Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients

Journal of Reproductive Immunology

Volumn 84, Issue 2, 2010, Pages 164-170

  Wang, Wen Juan ^a,b   Hao, Cui Fang ^b   Yi Lin, ^a   Yin, Guang Jie ^a   Bao, Shi Hua ^a   Qiu, Li Hua ^a   Lin, Qi De ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Pregnancy; Recurrent; Spontaneous abortion; Th17 cells; Th17 Treg balance

Indexed keywords

CD4 ANTIGEN; CELL NUCLEUS RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23; INTERLEUKIN 7 RECEPTOR;

ADULT; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DECIDUA; FEMALE; FIRST TRIMESTER PREGNANCY; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE SUBPOPULATION; PERIPHERAL LYMPHOCYTE; PREGNANCY; PREGNANCY OUTCOME; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT ABORTION; REGULATORY T LYMPHOCYTE; SPONTANEOUS ABORTION; TH17 CELL;

ABORTION, SPONTANEOUS; ADULT; CELL SEPARATION; CELLS, CULTURED; DECIDUA; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-17; INTERLEUKIN-23; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PREGNANCY; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 76749131032     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2009.12.003     Document Type: Article

References (26)

1. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
2. Cheng X., Yu X., Ding Y.J., Fu Q.Q., Xie J.J., Tang T.T., Yao R., Chen Y., and Liao Y.H. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin. Immunol. 127 (2008) 89-97
3. Favre D., Lederer S., Kanwar B., Ma Z.M., Proll S., Kasakow Z., Mold J., Swainson L., Barbour J.D., Baskin C.R., Palermo R., Pandrea I., Miller C.J., Katze M.G., and McCune J.M. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 5 (2009) e1000295
4. Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 (2005) 1123-1132
5. Hill J.A. T helper 1 immunity to trophoblast: evidence for a new immunological mechanism for recurrent abortion in women. Hum. Reprod. 10 (1995) 114-120
6. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+T helper cells. Cell 126 (2006) 1121-1133
7. Iwakura Y., and Ishigame H. The IL-23/IL-17 axis in inflammation. J. Clin. Invest. 116 (2006) 1218-1222
8. Klentzeris L.D., Bulmer J.N., Warren M.A., Morrison L., Li T.C., and Cooke I.D. Lymphoid tissue in the endometrium of women with unexplained infertility: morphometric and immunohistochemical aspects. Hum. Reprod. 9 (1994) 646-652
9. Liu W., Putnam A.L., Xu-Yu Z., Szot G.L., Lee M.R., Zhu S., Gottlieb P.A., Kapranov P., Gingeras T.R., Fazekas de St Groth B., Clayberger C., Soper D.M., Ziegler S.F., and Bluestone J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203 (2006) 1701-1711
10. Li J., Simeoni E., Fleury S., Fiorini E., Kappenberger L., von Segesser L.K., and Vassalli G. Gene transfer of soluble interleukin-17 receptor prolongs cardiac allograft survival in a rat model. Eur. J. Cardiothorac. Surg. 29 (2006) 779-783
11. Lohr J., Knoechel B., Wang J.J., Villarino A.V., and Abbas A.K. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 203 (2006) 2785-2791
12. Loong C.C., Hsieh H.G., Lui W.Y., Chen A., and Lin C.Y. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J. Pathol. 197 (2002) 322-332
13. Manel N., Unutmaz D., and Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9 (2008) 641-649
14. McGeachy M.J., and Cua D.J. Th17 cell differentiation: the long and winding road. Immunity 28 (2008) 445-453
15. Medawar P.B. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp. Soc. Exp. Biol. 7 (1953) 320-338
16. Ogura H., Murakami M., Okuyama Y., Tsuruoka M., Kitabayashi C., Kanamoto M., Nishihara M., Iwakura Y., and Hirano T. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29 (2008) 628-636
17. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., Wang Y., Hood L., Zhu Z., Tian Q., and Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6 (2005) 1133-1141
18. Piccinni M.P., Beloni L., Livi C., Maggi E., Scarselli G., and Romagnani S. Defective production of both leukaemia inhibitory factor and type 2 T helper cytokines by decidual T cells in unexplained recurrent abortions. Nat. Med. 4 (1998) 1020-1024
19. Sasaki Y., Sakai M., Miyazaki S., Higuma S., Shiozaki A., and Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 10 (2004) 347-353
20. Saito S., Sasaki Y., and Sakai M. CD4(+)CD25high regulatory T cells in human pregnancy. J. Reprod. Immunol. 65 (2005) 111-120
21. Seddiki N., Santner-Nanan B., Martinson J., Zaunders J., Sasson S., Landay A., Solomon M., Selby W., Alexander S.I., Nanan R., Kelleher A., and Fazekas de St Groth B. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203 (2006) 1693-1700
22. Tang J.L., Subbotin V.M., Antonysamy M.A., Troutt A.B., Rao A.S., and Thomson A.W. Interleukin-17 antagonism inhibits acute but not chronic vascular rejection. Transplantation 72 (2001) 348-350
23. Trowsdale J., and Betz A.G. Mother's little helpers: mechanisms of maternal-fetal tolerance. Nat. Immunol. 7 (2006) 241-246
24. Van Kooten C., Boonstra J.G., Paape M.E., Fossiez F., Banchereau J., Lebecque S., Bruijn J.A., De Fijter J.W., Van Es L.A., and Daha M.R. Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J. Am. Soc. Nephrol. 9 (1998) 1526-1534
25. World Health Organization. Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction (1999), Cambridge University Press, New York
26. Yang H., Qiu L., Di W., Zhao A., Chen G., Hu K., and Lin Q. Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients. Fertil. Steril. 89 (2008) 656-661