Factors influencing the anti-inflammatory effect of dexamethasone therapy in experimental pneumococcal meningitis

Journal of Antimicrobial Chemotherapy

Volumn 52, Issue 4, 2003, Pages 651-655

  Lutsar, Irja ^a,b   Friedland, I R ^a   Jafri, H S ^a   Wubbel, L ^a   Ahmed, A ^a   Trujillo, M ^a   McCoig, C C ^a   McCracken Jr , G H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Animal models; CSF; Experimental meningitis; Inflammatory response; S. pneumoniae

Indexed keywords

AMPICILLIN; CEFTRIAXONE; DEXAMETHASONE; INTERLEUKIN 1; LACTIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL MENINGITIS; CEREBROSPINAL FLUID ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; EXPERIMENTAL MODEL; HAEMOPHILUS; INFLAMMATION; LEUKOCYTE COUNT; NONHUMAN; PROTEIN CEREBROSPINAL FLUID LEVEL; RABBIT; REFERENCE VALUE; STREPTOCOCCUS PNEUMONIAE; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; HUMANS; LEUKOCYTES; MENINGITIS, PNEUMOCOCCAL; RABBITS;

EID: 0141997707     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg417     Document Type: Article

References (26)

1. Spellerberg, B. & Tuomanen, E. I. (1994). Pathophysiology of pneumococcal meningitis. Annals of Medicine 26, 411-18.
2. Nau, R., Zysk, G., Schmidt, H. et al. (1997). Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis. Journal of Antimicrobial Chemotherapy 39, 781-8.
3. Mustafa, M. M., Ramilo, O., Mertsola, J. et al. (1989). Modulation of inflammation and cachectin activity in relation to treatment of experimental Haemophilus influenzae type b meningitis. Journal of Infectious Diseases 160, 818-25.
4. Friedland, I. R., Jafari, H., Ehrett, S. et al. (1993). Comparison of endotoxin release by different antimicrobial agents and the effect on inflammation in experimental E. coli meningitis. Journal of Infectious Diseases 168, 657-62.
5. Fischer, H. & Tomasz, A. (1984). Production and release of peptidoglycan and wall teichoic acid polymers in pneumococci treated with beta lactam antibiotics. Journal of Bacteriology 157, 507-13.
6. McIntyre, P. B., Barkey, C. S., King, S. M. et al. (1997). Dexamethasone as adjunctive therapy in bacterial meningitis: a meta-analysis of randomized clinical trials since 1988. Journal of the American Medical Association 278, 925-31.
7. Täuber, M. G., Khayam-Bashi, H. & Sande, M. A. (1985). Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis. Journal of Infectious Diseases 151, 528-34.
8. Tuomanen, E., Hengstler, B., Rich, R. et al. (1987). Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis. Journal of Infectious Diseases 155, 985-90.
9. de Gans, J. & van de Beek, D. (2002). Dexamethasone in adults with bacterial meningitis. New England Journal of Medicine 347, 1549-56.
10. Tuomanen, E., Liu, H., Hengstler, B. et al. (1985). The induction of meningeal inflammation by components of the pneumococcal cell wall. Journal of Infectious Diseases 151, 859-68.
11. Dacey, R. G. & Sande, M. A. (1974). Effect of probenecid on cerebrospinal fluid concentration of penicillin and cephalosporin derivates. Antimicrobial Agents and Chemotherapy 6, 437-41.
12. Flick, D. A. & Gifford, G. E. (1984). Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. Journal of Immunological Methods 68, 167-75.
13. Stuertz, K., Schmidt, H., Eiffert, H. et al. (1998). Differential release of lipoteichoic and teichoic acids from Streptococcus pneumoniae as a result of exposure to β-lactam antibiotics, rifamycins, trovafloxacin, and quinupristin-dalfopristin. Antimicrobial Agents and Chemotherapy 42, 277-81.
14. Pfister, H.-W., Fontana, A., Täuber, M. G. et al. (1994). Mechanism of brain injury in bacterial meningitis: workshop summary. Clinical Infectious Diseases 19, 463-79.
15. Tuomanen, E. I., Austrian, R. & Masure, H. R. (1995). Pathogenesis of pneumococcal infection. New England Journal of Medicine 332, 1280-4.
16. Täuber, M. G., Shibl, A. M., Hackbarth, C. J. et al. (1987). Antibiotic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherichia coli meningitis in rabbits. Journal of Infectious Diseases 156, 456-62.
17. Winter, A. J., Comis, S. D., Osborne, M. P. et al. (1998). Ototoxicity resulting from intracochlear perfusion of Streptococcus pneumoniae in the guinea pig is modified by cefotaxime or amoxycillin pretreatment. Journal of Infection 36, 73-7.
18. Lebel, M. H. & McCracken, G. H., Jr (1989). Delayed cerebrospinal fluid sterilization and adverse outcome of bacterial meningitis in infants and children. Pediatrics 83, 161-7.
19. Arditi, M., Mason, E. O., Bradley, J. S. et al. (1998). Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics 102, 1087-97.
20. Nakamura, H., Mizushima, Y., Seto, Y. et al. (1985). Dexamethasone fails to produce antipyretic and analgesic actions in experimental animals. Agents and Actions 16, 542-7.
21. Bingen, E., Lambert-Zechovsky, N., Mariani-Kurkdjian, P. et al. (1990). Bacterial counts in cerebrospinal fluid of children with meningitis. European Journal of Clinical Microbiology and Infectious Diseases 9, 278-81.
22. Feldman, W. E., Ginsburg, C. M., McCracken, G. H., Jr et al. (1982). Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis. Journal of Pediatrics 100, 209-12.
23. Schaad, U. B., Kaplan, S. L. & McCracken, G. H. (1994). Steroid therapy for bacterial meningitis. Clinical Infectious Diseases 20, 685-90.
24. Cabellos, C., Martinez-Lacasa, J., Tubau, F. et al. (2000). Evaluation of combined ceftriaxone and dexamethasone therapy in experimental cephalosporin-resistant pneumococcal meningitis. Journal of Antimicrobial Chemotherapy 45, 315-20.
25. Lutsar, I., McCracken, G. H. & Friedland, I. R. (1998). Antibiotic pharmacodynamics in cerebrospinal fluid. Clinical Infectious Diseases 27, 1117-29.
26. Weitbrecht, W. U. (1980). Influence of milieu and dexamethasone on in vitro phagocylosis of cerebrospinal fluid phagocytes. Pathological Research and Practice 167, 393-9.