메뉴 건너뛰기




Volumn 15, Issue 2, 2016, Pages 349-359

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TRIACYLGLYCEROL LIPASE; APOLIPOPROTEIN B; CARNITINE PALMITOYLTRANSFERASE I; GLUCOKINASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; CELL CYCLE PROTEIN; FATTY ACID; FOXO1 PROTEIN, MOUSE; G0S2 PROTEIN, MOUSE; GLUCOSE;

EID: 84962082073     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.03.021     Document Type: Article
Times cited : (60)

References (47)
  • 2
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37:911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 5
    • 71049158067 scopus 로고    scopus 로고
    • Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity
    • Bu S.Y., Mashek M.T., Mashek D.G. Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity. J. Biol. Chem. 2009, 284:30474-30483.
    • (2009) J. Biol. Chem. , vol.284 , pp. 30474-30483
    • Bu, S.Y.1    Mashek, M.T.2    Mashek, D.G.3
  • 6
    • 67649403606 scopus 로고    scopus 로고
    • FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
    • Chakrabarti P., Kandror K.V. FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J. Biol. Chem. 2009, 284:13296-13300.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13296-13300
    • Chakrabarti, P.1    Kandror, K.V.2
  • 8
    • 80054057662 scopus 로고    scopus 로고
    • Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling
    • Coleman R.A., Mashek D.G. Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling. Chem. Rev. 2011, 111:6359-6386.
    • (2011) Chem. Rev. , vol.111 , pp. 6359-6386
    • Coleman, R.A.1    Mashek, D.G.2
  • 9
    • 0037342151 scopus 로고    scopus 로고
    • Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
    • Daitoku H., Yamagata K., Matsuzaki H., Hatta M., Fukamizu A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 2003, 52:642-649.
    • (2003) Diabetes , vol.52 , pp. 642-649
    • Daitoku, H.1    Yamagata, K.2    Matsuzaki, H.3    Hatta, M.4    Fukamizu, A.5
  • 10
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • Dong X.C., Copps K.D., Guo S., Li Y., Kollipara R., DePinho R.A., White M.F. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008, 8:65-76.
    • (2008) Cell Metab. , vol.8 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 11
    • 37049241913 scopus 로고
    • Pyruvate metabolism and control: factors affecting pyruvic carboxylase activity
    • Freedman A.D., Kohn L. Pyruvate metabolism and control: factors affecting pyruvic carboxylase activity. Science 1964, 145:58-60.
    • (1964) Science , vol.145 , pp. 58-60
    • Freedman, A.D.1    Kohn, L.2
  • 12
    • 71449105535 scopus 로고    scopus 로고
    • FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol
    • Ganjam G.K., Dimova E.Y., Unterman T.G., Kietzmann T. FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol. J. Biol. Chem. 2009, 284:30783-30797.
    • (2009) J. Biol. Chem. , vol.284 , pp. 30783-30797
    • Ganjam, G.K.1    Dimova, E.Y.2    Unterman, T.G.3    Kietzmann, T.4
  • 13
    • 0002119889 scopus 로고
    • Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl-coenzyme A
    • Garland P.B., Randle P.J. Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl-coenzyme A. Biochem. J. 1964, 91:6C-7C.
    • (1964) Biochem. J. , vol.91 , pp. 6C-7C
    • Garland, P.B.1    Randle, P.J.2
  • 16
    • 0034730660 scopus 로고    scopus 로고
    • Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins
    • Hall R.K., Yamasaki T., Kucera T., Waltner-Law M., O'Brien R., Granner D.K. Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins. J. Biol. Chem. 2000, 275:30169-30175.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30169-30175
    • Hall, R.K.1    Yamasaki, T.2    Kucera, T.3    Waltner-Law, M.4    O'Brien, R.5    Granner, D.K.6
  • 17
    • 84868601291 scopus 로고    scopus 로고
    • The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond
    • Heckmann B.L., Zhang X., Xie X., Liu J. The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond. Biochim. Biophys. Acta 2013, 1831:276-281.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 276-281
    • Heckmann, B.L.1    Zhang, X.2    Xie, X.3    Liu, J.4
  • 18
    • 0038645860 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
    • Hirota K., Daitoku H., Matsuzaki H., Araya N., Yamagata K., Asada S., Sugaya T., Fukamizu A. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J. Biol. Chem. 2003, 278:13056-13060.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13056-13060
    • Hirota, K.1    Daitoku, H.2    Matsuzaki, H.3    Araya, N.4    Yamagata, K.5    Asada, S.6    Sugaya, T.7    Fukamizu, A.8
  • 19
    • 57749116021 scopus 로고    scopus 로고
    • A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding
    • Hirota K., Sakamaki J., Ishida J., Shimamoto Y., Nishihara S., Kodama N., Ohta K., Yamamoto M., Tanimoto K., Fukamizu A. A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. J. Biol. Chem. 2008, 283:32432-32441.
    • (2008) J. Biol. Chem. , vol.283 , pp. 32432-32441
    • Hirota, K.1    Sakamaki, J.2    Ishida, J.3    Shimamoto, Y.4    Nishihara, S.5    Kodama, N.6    Ohta, K.7    Yamamoto, M.8    Tanimoto, K.9    Fukamizu, A.10
  • 20
    • 69049098306 scopus 로고    scopus 로고
    • The Randle cycle revisited: a new head for an old hat
    • Hue L., Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E578-E591.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. E578-E591
    • Hue, L.1    Taegtmeyer, H.2
  • 23
    • 0030975131 scopus 로고    scopus 로고
    • Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    • Lewis G.F., Vranic M., Harley P., Giacca A. Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes 1997, 46:1111-1119.
    • (1997) Diabetes , vol.46 , pp. 1111-1119
    • Lewis, G.F.1    Vranic, M.2    Harley, P.3    Giacca, A.4
  • 24
    • 84867023428 scopus 로고    scopus 로고
    • Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice
    • Lian J., Wei E., Wang S.P., Quiroga A.D., Li L., Di Pardo A., van der Veen J., Sipione S., Mitchell G.A., Lehner R. Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice. Hepatology 2012, 56:2154-2162.
    • (2012) Hepatology , vol.56 , pp. 2154-2162
    • Lian, J.1    Wei, E.2    Wang, S.P.3    Quiroga, A.D.4    Li, L.5    Di Pardo, A.6    van der Veen, J.7    Sipione, S.8    Mitchell, G.A.9    Lehner, R.10
  • 28
    • 78751496304 scopus 로고    scopus 로고
    • Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
    • Ong K.T., Mashek M.T., Bu S.Y., Greenberg A.S., Mashek D.G. Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology 2011, 53:116-126.
    • (2011) Hepatology , vol.53 , pp. 116-126
    • Ong, K.T.1    Mashek, M.T.2    Bu, S.Y.3    Greenberg, A.S.4    Mashek, D.G.5
  • 29
    • 84871901684 scopus 로고    scopus 로고
    • Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
    • Ong K.T., Mashek M.T., Bu S.Y., Mashek D.G. Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation. FASEB J. 2013, 27:313-321.
    • (2013) FASEB J. , vol.27 , pp. 313-321
    • Ong, K.T.1    Mashek, M.T.2    Bu, S.Y.3    Mashek, D.G.4
  • 31
    • 69449087522 scopus 로고    scopus 로고
    • Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity
    • Sapiro J.M., Mashek M.T., Greenberg A.S., Mashek D.G. Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity. J. Lipid Res. 2009, 50:1621-1629.
    • (2009) J. Lipid Res. , vol.50 , pp. 1621-1629
    • Sapiro, J.M.1    Mashek, M.T.2    Greenberg, A.S.3    Mashek, D.G.4
  • 33
    • 84889686585 scopus 로고    scopus 로고
    • Desnutrin/ATGL activates PPARδ to promote mitochondrial function for insulin secretion in islet β cells
    • Tang T., Abbott M.J., Ahmadian M., Lopes A.B., Wang Y., Sul H.S. Desnutrin/ATGL activates PPARδ to promote mitochondrial function for insulin secretion in islet β cells. Cell Metab. 2013, 18:883-895.
    • (2013) Cell Metab. , vol.18 , pp. 883-895
    • Tang, T.1    Abbott, M.J.2    Ahmadian, M.3    Lopes, A.B.4    Wang, Y.5    Sul, H.S.6
  • 34
    • 84929148324 scopus 로고    scopus 로고
    • Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
    • Titchenell P.M., Chu Q., Monks B.R., Birnbaum M.J. Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nat. Commun. 2015, 6:7078.
    • (2015) Nat. Commun. , vol.6 , pp. 7078
    • Titchenell, P.M.1    Chu, Q.2    Monks, B.R.3    Birnbaum, M.J.4
  • 35
    • 79953787445 scopus 로고    scopus 로고
    • Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
    • Turpin S.M., Hoy A.J., Brown R.D., Rudaz C.G., Honeyman J., Matzaris M., Watt M.J. Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia 2011, 54:146-156.
    • (2011) Diabetologia , vol.54 , pp. 146-156
    • Turpin, S.M.1    Hoy, A.J.2    Brown, R.D.3    Rudaz, C.G.4    Honeyman, J.5    Matzaris, M.6    Watt, M.J.7
  • 37
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson J.R., Kreisberg R.A., Felts P.W. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc. Natl. Acad. Sci. USA 1966, 56:247-254.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.56 , pp. 247-254
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 38
    • 33745396347 scopus 로고
    • Lipolytic response to glucose infusion in human subjects
    • Wolfe R.R., Peters E.J. Lipolytic response to glucose infusion in human subjects. Am. J. Physiol. 1987, 252:E218-E223.
    • (1987) Am. J. Physiol. , vol.252 , pp. E218-E223
    • Wolfe, R.R.1    Peters, E.J.2
  • 39
    • 84883205274 scopus 로고    scopus 로고
    • Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis
    • Xiong X., Tao R., DePinho R.A., Dong X.C. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PLoS ONE 2013, 8:e74340.
    • (2013) PLoS ONE , vol.8 , pp. e74340
    • Xiong, X.1    Tao, R.2    DePinho, R.A.3    Dong, X.C.4
  • 40
    • 77249118270 scopus 로고    scopus 로고
    • The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
    • Yang X., Lu X., Lombès M., Rha G.B., Chi Y.I., Guerin T.M., Smart E.J., Liu J. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab. 2010, 11:194-205.
    • (2010) Cell Metab. , vol.11 , pp. 194-205
    • Yang, X.1    Lu, X.2    Lombès, M.3    Rha, G.B.4    Chi, Y.I.5    Guerin, T.M.6    Smart, E.J.7    Liu, J.8
  • 41
    • 0035823515 scopus 로고    scopus 로고
    • Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences
    • Yeagley D., Guo S., Unterman T., Quinn P.G. Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences. J. Biol. Chem. 2001, 276:33705-33710.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33705-33710
    • Yeagley, D.1    Guo, S.2    Unterman, T.3    Quinn, P.G.4
  • 43
    • 84862909028 scopus 로고    scopus 로고
    • Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
    • Zhang K., Li L., Qi Y., Zhu X., Gan B., DePinho R.A., Averitt T., Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 2012, 153:631-646.
    • (2012) Endocrinology , vol.153 , pp. 631-646
    • Zhang, K.1    Li, L.2    Qi, Y.3    Zhu, X.4    Gan, B.5    DePinho, R.A.6    Averitt, T.7    Guo, S.8
  • 44
    • 33744515637 scopus 로고    scopus 로고
    • FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
    • Zhang W., Patil S., Chauhan B., Guo S., Powell D.R., Le J., Klotsas A., Matika R., Xiao X., Franks R., et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 2006, 281:10105-10117.
    • (2006) J. Biol. Chem. , vol.281 , pp. 10105-10117
    • Zhang, W.1    Patil, S.2    Chauhan, B.3    Guo, S.4    Powell, D.R.5    Le, J.6    Klotsas, A.7    Matika, R.8    Xiao, X.9    Franks, R.10
  • 45
    • 84894484467 scopus 로고    scopus 로고
    • Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis
    • Zhang X., Xie X., Heckmann B.L., Saarinen A.M., Czyzyk T.A., Liu J. Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes 2014, 63:934-946.
    • (2014) Diabetes , vol.63 , pp. 934-946
    • Zhang, X.1    Xie, X.2    Heckmann, B.L.3    Saarinen, A.M.4    Czyzyk, T.A.5    Liu, J.6
  • 46
    • 1642464560 scopus 로고    scopus 로고
    • Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms
    • Zhao X., Gan L., Pan H., Kan D., Majeski M., Adam S.A., Unterman T.G. Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem. J. 2004, 378:839-849.
    • (2004) Biochem. J. , vol.378 , pp. 839-849
    • Zhao, X.1    Gan, L.2    Pan, H.3    Kan, D.4    Majeski, M.5    Adam, S.A.6    Unterman, T.G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.