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Volumn 80, Issue 5, 2009, Pages 1036-1045

Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice

Author keywords

Female reproductive tract; Immunology; Pregnancy; Seminal fluid; Seminal vesicles; T regulatory cells; Tolerance

Indexed keywords

ALLOANTIGEN; ANTIGEN; CYTOKINE; TRANSCRIPTION FACTOR FOXP3;

EID: 65949108012     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.074658     Document Type: Article
Times cited : (301)

References (68)
  • 1
    • 33645098806 scopus 로고    scopus 로고
    • Mother's little helpers: Mechanisms of maternal-fetal tolerance
    • Trowsdale J, Betz AG. Mother's little helpers: mechanisms of maternal-fetal tolerance. Nat Immunol 2006; 7:241-246.
    • (2006) Nat Immunol , vol.7 , pp. 241-246
    • Trowsdale, J.1    Betz, A.G.2
  • 2
    • 33947233249 scopus 로고    scopus 로고
    • Maternal acceptance of the fetus: True human tolerance
    • Guleria I, Sayegh MH. Maternal acceptance of the fetus: true human tolerance. J Immunol 2007; 178:3345-3351. (Pubitemid 46417596)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3345-3351
    • Guleria, I.1    Sayegh, M.H.2
  • 4
    • 0032037668 scopus 로고    scopus 로고
    • Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft"
    • Jiang SP, Vacchio MS. Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft." J Immunol 1998; 160:3086-3090.
    • (1998) J Immunol , vol.160 , pp. 3086-3090
    • Jiang, S.P.1    Vacchio, M.S.2
  • 5
    • 0032447509 scopus 로고    scopus 로고
    • + T-cells specific for paternal MHC class I accumulate during pregnancy
    • + T-cells specific for paternal MHC class I accumulate during pregnancy. J Reprod Immunol 1998; 40:47-62.
    • (1998) J Reprod Immunol , vol.40 , pp. 47-62
    • Zhou, M.1    Mellor, A.L.2
  • 6
    • 1542287265 scopus 로고    scopus 로고
    • Regulatory T cells mediate maternal tolerance to the fetus
    • DOI 10.1038/ni1037
    • Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004; 5:266-271. (Pubitemid 38332123)
    • (2004) Nature Immunology , vol.5 , Issue.3 , pp. 266-271
    • Aluvihare, V.R.1    Kallikourdis, M.2    Betz, A.G.3
  • 7
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000; 101:455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 8
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat Rev Immunol 2002; 2:389-400.
    • (2002) Nat Rev Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 9
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 11
    • 33746329271 scopus 로고    scopus 로고
    • The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function
    • DOI 10.1111/j.0105-2896.2006.00404.x
    • Samy ET, Setiady YY, Ohno K, Pramoonjago P, Sharp C, Tung KS. The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function. Immunol Rev 2006; 212:170-184. (Pubitemid 44116708)
    • (2006) Immunological Reviews , vol.212 , pp. 170-184
    • Samy, E.T.1    Setiady, Y.Y.2    Ohno, K.3    Pramoonjago, P.4    Sharp, C.5    Tung, K.S.K.6
  • 12
    • 33746324214 scopus 로고    scopus 로고
    • The role of regulatory T cells in alloantigen tolerance
    • DOI 10.1111/j.0105-2896.2006.00408.x
    • Aluvihare VR, Betz AG. The role of regulatory T cells in alloantigen tolerance. Immunol Rev 2006; 212:330-343. (Pubitemid 44116718)
    • (2006) Immunological Reviews , vol.212 , pp. 330-343
    • Aluvihare, V.R.1    Betz, A.G.2
  • 13
    • 65949102692 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance in pregnancy: A new target for infertility treatment?
    • (in press). published online ahead of print 11 March 2009; DOI 10.1093/humupd/dmp004.
    • Guerin LR, Prins JR, Robertson SA. Regulatory T cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 2009; (in press). published online ahead of print 11 March 2009; DOI 10.1093/humupd/dmp004.
    • (2009) Hum Reprod Update
    • Guerin, L.R.1    Prins, J.R.2    Robertson, S.A.3
  • 14
    • 34248214561 scopus 로고    scopus 로고
    • Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus
    • DOI 10.1172/JCI28214
    • Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 2007; 117:1399-1411. (Pubitemid 46718428)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1399-1411
    • Erlebacher, A.1    Vencato, D.2    Price, K.A.3    Zhang, D.4    Glimcher, L.H.5
  • 16
    • 34548544016 scopus 로고    scopus 로고
    • + regulatory T cell pool during pregnancy
    • DOI 10.1016/j.jri.2007.06.052, PII S0165037807001738
    • Zhao JX, Zeng YY, Liu Y. Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy. J Reprod Immunol 2007; 75:71-81. (Pubitemid 47384866)
    • (2007) Journal of Reproductive Immunology , vol.75 , Issue.2 , pp. 71-81
    • Zhao, J.-X.1    Zeng, Y.-Y.2    Liu, Y.3
  • 18
    • 0034915964 scopus 로고    scopus 로고
    • The role of semen in induction of maternal immune tolerance to pregnancy
    • DOI 10.1006/smim.2000.0320
    • Robertson SA, Sharkey DJ. The role of semen in induction of maternal immune tolerance to pregnancy. Semin Immunol 2001; 13:243-254. (Pubitemid 32666204)
    • (2001) Seminars in Immunology , vol.13 , Issue.4 , pp. 243-254
    • Robertson, S.A.1    Sharkey, D.J.2
  • 20
    • 0029742982 scopus 로고    scopus 로고
    • Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice
    • Robertson SA, Mau VJ, Tremellen KP, Seamark RF. Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice. J Reprod Fertil 1996; 107:265-277.
    • (1996) J Reprod Fertil , vol.107 , pp. 265-277
    • Robertson, S.A.1    Mau, V.J.2    Tremellen, K.P.3    Seamark, R.F.4
  • 22
    • 78651037930 scopus 로고
    • Studies in a tumor spectrum. III. The effect of phosphoramides on the growth of a variety of mouse and rat tumors
    • Sugiura K, Stock CC. Studies in a tumor spectrum. III. The effect of phosphoramides on the growth of a variety of mouse and rat tumors. Cancer Res 1955; 15:38-51.
    • (1955) Cancer Res , vol.15 , pp. 38-51
    • Sugiura, K.1    Stock, C.C.2
  • 23
    • 2542533765 scopus 로고    scopus 로고
    • Semen activates the female immune response during early pregnancy in mice
    • DOI 10.1111/j.1365-2567.2004.01876.x
    • Johansson M, Bromfield JJ, Jasper MJ, Robertson SA. Semen activates the female immune response during early pregnancy in mice. Immunology 2004; 112:290-300. (Pubitemid 38703575)
    • (2004) Immunology , vol.112 , Issue.2 , pp. 290-300
    • Johansson, M.1    Bromfield, J.J.2    Jasper, M.J.3    Robertson, S.A.4
  • 25
    • 0003110529 scopus 로고
    • Host responses to intra-uterine tissue, cellular and fetal allografts
    • Beer AE, Billingham RE. Host responses to intra-uterine tissue, cellular and fetal allografts. J Reprod Fertil Suppl 1974; 21:59-88.
    • (1974) J Reprod Fertil Suppl , vol.21 , pp. 59-88
    • Beer, A.E.1    Billingham, R.E.2
  • 26
    • 0022383743 scopus 로고
    • Early increase in graft-versus-host reactivity during pregnancy in the mouse
    • DOI 10.1016/0165-0378(85)90036-1
    • Piazzon I, Matusevich M, Deroche A, Nepomnaschy I, Pasqualini CD. Early increase in graft-versus-host reactivity during pregnancy in the mouse. J Reprod Immunol 1985; 8:129-137. (Pubitemid 16174693)
    • (1985) Journal of Reproductive Immunology , vol.8 , Issue.2-3 , pp. 129-137
    • Piazzon, I.1    Matusevich, M.2    Deroche, A.3
  • 27
    • 0022872393 scopus 로고
    • Assessment of immune responses to H-Y antigen in naturally inseminated and sperm-injected mice using cell-mediated cytotoxicity assays
    • DOI 10.1016/0165-0378(86)90012-4
    • Hancock RJ, Faruki S. Assessment of immune responses to H-Y antigen in naturally inseminated and sperm-injected mice using cell-mediated cytotoxicity assays. J Reprod Immunol 1986; 9:187-194. (Pubitemid 17224866)
    • (1986) Journal of Reproductive Immunology , vol.9 , Issue.3 , pp. 187-194
    • Hancock, R.J.T.1    Faruki, S.2
  • 29
    • 0017757503 scopus 로고
    • The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells
    • DOI 10.1084/jem.146.3.899
    • Smith RN, Powell AE. The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells. J Exp Med 1977; 146:899-904. (Pubitemid 8175998)
    • (1977) Journal of Experimental Medicine , vol.146 , Issue.3 , pp. 899-904
    • Smith, R.N.1    Powell, A.E.2
  • 31
    • 0024953641 scopus 로고
    • Immunological role for seminal plasma in insemination and pregnancy
    • Thaler CJ. Immunological role for seminal plasma in insemination and pregnancy. Am J Reprod Immunol 1989; 21:147-150. (Pubitemid 20173974)
    • (1989) American Journal of Reproductive Immunology , vol.21 , Issue.3-4 , pp. 147-150
    • Thaler, C.J.1
  • 32
    • 0031854677 scopus 로고    scopus 로고
    • HLA expression on immature and mature human germ cells
    • DOI 10.1016/S0165-0378(98)00032-1, PII S0165037898000321
    • Hutter H, Dohr G. HLA expression on immature and mature human germ cells. J Reprod Immunol 1998; 38:101-122. (Pubitemid 28342648)
    • (1998) Journal of Reproductive Immunology , vol.38 , Issue.2 , pp. 101-122
    • Hutter, H.1    Dohr, G.2
  • 33
    • 0032974266 scopus 로고    scopus 로고
    • A critical review of the role of the major histocompatibility complex in fertilization, preimplantation development and feto-maternal interactions
    • DOI 10.1093/humupd/5.3.234
    • Fernandez N, Cooper J, Sprinks M, AbdElrahman M, Fiszer D, Kurpisz M, Dealtry G. A critical review of the role of the major histocompatibility complex in fertilization, preimplantation development and feto-maternal interactions. Hum Reprod Update 1999; 5:234-248. (Pubitemid 29271962)
    • (1999) Human Reproduction Update , vol.5 , Issue.3 , pp. 234-248
    • Fernandez, N.1    Cooper, J.2    Sprinks, M.3    Abdelrahman, M.4    Fiszer, D.5    Kurpisz, M.6    Dealtry, G.7
  • 34
    • 0024407307 scopus 로고
    • Localization of fetal major histocompatibility complex antigens and maternal leukocytes in murine placenta. Implications for maternal-fetal immunological relationship
    • Redline RW, Lu CY. Localization of fetal major histocompatibility complex antigens and maternal leukocytes in murine placenta. Implications for maternal-fetal immunological relationship. Lab Invest 1989; 61:27-36.
    • (1989) Lab Invest , vol.61 , pp. 27-36
    • Redline, R.W.1    Lu, C.Y.2
  • 35
    • 0025951629 scopus 로고
    • Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development
    • Jaffe L, Robertson EJ, Bikoff EK. Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development. J Immunol 1991; 147:2740-2749.
    • (1991) J Immunol , vol.147 , pp. 2740-2749
    • Jaffe, L.1    Robertson, E.J.2    Bikoff, E.K.3
  • 37
    • 0032749954 scopus 로고    scopus 로고
    • Cyclic expression of HLA class I and II molecules on the surface of purified human spermatozoa and their control by serum inhibin B levels
    • Martin-Villa JM, Longas J, Arnaiz-Villena A. Cyclic expression of HLA class I and II molecules on the surface of purified human spermatozoa and their control by serum inhibin B levels. Biol Reprod 1999; 61:1381-1386.
    • (1999) Biol Reprod , vol.61 , pp. 1381-1386
    • Martin-Villa, J.M.1    Longas, J.2    Arnaiz-Villena, A.3
  • 39
    • 38149006373 scopus 로고    scopus 로고
    • Human sperm protein encyclopedia and alloantigen index: Mining novel allo-antigens using sera from ASA-positive infertile patients and vasectomized men
    • Shetty J, Bronson RA, Herr JC. Human sperm protein encyclopedia and alloantigen index: mining novel allo-antigens using sera from ASA-positive infertile patients and vasectomized men. J Reprod Immunol 2007; 77:23-31.
    • (2007) J Reprod Immunol , vol.77 , pp. 23-31
    • Shetty, J.1    Bronson, R.A.2    Herr, J.C.3
  • 41
    • 4544297110 scopus 로고    scopus 로고
    • Seminal plasma regulates corpora lutea macrophage populations during early pregnancy in mice
    • DOI 10.1095/biolreprod.104.027425
    • Gangnuss S, Sutton-McDowall ML, Robertson SA, Armstrong DT. Seminal plasma regulates corpora lutea macrophage populations during early pregnancy in mice. Biol Reprod 2004; 71:1135-1141. (Pubitemid 39255435)
    • (2004) Biology of Reproduction , vol.71 , Issue.4 , pp. 1135-1141
    • Gangnuss, S.1    Sutton-McDowall, M.L.2    Robertson, S.A.3    Armstrong, D.T.4
  • 42
    • 0026523124 scopus 로고
    • Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period
    • McMaster MT, Newton RC, Dey SK, Andrews GK. Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period. J Immunol 1992; 148:1699-1705.
    • (1992) J Immunol , vol.148 , pp. 1699-1705
    • McMaster, M.T.1    Newton, R.C.2    Dey, S.K.3    Andrews, G.K.4
  • 43
    • 0000043046 scopus 로고    scopus 로고
    • Molecular regulation of uterine leukocyte recruitment during early pregnancy in the mouse
    • Robertson SA, Allanson M, Mau VJ. Molecular regulation of uterine leukocyte recruitment during early pregnancy in the mouse. Troph Research 1998; 11:101-120.
    • (1998) Troph Research , vol.11 , pp. 101-120
    • Robertson, S.A.1    Allanson, M.2    Mau, V.J.3
  • 44
    • 1642387469 scopus 로고    scopus 로고
    • Lineage, Maturity, and Phenotype of Uterine Murine Dendritic Cells Throughout Gestation Indicate a Protective Role in Maintaining Pregnancy
    • DOI 10.1095/biolreprod.103.022640
    • Blois SM, Alba Soto CD, Tometten M, Klapp BF, Margni RA, Arck PC. Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy. Biol Reprod 2004; 70:1018-1023. (Pubitemid 38387711)
    • (2004) Biology of Reproduction , vol.70 , Issue.4 , pp. 1018-1023
    • Blois, S.M.1    Soto, C.D.A.2    Tometten, M.3    Klapp, B.F.4    Margni, R.A.5    Arck, P.C.6
  • 45
    • 27944465772 scopus 로고    scopus 로고
    • Seminal plasma and male factor signalling in the female reproductive tract
    • DOI 10.1007/s00441-005-1127-3
    • Robertson SA. Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 2005; 322:43-52. (Pubitemid 41679402)
    • (2005) Cell and Tissue Research , vol.322 , Issue.1 , pp. 43-52
    • Robertson, S.A.1
  • 47
    • 0033830511 scopus 로고    scopus 로고
    • Control of the immunological environment of the uterus
    • Robertson SA. Control of the immunological environment of the uterus. Rev Reprod 2000; 5:164-174.
    • (2000) Rev Reprod , vol.5 , pp. 164-174
    • Robertson, S.A.1
  • 48
    • 0030844074 scopus 로고    scopus 로고
    • Immunomodulation by human seminal plasma: A benefit for spermatozoon and pathogen?
    • Kelly RW, Critchley HO. Immunomodulation by human seminal plasma: a benefit for spermatozoon and pathogen? Hum Reprod 1997; 12:2200-2207.
    • (1997) Hum Reprod , vol.12 , pp. 2200-2207
    • Kelly, R.W.1    Critchley, H.O.2
  • 53
    • 65949085501 scopus 로고    scopus 로고
    • Conceptus antigens activate the maternal immune response in pregnancy utilising maternal antigen presenting cells
    • (abstract)
    • Moldenhauer LM, Hayball JD, Robertson SA. Conceptus antigens activate the maternal immune response in pregnancy utilising maternal antigen presenting cells. J Reprod Immunol 2006; 71:148 (abstract).
    • (2006) J Reprod Immunol , vol.71 , pp. 148
    • Moldenhauer, L.M.1    Hayball, J.D.2    Robertson, S.A.3
  • 54
    • 0036851172 scopus 로고    scopus 로고
    • Epigenetic risks related to assisted reproductive technologies: Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?
    • Thompson JG, Kind KL, Roberts CT, Robertson SA, Robinson JS. Epigenetic risks related to assisted reproductive technologies: short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution? Hum Reprod 2002; 17:2783-2786.
    • (2002) Hum Reprod , vol.17 , pp. 2783-2786
    • Thompson, J.G.1    Kind, K.L.2    Roberts, C.T.3    Robertson, S.A.4    Robinson, J.S.5
  • 55
    • 34548025149 scopus 로고    scopus 로고
    • Seminal fluid signaling in the female reproductive tract: Lessons from rodents and pigs
    • Robertson SA. Seminal fluid signaling in the female reproductive tract: lessons from rodents and pigs. J Anim Sci 2007; 85:E36-E44.
    • (2007) J Anim Sci , vol.85
    • Robertson, S.A.1
  • 56
    • 0020541577 scopus 로고
    • Reproduction in mice: The fate of spermatozoa not involved in fertilization
    • Watson JG, Carroll J, Chaykin S. Reproduction in mice: the fate of spermatozoa not involved in fertilization. Gamete Res 1983; 7:75-84.
    • (1983) Gamete Res , vol.7 , pp. 75-84
    • Watson, J.G.1    Carroll, J.2    Chaykin, S.3
  • 57
    • 27944468164 scopus 로고    scopus 로고
    • Seminal plasma programs uterine receptivity and pregnancy outcome
    • Abstracts of the 37th Annual Meeting of the Society for the Study of Reproduction, August 1-4, 2004, Vancouver, BC, Canada special issue: Abstract 7
    • Bromfield JJ, Roberts CT, Robertson SA. Seminal plasma programs uterine receptivity and pregnancy outcome. In: Abstracts of the 37th Annual Meeting of the Society for the Study of Reproduction, August 1-4, 2004, Vancouver, BC, Canada. Biol Reprod 2004; special issue: Abstract 7.
    • (2004) Biol Reprod
    • Bromfield, J.J.1    Roberts, C.T.2    Robertson, S.A.3
  • 59
    • 34447320193 scopus 로고    scopus 로고
    • Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    • DOI 10.1093/molehr/gam028
    • Sharkey DJ, Macpherson AM, Tremellen KP, Robertson SA. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod 2007; 13:491-501. (Pubitemid 47062888)
    • (2007) Molecular Human Reproduction , vol.13 , Issue.7 , pp. 491-501
    • Sharkey, D.J.1    Macpherson, A.M.2    Tremellen, K.P.3    Robertson, S.A.4
  • 60
    • 0022448165 scopus 로고
    • The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program
    • Bellinge BS, Copeland CM, Thomas TD, Mazzucchelli RE, O'Neil G, Cohen MJ. The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program. Fertil Steril 1986; 46:2523-2526.
    • (1986) Fertil Steril , vol.46 , pp. 2523-2526
    • Bellinge, B.S.1    Copeland, C.M.2    Thomas, T.D.3    Mazzucchelli, R.E.4    O'Neil, G.5    Cohen, M.J.6
  • 62
    • 0029257980 scopus 로고
    • Effect of seminal plasma on implantation rates
    • Coulam CB, Stern JJ. Effect of seminal plasma on implantation rates. Early Pregnancy 1995; 1:33-36.
    • (1995) Early Pregnancy , vol.1 , pp. 33-36
    • Coulam, C.B.1    Stern, J.J.2
  • 63
    • 0042669785 scopus 로고    scopus 로고
    • Th1/Th2 balance in preeclampsia
    • DOI 10.1016/S0165-0378(03)00045-7
    • Saito S, Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol 2003; 59:161-173. (Pubitemid 36945234)
    • (2003) Journal of Reproductive Immunology , vol.59 , Issue.2 , pp. 161-173
    • Saito, S.1    Sakai, M.2
  • 66
    • 0028023436 scopus 로고
    • Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception
    • Robillard PY, Hulsey TC, Perianin J, Janky E, Miri EH, Papiernik E. Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception. Lancet 1995; 344:973-975.
    • (1995) Lancet , vol.344 , pp. 973-975
    • Robillard, P.Y.1    Hulsey, T.C.2    Perianin, J.3    Janky, E.4    Miri, E.H.5    Papiernik, E.6
  • 68
    • 33744768353 scopus 로고    scopus 로고
    • Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue
    • DOI 10.1093/molehr/gal032
    • Jasper MJ, Tremellen KP, Robertson SA. Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006; 12:301-308. (Pubitemid 43821793)
    • (2006) Molecular Human Reproduction , vol.12 , Issue.5 , pp. 301-308
    • Jasper, M.J.1    Tremellen, K.P.2    Robertson, S.A.3


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