Corrigendum to: The T helper type 17/regulatory T cell paradigm in pregnancy (Immunology, (2016), 148, 1, (13-21), 10.1111/imm.12595);The T helper type 17/regulatory T cell paradigm in pregnancy

Immunology

Volumn 148, Issue 1, 2016, Pages 13-21

  Figueiredo, Ana Sofia ^a   Schumacher, Anne ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Autoimmunity; Defence; Mathematical modelling; Pregnancy; Systems biology; T helper type 17 regulatory T cell ratio; Tolerance

Indexed keywords

ABORTION; ARTICLE; AUTOIMMUNITY; HUMAN; IMMUNOCOMPETENT CELL; MATHEMATICAL MODEL; MULTIPLE SCLEROSIS; NONHUMAN; PREECLAMPSIA; PREGNANCY; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMS BIOLOGY; TH17 CELL; ANIMAL; AUTOIMMUNE DISEASES; FEMALE; IMMUNOLOGY; PREGNANCY COMPLICATIONS; PREMATURITY; RECURRENT ABORTION; THEORETICAL MODEL;

ABORTION, HABITUAL; ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; FEMALE; HUMANS; MODELS, THEORETICAL; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; PREMATURE BIRTH; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84962023313     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.13014     Document Type: Erratum

References (121)

1. Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Front Immunol 2014; 5:253.
2. Schjenken JMT, Paul JW, Clifton VL, Smith R. Mechanisms of maternal immune tolerance during pregnancy. In: Zheng J, ed. Recent Advances in Research on the Human Placenta. Shanghai, China: InTechOpen, 2012:211-242.
3. McClory S, Hughes T, Freud AG, Briercheck EL, Martin C, Trimboli AJ et al. Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest 2012; 122:1403-15.
4. Valor L, Teijeiro R, Aristimuño C, Faure F, Alonso B, Andrés Cd et al. Estradiol-dependent perforin expression by human regulatory T-cells. Eur J Clin Invest 2011; 41:357-64.
5. Aluvihare VR, Betz AG. The role of regulatory T cells in alloantigen tolerance. Immunol Rev 2006; 212:330-43.
6. + regulatory T cells and inducing indoleamine 2, 3-dioxygenase. J Reprod Immunol 2009; 80:1-11.
7. Jimeno R, Leceta J, Garin M, Ortiz AM, Mellado M, Rodriguez-Frade JM et al. Th17 polarization of memory Th cells in early arthritis: the vasoactive intestinal peptide effect. J Leukoc Biol 2015; 98:257-69.
8. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010; 63:601-10.
9. Li X, Wang B, Li Y, Wang L, Zhao X, Zhou X et al. The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice. J Ethnopharmacol 2013; 145:241-53.
10. Nie H, Zheng Y, Li R, Guo TB, He D, Fang L et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med 2013; 19:322-8.
11. Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell 2012; 150:29-38.
12. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K et al. IL-10 and TGF-β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33:1205-14.
13. Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010; 40:1830-5.
14. Wichner K, Stauss D, Kampfrath B, Kruger K, Muller G, Rehm A et al. Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt. FASEB J 2015; 30:761-4.
15. Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol 2013; 25:305-12.
16. Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 2011; 12:255-63.
17. Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007; 445:766-70.
18. Muranski P, Borman ZA, Kerkar SP, Klebanoff CA, Ji Y, Sanchez-Perez L et al. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity 2011; 35:972-85.
19. + T cells into TH17 cells in autoimmune arthritis. Nat Med 2014; 20:62-8.
20. Bellemore SM, Nikoopour E, Schwartz JA, Krougly O, Lee-Chan E, Singh B. Preventative role of interleukin-17 producing regulatory T helper type 17 (T 17) cells in type 1 diabetes in non-obese diabetic mice. Clin Exp Immunol 2015; 182:261-9.
21. Koucky M, Malickova K, Cindrova-Davies T, Germanova A, Parizek A, Kalousova M et al. Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor. J Reprod Immunol 2014; 106:110-7.
22. Vargas-Rojas MI, Solleiro-Villavicencio H, Soto V. Th1, Th2, Th17 and Treg levels in umbilical cord blood in preeclampsia. J Matern Fetal Neonatal Med 2015; 29:1642-5.
23. Wang WJ, Hao CF, Yi L, Yin GJ, Bao SH, Qiu LH et al. Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J Reprod Immunol 2010; 84:164-70.
24. + regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 2009; 183:7602-10.
25. Wang W, Shao S, Jiao Z, Guo M, Xu H, Wang S. The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int 2012; 32:887-93.
26. Schumacher A, Zenclussen AC. The paternal contribution to fetal tolerance. Adv Exp Med Biol 2015; 868:211-25.
27. Schjenken JE, Robertson SA. Seminal fluid signalling in the female reproductive tract: implications for reproductive success and offspring health. Adv Exp Med Biol 2015; 868:127-58.
28. Schumacher A, Zenclussen AC. Regulatory T cells: regulators of life. Am J Reprod Immunol 2014; 72:158-70.
29. De M, Choudhuri R, Wood GW. Determination of the number and distribution of macrophages, lymphocytes, and granulocytes in the mouse uterus from mating through implantation. J Leukoc Biol 1991; 50:252-62.
30. + T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod 2009; 80:1036-45.
31. Sharkey DJ, Macpherson AM, Tremellen KP, Robertson SA. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod 2007; 13:491-501.
32. + regulatory T-cell phenotype and transforming growth factor-β1 expression. Am J Reprod Immunol 2012; 68:322-30.
33. Srivastava MD, Lippes J, Srivastava BI. Cytokines of the human reproductive tract. Am J Reprod Immunol 1996; 36:157-66.
34. Thuere C, Zenclussen ML, Schumacher A, Langwisch S, Schulte-Wrede U, Teles A et al. Kinetics of regulatory T cells during murine pregnancy. Am J Reprod Immunol 2007; 58:514-23.
35. Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004; 5:266-71.
36. Lee JH, Ulrich B, Cho J, Park J, Kim CH. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol 2011; 187:1778-87.
37. + regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004; 10:347-53.
38. + regulatory T-cell subset. Immunology 2004; 112:38-43.
39. Steinborn A, Engst M, Haensch GM, Mahnke K, Schmitt E, Meuer S et al. Small for gestational age (SGA) neonates show reduced suppressive activity of their regulatory T cells. Clin Immunol 2010; 134:188-97.
40. + Tregs in human second trimester pregnancy is induced by progesterone and 17β-estradiol. J Immunol 2009; 183:759-69.
41. Rowe JH, Ertelt JM, Xin L, Way SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature 2012; 490:102-6.
42. Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M et al. Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol 2009; 182:5488-97.
43. Schumacher A, Heinze K, Witte J, Poloski E, Linzke N, Woidacki K et al. Human chorionic gonadotropin as a central regulator of pregnancy immune tolerance. J Immunol 2013; 190:2650-8.
44. + cells facilitates embryo implantation. Front Immunol 2013; 4:158.
45. Martínez FF, Knubel CP, Sánchez MC, Cervi L, Motrán CC. Pregnancy-specific glycoprotein 1a activates dendritic cells to provide signals for Th17-, Th2-, and Treg-cell polarization. Eur J Immunol 2012; 42:1573-84.
46. DiGiulio DB, Callahan BJ, McMurdie PJ, Costello EK, Lyell DJ, Robaczewska A et al. Temporal and spatial variation of the human microbiota during pregnancy. Proc Natl Acad Sci U S A 2015; 112:11060-5.
47. Steer P. The epidemiology of preterm labour. BJOG 2005; 112(Suppl. 1):1-3.
48. Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller AB et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health 2013; 10(Suppl. 1):S2.
49. Wardlaw T, You D, Hug L, Amouzou A, Newby H. UNICEF report: enormous progress in child survival but greater focus on newborns urgently needed. Reprod Health 2014; 11:82.
50. Isojima T, Kushima R, Goishi K, Tsuchida S, Watanabe T, Takahashi N et al. Mineral status of premature infants in early life and linear growth at age three. Pediatr Int 2015; 57:864-9.
51. Pryhuber GS, Maitre NL, Ballard RA, Cifelli D, Davis SD, Ellenberg JH et al. Prematurity and respiratory outcome program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States. BMC Pediatr 2015; 15:37.
52. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281:1191-3.
53. Prins JR, Gomez-Lopez N, Robertson SA. Interleukin-6 in pregnancy and gestational disorders. J Reprod Immunol 2012; 95:1-14.
54. Cabrera-Garcia L, Cruz-Melguizo S, Ruiz-Antoran B, Torres F, Velasco A, Martinez-Payo C et al. Evaluation of two treatment strategies for the prevention of preterm birth in women identified as at risk by ultrasound (PESAPRO Trial): study protocol for a randomized controlled trial. Trials 2015; 16:427.
55. Areia A, Vale-Pereira S, Alves V, Rodrigues-Santos P, Moura P, Mota-Pinto A. Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy. BJOG 2015; 122:1544-50.
56. Organization WH. WHO Recommendations for Prevention and Treatment of Pre-Eclampsia and Eclampsia. WHO Guidelines Approved by the Guidelines Review Committee. Geneva: Organization WH, 2011.
57. Perez-Sepulveda A, Torres MJ, Khoury M, Illanes SE. Innate immune system and preeclampsia. Front Immunol 2014; 5:244.
58. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet 2010; 376:631-44.
59. Hiby SE, Walker JJ, O'Shaughnessy KM, Redman CW, Carrington M, Trowsdale J et al. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 2004; 200:957-65.
60. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111:649-58.
61. Stepan H, Herraiz I, Schlembach D, Verlohren S, Brennecke S, Chantraine F et al. Implementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice. Ultrasound Obstet Gynecol 2015; 45:241-6.
62. Molvarec A, Shiozaki A, Ito M, Toldi G, Stenczer B, Szarka A et al. Increased prevalence of peripheral blood granulysin-producing cytotoxic T lymphocytes in preeclampsia. J Reprod Immunol 2011; 91:56-63.
63. de Groot CJ, van der Mast BJ, Visser W, De Kuiper P, Weimar W, Van Besouw NM. Preeclampsia is associated with increased cytotoxic T-cell capacity to paternal antigens. Am J Obstet Gynecol 2010; 203:496.e1-6.
64. Hiby SE, Apps R, Sharkey AM, Farrell LE, Gardner L, Mulder A et al. Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. J Clin Invest 2010; 120:4102-10.
65. Loewendorf AI, Nguyen TA, Yesayan MN, Kahn DA. Preeclampsia is characterized by fetal NK cell activation and a reduction in regulatory T cells. Am J Reprod Immunol 2015; 74:258-67.
66. Stirrat GM. Recurrent miscarriage. Lancet 1990; 336:673-5.
67. McNamee K, Dawood F, Farquharson RG. Thrombophilia and early pregnancy loss. Best Pract Res Clin Obstet Gynaecol 2012; 26:91-102.
68. Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril 2010; 93:1234-43.
69. Saravelos SH, Li TC. Unexplained recurrent miscarriage: how can we explain it? Hum Reprod 2012; 27:1882-6.
70. Wang WJ, Hao CF, Qu QL, Wang X, Qiu LH, Lin QD. The deregulation of regulatory T cells on interleukin-17-producing T helper cells in patients with unexplained early recurrent miscarriage. Hum Reprod 2010; 25:2591-6.
71. Zenclussen AC, Blois S, Stumpo R, Olmos S, Arias K, Malan Borel I et al. Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface. Cytokine 2003; 24:150-60.
72. Yuan X, Lin HY, Wang Q, Li TC. Is premature ovarian ageing a cause of unexplained recurrent miscarriage? J Obstet Gynaecol 2012; 32:464-6.
73. Crispin JC, Martínez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003; 21:273-6.
74. high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178:2579-88.
75. Bonelli M, Savitskaya A, Dalwigk KV, Steiner CW, Aletaha D, Smolen JS et al. Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol 2008; 20:861-8.
76. Hsu W-T, Suen J-L, Chiang B-L. The role of CD4CD25 T cells in autoantibody production in murine lupus. Clin Exp Immunol 2006; 145:513-9.
77. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol 2006; 177:1451-9.
78. Kleczynska W, Jakiela B, Plutecka H, Milewski M, Sanak M, Musial J. Imbalance between Th17 and regulatory T-cells in systemic lupus erythematosus. Folia Histochem Cytobiol 2011; 49:646-53.
79. Liu M-F, Wang C-R. Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus erythematosus. Lupus Sci Med 2014; 1:e000062.
80. Mengya Z, Hanyou M, Dong L, Xiaohong L, Lihua Z. Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with systemic lupus erythematosus (SLE). Clin Rheumatol 2013; 32:1045-52.
81. Szmyrka-Kaczmarek M, Kosmaczewska A, Ciszak L, Szteblich A, Wiland P. Peripheral blood Th17/Treg imbalance in patients with low-active systemic lupus erythematosus. Postȩpy Hig Med Dośw (Online) 2014; 68:893-8.
82. Szodoray P, Nakken B, Barath S, Csipo I, Nagy G, El-Hage F et al. Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders. Hum Immunol 2013; 74:1510-8.
83. Talaat RM, Mohamed SF, Bassyouni IH, Raouf AA. Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity. Cytokine 2015; 72:146-53.
84. + Treg cells decrease in patients with lupus nephritis. Rheumatol Int 2012; 32:949-58.
85. + T cells in lupus patients. Clin Rheumatol 2010; 29:1251-8.
86. Niu Q, Cai B, Huang Z-C, Shi Y-Y, Wang L-L. Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatol Int 2012; 32:2731-6.
87. Dong L, Wang X, Tan J, Li H, Qian W, Chen J et al. Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis. J Cell Mol Med 2014; 18:2213-24.
88. Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A, Frieman MB et al. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ. Clin Immunol 2015; 157:228-38.
89. Tong L, Nanjundaiah SM, Venkatesha SH, Astry B, Yu H, Moudgil KD. Pristimerin, a naturally occurring triterpenoid, protects against autoimmune arthritis by modulating the cellular and soluble immune mediators of inflammation and tissue damage. Clin Immunol 2014; 155:220-30.
90. Son H-J, Lee J, Lee S-Y, Kim E-K, Park M-J, Kim K-W et al. Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis. Mediators Inflamm 2014; 2014:973986.
91. Estrada-Capetillo L, Hernández-Castro B, Monsiváis-Urenda A, Alvarez-Quiroga C, Layseca-Espinosa E, Abud-Mendoza C et al. Induction of Th17 lymphocytes and Treg cells by monocyte-derived dendritic cells in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Dev Immunol 2013; 2013:1-9.
92. Ju JH, Heo Y-J, Cho M-L, Jhun J-Y, Park J-S, Lee S-Y et al. Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells. Arthritis Rheum 2012; 64:3543-52.
93. Moon S-J, Park J-S, Woo Y-J, Lim M-A, Kim S-M, Lee S-Y et al. Rebamipide suppresses collagen-induced arthritis through reciprocal regulation of Th17/Treg cell differentiation and heme oxygenase 1 induction. Arthritis Rheumatol 2014; 66:874-85.
94. + regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199:971-9.
95. Trinschek B, Luessi F, Gross CC, Wiendl H, Jonuleit H. Interferon-β therapy of multiple sclerosis patients improves the responsiveness of T cells for immune suppression by regulatory T cells. Int J Mol Sci 2015; 16:16330-46.
96. Matusevicius D, Kivisäkk P, He B, Kostulas N, Ozenci V, Fredrikson S et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999; 5:101-4.
97. Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009; 132:3329-41.
98. Nyirenda MH, Morandi E, Vinkemeier U, Constantin-Teodosiu D, Drinkwater S, Mee M et al. TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis. J Immunol 2015; 194:5761-74.
99. Jamshidian A, Shaygannejad V, Pourazar A, Zarkesh-Esfahani S-H, Gharagozloo M. Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms. J Neuroimmunol 2013; 262:106-12.
100. Naghavian R, Ghaedi K, Kiani-Esfahani A, Ganjalikhani-Hakemi M, Etemadifar M, Nasr-Esfahani MH, et al. miR-141 and miR-200a, Revelation of new possible players in modulation of Th17/Treg differentiation and pathogenesis of multiple sclerosis. PLoS ONE 2015; 10:e0124555.
101. Wang T, Sun X, Zhao J, Zhang J, Zhu H, Li C et al. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. Ann Rheum Dis 2015; 74:1293-301.
102. Saboor-Yaraghi AA, Harirchian MH, Mohammadzadeh Honarvar N, Bitarafan S, Abdolahi M, Siassi F et al. The effect of vitamin A supplementation on FoxP3 and TGF-β gene expression in avonex-treated multiple sclerosis patients. J Mol Neurosci 2015; 56:608-12.
103. Kürtüncü M, Tüzün E, Türkoğlu R, Petek-Balcidotless B, Içöz S, Pehlivan M et al. Effect of short-term interferon-β treatment on cytokines in multiple sclerosis: significant modulation of IL-17 and IL-23. Cytokine 2012; 59:400-2.
104. Álvarez-Sánchez N, Cruz-Chamorro I, López-González A, Utrilla JC, Fernández-Santos JM, Martínez-López A et al. Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance. Brain Behav Immun 2015; 50:101-14.
105. high regulatory T cells in patients with rheumatoid arthritis. Ann Rheum Dis 2008; 67:984-90.
106. Munoz-Suano A, Kallikourdis M, Sarris M, Betz AG. Regulatory T cells protect from autoimmune arthritis during pregnancy. J Autoimmun 2012; 38:J103-8.
107. Neuteboom RF, Verbraak E, Wierenga-Wolf AF, van Meurs M, Steegers EA, Groot CJd et al. Pregnancy-induced fluctuations in functional T-cell subsets in multiple sclerosis patients. Mult Scler 2010; 16:1073-8.
108. Sánchez-Ramón S, Navarro AJ, Aristimuño C, Rodríguez-Mahou M, Bellón JM, Fernández-Cruz E et al. Pregnancy-induced expansion of regulatory T-lymphocytes may mediate protection to multiple sclerosis activity. Immunol Lett 2005; 96:195-201.
109. Hong T, Xing J, Li L, Tyson JJ. A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells. PLoS Comput Biol 2011; 7:e1002122.
110. Busse D, de la Rosa M, Hobiger K, Thurley K, Flossdorf M, Scheffold A et al. Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc Natl Acad Sci U S A 2010; 107:3058-63.
111. Naldi A, Carneiro J, Chaouiya C, Thieffry D. Diversity and plasticity of Th cell types predicted from regulatory network modelling. PLoS Comput Biol 2010; 6:e1000912.
112. Mendoza L, Pardo F. A robust model to describe the differentiation of T-helper cells. Theory Biosci 2010; 129:283-93.
113. + regulatory T cells in women with idiopathic recurrent pregnancy loss. Hum Reprod 2011; 26:2964-71.
114. Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007; 148:32-46.
115. Tsur A, Hughes GC, Shoenfeld Y, Carp H. Interdisciplinary exchange of ideas: progestagens for autoimmunity, biologics for pregnancy complications. Immunol Res 2015; 61:31-4.
116. Schumacher A, Poloski E, Spörke D, Zenclussen AC. Luteinizing hormone contributes to fetal tolerance by regulating adaptive immune responses. Am J Reprod Immunol 2014; 71:434-40.
117. bright regulatory T cells in pre-eclampsia. Clin Exp Immunol 2007; 149:139-45.
118. Teles A, Zenclussen AC, Schumacher A. Regulatory T cells are baby's best friends. Am J Reprod Immunol 2013; 69:331-9.
119. Lee SK, Kim JY, Lee M, Gilman-Sachs A, Kwak-Kim J. Th17 and regulatory T cells in women with recurrent pregnancy loss. Am J Reprod Immunol 2012; 67:311-8.
120. Zenclussen AC, Sollwedel A, Bertoja AZ, Gerlof K, Zenclussen ML, Woiciechowsky C et al. Heme oxygenase as a therapeutic target in immunological pregnancy complications. Int Immunopharmacol 2005; 5:41-51.
121. Wafula PO, Teles A, Schumacher A, Pohl K, Yagita H, Volk HD et al. PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model. Am J Reprod Immunol 2009; 62:283-92.