Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease

Plant Foods for Human Nutrition

Volumn 71, Issue 2, 2016, Pages 174-182

  Sabbione, Ana Clara ^a,b,c   Ibañez, Sabrina M ^b   Martínez, E Nora ^a,b,c   Añón, María Cristina ^a,b,c   Scilingo, Adriana A ^a,b  

^a CENTRO DE INVESTIGACIÓN Y DESARROLLO EN CRIOTECNOLOGÍA DE ALIMENTOS CIDCA   (Argentina)

^b FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^c CCT La Plata ^*  (Argentina)

Author keywords

Amaranth proteins; Antithrombotic and antioxidant activity; Bioactive peptides; Endogenous aspartic protease

Indexed keywords

ANTIOXIDANT; ASPARTIC PROTEINASE; FIBRINOLYTIC AGENT; PEPTIDE; PLANT PROTEIN;

AMARANTHUS; ANALYSIS; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; FUNCTIONAL FOOD; HYDROLYSIS; ISOLATION AND PURIFICATION; METABOLISM; PH;

AMARANTHUS; ANTIOXIDANTS; ASPARTIC ACID PROTEASES; ENZYME ACTIVATION; FIBRINOLYTIC AGENTS; FUNCTIONAL FOOD; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; PEPTIDES; PLANT PROTEINS;

EID: 84962231891     PISSN: 09219668     EISSN: 15739104     Source Type: Journal    
DOI: 10.1007/s11130-016-0540-y     Document Type: Article

References (35)

1. Hasler CM, Bloch AS, Thomson CA, Enrione E, Manning C (2004) Position of the American Dietetic Association: functional foods. J Am Diet Assoc 104:814–826
2. Martínez-Maqueda D, Miralles B, Recio I, Hernández-Ledesma B (2012) Antihypertensive peptides from food proteins: a review. Food Funct 3:350–361
3. Madureira AR, Tavares T, Gomes AMP, Pintado ME, Malcata FX (2010) Invited review: physiological properties of bioactive peptides obtained from whey proteins. J Dairy Sci 93:437–455
4. Kim SK, Wijesekara I (2010) Development and biological activities of marine-derived bioactive peptides: a review. J Funct Foods 2:1–9
5. Udenigwe CC, Aluko RE (2012) Food protein-derived bioactive peptides: production, processing, and potential health benefits. J Food Sci 77:11–24
6. Silva-Sánchez C, Barba de la Rosa AP, León-Galván MF, De Lumen BO, De León-Rodríguez A, González de Mejía E (2008) Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed. J Agric Food Chem 56:1233–1240
7. López VRL, Razzeto GS, Escudero NL, Giménez MS (2013) Biochemical and molecular study of the influence of Amaranthus hypochondriacus flour on serum and liver lipids in rats treated with ethanol. Plant Foods Hum Nutr 68:396–402
8. Tironi V, Añón MC (2010) Amaranth as a source of antioxidant peptides: effect of proteolysis. Food Res Int 43:315–322
9. Sabbione AC, Scilingo A, Añón MC (2015) Potential antithrombotic activity detected in amaranth proteins and its hydrolysates. LWT-Food Sci Technol 60:171–177
10. Ventureira JL, Martínez EN, Añón MC (2012) Effect of acid treatment on structural and foaming properties of soy amaranth protein mixtures. Food Hydrocoll 29:272–279
11. Hemalatha KPJ, Siva Prasad D (2003) Changes in the metabolism of protein during germination of sesame (Sesamum indicum L.) seeds. Plant Foods Hum Nutr 58:1–10
12. Schaller A (2004) A cut above the rest: the regulatory function of plant proteases. Planta 220:183–197
13. Martínez EN, Añón MC (1996) Composition and structural characterization of amaranth proteins isolates. An electrophoretic and calorimetric study. J Agric Food Chem 44:2523–2530
14. Paredes-López O (1994) Amaranth: biology, chemistry and technology. CRC Press, Boca Raton, FL
15. Martínez EN, Castellani OF, Añón MC (1997) Common molecular features among amaranth storage proteins. J Agric Food Chem 45:3832–3839
16. Schägger H (2006) Tricine-SDS-PAGE. Nat Protoc 1:16–22
17. Nielsen PM, Petersen D, Dambmann C (2001) Improved method for determining food protein degree of hydrolysis. J Food Sci 66:642–646
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275
19. Yang WG, Wang Z, Xu SY (2007) A new method for determination of antithrombotic activity of egg white protein hydrolysate by microplate reader. Chin Chem Lett 18:449–451
20. Zhang S, Wang Z, Xu SY (2008) Antioxidant and antithrombotic activities of rapeseed peptides. JAOCS 85:521–527
21. Orsini Delgado MC, Galleano M, Añón MC, Tironi VA (2015) Amaranth peptides from simulated gastrointestinal digestion: antioxidant activity against reactive species. Plant Foods Hum Nutr 70:27–34
22. Siddhuraju P (2006) The antioxidant activity and free radical-scavenging capacity of phenolics of raw and dry heated moth bean (Vigna aconitifolia) (jacq.) marechal seed extracts. Food Chem 99:149–157
23. Atanassov A, Tchorbanov B (2009) Synthetic and natural peptides as antithrombotic agents. A view on the current development. Biotechnol Biotechnol Equip 23:1109–1114
24. Abugoch LE, Martínez EN, Añón MC (2010) Influence of pH on structure and function of amaranth (A. hypochondriacus) protein isolates. Cereal Chem 87:448–453
25. Walsh R, Martin E, Darvesh S (2010) A method to describe enzyme-catalyzed reactions by combining steady state and time course enzyme kinetic parameters. Biochim Biophys Acta 1800:1–5
26. Condés MC, Scilingo A, Añón MC (2009) Characterization of amaranth proteins modified by trypsin proteolysis. Structural and functional changes LWT 42:963–970
27. Marcone MF, Kakuda Y (1999) A comparative study of functional properties of amaranth and soybean globulins isolates. Nahrung 43:368–373
28. Quiroga AV, Martínez EN, Rogniaux H, Geairon A, Añón MC (2010) Amaranth (Amaranthus hypochondriacus) vicilin subunit structure. J Agric Food Chem 58:12957–12963
29. Laudano AP, Doolittle RF (1978) Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers. Proc Natl Acad Sci USA 75:3085–3089
30. Lee KA, Kim SH (2005) SSGE and DEE, new peptides isolated from a soy protein hydrolysate that inhibit platelet aggregation. Food Chem 90:389–394
31. Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS (2006) Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 27:1173–1178
32. Jo HY, Jung WK, Kim SK (2008) Purification and characterization of a novel anticoagulant peptide from marine echiuroid worm Urechis unicinctus. Process Biochem 43:179–184
33. Gan ZR, Gould RJ, Jacobs JW, Freidman PA, Polokoff MA (1988) Echistatin, a potent platelet aggregation inhibitor from venom of viper, Echis carinatus. J Biol Chem 263:19827–19832
34. Re R, Pellegrini A, Proteggente A, Pannala M, Yang C, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231–1237
35. Orsini Delgado MC, Tironi VA, Añón MC (2011) Antioxidant activity of amaranth protein or their hydrolysates under simulated gastrointestinal digestion. LWT 44:1752–1760