RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver

Journal of Hepatology

Volumn 64, Issue 4, 2016, Pages 899-907

  Yin, Hao ^a   Bogorad, Roman L ^a   Barnes, Carmen ^b   Walsh, Stephen ^a   Zhuang, Iris ^a   Nonaka, Hidenori ^c   Ruda, Vera ^a   Kuchimanchi, Satya ^b   Nechev, Lubomir ^b   Akinc, Akin ^b   Xue, Wen ^d   Zerial, Marino ^c   Langer, Robert ^a,e,f   Anderson, Daniel G ^a,e,f   Koteliansky, Victor ^g,h  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

^f HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^g SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^h MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Bile acids; Hippo pathway; Nanoparticles; p53; siRNA

Indexed keywords

MERLIN; MST 1 PROTEIN; MST 2 PROTEIN; NANOPARTICLE; PROTEIN P53; SIRNA NANOPARTICLE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR YAP1; UNCLASSIFIED DRUG; MACROPHAGE STIMULATING PROTEIN; MST2 PROTEIN, MOUSE; ONCOPROTEIN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SCATTER FACTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; YAP PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HEPATOMEGALY; HUMAN; HUMAN CELL; LIVER CELL; LIVER SIZE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION; ANIMAL; C57BL MOUSE; GENETICS; GENOMICS; GROWTH, DEVELOPMENT AND AGING; LIVER; METABOLISM; ORGAN SIZE; PHYSIOLOGY; PROCEDURES; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; GENE EXPRESSION; GENES, NEUROFIBROMATOSIS 2; GENOMICS; HEPATOCYTE GROWTH FACTOR; HEPATOMEGALY; LIVER; MICE; MICE, INBRED C57BL; NANOPARTICLES; ORGAN SIZE; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84961917299     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.11.028     Document Type: Article

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