatr 2000; 136: 734-8
    • (2000) J Pediatr , vol.136 , pp. 734-738
    • Lavine, J.E.1
  • 36
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-Tocopherol in patients with non-Alcoholic steatohepatitis: A pilot study
    • Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-beta1 level and efficacy of alpha-Tocopherol in patients with non-Alcoholic steatohepatitis: A pilot study. Aliment Pharmacol Ther 2001; 15: 1667-72
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 37
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and Vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2003; 98: 2348-50
    • (2003) Am J Gastroenterol , vol.98 , pp. 2348-2350
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 39
  • 40
    • 74049085892 scopus 로고    scopus 로고
    • A placebo-controlled trial of silymarin in patients with nonalcoholic fatty liver disease
    • Hashemi SJ, Hajiani E, Sardabi EH. A placebo-controlled trial of silymarin in patients with nonalcoholic fatty liver disease. Hepat Mon 2009; 9: 265-70
    • (2009) Hepat Mon , vol.9 , pp. 265-270
    • Hashemi, S.J.1    Hajiani, E.2    Sardabi, E.H.3
  • 41
    • 79953763871 scopus 로고    scopus 로고
    • Systematic review on the treatment of pentoxifylline in patients with non-Alcoholic fatty liver disease
    • Li W, Zheng L, Sheng C, Cheng X, Qing L, Qu S. Systematic review on the treatment of pentoxifylline in patients with non-Alcoholic fatty liver disease. Lipids Health Dis 2011; 10: 49
    • (2011) Lipids Health Dis , vol.10 , pp. 49
    • Li, W.1    Zheng, L.2    Sheng, C.3    Cheng, X.4    Qing, L.5    Qu, S.6
  • 42
    • 80055028155 scopus 로고    scopus 로고
    • Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
    • Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, et al. Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial. Hepatology 2011; 54: 1610-9
    • (2011) Hepatology , vol.54 , pp. 1610-1619
    • Zein, C.O.1    Yerian, L.M.2    Gogate, P.3    Lopez, R.4    Kirwan, J.P.5    Feldstein, A.E.6
  • 43
    • 66549124116 scopus 로고    scopus 로고
    • Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option?
    • Georgescu EF. Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option?. Adv Ther 2008; 25: 1141-74
    • (2008) Adv Ther , vol.25 , pp. 1141-1174
    • Georgescu, E.F.1
  • 44
    • 79952453566 scopus 로고    scopus 로고
    • The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C trial cohort
    • Abu Dayyeh BK, Yang M, Dienstag JL, Chung RT. The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C trial cohort. Dig Dis Sci 2011; 56: 564-8
    • (2011) Dig Dis Sci , vol.56 , pp. 564-568
    • Abu Dayyeh, B.K.1    Yang, M.2    Dienstag, J.L.3    Chung, R.T.4
  • 46
    • 7044222556 scopus 로고    scopus 로고
    • Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
    • Yokohama S, Yoneda M, Haneda M, Okamoto S, Okada M, Aso K, et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology 2004; 40: 1222-5
    • (2004) Hepatology , vol.40 , pp. 1222-1225
    • Yokohama, S.1    Yoneda, M.2    Haneda, M.3    Okamoto, S.4    Okada, M.5    Aso, K.6
  • 47
    • 0023879674 scopus 로고
    • Randomized placebo-controlled double-blind trial on 'essential' phospholipids in the treatment of fatty liver associated with diabetes
    • Gonciarz Z, Besser P, Lelek E, Gundermann KJ, Johannes KJ. Randomized placebo-controlled double-blind trial on 'essential' phospholipids in the treatment of fatty liver associated with diabetes. Med Chir Dig 1988; 17: 61-5
    • (1988) Med Chir Dig , vol.17 , pp. 61-65
    • Gonciarz, Z.1    Besser, P.2    Lelek, E.3    Gundermann, K.J.4    Johannes, K.J.5
  • 48
    • 80051512153 scopus 로고    scopus 로고
    • Therapy for NAFLD: A comparative study of essential phospholipids vs ursodeoxycholic acid
    • Arvind N, Savaikar P, Rajkumar JS. Therapy for NAFLD: A comparative study of essential phospholipids vs. ursodeoxycholic acid. Ind J Clin Pract 2006; 16: 21-4
    • (2006) Ind J Clin Pract , vol.16 , pp. 21-24
    • Arvind, N.1    Savaikar, P.2    Rajkumar, J.S.3
  • 50
    • 79955589142 scopus 로고    scopus 로고
    • Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine-And choline-deficient diet
    • Kajikawa S, Imada K, Takeuchi T, Shimizu Y, Kawashima A, Harada T, et al. Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine-And choline-deficient diet. Dig Dis Sci 2011; 56: 1065-74
    • (2011) Dig Dis Sci , vol.56 , pp. 1065-1074
    • Kajikawa, S.1    Imada, K.2    Takeuchi, T.3    Shimizu, Y.4    Kawashima, A.5    Harada, T.6
  • 52
    • 84904661185 scopus 로고    scopus 로고
    • No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial
    • e1
    • Sanyal AJ, Abdelmalek MF, Suzuki A, Cummings OW, Chojkier M; EPE-A Study Group. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology 2014; 147: 377-84.e1
    • (2014) Gastroenterology , vol.147 , pp. 377-384
    • Sanyal, A.J.1    Abdelmalek, M.F.2    Suzuki, A.3    Cummings, O.W.4    Chojkier, M.5    Study Group, E.6
  • 53
    • 84886999533 scopus 로고    scopus 로고
    • Effects of probiotics on nonalcoholic fatty liver disease: A meta-Analysis
    • Ma YY, Li L, Yu CH, Shen Z, Chen LH, Li YM. Effects of probiotics on nonalcoholic fatty liver disease: A meta-Analysis. World J Gastroenterol 2013; 19: 6911-8
    • (2013) World J Gastroenterol , vol.19 , pp. 6911-6918
    • Ma, Y.Y.1    Li, L.2    Yu, C.H.3    Shen, Z.4    Chen, L.H.5    Li, Y.M.6
  • 56
    • 85027210867 scopus 로고    scopus 로고
    • Targeting Lysyl Oxidase like 2 (LOXL2) Inhibits Collagen Cross-Linking and Accelerates Reversal of Pre-Established Liver Fibrosis
    • Ikenaga N, Yoshida S, Liu SB, Chung J, Sverdlov D, Marshall D, et al. Targeting Lysyl Oxidase like 2 (LOXL2) Inhibits Collagen Cross-Linking and Accelerates Reversal of Pre-Established Liver Fibrosis. Hepatology 2013; 58: 219A-20A
    • (2013) Hepatology , vol.58 , pp. 219A-220A
    • Ikenaga, N.1    Yoshida, S.2    Liu, S.B.3    Chung, J.4    Sverdlov, D.5    Marshall, D.6
  • 57
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • e1
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574-82.e1
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5    Kipnes, M.6
  • 58
    • 84907056944 scopus 로고    scopus 로고
    • GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes
    • Cariou B, Staels B. GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes. Expert Opin Investig Drugs 2014; 23: 1441-8
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1441-1448
    • Cariou, B.1    Staels, B.2
  • 59
    • 84888285959 scopus 로고    scopus 로고
    • Hepatoprotective effects of the dual peroxisome proliferator-Activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, et al. Hepatoprotective effects of the dual peroxisome proliferator-Activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology 2013; 58: 1941-52
    • (2013) Hepatology , vol.58 , pp. 1941-1952
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3    Rigou, G.4    Delataille, P.5    Millatt, L.J.6
  • 60
    • 84962357612 scopus 로고    scopus 로고
    • Available from [Last accessed on 2015 May 25]
    • DUR-928. Available from: http: //www.durect.com/wt/durect/page name/DUR-928. [Last accessed on 2015 May 25]
    • DUR-928
  • 61
    • 84885155926 scopus 로고    scopus 로고
    • Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease
    • Traber PG, Chou H, Zomer E, Hong F, Klyosov A, Fiel MI, et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS One 2013; 8: e75361
    • (2013) PLoS One , vol.8 , pp. e75361
    • Traber, P.G.1    Chou, H.2    Zomer, E.3    Hong, F.4    Klyosov, A.5    Fiel, M.I.6
  • 62
    • 84962357617 scopus 로고    scopus 로고
    • Galectin therapeutics': Phase 1 data advances gr-md-02 in to phase 2 clinical development
    • Available from. [Last accessed on 2015 May 25]
    • Harrison S. Galectin Therapeutics': Phase 1 Data Advances GR-MD-02 in to Phase 2 Clinical Development. Presented at AASLD Annual Meeting 2014. Available from: www.galactintherapeutics.com/releasedetail.cfm?ReleaseID=897897. [Last accessed on 2015 May 25]
    • (2014) Presented at AASLD Annual Meeting
    • Harrison, S.1
  • 63
    • 84918843434 scopus 로고    scopus 로고
    • The fatty acid-bile acid conjugate aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    • e1
    • Safadi R, Konikoff FM, Mahamid M, Zelber-Sagi S, Halpern M, Gilat T, et al. The fatty acid-bile acid conjugate aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2014; 12: 2085-91.e1
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 2085-2091
    • Safadi, R.1    Konikoff, F.M.2    Mahamid, M.3    Zelber-Sagi, S.4    Halpern, M.5    Gilat, T.6
  • 64
    • 84962357588 scopus 로고    scopus 로고
    • Available from [Last accessed on 2015 May 25]
    • Regulus Reports First Quarter 2015 Financial Results and Recent Highlights. Available from: http: //www.researchviews.com/healthcare/pharma/infectiousdisease/NewsReport.aspx?Type=1andsector=Infectious DiseaseandArticleID=4571857. [Last accessed on 2015 May 25]
    • Regulus Reports First Quarter 2015 Financial Results and Recent Highlights
  • 65
    • 84925374835 scopus 로고    scopus 로고
    • Findings and recommendations from an American association for the study of liver diseases-us food and drug administration joint workshop
    • American Association for the Study of Liver Diseases; United States Food and Drug Administration. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis
    • Sanyal AJ, Friedman SL, McCullough AJ, Dimick-Santos L; American Association for the Study of Liver Diseases; United States Food and Drug Administration. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop. Hepatology 2015; 61: 1392-405
    • (2015) Hepatology , vol.61 , pp. 1392-1405
    • Sanyal, A.J.1    Friedman, S.L.2    McCullough, A.J.3    Dimick-Santos, L.4
  • 66
    • 73949147212 scopus 로고    scopus 로고
    • Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status
    • Stein LL, Dong MH, Loomba R. Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status. Adv Ther 2009; 26: 893-907
    • (2009) Adv Ther , vol.26 , pp. 893-907
    • Stein, L.L.1    Dong, M.H.2    Loomba, R.3
  • 67
    • 3142670354 scopus 로고    scopus 로고
    • Metformin in the treatment of non-Alcoholic steatohepatitis: A pilot open label trial
    • Nair S, Diehl AM, Wiseman M, Farr GH Jr, Perrillo RP. Metformin in the treatment of non-Alcoholic steatohepatitis: A pilot open label trial. Aliment Pharmacol Ther 2004; 20: 23-8
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 23-28
    • Nair, S.1    Diehl, A.M.2    Wiseman, M.3    Farr, G.H.4    Perrillo, R.P.5
  • 68
    • 84962344297 scopus 로고    scopus 로고
    • Therapies for nonalcoholic steatohepatitis
    • Mahady S. Therapies for nonalcoholic steatohepatitis. Gastroenterol Hepatol (N Y) 2013; 9: 40-2
    • (2013) Gastroenterol Hepatol (N y , vol.9 , pp. 40-42
    • Mahady, S.1
  • 69
    • 84880196140 scopus 로고    scopus 로고
    • The effects of pioglitazone on biochemical markers of bone turnover in the patients with type 2 diabetes
    • Xiao WH, Wang YR, Hou WF, Xie C, Wang HN, Hong TP, et al. The effects of pioglitazone on biochemical markers of bone turnover in the patients with type 2 diabetes. Int J Endocrinol 2013; 2013: 290734
    • (2013) Int J Endocrinol , vol.2013 , pp. 290734
    • Xiao, W.H.1    Wang, Y.R.2    Hou, W.F.3    Xie, C.4    Wang, H.N.5    Hong, T.P.6
  • 71
    • 84872196813 scopus 로고    scopus 로고
    • Statins in nonalcoholic fatty liver disease and steatohepatitis: Updated review
    • Nseir W, Mahamid M. Statins in nonalcoholic fatty liver disease and steatohepatitis: Updated review. Curr Atheroscler Rep 2013; 15: 305
    • (2013) Curr Atheroscler Rep , vol.15 , pp. 305
    • Nseir, W.1    Mahamid, M.2
  • 72
    • 84879480286 scopus 로고    scopus 로고
    • Pleiotropic effects of rosuvastatin on the glucose metabolism and the subcutaneous and visceral adipose tissue behavior in C57Bl/6 mice
    • Neto-Ferreira R, Rocha VN, Souza-Mello V, Mandarim-de-Lacerda CA, de Carvalho JJ. Pleiotropic effects of rosuvastatin on the glucose metabolism and the subcutaneous and visceral adipose tissue behavior in C57Bl/6 mice. Diabetol Metab Syndr 2013; 5: 32
    • (2013) Diabetol Metab Syndr , vol.5 , pp. 32
    • Neto-Ferreira, R.1    Rocha, V.N.2    Souza-Mello, V.3    Mandarim-De-Lacerda, C.A.4    De Carvalho, J.J.5
  • 73
    • 49649106710 scopus 로고    scopus 로고
    • Statins in liver disease: A molehill, an iceberg, or neither?
    • Argo CK, Loria P, Caldwell SH, Lonardo A. Statins in liver disease: A molehill, an iceberg, or neither?. Hepatology 2008; 48: 662-9
    • (2008) Hepatology , vol.48 , pp. 662-669
    • Argo, C.K.1    Loria, P.2    Caldwell, S.H.3    Lonardo, A.4
  • 74
    • 84892880355 scopus 로고    scopus 로고
    • Resistant nonalcoholic fatty liver disease amelioration with rosuvastatin and pioglitazone combination therapy in a patient with metabolic syndrome
    • Riche DM, Fleming JW, Malinowski SS, Black CA, Miller KH, Wofford MR. Resistant nonalcoholic fatty liver disease amelioration with rosuvastatin and pioglitazone combination therapy in a patient with metabolic syndrome. Ann Pharmacother 2014; 48: 137-41
    • (2014) Ann Pharmacother , vol.48 , pp. 137-141
    • Riche, D.M.1    Fleming, J.W.2    Malinowski, S.S.3    Black, C.A.4    Miller, K.H.5    Wofford, M.R.6
  • 75
    • 77953231187 scopus 로고    scopus 로고
    • The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients
    • Nakou ES, Filippatos TD, Agouridis AP, Kostara C, Bairaktari ET, Elisaf MS. The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients. Lipids 2010; 45: 445-50
    • (2010) Lipids , vol.45 , pp. 445-450
    • Nakou, E.S.1    Filippatos, T.D.2    Agouridis, A.P.3    Kostara, C.4    Bairaktari, E.T.5    Elisaf, M.S.6
  • 76
    • 84858829184 scopus 로고    scopus 로고
    • Role of ezetimibe in non-Alcoholic fatty liver disease
    • Filippatos TD, Elisaf MS. Role of ezetimibe in non-Alcoholic fatty liver disease. World J Hepatol 2011; 30: 265-7
    • (2011) World J Hepatol , vol.30 , pp. 265-267
    • Filippatos, T.D.1    Elisaf, M.S.2
  • 77
    • 84962344304 scopus 로고    scopus 로고
    • Vitamin E therapy in non-Alcoholic fatty liver disease
    • Shu X, Zhang L, Ji G. Vitamin E therapy in non-Alcoholic fatty liver disease. Int J Clin Med 2014; 5: 87-92
    • (2014) Int J Clin Med , vol.5 , pp. 87-92
    • Shu, X.1    Zhang, L.2    Ji, G.3
  • 79
    • 84908362139 scopus 로고    scopus 로고
    • Review article: The management of paediatric nonalcoholic fatty liver disease
    • Mitchel EB, Lavine JE. Review article: The management of paediatric nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2014; 40: 1155-70
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 1155-1170
    • Mitchel, E.B.1    Lavine, J.E.2
  • 80
    • 33645536593 scopus 로고    scopus 로고
    • Treatment of non-Alcoholic fatty liver disease
    • Adams LA, Angulo P. Treatment of non-Alcoholic fatty liver disease. Postgrad Med J 2006; 82: 315-22
    • (2006) Postgrad Med J , vol.82 , pp. 315-322
    • Adams, L.A.1    Angulo, P.2
  • 81
    • 84863479772 scopus 로고    scopus 로고
    • Non-Alcoholic steatohepatitis: The therapeutic challenge of a global epidemic
    • Mouzaki M, Allard J. Non-Alcoholic steatohepatitis: The therapeutic challenge of a global epidemic. Ann Gastroenterol 2012; 25: 207-17
    • (2012) Ann Gastroenterol , vol.25 , pp. 207-217
    • Mouzaki, M.1    Allard, J.2
  • 82
    • 84864371596 scopus 로고    scopus 로고
    • Molecular mechanisms of ursodeoxycholic Acid toxicity and side effects: Ursodeoxycholic Acid freezes regeneration & induces hibernation mode
    • Kotb MA. Molecular mechanisms of ursodeoxycholic Acid toxicity and side effects: Ursodeoxycholic Acid freezes regeneration & induces hibernation mode. Int J Mol Sci 2012; 13: 8882-914
    • (2012) Int J Mol Sci , vol.13 , pp. 8882-8914
    • Kotb, M.A.1
  • 83
    • 84902661992 scopus 로고    scopus 로고
    • Incretin based therapies: A novel treatment approach for non-Alcoholic fatty liver disease
    • Blaslov K, Bulum T, Zibar K, Duvnjak L. Incretin based therapies: A novel treatment approach for non-Alcoholic fatty liver disease. World J Gastroenterol 2014; 20: 7356-65
    • (2014) World J Gastroenterol , vol.20 , pp. 7356-7365
    • Blaslov, K.1    Bulum, T.2    Zibar, K.3    Duvnjak, L.4
  • 84
    • 84928210527 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: Effects on the progression of non-Alcoholic fatty liver disease
    • Liu J, Wang G, Jia Y, Xu Y. GLP-1 receptor agonists: Effects on the progression of non-Alcoholic fatty liver disease. Diabetes Metab Res Rev 2015; 31: 329-35
    • (2015) Diabetes Metab Res Rev , vol.31 , pp. 329-335
    • Liu, J.1    Wang, G.2    Jia, Y.3    Xu, Y.4
  • 86
    • 84900451257 scopus 로고    scopus 로고
    • Pentoxifylline for the treatment of nonalcoholic fatty liver disease: A meta-Analysis of randomized double-blind, placebo-controlled studies
    • Zeng T, Zhang CL, Zhao XL, Xie KQ. Pentoxifylline for the treatment of nonalcoholic fatty liver disease: A meta-Analysis of randomized double-blind, placebo-controlled studies. Eur J Gastroenterol Hepatol 2014; 26: 646-53
    • (2014) Eur J Gastroenterol Hepatol , vol.26 , pp. 646-653
    • Zeng, T.1    Zhang, C.L.2    Zhao, X.L.3    Xie, K.Q.4
  • 87
    • 84892838265 scopus 로고    scopus 로고
    • Effects of pentoxifylline on nonalcoholic fatty liver disease: A meta-Analysis
    • Du J, Ma YY, Yu CH, Li YM. Effects of pentoxifylline on nonalcoholic fatty liver disease: A meta-Analysis. World J Gastroenterol 2014; 20: 569-77
    • (2014) World J Gastroenterol , vol.20 , pp. 569-577
    • Du, J.1    Ma, Y.Y.2    Yu, C.H.3    Li, Y.M.4
  • 88
    • 84886906559 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and the renin-Angiotensin system: Implications for treatment
    • Paschos P, Tziomalos K. Nonalcoholic fatty liver disease and the renin-Angiotensin system: Implications for treatment. World J Hepatol 2012; 4: 327-31
    • (2012) World J Hepatol , vol.4 , pp. 327-331
    • Paschos, P.1    Tziomalos, K.2
  • 89
    • 84867573089 scopus 로고    scopus 로고
    • S-Adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility
    • Anstee QM, Day CP. S-Adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility. J Hepatol 2012; 57: 1097-109
    • (2012) J Hepatol , vol.57 , pp. 1097-1109
    • Anstee, Q.M.1    Day, C.P.2
  • 90
    • 77953444310 scopus 로고    scopus 로고
    • Treatment options for nonalcoholic fatty liver disease
    • Lam B, Younossi ZM. Treatment options for nonalcoholic fatty liver disease. Therap Adv Gastroenterol 2010; 3: 121-37
    • (2010) Therap Adv Gastroenterol , vol.3 , pp. 121-137
    • Lam, B.1    Younossi, Z.M.2
  • 92
    • 84876725499 scopus 로고    scopus 로고
    • Treatment of nonalcoholic steatohepatitis with probiotics A proof-of-concept study
    • Wong VW, Won GL, Chim AM, Chu WC, Yeung DK, Li KC, et al. Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study. Ann Hepatol 2013; 12: 256-62
    • (2013) Ann Hepatol , vol.12 , pp. 256-262
    • Wong, V.W.1    Won, G.L.2    Chim, A.M.3    Chu, W.C.4    Yeung, D.K.5    Li, K.C.6
  • 93
    • 84866700091 scopus 로고    scopus 로고
    • VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation
    • Mencarelli A, Cipriani S, Renga B, Bruno A, D'Amore C, Distrutti E, et al. VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation. PLoS One 2012; 7: e45425
    • (2012) PLoS One , vol.7 , pp. e45425
    • Mencarelli, A.1    Cipriani, S.2    Renga, B.3    Bruno, A.4    D'Amore, C.5    Distrutti, E.6
  • 94
    • 84876273939 scopus 로고    scopus 로고
    • Probiotics as a novel treatment for non-Alcoholic fatty liver disease; A systematic review on the current evidences
    • Kelishadi R, Farajian S, Mirlohi M. Probiotics as a novel treatment for non-Alcoholic fatty liver disease; a systematic review on the current evidences. Hepat Mon 2013; 13: e7233
    • (2013) Hepat Mon , vol.13 , pp. e7233
    • Kelishadi, R.1    Farajian, S.2    Mirlohi, M.3
  • 96
    • 85015459213 scopus 로고    scopus 로고
    • Recent advances in the development of farnesoid X receptor agonists
    • Ali AH, Carey EJ, Lindor KD. Recent advances in the development of farnesoid X receptor agonists. Ann Transl Med 2015; 3: 5
    • (2015) Ann Transl Med , vol.3 , pp. 5
    • Ali, A.H.1    Carey, E.J.2    Lindor, K.D.3
  • 97
    • 79960988152 scopus 로고    scopus 로고
    • Effects of the new dual PPAR α /δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism
    • Cariou B, Zair Y, Staels B, Bruckert E. Effects of the new dual PPAR α /δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care 2011; 34: 2008-14
    • (2011) Diabetes Care , vol.34 , pp. 2008-2014
    • Cariou, B.1    Zair, Y.2    Staels, B.3    Bruckert, E.4
  • 98
    • 84885405205 scopus 로고    scopus 로고
    • Dual peroxisome proliferator-Activated receptor α /δ agonist GFT505 improves hepatic and peripheral Insulin sensitivity in abdominally obese subjects
    • Cariou B, Hanf R, Lambert-Porcheron S, Zaïr Y, Sauvinet V, Noël B, et al. Dual peroxisome proliferator-Activated receptor α /δ agonist GFT505 improves hepatic and peripheral Insulin sensitivity in abdominally obese subjects. Diabetes Care 2013; 36: 2923-30
    • (2013) Diabetes Care , vol.36 , pp. 2923-2930
    • Cariou, B.1    Hanf, R.2    Lambert-Porcheron, S.3    Zaïr, Y.4    Sauvinet, V.5    Noël, B.6
  • 100
    • 84898408078 scopus 로고    scopus 로고
    • State of the art: Treatment of nonalcoholic steatohepatitis
    • Pearlman M, Loomba R. State of the art: Treatment of nonalcoholic steatohepatitis. Curr Opin Gastroenterol 2014; 30: 223-37
    • (2014) Curr Opin Gastroenterol , vol.30 , pp. 223-237
    • Pearlman, M.1    Loomba, R.2
  • 102
    • 84883259255 scopus 로고    scopus 로고
    • Vitamin D and nonalcoholic fatty liver disease (NAFLD): Is it more than just an association?
    • Kwok RM, Torres DM, Harrison SA. Vitamin D and nonalcoholic fatty liver disease (NAFLD): Is it more than just an association?. Hepatology 2013; 58: 1166-74
    • (2013) Hepatology , vol.58 , pp. 1166-1174
    • Kwok, R.M.1    Torres, D.M.2    Harrison, S.A.3
  • 103
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study
    • Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ, Saad F. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study. Clin Endocrinol (Oxf) 2010; 73: 602-12
    • (2010) Clin Endocrinol (Oxf , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3    Gooren, L.J.4    Giltay, E.J.5    Saad, F.6
  • 104
    • 84866672073 scopus 로고    scopus 로고
    • Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: A randomised placebo-controlled trial
    • Hoyos CM, Yee BJ, Phillips CL, Machan EA, Grunstein RR, Liu PY. Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: A randomised placebo-controlled trial. Eur J Endocrinol 2012; 167: 531-41
    • (2012) Eur J Endocrinol , vol.167 , pp. 531-541
    • Hoyos, C.M.1    Yee, B.J.2    Phillips, C.L.3    Machan, E.A.4    Grunstein, R.R.5    Liu, P.Y.6
  • 106
    • 35948957388 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK Effects on peroxisome proliferator-Activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP)
    • Stefano JT, de Oliveira CP, Corrê a-Giannella ML, de Lima VM, de SáSV, de Oliveira EP, et al. Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): Effects on peroxisome proliferator-Activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP). Dig Dis Sci 2007; 52: 3448-54
    • (2007) Dig Dis Sci , vol.52 , pp. 3448-3454
    • Stefano, J.T.1    De Oliveira, C.P.2    Corrêa-Giannella, M.L.3    De Lima, V.M.4    De Sá, S.V.5    De Oliveira, E.P.6
  • 107
    • 33748435506 scopus 로고    scopus 로고
    • Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): A randomized pilot study
    • Chande N, Laidlaw M, Adams P, Marotta P. Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): A randomized pilot study. Dig Dis Sci 2006; 51: 1183-9
    • (2006) Dig Dis Sci , vol.51 , pp. 1183-1189
    • Chande, N.1    Laidlaw, M.2    Adams, P.3    Marotta, P.4
  • 109
    • 7244231126 scopus 로고    scopus 로고
    • Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: Relationship between homocysteine levels and hyperinsulinemia
    • Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R, et al. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: Relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 2004; 151: 483-9
    • (2004) Eur J Endocrinol , vol.151 , pp. 483-489
    • Setola, E.1    Monti, L.D.2    Galluccio, E.3    Palloshi, A.4    Fragasso, G.5    Paroni, R.6
  • 110
    • 44849131936 scopus 로고    scopus 로고
    • Resveratrol improves non-Alcoholic fatty liver disease by activating AMP-Activated protein kinase
    • Shang J, Chen LL, Xiao FX, Sun H, Ding HC, Xiao H. Resveratrol improves non-Alcoholic fatty liver disease by activating AMP-Activated protein kinase. Acta Pharmacol Sin 2008; 29: 698-706
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 698-706
    • Shang, J.1    Chen, L.L.2    Xiao, F.X.3    Sun, H.4    Ding, H.C.5    Xiao, H.6
  • 111
    • 84888800151 scopus 로고    scopus 로고
    • Resveratrol modulates autophagy and NF-κ B activity in a murine model for treating non-Alcoholic fatty liver disease
    • Li L, Hai J, Li Z, Zhang Y, Peng H, Li K, et al. Resveratrol modulates autophagy and NF-κ B activity in a murine model for treating non-Alcoholic fatty liver disease. Food Chem Toxicol 2014; 63: 166-73
    • (2014) Food Chem Toxicol , vol.63 , pp. 166-173
    • Li, L.1    Hai, J.2    Li, Z.3    Zhang, Y.4    Peng, H.5    Li, K.6
  • 112
    • 79954989314 scopus 로고    scopus 로고
    • Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ
    • Guo H, Li D, Ling W, Feng X, Xia M. Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ . J Lipid Res 2011; 52: 908-22
    • (2011) J Lipid Res , vol.52 , pp. 908-922
    • Guo, H.1    Li, D.2    Ling, W.3    Feng, X.4    Xia, M.5
  • 114
    • 84869121923 scopus 로고    scopus 로고
    • Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis
    • Marcolin E, San-Miguel B, Vallejo D, Tieppo J, Marroni N, González-Gallego J, et al. Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. J Nutr 2012; 142: 1821-8
    • (2012) J Nutr , vol.142 , pp. 1821-1828
    • Marcolin, E.1    San-Miguel, B.2    Vallejo, D.3    Tieppo, J.4    Marroni, N.5    González-Gallego, J.6
  • 115
    • 84904618577 scopus 로고    scopus 로고
    • Quercetin improves insulin resistance and hepatic lipid accumulationin vitro in a NAFLD cell model
    • Li X, Wang R, Zhou N, Wang X, Liu Q, Bai Y, et al. Quercetin improves insulin resistance and hepatic lipid accumulationin vitro in a NAFLD cell model. Biomed Rep 2013; 1: 71-6
    • (2013) Biomed Rep , vol.1 , pp. 71-76
    • Li, X.1    Wang, R.2    Zhou, N.3    Wang, X.4    Liu, Q.5    Bai, Y.6
  • 116
    • 84879357128 scopus 로고    scopus 로고
    • Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
    • Wang W, Wang C, Ding XQ, Pan Y, Gu TT, Wang MX, et al. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol 2013; 169: 1352-71
    • (2013) Br J Pharmacol , vol.169 , pp. 1352-1371
    • Wang, W.1    Wang, C.2    Ding, X.Q.3    Pan, Y.4    Gu, T.T.5    Wang, M.X.6
  • 117
    • 46749151014 scopus 로고    scopus 로고
    • Acarbose treatment increases serum total adiponectin levels in patients with type 2 diabetes
    • Ochiai H, Ooka H, Shida C, Ishikawa T, Inoue D, Okazaki R. Acarbose treatment increases serum total adiponectin levels in patients with type 2 diabetes. Endocr J 2008; 55: 549-56
    • (2008) Endocr J , vol.55 , pp. 549-556
    • Ochiai, H.1    Ooka, H.2    Shida, C.3    Ishikawa, T.4    Inoue, D.5    Okazaki, R.6
  • 118
    • 84891593468 scopus 로고    scopus 로고
    • A comparison of ezetimibe and acarbose in decreasing liver transaminase in nonalcoholic fatty liver disease: A randomized clinical trial
    • Hajiaghamohammadi AA, Miroliaee A, Samimi R, Alborzi F, Ziaee A. A comparison of ezetimibe and acarbose in decreasing liver transaminase in nonalcoholic fatty liver disease: A randomized clinical trial. Govaresh 2013; 18: 186-90
    • (2013) Govaresh , vol.18 , pp. 186-190
    • Hajiaghamohammadi, A.A.1    Miroliaee, A.2    Samimi, R.3    Alborzi, F.4    Ziaee, A.5
  • 119
    • 68049123104 scopus 로고    scopus 로고
    • Long-Term combination therapy of ezetimibe and acarbose for non-Alcoholic fatty liver disease
    • Nozaki Y, Fujita K, Yoneda M, Wada K, Shinohara Y, Takahashi H, et al. Long-Term combination therapy of ezetimibe and acarbose for non-Alcoholic fatty liver disease. J Hepatol 2009; 51: 548-56
    • (2009) J Hepatol , vol.51 , pp. 548-556
    • Nozaki, Y.1    Fujita, K.2    Yoneda, M.3    Wada, K.4    Shinohara, Y.5    Takahashi, H.6
  • 120
    • 84905756974 scopus 로고    scopus 로고
    • Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis
    • Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).
    • Bambha K, Wilson LA, Unalp A, Loomba R, Neuschwander-Tetri BA, Brunt EM, et al.; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis. Liver Int 2014; 34: 1250-8
    • (2014) Liver Int , vol.34 , pp. 1250-1258
    • Bambha, K.1    Wilson, L.A.2    Unalp, A.3    Loomba, R.4    Neuschwander-Tetri, B.A.5    Brunt, E.M.6
  • 121
    • 84895794335 scopus 로고    scopus 로고
    • Impact of coffee on liver diseases: A systematic review
    • Saab S, Mallam D, Cox GA 2nd, Tong MJ. Impact of coffee on liver diseases: A systematic review. Liver Int 2014; 34: 495-504
    • (2014) Liver Int , vol.34 , pp. 495-504
    • Saab, S.1    Mallam, D.2    Cox, I.I.G.A.3    Tong, M.J.4
  • 122
    • 20444448944 scopus 로고    scopus 로고
    • Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid
    • Buang Y, Wang YM, Cha JY, Nagao K, Yanagita T. Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid. Nutrition 2005; 21: 867-73
    • (2005) Nutrition , vol.21 , pp. 867-873
    • Buang, Y.1    Wang, Y.M.2    Cha, J.Y.3    Nagao, K.4    Yanagita, T.5
  • 123
    • 80051530692 scopus 로고    scopus 로고
    • Activity of essential phospholipids (EPL) from soybean in liver diseases
    • Gundermann KJ, Kuenker A, Kuntz E, Droź dzik M. Activity of essential phospholipids (EPL) from soybean in liver diseases. Pharmacol Rep, 2011. 63. p. 643-59
    • (2011) Pharmacol Rep , vol.63 , pp. 643-659
    • Gundermann, K.J.1    Kuenker, A.2    Kuntz, E.3    Droździk, M.4
  • 124
    • 84973640002 scopus 로고    scopus 로고
    • Observation for curative effect of essentiale in treatment of fatty liver caused by diabetes mellitus
    • Yin D, Kong L. Observation for curative effect of essentiale in treatment of fatty liver caused by diabetes mellitus. Med J Q Ilu 2000; 15: 277-8
    • (2000) Med J Q Ilu , vol.15 , pp. 277-278
    • Yin, D.1    Kong, L.2
  • 125
    • 84962395373 scopus 로고    scopus 로고
    • Treatment of 52 cases with hepatic dysfunctional fatty liver with essentiale
    • Du Q. Treatment of 52 cases with hepatic dysfunctional fatty liver with essentiale. Chin J Gastro Heap 2004; 13: 21-4
    • (2004) Chin J Gastro Heap , vol.13 , pp. 21-24
    • Du, Q.1
  • 126
    • 84962477955 scopus 로고    scopus 로고
    • An Observational Study of Essentiale-L in the treatment of Patients with Fatty Liver Disease
    • Padma L, Mukaddam Q, Trailokya A. An Observational Study of Essentiale-L in the treatment of Patients with Fatty Liver Disease. Indian J Clin Pract 2013; 23: 735-9
    • (2013) Indian J Clin Pract , vol.23 , pp. 735-739
    • Padma, L.1    Mukaddam, Q.2    Trailokya, A.3
  • 127
    • 85016996253 scopus 로고    scopus 로고
    • Clinical observation on polyene phosphatidyl choline and metformin in the treatment of type-2 diabetes and non-Alcoholic fatty liver disease
    • Sun C, Zheng X, Tan Z, Cui F, Zhang R, Zhang H. Clinical observation on polyene phosphatidyl choline and metformin in the treatment of type-2 diabetes and non-Alcoholic fatty liver disease. Clinical Focus 2008; 23: 1272-3
    • (2008) Clinical Focus , vol.23 , pp. 1272-1273
    • Sun, C.1    Zheng, X.2    Tan, Z.3    Cui, F.4    Zhang, R.5    Zhang, H.6
  • 128
    • 85105557625 scopus 로고    scopus 로고
    • Effective analysis of type 2 diabetic united adiposis hepatica with polyene phosphatidylcholine
    • Wu Y. Effective analysis of type 2 diabetic united adiposis hepatica with polyene phosphatidylcholine. J Tradit Chin Med 2009; 29: 41-2
    • (2009) J Tradit Chin Med , vol.29 , pp. 41-42
    • Wu, Y.1
  • 129
    • 84858959526 scopus 로고    scopus 로고
    • Silybin combined with phosphatidylcholine and Vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial
    • Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial. Free Radic Biol Med 2012; 52: 1658-65
    • (2012) Free Radic Biol Med , vol.52 , pp. 1658-1665
    • Loguercio, C.1    Andreone, P.2    Brisc, C.3
  • 130
    • 84973609623 scopus 로고    scopus 로고
    • Beneficial influence of polyunsaturated Phosphatidylcholine enhances functional liver condition and liver structure in patients with Nonalcoholic steatohepatitis Results of prolonged randomized blinded prospective clinical study
    • Sas E, Grinevich V, Efimov O, Shcherbina N. Beneficial influence of polyunsaturated Phosphatidylcholine enhances functional liver condition and liver structure in patients with Nonalcoholic steatohepatitis. Results of prolonged randomized blinded prospective clinical study. J Hepatol 2013; 58(Suppl 1): S549
    • (2013) J Hepatol , vol.58 , pp. S549
    • Sas, E.1    Grinevich, V.2    Efimov, O.3    Shcherbina, N.4
  • 131
    • 80051512153 scopus 로고    scopus 로고
    • Therapy for NAFLD A comparative study of essential phospholipids vs ursodeoxycholic acid
    • Arvind N, Savaikar P, Rajkumar J. Therapy for NAFLD. A comparative study of essential phospholipids vs ursodeoxycholic acid. Indian J Clin Pract 2006; 16: 21-4
    • (2006) Indian J Clin Pract , vol.16 , pp. 21-24
    • Arvind, N.1    Savaikar, P.2    Rajkumar, J.3
  • 132
    • 84962421075 scopus 로고    scopus 로고
    • Clinical observation on the results in treatment of NAFLD with polyene phosphatidylcholine combined with Xuezhikang capsules
    • Zeng JT, Chen J. Clinical observation on the results in treatment of NAFLD with polyene phosphatidylcholine combined with Xuezhikang capsules. China Trop Med 2008; 8: 778-9
    • (2008) China Trop Med , vol.8 , pp. 778-779
    • Zeng, J.T.1    Chen, J.2
  • 133
    • 85027211042 scopus 로고    scopus 로고
    • Essential phospholipids as a supportive adjunct to the management of patients with primary NAFLD and NAFLD associated with type 2 diabetes mellitus or hyperlipidaemia
    • Dajani AI, Abu Hammour AM, Zakaria MA, Al Jaberi M, Nounou MA. Essential phospholipids as a supportive adjunct to the management of patients with primary NAFLD and NAFLD associated with type 2 diabetes mellitus or hyperlipidaemia. Hepatol Int 2013; 7(Suppl 1): S1-754
    • (2013) Hepatol Int , vol.7 , pp. S1-754
    • Dajani, A.I.1    Abu Hammour, A.M.2    Zakaria, M.A.3    Al Jaberi, M.4    Nounou, M.A.5
  • 134
  • 135
    • 77956852506 scopus 로고    scopus 로고
    • Milk thistle in liver diseases: Past, present, future
    • Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: Past, present, future. Phytother Res 2010; 24: 1423-32
    • (2010) Phytother Res , vol.24 , pp. 1423-1432
    • Abenavoli, L.1    Capasso, R.2    Milic, N.3    Capasso, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.