메뉴 건너뛰기




Volumn 30, Issue 2, 2016, Pages 761-774

Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt

Author keywords

B cell activating factor; Germinal center reaction; Proinflammatory cytokines; Th17 cell differentiation

Indexed keywords

B CELL ACTIVATING FACTOR; INTERLEUKIN 17; INTERLEUKIN 21; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR GAMMA T; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; BATF PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR-4; INTERLEUKIN DERIVATIVE; TNFSF13B PROTEIN, MOUSE;

EID: 84958811422     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-274001     Document Type: Article
Times cited : (28)

References (46)
  • 1
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., and Förster, R. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192, 1545-1552
    • (2000) J. Exp. Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6    Förster, R.7
  • 2
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(hi) ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed, A. U., Rahn, H. P., Sallusto, F., Lipp, M., and Müller, G. (2006) Follicular B helper T cell activity is confined to CXCR5(hi) ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 36, 1892-1903
    • (2006) Eur. J. Immunol , vol.36 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Müller, G.5
  • 4
    • 84864303294 scopus 로고    scopus 로고
    • The origins, function, and regulation of T follicular helper cells
    • Ma, C. S., Deenick, E. K., Batten, M., and Tangye, S. G. (2012) The origins, function, and regulation of T follicular helper cells. J. Exp. Med. 209, 1241-1253
    • (2012) J. Exp. Med , vol.209 , pp. 1241-1253
    • Ma, C.S.1    Deenick, E.K.2    Batten, M.3    Tangye, S.G.4
  • 5
    • 72949104221 scopus 로고    scopus 로고
    • Dysregulation of germinal centres in autoimmune disease
    • Vinuesa, C. G., Sanz, I., and Cook, M. C. (2009) Dysregulation of germinal centres in autoimmune disease. Nat. Rev. Immunol. 9, 845-857
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 845-857
    • Vinuesa, C.G.1    Sanz, I.2    Cook, M.C.3
  • 7
    • 77953255484 scopus 로고    scopus 로고
    • The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease
    • Leung, S., Liu, X., Fang, L., Chen, X., Guo, T., and Zhang, J. (2010) The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease. Cell. Mol. Immunol. 7, 182-189
    • (2010) Cell. Mol. Immunol , vol.7 , pp. 182-189
    • Leung, S.1    Liu, X.2    Fang, L.3    Chen, X.4    Guo, T.5    Zhang, J.6
  • 8
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu, D., and Vinuesa, C. G. (2010) The elusive identity of T follicular helper cells. Trends Immunol. 31, 377-383
    • (2010) Trends Immunol , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 10
    • 84869213212 scopus 로고    scopus 로고
    • Interferon-g excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
    • Lee, S. K., Silva, D. G., Martin, J. L., Pratama, A., Hu, X., Chang, P. P., Walters, G., and Vinuesa, C. G. (2012) Interferon-g excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 37, 880-892
    • (2012) Immunity , vol.37 , pp. 880-892
    • Lee, S.K.1    Silva, D.G.2    Martin, J.L.3    Pratama, A.4    Hu, X.5    Chang, P.P.6    Walters, G.7    Vinuesa, C.G.8
  • 11
    • 84869870503 scopus 로고    scopus 로고
    • Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity
    • Sweet, R. A., Lee, S. K., and Vinuesa, C. G. (2012) Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity. Curr. Opin. Immunol. 24, 658-664
    • (2012) Curr. Opin. Immunol , vol.24 , pp. 658-664
    • Sweet, R.A.1    Lee, S.K.2    Vinuesa, C.G.3
  • 12
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet, A. T., Jin, H., Paterson, A. M., Mitsdoerffer, M., Ho, I. C., Sharpe, A. H., and Kuchroo, V. K. (2009) The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10, 167-175
    • (2009) Nat. Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5    Sharpe, A.H.6    Kuchroo, V.K.7
  • 13
    • 58749093614 scopus 로고    scopus 로고
    • Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    • Wu, H. Y., Quintana, F. J., and Weiner, H. L. (2008) Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J. Immunol. 181, 6038-6050
    • (2008) J. Immunol , vol.181 , pp. 6038-6050
    • Wu, H.Y.1    Quintana, F.J.2    Weiner, H.L.3
  • 15
    • 84877140255 scopus 로고    scopus 로고
    • T follicular helper cell diversity and plasticity
    • Cannons, J. L., Lu, K. T., and Schwartzberg, P. L. (2013) T follicular helper cell diversity and plasticity. Trends Immunol. 34, 200-207
    • (2013) Trends Immunol , vol.34 , pp. 200-207
    • Cannons, J.L.1    Lu, K.T.2    Schwartzberg, P.L.3
  • 16
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., and Littman, D. R. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 19
    • 33846365298 scopus 로고    scopus 로고
    • Faithful activation of an extra-bright red fluorescent protein inknock-in Cre-reporter mice ideally suited for lineage tracing studies
    • Luche, H., Weber, O., NageswaraRao, T., Blum, C., and Fehling, H. J. (2007) Faithful activation of an extra-bright red fluorescent protein in knock-in Cre-reporter mice ideally suited for lineage tracing studies. Eur. J. Immunol. 37, 43-53
    • (2007) Eur. J. Immunol , vol.37 , pp. 43-53
    • Luche, H.1    Weber, O.2    NageswaraRao, T.3    Blum, C.4    Fehling, H.J.5
  • 20
    • 84888202649 scopus 로고    scopus 로고
    • Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORgt double-deficientmice is dependent on gut microbiota
    • Wichner, K., Fischer, A., Winter, S., Tetzlaff, S., Heimesaat, M. M., Bereswill, S., Rehm, A., Lipp, M., and Höpken, U. E. (2013) Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORgt double-deficientmice is dependent on gut microbiota. J. Autoimmun. 47, 58-72
    • (2013) J. Autoimmun , vol.47 , pp. 58-72
    • Wichner, K.1    Fischer, A.2    Winter, S.3    Tetzlaff, S.4    Heimesaat, M.M.5    Bereswill, S.6    Rehm, A.7    Lipp, M.8    Höpken, U.E.9
  • 21
    • 77953240156 scopus 로고    scopus 로고
    • Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunitys
    • Yu, D., and Vinuesa, C. G. (2010) Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity. Cell. Mol. Immunol. 7, 198-203
    • (2010) Cell. Mol. Immunol , vol.7 , pp. 198-203
    • Yu, D.1    Vinuesa, C.G.2
  • 26
    • 84904245092 scopus 로고    scopus 로고
    • Neutrophils contribute toexcess serumBAFF levels and promoteCD4+Tcell and B cell responses in lupus-prone mice
    • Coquery, C.M., Wade, N. S., Loo, W.M., Kinchen, J.M., Cox, K.M., Jiang, C., Tung, K. S., and Erickson, L. D. (2014) Neutrophils contribute toexcess serumBAFF levels and promoteCD4+Tcell and B cell responses in lupus-prone mice. PLoS One 9, e102284
    • (2014) PLoS One , vol.9 , pp. e102284
    • Coquery, C.M.1    Wade, N.S.2    Loo, W.M.3    Kinchen, J.M.4    Cox, K.M.5    Jiang, C.6    Tung, K.S.7    Erickson, L.D.8
  • 27
    • 54449087291 scopus 로고    scopus 로고
    • Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
    • Lai Kwan Lam, Q., KingHungKo, O., Zheng, B. J., and Lu, L. (2008) Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc. Natl. Acad. Sci. USA 105, 14993-14998
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14993-14998
    • Lai Kwan Lam, Q.1    KingHungKo, O.2    Zheng, B.J.3    Lu, L.4
  • 31
    • 77953640886 scopus 로고    scopus 로고
    • Signaling pathways in T follicular helper cells
    • Rolf, J., Fairfax, K., and Turner, M. (2010) Signaling pathways in T follicular helper cells. J. Immunol. 184, 6563-6568
    • (2010) J. Immunol , vol.184 , pp. 6563-6568
    • Rolf, J.1    Fairfax, K.2    Turner, M.3
  • 32
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty, S. (2011) Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621-663
    • (2011) Annu. Rev. Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 33
    • 70350492504 scopus 로고    scopus 로고
    • New insights into the differentiation and function of T follicular helper cells
    • King, C. (2009)New insights into the differentiation and function of T follicular helper cells. Nat. Rev. Immunol. 9, 757-766
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 757-766
    • King, C.1
  • 35
    • 84928901428 scopus 로고    scopus 로고
    • Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells
    • Kim, Y. U., Lim, H., Jung, H. E., Wetsel, R. A., and Chung, Y. (2015) Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS One 10, e0120294
    • (2015) PLoS One , vol.10 , pp. e0120294
    • Kim, Y.U.1    Lim, H.2    Jung, H.E.3    Wetsel, R.A.4    Chung, Y.5
  • 38
    • 65649117701 scopus 로고    scopus 로고
    • Suppression ofmurine SLE by oral anti-CD3: Inducible CD4+CD25- LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
    • Wu, H. Y., Center, E. M., Tsokos, G. C., and Weiner, H. L. (2009) Suppression ofmurine SLE by oral anti-CD3: inducible CD4+CD25- LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus 18, 586-596
    • (2009) Lupus , vol.18 , pp. 586-596
    • Wu, H.Y.1    Center, E.M.2    Tsokos, G.C.3    Weiner, H.L.4
  • 43
    • 84867894231 scopus 로고    scopus 로고
    • Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors
    • Oestreich, K. J., and Weinmann, A. S. (2012) Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat. Rev. Immunol. 12, 799-804
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 799-804
    • Oestreich, K.J.1    Weinmann, A.S.2
  • 45
    • 78651500757 scopus 로고    scopus 로고
    • Microbiota-induced tertiary lymphoid tissues aggravate inflam matory disease intheabsenceofRORgamma t and LTi cells
    • Lochner, M., Ohnmacht, C., Presley, L., Bruhns, P., Si-Tahar, M., Sawa, S., and Eberl, G. (2011)Microbiota-induced tertiary lymphoid tissues aggravate inflam matory disease intheabsenceofRORgamma t and LTi cells. J. Exp. Med. 208, 125-134
    • (2011) J. Exp. Med , vol.208 , pp. 125-134
    • Lochner, M.1    Ohnmacht, C.2    Presley, L.3    Bruhns, P.4    Si-Tahar, M.5    Sawa, S.6    Eberl, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.