Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice

Vaccine

Volumn 16, Issue 8, 1998, Pages 768-774

  Costa, Fabio ^a   Franchin, Giovanni ^a   Pereira Chioccola, Vera Lucia ^a,b   Ribeirão, Marcelo ^a   Schenkman, Sergio ^a   Rodrigues, Mauricio M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO DANTE PAZZANESE DE CARDIOLOGIA   (Brazil)

Author keywords

DNA immunization; Trypanosoma cruzi

Indexed keywords

ANTIBODY; PLASMID DNA; SIALIDASE; VIRULENCE FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IMMUNITY; IN VITRO STUDY; INTRAMUSCULAR DRUG ADMINISTRATION; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; T LYMPHOCYTE; TRYPANOSOMA CRUZI; VACCINATION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CHAGAS DISEASE; DNA, PROTOZOAN; FEMALE; GLYCOPROTEINS; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED A; MICE, INBRED BALB C; NEURAMINIDASE; PLASMIDS; PROTOZOAN VACCINES; T-LYMPHOCYTES; TRYPANOSOMA CRUZI; VACCINES, DNA;

EID: 0032077290     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00277-6     Document Type: Article

References (20)

1. 1 Ulmer, J.B., Sadoff, J.C. and Liu, M.A. DNA vaccines. Current Opinion in Immunology 1996, 8, 531-536.
2. 2 Ertl, H.C. and Xianq, Z.Q. Genetic immunisation. Viral Immunol. 1996, 9, 1-9.
3. 3 Sedegah, M., Hedstrom, R., Hobart, P. and Hoffman, S.L. Protection against malaria by immunisation with plasmid DNA encoding circumsporozoite protein. Proc. Natl Acad. Sci. USA 1994, 91, 9866-9870.
4. 4 Xu, D. and Liew, F.Y. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology 1995, 84, 173-176.
5. 5 de Andrade, A.L., Zicker, F. and de Oliveira, R.M. et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 1996, 348, 1407-1413.
6. 6 Viotti, R., Vigliano, C., Armenti, H. and Segura, E. Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow up. Am. Heart J. 1994, 127, 151-162.
7. 7 Schenkman, S., Man-Shiow, J., Hart, G.W. and Nussenzweig, V. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell 1991, 65, 117-1125.
8. 8 Schenkman, R.P.F., Vandekerckhove, F. and Schenkman, S. Mammalian cell sialic acid enhances Trypanosoma cruzi invasion. Inf. Immun. 1993, 61, 898-902.
9. 9 Pereira-Chioccola, V.L., Schenkman, S. and Kloetzel, J. Sera from chronic Chagasic patients and animals infected with Trypanosoma cruzi inhibit trans-sialidase by recognizing its catalytic domain. Inf. Immun. 1994, 62, 2973-2978.
10. 10 Chuenkova, M. and Pereira, M.E.A. Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease. J. Exp. Med. 1995, 181, 1693-1703
11. 11 Franchin, G., Pereira-Chioccola, V.L., Schenkman, S. and Rodrigues, M.M. Passive transfer of a monoclonal antibody specific for a sialic acid-dependent epitope on the surface of Trypanosoma cruzi trypomastigotes reduces infection in mice. Inf. Immun. 1997, 65, 2548-2554.
12. 12 Schenkman, S., De Carvalho, L.P. and Nussenzweig, V. Trypanosoma cruzi trans-sialidase and neurammidase activities can be mediated by the same enzymes. J. Exp. Med. 1992, 175, 567-575.
13. 13 Schenkman, S., Chaves, L.B., Pontes de Carvalho, L. and Eichinger, D. A proteolytic fragment of Trypanosoma cruzi trans-sialidase lacking the carboxy-terminal domain is active, monomeric and generates antibodies that inhibit enzymatic activity. J. Biol. Chem. 1994, 269, 7970-7975.
14. 14 Uemura, H., Schenkman, S., Nussenzweig, V. and Eichinger, D. Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities. EMBO J. 1992, 11, 3837-3844.
15. 15 Sambrook, J., Fritsch, E.F. and Maniatis, T. Molecular Cloning. A Laboratory Manual, Vol. 1. Cold Spring Harbour Laboratory Press, New York, 1989, p. 42.
16. 16 Michel, M.L., Davis, H.L., Schleef, M., Mancini, M., Tiollais, P. and Whalen, R.G. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of humoral immune response mimic hepatitis B viral infection in humans. Proc. Natl Acad. Sci. USA 1995, 92, 5307-5311.
17. 17 Pereira, M.E.A., Zhang, K., Gong, Y., Herrera, E.M. and Ming, M. Invasive phenotype of Trypanosoma cruzi is restricted to a population expressing trans-sialidase. Inf. Immun. 1996, 64, 3884-3892.
18. 18 Schenkman, S., Kurosaki, T., Ravetch, J.V. and Nussenzweig, V. Evidence for the participation of the Ssp-3 antigen in the invasion of non-phagocytic mammalian cells by Trypanosoma cruzi. J. Exp. Med. 1992, 175, 1635-1641.
19. 19 Cross, G.A.M. and Tackle, G.B. The surface trans-sialidase family of Trypanosma cruzi. Ann. Rev. Microbiol. 1993, 46, 383-411.
20. 20 Tarleton, R.L. The role of T cells in Trypanosoma cruzi infections. Parasitol. Today 1995, 11, 7-12.