Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 49, 2014, Pages 17450-17455

  Mullins, Garrett R ^a   Wang, Lifu ^a   Raje, Vidisha ^a   Sherwood, Samantha G ^a   Grande, Rebecca C ^a   Boroda, Salome ^a   Eaton, James M ^a   Blancquaert, Sara ^b   Roger, Pierre P ^b   Leitinger, Norbert ^a   Harris, Thurl E ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Adrenergic; ATGL; Insulin; Lipase; Torin 1

Indexed keywords

CATECHOLAMINE; GLUCOSE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; 1-(4-(4-PROPIONYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL)-9-(QUINOLIN-3-YL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; LIPID; MTOR PROTEIN, MOUSE; NAPHTHYRIDINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

ADIPOCYTE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC STIMULATION; CELL METABOLISM; CONTROLLED STUDY; DISSOCIATION; GLUCOSE TRANSPORT; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; LIPOLYSIS; OBESITY; REGULATORY MECHANISM; 3T3 CELL LINE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CYTOLOGY; HOMEOSTASIS; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CATECHOLAMINES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GLUCOSE; HOMEOSTASIS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; LIPIDS; LIPOLYSIS; MICE; MODELS, BIOLOGICAL; NAPHTHYRIDINES; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84918534812     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410530111     Document Type: Article

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