Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Journal of Reproductive Immunology

Volumn 106, Issue , 2014, Pages 110-117

  Koucký, Michal ^a   Malíčková, Karin ^a   Cindrová Davies, Tereza ^b   Germanová, Anna ^a   Pařízek, Antonín ^a   Kalousová, Marta ^a   Hájek, Zdeněk ^a   Zima, Tomáš ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cervical incompetence; Preterm labor; T regulatory lymphocytes; Ultrasound cervical length

Indexed keywords

PROGESTERONE;

ADULT; ARTICLE; BLOOD SAMPLING; CERVICAL LENGTH MEASUREMENT; CONTROLLED STUDY; EVENING DOSAGE; FEMALE; FLOW CYTOMETRY; GESTATIONAL AGE; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PERIPHERAL LYMPHOCYTE; PREMATURE LABOR; PROSPECTIVE STUDY; REGULATORY T LYMPHOCYTE; RISK ASSESSMENT; TRANSVAGINAL ECHOGRAPHY; UTERINE CERVIX; UTERINE CERVIX INCOMPETENCE; CD4 LYMPHOCYTE COUNT; CYTOLOGY; IMMUNOLOGY; NEWBORN; OBSTETRIC LABOR, PREMATURE; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; RISK;

ADULT; CD4 LYMPHOCYTE COUNT; CERVICAL LENGTH MEASUREMENT; CERVIX UTERI; FEMALE; HUMANS; INFANT, NEWBORN; OBSTETRIC LABOR, PREMATURE; PREGNANCY; PROGESTERONE; PROSPECTIVE STUDIES; RISK; T-LYMPHOCYTES, REGULATORY;

EID: 84908599732     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2014.04.001     Document Type: Article

References (40)

1. Berghella V., Roman A., Daskalakis C., Ness A., Baxter J.K. Gestational age at cervical length measurement and incidence of preterm birth. Obstet. Gynecol. 2007, 110(2 (Pt 1)):311-317.
2. Berghella V., Hayes E., Visintine J., Baxter J.K. Fetal fibronectin testing for reducing the risk of preterm birth. Cochrane Database Syst. Rev. 2008, 4. p. CD006843.
3. Berghella V., Baxter J.K., Hendrix N.W. Cervical assessment by ultrasound for preventing preterm delivery. Cochrane Database Syst. Rev. 2013, 1. p. CD007235.
4. Clark D.A., Chaouat G. Regulatory T cells and reproduction: how do they do it?. J. Reprod. Immunol. 2012, 96(1/2):1-7.
5. Crane J.M., Hutchens D. 'Transvaginal sonographic measurement of cervical length to predict preterm birth in asymptomatic women at increased risk: a systematic review'. Ultrasound Obstet. Gynecol. 2008, 31(5):579-587.
6. DeFranco E.A., O'Brien J.M., Adair C.D., Lewis D.F., Hall D.R., Fusey S., Soma-Pillay P., Porter K., How H., Schakis R., Eller D., Trivedi Y., Vanburen G., Khandelwal M., Trofatter K., Vidyadhari D., Vijayaraghavan J., Weeks J., Dattel B., Newton E., Chazotte C., Valenzuela G., Calda P., Bsharat M., Creasy G.W. Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial'. Ultrasound Obstet. Gynecol. 2007, 30(5):697-705.
7. Dodd J.M., Crowther C.A., McPhee A.J., Flenady V., Robinson J.S. Progesterone after previous preterm birth for prevention of neonatal respiratory distress syndrome (PROGRESS): a randomised controlled trial. BMC Pregnancy Childbirth 2009, 9:6.
8. Gomez R., Romero R., Ghezzi F., Yoon B.H., Mazor M., Berry S.M. The fetal inflammatory response syndrome. Am. J. Obstet. Gynecol. 1998, 179(1):194-202.
9. Hassan S.S., Romero R., Berry S.M., Dang K., Blackwell S.C., Treadwell M.C., Wolfe H.M. Patients with an ultrasonographic cervical length < or =15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am. J. Obstet. Gynecol. 2000, 182(6):1458-1467.
10. Iams J.D., Goldenberg R.L., Meis P.J., Mercer B.M., Moawad A., Das A., Thom E., McNellis D., Copper R.L., Johnson F., Roberts J.M. The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N. Engl. J. Med. 1996, 334(9):567-572.
11. Leber A., Teles A., Zenclussen A.C. Regulatory T cells and their role in pregnancy. Am. J. Reprod. Immunol. 2010, 63(6):445-459.
12. Lee J.H., Ulrich B., Cho J., Park J., Kim C.H. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J. Immunol. 2011, 187(4):1778-1787.
13. Liu W., Putnam A.L., Xu-Yu Z., Szot G.L., Lee M.R., Zhu S., Gottlieb P.A., Kapranov P., Gingeras T.R., Fazekas de St Groth B., Clayberger C., Soper D.M., Ziegler S.F., Bluestone J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 2006, 203(7):1701-1711.
14. Mao G., Wang J., Kang Y., Tai P., Wen J., Zou Q., Li G., Ouyang H., Xia G., Wang B. Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice. Endocrinology 2010, 151(11):5477-5488.
15. McIntire D.D., Leveno K.J. Neonatal mortality and morbidity rates in late preterm births compared with births at term. Obstet. Gynecol. 2008, 111(1):35-41.
16. Norwitz E.R., Caughey A.B. Progesterone supplementation and the prevention of preterm birth. Rev. Obstet. Gynecol. 2011, 4(2):60-72.
17. Parizek A., Koucky M., Duskova M. Progesterone, inflammation and preterm labor. J. Steroid Biochem. Mol. Biol. 2014, 139:159-165.
18. Piccinni M.P. T cell tolerance towards the fetal allograft. J. Reprod. Immunol. 2010, 85(1):71-75.
19. Prins J.R., Boelens H.M., Heimweg J., Van der Heide S., Dubois A.E., Van Oosterhout A.J., Erwich J.J. Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood. Hypertens. Pregnancy 2009, 28(3):300-311.
20. Roberts D., Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst. Rev. 2006, (3). p. CD004454.
21. Rode L., Klein K., Nicolaides K.H., Krampl-Bettelheim E., Tabor A. Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound Obstet. Gynecol. 2011, 38(3):272-280.
22. Romero R., Espinoza J., Erez O., Hassan S. The role of cervical cerclage in obstetric practice: can the patient who could benefit from this procedure be identified?. Am. J. Obstet. Gynecol. 2006, 194(1):1-9.
23. Romero R., Espinoza J., Goncalves L.F., Kusanovic J.P., Friel L.A., Nien J.K. Inflammation in preterm and term labour and delivery. Semin. Fetal. Neonatal. Med. 2006, 11(5):317-326.
24. Romero R., Espinoza J., Kusanovic J.P., Gotsch F., Hassan S., Erez O., Chaiworapongsa T., Mazor M. The preterm parturition syndrome. BJOG 2006, 113(Suppl. 3):17-42.
25. Romero R., Nicolaides K., Conde-Agudelo A., Tabor A., O'Brien J.M., Cetingoz E., Da Fonseca E., Creasy G.W., Klein K., Rode L., Soma-Pillay P., Fusey S., Cam C., Alfirevic Z., Hassan S.S. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am. J. Obstet. Gynecol. 2012, 206(2). 124 e1-124 e19.
26. Rowe J.H., Ertelt J.M., Aguilera M.N., Farrar M.A., Way S.S. Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens. Cell Host Microbe 2011, 10(1):54-64.
27. Rowe J.H., Ertelt J.M., Xin L., Way S.S. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature 2012, 490(7418):102-106.
28. Saito S., Nakashima A., Shima T., Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am. J. Reprod. Immunol. 2010, 63(6):601-610.
29. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101(5):455-458.
30. Sasaki Y., Sakai M., Miyazaki S., Higuma S., Shiozaki A., Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 2004, 10(5):347-353.
31. Schober L., Radnai D., Schmitt E., Mahnke K., Sohn C., Steinborn A. Term and preterm labor: decreased suppressive activity and changes in composition of the regulatory T-cell pool. Immunol. Cell Biol. 2012, 90(10):935-944.
32. Shevach E.M. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002, 2(6):389-400.
33. Somerset D.A., Zheng Y., Kilby M.D., Sansom D.M., Drayson M.T. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 2004, 112(1):38-43.
34. Steinborn A., Schmitt E., Kisielewicz A., Rechenberg S., Seissler N., Mahnke K., Schaier M., Zeier M., Sohn C. Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs. Clin. Exp. Immunol. 2012, 167(1):84-98.
35. To M.S., Skentou C., Liao A.W., Cacho A., Nicolaides K.H. Cervical length and funneling at 23 weeks of gestation in the prediction of spontaneous early preterm delivery. Ultrasound Obstet. Gynecol. 2001, 18(3):200-203.
36. Vaisbuch E., Hassan S.S., Mazaki-Tovi S., Nhan-Chang C.L., Kusanovic J.P., Chaiworapongsa T., Dong Z., Yeo L., Mittal P., Yoon B.H., Romero R. Patients with an asymptomatic short cervix (
37. Wood K.J., Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 2003, 3(3):199-210.
38. Xiong H., Zhou C., Qi G. Proportional changes of CD4+CD25+Foxp3+ regulatory T cells in maternal peripheral blood during pregnancy and labor at term and preterm. Clin. Invest. Med. 2010, 33(6):pE422.
39. Yost N.P., Bloom S.L., Twickler D.M., Leveno K.J. Pitfalls in ultrasonic cervical length measurement for predicting preterm birth. Obstet. Gynecol. 1999, 93(4):510-516.
40. Ziegler S.F., Buckner J.H. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect. 2009, 11(5):594-598.