Corticosteroids for acute bacterial meningitis

Cochrane Database of Systematic Reviews

Volumn 2016, Issue 3, 2015, Pages

  Brouwer, Matthijs C ^a   Mcintyre, Peter ^b   Prasad, Kameshwar ^c   van de Beek, Diederik ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CORTICOSTEROID; DEXAMETHASONE; PLACEBO; ANTIINFLAMMATORY AGENT; GLUCOCORTICOID; HYDROCORTISONE; PREDNISOLONE;

BACTERIAL MENINGITIS; BILATERAL HEARING LOSS; CORTICOSTEROID THERAPY; EPIDEMIC MENINGITIS; GASTROINTESTINAL HEMORRHAGE; HERPES ZOSTER; HUMAN; MORTALITY; MYCOSIS; NEUROLOGIC DISEASE; PNEUMOCOCCAL MENINGITIS; REACTIVE ARTHRITIS; RECURRENT FEVER; REVIEW; SYSTEMATIC REVIEW; ACUTE DISEASE; ADOLESCENT; ADULT; CHILD; COMPLICATION; DEVELOPED COUNTRY; DEVELOPING COUNTRY; HEARING LOSS; MENINGITIS, BACTERIAL; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ACUTE DISEASE; ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; CHILD; DEVELOPED COUNTRIES; DEVELOPING COUNTRIES; DEXAMETHASONE; GLUCOCORTICOIDS; HEARING LOSS; HUMANS; HYDROCORTISONE; MENINGITIS, BACTERIAL; PREDNISOLONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84961886531     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD004405.pub5     Document Type: Review

References (95)

1. Bademosi O, Osuntokun BO. Prednisolone in the treatment of pneumococcal meningitis. Tropical and Geographical Medicine 1979;31(1):53-6.
2. Belsey MA, Hoffpauir CW, Smith MH. Dexamethasone in the treatment of acute bacterial meningitis: the effect of study design on the interpretation of results. Pediatrics 1969;44(4):503-13.
3. Bennett IL, Finland M, Hamburger M, Kass EH, Lepper M, Waisbren BA. The effectiveness of hydrocortisone in the management of severe infections. JAMA 1963;183(6):462-5.
4. Bhaumik S, Behari M. Role of dexamethasone as adjunctive therapy in acute bacterial meningitis in adults. Neurology India 1998;46:225-8.
5. Ciana G, Parmar N, Antonio C, Pivetta S, Tamburlini G, Cuttini M. Effectiveness of adjunctive treatment with steroids in reducing short-term mortality in a high-risk population of children with bacterial meningitis. Journal of Tropical Pediatrics 1995;41(3):164-8.
6. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. New England Journal of Medicine 2002;347(20):1549-56.
7. DeLemos RA, Haggerty RJ. Corticosteroids as an adjunct to treatment in bacterial meningitis. A controlled clinical trial. Pediatrics 1969;44(1):30-4.
8. Girgis NI, Farid Z, Mikhail IA, Farrag I, Sultan Y, Kilpatrick ME. Dexamethasone treatment for bacterial meningitis in children and adults. Pediatric Infectious Disease Journal 1989;8(12):848-51.
9. Kanra GY, Ozen H, Secmeer G, Ceyhan M, Ecevit Z, Belgin E. Beneficial effects of dexamethasone in children with pneumococcal meningitis. Pediatric Infectious Disease Journal 1995;14(6):490-4.
10. Kilpi T, Peltola H, Jauhiainen T, Kallio MJ. Oral glycerol and intravenous dexamethasone in preventing neurologic and audiologic sequelae of childhood bacterial meningitis. The Finnish Study Group. Pediatric Infectious Disease Journal 1995;14(4):270-8.
11. King SM, Law B, Langley JM, Heurter H, Bremner D, Wang EE, et al. Dexamethasone therapy for bacterial meningitis: better never than late?. Canadian Journal of Infectious Diseases 1994;5:210-5.
12. Lebel MH, Freij BJ, Syrogiannopoulos GA, Chrane DF, Hoyt MJ, Stewart SM, et al. Dexamethasone therapy for bacterial meningitis. Results of two double-blind, placebo-controlled trials. New England Journal of Medicine 1988;319(15):964-71.
13. Lebel MH, Freij BJ, Syrogiannopoulos GA, Chrane DF, Hoyt MJ, Stewart SM, et al. Dexamethasone therapy for bacterial meningitis. Results of two double-blind, placebo-controlled trials. New England Journal of Medicine 1988;319(15):964-71.
14. Lebel MH, Hoyt MJ, Waagner DC, Rollins NK, Finitzo T, McCracken GH Jr, et al. Magnetic resonance imaging and dexamethasone therapy for bacterial meningitis. American Journal of Diseases of Children 1989;143(3):301-6.
15. Mathur NB, Garg A, Mishra TK. Role of dexamethasone in neonatal meningitis: a randomized controlled trial. Indian Journal of Pediatrics 2013;80(2):102-7.
16. Molyneux EM, Walsh AL, Forsyth H, Tembo M, Mwenechanya J, Kayira K, et al. Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet 2002;360(9328):211-8.
17. Nguyen TH, Tran TH, Thwaites G, Ly VC, Dinh XS, Ho Dang TN, et al. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. New England Journal of Medicine 2007;357:2431-40.
18. Odio CM, Faingezicht I, Paris M, Nassar M, Baltodano A, Rogers J, et al. The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis. New England Journal of Medicine 1991;324(22):1525-31.
19. Peltola H, Roine I, Fernández J, Zavala I, Ayala SG, Mata AG, et al. Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial. Clinical Infectious Diseases 2007;45:1277-86.
20. Qazi SA, Khan MA, Mughal N, Ahmad M, Joomro B, Sakata Y, et al. Dexamethasone and bacterial meningitis in Pakistan. Archives of Disease in Childhood 1996;75(6):482-8.
21. Sankar J, Singhi P, Bansal A, Ray P, Singhi S. Role of dexamethasone and oral glycerol in reducing hearing and neurological sequelae in children with bacterial meningitis. Indian Pediatrics 2007;44:649-56.
22. Scarborough M, Gordon SB, Whitty CJ, French N, Njalale Y, Chitani A, et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. New England Journal of Medicine 2007;357:2441-50.
23. Schaad UB, Lips U, Gnehm HE, Blumberg A, Heinzer I, Wedgwood J. Dexamethasone therapy for bacterial meningitis in children. Swiss Meningitis Study Group. Lancet 1993;342(8869):457-61.
24. Thomas R, Le Tulzo Y, Bouget J, Camus C, Michelet C, Le Corre P, et al. Trial of dexamethasone treatment for severe bacterial meningitis in adults. Adult Meningitis Steroid Group. Intensive Care Medicine 1999;25(5):475-80.
25. Wald ER, Kaplan SL, Mason EOJ, Sabo D, Ross L, Arditi M, et al. Dexamethasone therapy for children with bacterial meningitis. Meningitis Study Group. Pediatrics 1995;95(1):21-8.
26. Ayaz C, Celen MK, Geyik MF, Ulug M. The efficacy of dexamethasone treatment in adult patients with acute bacterial meningitis. Neurosciences 2008;13:146-50.
27. Baldy JL, Passos JN. Dexamethasone in the treatment of meningococcal meningitis. Revista Paulista de Medicina 1986;104(2):61-5.
28. Daoud AS, Batieha A, Al-Sheyyab M, Abuekteish F, Obeidat A, Mahafza T. Lack of effectiveness of dexamethasone in neonatal bacterial meningitis. European Journal of Pediatrics 1999;158(3):230-3.
29. Farina JSL, Alencastro R, Dalligna C, Rotta NT. Dexamethasone and bacterial meningitis: a randomised controlled trial in Brazilian children and a meta-analysis study. Neurology 1995;45(A349):45.
30. Gijwani D, Kumhar MR, Singh VB, Chadda VS, Soni PK, Nayak KC, et al. Dexamethasone therapy for bacterial meningitis in adults: a double blind placebo control study. Neurology India 2002;50(1):63-7.
31. Gupta A, Singh NK. Dexamethasone in adults with bacterial meningitis. Journal of the Association of Physicians of India 1996;44(2):90-2.
32. Jensen K, Ranek L, Rosdahl N. Bacterial meningitis; a review of 356 cases with special reference to corticosteroid and antiserum treatment. Scandinavian Journal of Infectious Diseases 1969;1(1):21-30.
33. Lepper M, Spies HW. Treatment of pneumococcic meningitis. Archives of Internal Medicine 1959;104(3):253-9.
34. Marguet C, Mallet E. Value of dexamethasone in purulent meningitis in children. Apropos of a comparative study of 85 children. Archives Français Pediatrie 1993;50(2):111-7.
35. Ozen M, Kanra G, Kara A, Bakar EE, Ceyhan M, Secmeer G, et al. Long-term beneficial effects of dexamethasone on intellectual and neuropsychological outcome of children with pneumococcal meningitis. Scandinavian Journal of Infectious Diseases 2006;38(2):104-9.
36. Passos JN, Baldy JL. Evaluation of the use of dexamethasone in the therapeutic schedule for purulent meningitis. Revista do Instituto de Medicina Tropical de São Paulo 1979;21(2):90-8.
37. Peltola H. Childhood bacterial meningitis relieved better by glycerol than dexamethasone. 44th ICAAC, Chicago. Chicago, 2004.
38. Shembesh NM, Elbargathy SM, Kashbur IM, Rao BN, Mahmoud KS. Dexamethasone as an adjunctive treatment of bacterial meningitis. Indian Journal of Pediatrics 1997;64(4):517-22.
39. Singhi S, Järvinen A, Peltola H. Increase in serum osmolality is possible mechanism for the beneficial effects of glycerol in childhood bacterial meningitis. Pediatric Infectious Disease Journal 2008;27:892-6.
40. Syrogiannopoulos GA, Lourida AN, Theodoridou MC, Pappas IG, Babilis, GC, Economidis JJ, et al. Dexamethasone therapy for bacterial meningitis in children: 2- versus 4-day regimen. Journal of Infectious Diseases 1994;169(4):853-8.
41. Tolaj I, Dreshaj S, Qehaja E, Tolaj J, Doda-Ejupi T, Mehmeti M. Dexamethasone as adjuvant therapy in the treatment of invasive meningococcal diseases. Medicinski Arhiv 2010;64(4):228-30.
42. Assiri AM, Alasmari FA, Zimmerman VA, Baddour LM, Erwin PJ, Tleyjeh IM. Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: a meta-analysis. Mayo Clinic Proceedings 2009;84(5):403-9.
43. Balis FM, Lester CM, Chrousos GP, Heideman RL, Poplack DG. Differences in cerebrospinal fluid penetration of corticosteroids: possible relationship to the prevention of meningeal leukemia. Journal of Clinical Oncology 1987;5:202-7.
44. Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children: a meta-analysis. Pediatric Infectious Disease Journal 1993;12(5):389-94.
45. Bernardo WM, Aires FT, Sá FP. Effectiveness of the association of dexamethasone with antibiotic therapy in pediatric patients with bacterial meningitis. Revista da Associação Médica Brasileira 2012;58(3):319-22.
46. Bodilsen J, Dalager-Pedersen M, Schønheyder HC, Nielsen H. Dexamethasone treatment and prognostic factors in community-acquired bacterial meningitis: a Danish retrospective population-based cohort study. Scandinavian Journal of Infectious Diseases 2014;46:418-25.
47. Bohr V, Hansen B, Jessen O, Johnsen N, Kjersem H, Kristensen HS, et al. Eight hundred and seventy-five cases of bacterial meningitis. Part I of a three-part series: clinical data, prognosis, and the role of specialised hospital departments. Journal of Infection 1983;7(1):21-30.
48. Borchorst S, Moller K. The role of dexamethasone in the treatment of bacterial meningitis - a systematic review. Acta Anaesthesiologica Scandinavica 2012;56:1210-21.
49. Brouwer MC, Heckenberg SG, de Gans J, Spanjaard L, Reitsma JB, van de Beek D. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. Neurology 2010;75(17):1533-9.
50. Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clinical Microbiology Reviews 2010;23(3):467-92.
51. Brouwer MC, van der Ende A, Baas F, van de Beek D. Genetic variation in GLCCI1 and dexamethasone in bacterial meningitis. Journal of Infection 2012;65(5):465-7.
52. Castelblanco RL, Lee M, Hasbun R. Epidemiology of bacterial meningitis in the USA from 1997 to 2010: a population-based observational study. Lancet Infectious Diseases 2014;14:813-9.
53. Cornelis AS, Hachimi-Idrissi S. The use of dexamethasone in bacterial meningitis in children and adults: a retrospective analysis. ISRN Pediatrics 2011;2011:380283.
54. Fritz D, Brouwer MC, van de Beek D. Dexamethasone and long-term survival in bacterial meningitis. Neurology 2012;79(22):2177-9.
55. Geiman BJ, Smith AL. Dexamethasone and bacterial meningitis. A meta-analysis of randomized clinical trials. Western Journal of Medicine 1992;157:27-31.
56. Glasziou PP, Irwig LM. An evidence based approach to individualising treatment. BMJ 1995;311(7016):1356-9.
57. Havens PL, Wendelberger KJ, Hoffman GM, Lee MB, Chusid MJ. Corticosteroids as adjunctive therapy in bacterial meningitis. A meta-analysis of clinical trials. American Journal of Diseases of Children 1989;143:1051-5.
58. Heckenberg SG, Brouwer MC, van der Ende A, Hensen EF, van de Beek D. Hearing loss in adults surviving pneumococcal meningitis is associated with otitis and pneumococcal serotype. Clinical Microbiology and Infection 2012;18(9):849-55.
59. Heckenberg SG, Brouwer MC, van der Ende A, van de Beek D. Adjunctive dexamethasone in adults with meningococcal meningitis. Neurology 2012;79(15):1563-9.
60. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. Chichester, UK: Wiley-Blackwell.
61. Klugman KP, Friedland IR, Bradley JS. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrobial Agents and Chemotherapy 1995;39(9):1988-92.
62. Koopmans MM, Brouwer MC, Bijlsma MW, Bovenkerk S, Keijzers W, van der Ende A, et al. Listeria monocytogenes sequence type 6 and increased rate of unfavorable outcome in meningitis: epidemiologic cohort study. Clinical Infectious Diseases 2013;57:247-53.
63. Køster-Rasmussen R, Korshin A, Meyer CN. Antibiotic treatment delay and outcome in acute bacterial meningitis. Journal of Infection 2008;57:449-54.
64. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
65. Lutsar I, Friedland IR, Jafri HS, Wubbel L, Ahmed A, Trujillo M, et al. Factors influencing the anti-inflammatory effect of dexamethasone therapy in experimental pneumococcal meningitis. Journal of Antimicrobial Chemotherapy 2003;52(4):651-5.
66. McIntyre PB, Berkey CS, King SM, Schaad UB, Kilpi T, Kanra GY, et al. Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA 1997;278(11):925-31.
67. McIntyre P. Adjunctive dexamethasone in meningitis: does value depend on clinical setting?. Lancet Neurology 2010;9:229-31.
68. McIntyre PB, O'Brien KL, Greenwood B, van de Beek D. Effect of vaccines on bacterial meningitis world-wide. Lancet 2012;380(9854):1703-11.
69. McMillan DA, Lin CY, Aronin SI, Quagliarello VJ. Community-acquired bacterial meningitis in adults: categorization of causes and timing of death. Clinical Infectious Diseases 2001;33:969-75.
70. Molyneux E, Riordan FA, Walsh A. Acute bacterial meningitis in children presenting to the Royal Liverpool Children's Hospital, Liverpool, UK and the Queen Elizabeth Central Hospital in Blantyre, Malawi: a world of difference. Annals of Tropical Paediatrics 2006;26(1):29-37.
71. Peltola H. Worldwide Haemophilus influenzae type B disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clinical Microbiology Reviews 2000;13(2):302-17.
72. Peterković V, Trkulja V, Kutleša M, Krajinović V, Lepur D. Dexamethasone for adult community-acquired bacterial meningitis: 20 years of experience in daily practice. Journal of Neurology 2012;259(2):225-36.
73. Prasad K, Haines T. Dexamethasone treatment for acute bacterial meningitis: how strong is the evidence for routine use?. Journal of Neurology, Neurosurgery and Psychiatry 1995;59(1):31-7.
74. Proulx N, Fréchette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005;94:291-8.
75. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
76. Ricard JD, Wolff M, Lacherade JC, Mourvillier B, Hidri N, Barnaud G, et al. Levels of vancomycin in cerebrospinal fluid of adult patients receiving adjunctive corticosteroids to treat pneumococcal meningitis: a prospective multicenter observational study. Clinical Infectious Diseases 2007;44:250-5.
77. Sapolsky RM, Pulsinelli WA. Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications. Science 1985;229(4720):1397-400.
78. Scheld WM, Dacey RG, Winn HR, Welsh JE, Jane JA, Sande MA. Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis. Alterations with penicillin and methylprednisolone. Journal of Clinical Investigation 1980;66(2):243-53.
79. Tauber MG, Khayam-Bashi H, Sande MA. Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis. Journal of Infectious Diseases 1985;151(3):528-34.
80. Török ME, Nguyen DB, Tran TH, Nguyen TB, Thwaites GE, Hoang TQ, et al. Dexamethasone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents. PLoS One 2011;6(12):e27821.
81. United Nations Human Development Index. Human Development Index. http://hdr.undp.org/en/statistics/ 2009 (accessed 25 November 2009).
82. van de Beek D, Schmand B, De Gans J, Weisfelt M, Vaessen H, Dankert J, et al. Cognitive impairment in adults with good recovery after bacterial meningitis. Journal of Infectious Diseases 2002;186(7):1047-52.
83. van de Beek D, de Gans J. Dexamethasone and pneumococcal meningitis. Annals of Internal Medicine 2004;141(4):327.
84. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. New England Journal of Medicine 2004;351(18):1849-59.
85. van de Beek D, de Gans J, Tunkel AR, Wijdicks EFM. Community-acquired bacterial meningitis in adults. New England Journal of Medicine 2006;354(1):44-53. [MEDLINE: 16394301]
86. van de Beek D, de Gans J. Dexamethasone in adults with community-acquired bacterial meningitis. Drugs 2006;66(4):415-27.
87. van de Beek D, Farrar JJ, de Gans J, Mai NT, Molyneux EM, Peltola H, et al. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurology 2010;9:254-63.
88. Vardakas KZ, Matthaiou DK, Falagas ME. Adjunctive dexamethasone therapy for bacterial meningitis in adults: a meta-analysis of randomized controlled trials. European Journal of Neurology 2009;16:662-73.
89. Viladrich PF, Gudiol F, Linares J, Pallares R, Sabate I, Rufi G, et al. Evaluation of vancomycin for therapy of adult pneumococcal meningitis. Antimicrobial Agents and Chemotherapy 1991;35(12):2467-72.
90. Weisfelt M, Hoogman M, van de Beek D, de Gans J, Dresschler WA, Schmand B. Dexamethasone and long-term outcome in adults with bacterial meningitis. Annals of Neurology 2006;60(4):456-68.
91. Beek D van de, Gans J de, McIntyre P, Prasad K. Corticosteroids as adjunctive therapy in acute bacterial meningitis. Cochrane Database of Systematic Reviews 1998, Issue 3. [DOI: 10.1002/14651858.CD001170]
92. Brouwer MC, McIntyre P, de Gans J, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database of Systematic Reviews 2010, Issue 9. [DOI: 10.1002/14651858.CD004405.pub3]
93. Brouwer MC, McIntyre P, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD004405.pub4]
94. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids in acute bacterial meningitis. Cochrane Database of Systematic Reviews 2003, Issue 3. [DOI: 10.1002/14651858.CD004405.pub2]
95. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database of Systematic Reviews 2007, Issue 1. [DOI: 10.1002/14651858.CD004405.pub2]