Glycosidase mechanisms

Current Opinion in Chemical Biology

Volumn 4, Issue 5, 2000, Pages 573-580

  Rye, Carl S ^a   Withers, Stephen G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS CIRCULANS; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; REVIEW; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

EID: 0033780356     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00135-6     Document Type: Review

References (60)

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2. Structures and mechanisms of glycosyl hydrolases
3. Glycosyl transfer
4. Mutagenesis of glycosidases
5. Mechanisms of enzymatic glycoside hydrolysis
6. Mechanism of catalysis by retaining betaglycosyl hydrolases
7. Glycosyl transferase mechanisms
8. Glycosidase mechanisms: Anatomy of a finely tuned catalyst
9. Recent insights into inhibition, structure, and mechanism of configuration-retaining glycosidases
10. Structural and sequence-based classification of glycoside hydrolases
11. Glycosidase families
12. Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase
13. Crystal structure of a class I alpha 1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control
14. The crystal structure of the processive endocellulase CeLF of Clostridium cellulolyticum in complex with a thiooligosaccharide inhibitor at 2.0 A resolution
15. Crystal structure of amylomaltase from Thermus aquaticus, a glycosyltransferase catalysing the production of large cyclic glucans
16. Changing enzymatic reaction mechanisms by mutagenesis: Conversion of a retaining glucosidase to an inverting enzyme
17. Snapshots along an enzymatic reaction coordinate: Analysis of a retaining β-glycoside hydrolase
18. Structure of the Fusarium oxysporum endoglucanase I with a nonhydrolyzable substrate analogue - Substrate distortion gives rise to the preferred axial orientation for the leaving group
19. Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease
20. Insights into transition state stabilization of the β-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutants
21. The crystal structures of Sinapis alba myrosinase and a covalent glycosyl-enzyme intermediate provide insights into the substrate recognition and active-site machinery of an S-glycosidase
22. Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase
23. 2,5B conformation for the glycosyl-enzyme intermediate revealed by the structure of the Bacillus agaradhaerens family 11 xylanase
24. Nucleoside hydrolase from Leishmania major - Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5 Å crystal structure
25. Crystallographic observation of a covalent catalytic intermediate in a beta-glycosidase
26. A new, simple, high-affinity glycosidase inhibitor: Analysis of binding through X-ray crystallography, mutagenesis, and kinetic analysis
27. Asparagine-127 of xylanase A from Streptomyces lividans, a key residue in glycosyl hydrolases of superfamily 4/7: Kinetic evidence for its involvement in stabilization of the catalytic intermediate
28. X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the α-amylase family
29. The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a gamma-cyclodextrin-CGTase complex at 1.8 Å resolution
30. Glycoside hydrolysis. II. Intramolecular carboxyl and acetamido group catalysis in β-glycosilde hydrolysis
31. Mutations of endo-β-N-acetylglucosaminidase H active site residues Asp130 and Glu132: Activities and conformations
32. Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and x-ray structure of a complex with allosamidin: Evidence for substrate assisted catalysis
33. Serratia marcescens chitobiase is a retaining glycosidase utilizing substrate acetamido group participation
34. NAG-thiazoline, an N-acetyl-β-hexosaminidase inhibitor that implicates acetamido participation
35. A novel method for synthesis of chitobiose via enzymatic glycosylation using a sugar oxazoline as glycosyl donor
36. Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-β-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-α-L-idopyranosyl fluoride
37. α-1,4-Glucan lyases producing 1,5-anhydro-D-fructose from starch and glycogen have sequence similarity to α-glucosidases
38. Cellobiose-6-phosphate hydrolase (CelF) of Escherichia coli: Characterization and assignment to the unusual family 4 of glycosylhydrolases
39. The gene glvA of Bacillus subtilis 168 encodes a metal-requiring, NAD(H)-dependent 6-phospho-α-glucosidase
40. Crystallization and preliminary X-ray analysis of the 6-phosphoalpha-glucosidase from Bacillus subtilis
41. Evidence that galactanase A from Pseudomonas fluorescens subspecies cellulosa is a retaining family 53 glycosyl hydrolase in which E161 and E270 are the catalytic residues
42. Restoration of the activity of active-site mutants of the hyperthermophilic β-glycosidase from Sulfolobus solfataricus: Dependence of the mechanism on the action of external nucleophiles
43. Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site
44. Restoration of Catalytic-activity beyond wild-type level in glucoamylase from Aspergillus awamori by oxidation of the Glu400→Cys catalytic-base mutant to cysteinesulfinic acid
45. Enzymatic properties of the cysteinesulfinic acid derivative of the catalytic-base mutant Glu400→Cys of glucoamylase from Aspergillus awamori
46. Substrate specificity in glycoside hydrolase family 10: Tyrosine 87 and leucine 314 play a pivotal role in discriminating between glucose and xylose binding in the proximal active site of Pseudomonas cellulosa xylanase 10A
47. Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening
48. Glycosynthases - Mutant glycosidases for oligosaccharide synthesis
49. The E358S mutant of Agrobacterium sp. β-glucosidase is a greatly improved glycosynthase
50. From beta-glucanase to beta-glucansynthase: Glycosyl transfer to alpha-glycosyl fluorides catalyzed by a mutant endoglucanase lacking its catalytic nucleophile
51. Highly efficient synthesis of β(1→4)-oligo- and polysaccharides using a mutant cellulase
52. A novel thermophilic glycosynthase that effects branching glycosylation
53. Lateral protonation of a glycosidase inhibitor. Structure of the Bacillus agaradhaerens Cel5A in complex with a cellobiose-derived imidazole at 0.97A resolution
54. Inhibition of cellobiohydrolases from Trichoderma reesei. Synthesis and evaluation of some glucose-, cellobiose-, and cellotriose derived hydroximinolactams and imidazoles
55. Nanomolar versus millimolar inhibition by xylobiose-derived azasugars: Significant differences between two structurally distinct xylanases
56. Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases
57. The 2.0 angstrom structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor
58. The 2.0 angstrom structure of human hypoxanthineguanine phosphoribosyltransferase in complex with a transition-state analog inhibitor
59. Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases