1H NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

Metabolomics

Volumn 9, Issue 5, 2013, Pages 974-983

  Graham, Stewart F ^a   Holscher, Christian ^b   McClean, Paula ^b   Elliott, Christopher T ^a   Green, Brian D ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Alzheimer's disease; APP PS1 mouse model; Brain; Metabolomics; Plasma

Indexed keywords

4 AMINOBUTYRIC ACID; ACETIC ACID; AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; BRAIN EXTRACT; CITRIC ACID; CREATINE; GLUTAMIC ACID; GLUTAMINE; METHIONINE; N ACETYLASPARTIC ACID; PRESENILIN 1;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ACETIC ACID BLOOD LEVEL; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID BRAIN LEVEL; BLOOD ANALYSIS; BLOOD CHEMISTRY; BLOOD LEVEL; BRAIN LEVEL; CITRIC ACID BLOOD LEVEL; CONTROLLED STUDY; CREATINE BRAIN LEVEL; DISCRIMINANT ANALYSIS; DISEASE MODEL; GLUTAMIC ACID BLOOD LEVEL; GLUTAMINE BLOOD LEVEL; HIGH THROUGHPUT SCREENING; METABOLIC DISORDER; METABOLITE; METABOLOMICS; METHIONINE BLOOD LEVEL; MOUSE; N ACETYLASPARTIC ACID BRAIN LEVEL; NEUROCHEMISTRY; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; STATISTICAL MODEL; STRAIN DIFFERENCE; TRANSGENIC MOUSE; WILD TYPE;

EID: 84884411346     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-013-0516-y     Document Type: Article

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