Glutamate receptor ligands: Synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

Chirality

Volumn 14, Issue 4, 2002, Pages 351-363

  Guldbrandt, Mette ^a   Johansen, Tommy N ^a   Frydenvang, Karla ^a   Bräuner Osborne, Hans ^a   Stensbøl, Tine B ^a   Nielsen, Birgitte ^a   Karla, Rolf ^a   Santi, Flavio ^a   Krogsgaard Larsen, Povl ^a   Madsen, Ulf ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Chiral HPLC; Excitatory amino acids; mGluR2 agonists; Resolution; X ray crystallography

Indexed keywords

2 AMINO 3 METHYLADIPIC ACID; 2 AMINO 4 METHYLADIPIC ACID; 2 AMINO 5 METHYL DELTA 4 ADIPIC ACID; 2 AMINO 5 METHYLADIPIC ACID; 2 AMINOADIPIC ACID; AMPA RECEPTOR AGONIST; EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHIRALITY; CIRCULAR DICHROISM; DIASTEREOISOMER; DRUG STRUCTURE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; RECEPTOR BINDING; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

2-AMINOADIPIC ACID; ANIMALS; CHO CELLS; CIRCULAR DICHROISM; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; LIGANDS; METHYLATION; MODELS, MOLECULAR; RATS; RECEPTORS, GLUTAMATE; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 0036113175     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10104     Document Type: Article

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