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Volumn 38, Issue , 2016, Pages 151-163

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome

Author keywords

Alzheimer's disease; APP PS1; Blood; Brain; Metabolites; Metabolomics

Indexed keywords

ACYLCARNITINE; BRANCHED CHAIN AMINO ACID; ESSENTIAL AMINO ACID; PHOSPHOLIPID; SEROTONIN; CARNITINE; POLYAMINE;

EID: 84962214982     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.11.014     Document Type: Article
Times cited : (102)

References (60)
  • 1
    • 79952158162 scopus 로고    scopus 로고
    • Ceramide and related sphingolipid levels are not altered in disease associated brain regions of APP and APP/PS1 mouse models of Alzheimer's disease: relationship with the lack of neurodegeneration?
    • Barrier L., Fauconneau B., Noel A., Ingrand S. Ceramide and related sphingolipid levels are not altered in disease associated brain regions of APP and APP/PS1 mouse models of Alzheimer's disease: relationship with the lack of neurodegeneration?. Int. J. Alzheimers Dis. 2010, 2011:920958.
    • (2010) Int. J. Alzheimers Dis. , vol.2011 , pp. 920958
    • Barrier, L.1    Fauconneau, B.2    Noel, A.3    Ingrand, S.4
  • 2
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • Beckonert O., Keun H.C., Ebbels T.M.D., Bundy J.G., Holmes E., Lindon J.C., Nicholson J.K. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat. Protoc. 2007, 2:2692-2703.
    • (2007) Nat. Protoc. , vol.2 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.D.3    Bundy, J.G.4    Holmes, E.5    Lindon, J.C.6    Nicholson, J.K.7
  • 6
    • 0043172479 scopus 로고    scopus 로고
    • The glutamatergic system and Alzheimer's disease-therapeutic implications
    • Butterfield D.A., Pocernich C.B. The glutamatergic system and Alzheimer's disease-therapeutic implications. CNS Drugs 2003, 17:641-652.
    • (2003) CNS Drugs , vol.17 , pp. 641-652
    • Butterfield, D.A.1    Pocernich, C.B.2
  • 7
    • 0032950029 scopus 로고    scopus 로고
    • The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease
    • Cacabelos R., Takeda M., Winblad B. The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease. Int. J. Geriatr. Psychiatry 1999, 14:3-47.
    • (1999) Int. J. Geriatr. Psychiatry , vol.14 , pp. 3-47
    • Cacabelos, R.1    Takeda, M.2    Winblad, B.3
  • 8
    • 16344389891 scopus 로고    scopus 로고
    • PermutMatrix: a graphical environment to arrange gene expression profiles in optimal linear order
    • Caraux G., Pinloche S. PermutMatrix: a graphical environment to arrange gene expression profiles in optimal linear order. Bioinformatics 2005, 21:1280-1281.
    • (2005) Bioinformatics , vol.21 , pp. 1280-1281
    • Caraux, G.1    Pinloche, S.2
  • 9
    • 84864565343 scopus 로고    scopus 로고
    • Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice
    • Chen S.Q., Cai Q., Shen Y.Y., Wang P.J., Teng G.J., Zhang W., Zang F.C. Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behav. Brain Res. 2012, 235:1-6.
    • (2012) Behav. Brain Res. , vol.235 , pp. 1-6
    • Chen, S.Q.1    Cai, Q.2    Shen, Y.Y.3    Wang, P.J.4    Teng, G.J.5    Zhang, W.6    Zang, F.C.7
  • 12
    • 84866735448 scopus 로고    scopus 로고
    • Evidence for premature lipid raft aging in APP/PS1 double transgenic mice, a model of familial Alzheimer disease
    • Fabelo N., Martin V., Marin R., Santpere G., Aso E., Ferrer I., Diaz M. Evidence for premature lipid raft aging in APP/PS1 double transgenic mice, a model of familial Alzheimer disease. J. Neuropathol. Exp. Neurol. 2012, 71:868-881.
    • (2012) J. Neuropathol. Exp. Neurol. , vol.71 , pp. 868-881
    • Fabelo, N.1    Martin, V.2    Marin, R.3    Santpere, G.4    Aso, E.5    Ferrer, I.6    Diaz, M.7
  • 13
    • 0034213298 scopus 로고    scopus 로고
    • Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders
    • Farooqui A.A., Horrocks L.A., Farooqui T. Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem. Phys. Lipids 2000, 106:1-29.
    • (2000) Chem. Phys. Lipids , vol.106 , pp. 1-29
    • Farooqui, A.A.1    Horrocks, L.A.2    Farooqui, T.3
  • 14
    • 34447300221 scopus 로고    scopus 로고
    • Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide
    • Farooqui A.A., Horrocks L.A., Farooqui T. Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide. J. Neurosci. Res. 2007, 85:1834-1850.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 1834-1850
    • Farooqui, A.A.1    Horrocks, L.A.2    Farooqui, T.3
  • 15
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics-the link between genotypes and phenotypes
    • Fiehn O. Metabolomics-the link between genotypes and phenotypes. Plant Mol. Biol. 2002, 48:155-171.
    • (2002) Plant Mol. Biol. , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 18
    • 84903372759 scopus 로고    scopus 로고
    • Inhibition of the polyamine system counteracts beta-amyloid peptide-induced memory impairment in mice: Involvement of extrasynaptic NMDA receptors
    • Gomes G.M., Dalmolin G.D., Baer J., Karpova A., Mello C.F., Kreutz M.R., Rubin M.A. Inhibition of the polyamine system counteracts beta-amyloid peptide-induced memory impairment in mice: Involvement of extrasynaptic NMDA receptors. PLoS One 2014, 9:e99184.
    • (2014) PLoS One , vol.9 , pp. e99184
    • Gomes, G.M.1    Dalmolin, G.D.2    Baer, J.3    Karpova, A.4    Mello, C.F.5    Kreutz, M.R.6    Rubin, M.A.7
  • 19
    • 84913592920 scopus 로고    scopus 로고
    • Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry
    • Gonzalez-Dominguez R., Garcia A., Garcia-Barrera T., Barbas C., Luis Gomez-Ariza J. Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry. Electrophoresis 2014, 35:3321-3330.
    • (2014) Electrophoresis , vol.35 , pp. 3321-3330
    • Gonzalez-Dominguez, R.1    Garcia, A.2    Garcia-Barrera, T.3    Barbas, C.4    Luis Gomez-Ariza, J.5
  • 20
    • 84921967784 scopus 로고    scopus 로고
    • Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
    • Gonzalez-Dominguez R., Garcia-Barrera T., Vitorica J., Gomez-Ariza J.L. Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches. Biochimie 2015, 110C:119-128.
    • (2015) Biochimie , vol.110C , pp. 119-128
    • Gonzalez-Dominguez, R.1    Garcia-Barrera, T.2    Vitorica, J.3    Gomez-Ariza, J.L.4
  • 21
    • 84922724734 scopus 로고    scopus 로고
    • Metabolomics reveals significant impairments in the immune system of the APP/PS1 transgenic mice of Alzheimer's disease
    • Gonzalez-Dominguez R., Garcia-Barrera T., Vitorica J., Gomez-Ariza J.L. Metabolomics reveals significant impairments in the immune system of the APP/PS1 transgenic mice of Alzheimer's disease. Electrophoresis 2015, 36:577-587.
    • (2015) Electrophoresis , vol.36 , pp. 577-587
    • Gonzalez-Dominguez, R.1    Garcia-Barrera, T.2    Vitorica, J.3    Gomez-Ariza, J.L.4
  • 22
  • 23
    • 84925834088 scopus 로고    scopus 로고
    • Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease
    • Graham S.F., Chevallier O.P., Elliott C.T., Holscher C., Johnston J., McGuinness B., Kehoe P.G., Passmore A.P., Green B.D. Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease. PLoS One 2015, 10:e0119452.
    • (2015) PLoS One , vol.10 , pp. e0119452
    • Graham, S.F.1    Chevallier, O.P.2    Elliott, C.T.3    Holscher, C.4    Johnston, J.5    McGuinness, B.6    Kehoe, P.G.7    Passmore, A.P.8    Green, B.D.9
  • 24
    • 84873388502 scopus 로고    scopus 로고
    • Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease
    • Graham S.F., Chevallier O.P., Roberts D., Hoelscher C., Elliott C.T., Green B.D. Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease. Anal. Chem. 2013, 85:1803-1811.
    • (2013) Anal. Chem. , vol.85 , pp. 1803-1811
    • Graham, S.F.1    Chevallier, O.P.2    Roberts, D.3    Hoelscher, C.4    Elliott, C.T.5    Green, B.D.6
  • 25
    • 84884411346 scopus 로고    scopus 로고
    • H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma
    • Graham S.F., Holscher C., McClean P., Elliott C.T., Green B.D. H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma. Metabolomics 2013, 9:974-983.
    • (2013) Metabolomics , vol.9 , pp. 974-983
    • Graham, S.F.1    Holscher, C.2    McClean, P.3    Elliott, C.T.4    Green, B.D.5
  • 27
    • 80053334820 scopus 로고    scopus 로고
    • From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry
    • Grimm M.O.W., Groesgen S., Riemenschneider M., Tanila H., Grimm H.S., Hartmann T. From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry. J. Chromatogr. A 2011, 1218:7713-7722.
    • (2011) J. Chromatogr. A , vol.1218 , pp. 7713-7722
    • Grimm, M.O.W.1    Groesgen, S.2    Riemenschneider, M.3    Tanila, H.4    Grimm, H.S.5    Hartmann, T.6
  • 29
    • 84859429769 scopus 로고    scopus 로고
    • The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease
    • Hamilton A., Holscher C. The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease. Brain Res. 2012, 1449:83-93.
    • (2012) Brain Res. , vol.1449 , pp. 83-93
    • Hamilton, A.1    Holscher, C.2
  • 32
    • 33645241830 scopus 로고    scopus 로고
    • VANTED: a system for advanced data analysis and visualization in the context of biological networks
    • Junker B.H., Klukas C., Schreiber F. VANTED: a system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics 2006, 7:109.
    • (2006) BMC Bioinformatics , vol.7 , pp. 109
    • Junker, B.H.1    Klukas, C.2    Schreiber, F.3
  • 33
    • 26244453388 scopus 로고    scopus 로고
    • Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/Delta E9 mice with amyloid plaques
    • Lalonde R., Kim H.D., Maxwell J.A., Fukuchi K. Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/Delta E9 mice with amyloid plaques. Neurosci. Lett. 2005, 390:87-92.
    • (2005) Neurosci. Lett. , vol.390 , pp. 87-92
    • Lalonde, R.1    Kim, H.D.2    Maxwell, J.A.3    Fukuchi, K.4
  • 34
    • 0001050519 scopus 로고    scopus 로고
    • The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene
    • Larsson Forsell P.K., Kennedy B.P., Claesson H.E. The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene. Eur. J. Biochem. 1999, 262:575-585.
    • (1999) Eur. J. Biochem. , vol.262 , pp. 575-585
    • Larsson Forsell, P.K.1    Kennedy, B.P.2    Claesson, H.E.3
  • 35
    • 0034616106 scopus 로고    scopus 로고
    • The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)
    • Mancuso D.J., Jenkins C.M., Gross R.W. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2). J. Biol. Chem. 2000, 275:9937-9945.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9937-9945
    • Mancuso, D.J.1    Jenkins, C.M.2    Gross, R.W.3
  • 37
    • 84881376185 scopus 로고    scopus 로고
    • Nutritional approaches in the risk reduction and management of Alzheimer's disease
    • Mi W., van Wijk N., Cansev M., Sijben J.W., Kamphuis P.J. Nutritional approaches in the risk reduction and management of Alzheimer's disease. Nutrition 2013, 29:1080-1089.
    • (2013) Nutrition , vol.29 , pp. 1080-1089
    • Mi, W.1    van Wijk, N.2    Cansev, M.3    Sijben, J.W.4    Kamphuis, P.J.5
  • 38
    • 82955194515 scopus 로고    scopus 로고
    • Induction of methionine sulfoxide reductases protects neurons from amyloid beta protein insults in vitro and in vivo
    • Moskovitz J., Maiti P., Lopes D.H.J., Oien D.B., Attar A., Liu T., Mittal S., Hayes J., Bitan G. Induction of methionine sulfoxide reductases protects neurons from amyloid beta protein insults in vitro and in vivo. Biochemistry 2011, 50:10687-10697.
    • (2011) Biochemistry , vol.50 , pp. 10687-10697
    • Moskovitz, J.1    Maiti, P.2    Lopes, D.H.J.3    Oien, D.B.4    Attar, A.5    Liu, T.6    Mittal, S.7    Hayes, J.8    Bitan, G.9
  • 41
    • 0031613423 scopus 로고    scopus 로고
    • Effect of lysophosphatidylcholine on transmembrane signal transduction
    • Prokazova N.V., Zvezdina N.D., Korotaeva A.A. Effect of lysophosphatidylcholine on transmembrane signal transduction. Biochemistry (Mosc) 1998, 63:31-37.
    • (1998) Biochemistry (Mosc) , vol.63 , pp. 31-37
    • Prokazova, N.V.1    Zvezdina, N.D.2    Korotaeva, A.A.3
  • 42
    • 0037490159 scopus 로고    scopus 로고
    • Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis
    • Puglielli L., Ellis B.C., Saunders A.J., Kovacs D.M. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J. Biol. Chem. 2003, 278:19777-19783.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19777-19783
    • Puglielli, L.1    Ellis, B.C.2    Saunders, A.J.3    Kovacs, D.M.4
  • 43
    • 79958152266 scopus 로고    scopus 로고
    • Metabolomic analysis of normal (C57BL/6J, 129S1/SvImJ) mice by gas chromatography-mass spectrometry: detection of strain and gender differences
    • Qiao Q., Li T., Sun J., Liu X., Ren J., Fei J. Metabolomic analysis of normal (C57BL/6J, 129S1/SvImJ) mice by gas chromatography-mass spectrometry: detection of strain and gender differences. Talanta 2011, 85:718-724.
    • (2011) Talanta , vol.85 , pp. 718-724
    • Qiao, Q.1    Li, T.2    Sun, J.3    Liu, X.4    Ren, J.5    Fei, J.6
  • 44
    • 84855875727 scopus 로고    scopus 로고
    • Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics
    • Roemisch-Margl W., Prehn C., Bogumil R., Roehring C., Suhre K., Adamski J. Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics. Metabolomics 2012, 8:133-142.
    • (2012) Metabolomics , vol.8 , pp. 133-142
    • Roemisch-Margl, W.1    Prehn, C.2    Bogumil, R.3    Roehring, C.4    Suhre, K.5    Adamski, J.6
  • 45
    • 59449085082 scopus 로고    scopus 로고
    • Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease
    • Schaeffer E.L., Forlenza O.V., Gattaz W.F. Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease. Psychopharmacology (Berl) 2009, 202:37-51.
    • (2009) Psychopharmacology (Berl) , vol.202 , pp. 37-51
    • Schaeffer, E.L.1    Forlenza, O.V.2    Gattaz, W.F.3
  • 46
    • 41549095973 scopus 로고    scopus 로고
    • Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A(2) enzyme
    • Schaeffer E.L., Gattaz W.F. Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A(2) enzyme. Psychopharmacology (Berl) 2008, 198:1-27.
    • (2008) Psychopharmacology (Berl) , vol.198 , pp. 1-27
    • Schaeffer, E.L.1    Gattaz, W.F.2
  • 47
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 48
    • 7944233158 scopus 로고    scopus 로고
    • Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
    • Selkoe D.J. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat. Cell Biol. 2004, 6:1054-1061.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1054-1061
    • Selkoe, D.J.1
  • 49
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics
    • Selkoe D.J., Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 2003, 43:545-584.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 50
    • 33645728523 scopus 로고    scopus 로고
    • Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications
    • Skovronsky D.M., Lee V.M.Y., Trojanowskiz J.Q. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annu. Rev. Pathol. 2006, 1:151-170.
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 151-170
    • Skovronsky, D.M.1    Lee, V.M.Y.2    Trojanowskiz, J.Q.3
  • 51
    • 0029657725 scopus 로고    scopus 로고
    • Cytosolic phospholipase A(2) (cPLA(2)) immunoreactivity is elevated in Alzheimer's disease brain
    • Stephenson D.T., Lemere C.A., Selkoe D.J., Clemens J.A. Cytosolic phospholipase A(2) (cPLA(2)) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol. Dis. 1996, 3:51-63.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 51-63
    • Stephenson, D.T.1    Lemere, C.A.2    Selkoe, D.J.3    Clemens, J.A.4
  • 52
    • 84877888815 scopus 로고    scopus 로고
    • Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
    • Trushina E., Dutta T., Persson X.M.T., Mielke M.M., Petersen R.C. Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One 2013, 8:e63644.
    • (2013) PLoS One , vol.8 , pp. e63644
    • Trushina, E.1    Dutta, T.2    Persson, X.M.T.3    Mielke, M.M.4    Petersen, R.C.5
  • 55
    • 77952875375 scopus 로고    scopus 로고
    • Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1 Delta E9-deleted transgenic mice model of beta-amyloidosis
    • Volianskis A., Kostner R., Molgaard M., Hass S., Jensen M.S. Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1 Delta E9-deleted transgenic mice model of beta-amyloidosis. Neurobiol. Aging 2010, 31:1173-1187.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1173-1187
    • Volianskis, A.1    Kostner, R.2    Molgaard, M.3    Hass, S.4    Jensen, M.S.5
  • 57
    • 80755125653 scopus 로고    scopus 로고
    • Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease
    • Xiong H., Callaghan D., Wodzinska J., Xu J., Premyslova M., Liu Q.Y., Connelly J., Zhang W. Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease. Neurosci. Bull. 2011, 27:221-232.
    • (2011) Neurosci. Bull. , vol.27 , pp. 221-232
    • Xiong, H.1    Callaghan, D.2    Wodzinska, J.3    Xu, J.4    Premyslova, M.5    Liu, Q.Y.6    Connelly, J.7    Zhang, W.8
  • 58
    • 58149465620 scopus 로고    scopus 로고
    • Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice
    • Yao J.K., Wengenack T.M., Curran G.L., Poduslo J.F. Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice. Neurochem. Res. 2009, 34:102-108.
    • (2009) Neurochem. Res. , vol.34 , pp. 102-108
    • Yao, J.K.1    Wengenack, T.M.2    Curran, G.L.3    Poduslo, J.F.4
  • 59
    • 0033583252 scopus 로고    scopus 로고
    • Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E
    • Yatin S.M., Yatin M., Aulick T., Ain K.B., Butterfield D.A. Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci. Lett. 1999, 263:17-20.
    • (1999) Neurosci. Lett. , vol.263 , pp. 17-20
    • Yatin, S.M.1    Yatin, M.2    Aulick, T.3    Ain, K.B.4    Butterfield, D.A.5
  • 60
    • 0035282733 scopus 로고    scopus 로고
    • Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity
    • Yatin S.M., Yatin M., Varadarajan S., Ain K.B., Butterfield D.A. Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity. J. Neurosci. Res. 2001, 63:395-401.
    • (2001) J. Neurosci. Res. , vol.63 , pp. 395-401
    • Yatin, S.M.1    Yatin, M.2    Varadarajan, S.3    Ain, K.B.4    Butterfield, D.A.5


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