Adjunctive dexamethasone therapy for bacterial meningitis in adults: A meta-analysis of randomized controlled trials

European Journal of Neurology

Volumn 16, Issue 6, 2009, Pages 662-673

  Vardakas, K Z ^a   Matthaiou, D K ^a   Falagas, M E ^a,b  

^a ALFA INSTITUTE OF BIOMEDICAL SCIENCES AIBS   (Greece)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Central nervous system; Corticosteroids; S. pneumoniae

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; PLACEBO;

BACTERIAL MENINGITIS; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE SEVERITY; DRUG EFFICACY; HEARING IMPAIRMENT; HUMAN; META ANALYSIS; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STREPTOCOCCUS PNEUMONIAE; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

ANTI-INFLAMMATORY AGENTS; DEVELOPED COUNTRIES; DEXAMETHASONE; EARLY DIAGNOSIS; HEALTH SERVICES ACCESSIBILITY; HUMANS; MENINGITIS, BACTERIAL; MORTALITY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STREPTOCOCCAL INFECTIONS; TREATMENT OUTCOME;

EID: 65449128065     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02615.x     Document Type: Review

References (49)

1. Scheld WM, Dacey RG, Winn HR, Welsh JE, Jane JA, Sande MA. Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis. Alterations with penicillin and methylprednisolone. J Clin Invest 1980 66 : 243 253. (Pubitemid 10092621)
2. Tauber MG, Khayam-Bashi H, Sande MA. Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis. J Infect Dis 1985 151 : 528 534. (Pubitemid 15103807)
3. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2007 1 : CD004405.
4. van de Beek D, de Gans J, McIntyre P, Prasad K. Steroids in adults with acute bacterial meningitis: a systematic review. Lancet Infect Dis 2004 4 : 139 143. (Pubitemid 38293137)
5. McIntyre PB, Berkey CS, King SM, Schaad UB, Perez CM. Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA 1997 278 : 925 931. (Pubitemid 27492246)
6. Prasad K, Haines T. Dexamethasone treatment for acute bacterial meningitis: how strong is the evidence for routine use? J Neurol Neurosurg Psychiatry 1995 59 : 31 37.
7. Ioannidis JP, Samarel MD, Lau J, Drapkin MS. Risk of gastrointestinal bleeding from dexamethasone in children with bacterial meningitis. Lancet 1994 343 : 792. (Pubitemid 24098706)
8. Yurkowski PJ, Plaisance KI. Prevention of auditory sequelae in pediatric bacterial meningitis: a meta-analysis. Pharmacotherapy 1993 13 : 494 499. (Pubitemid 23301973)
9. Geiman BJ, Smith AL. Dexamethasone and bacterial meningitis. A meta-analysis of randomized controlled trials. West J Med 1992 157 : 27 31.
10. Havens PL, Wendelberger KJ, Hoffman GM, Lee MB, Chusid MJ. Corticosteroids as adjunctive therapy in bacterial meningitis. A meta-analysis of clinical trial. Am J Dis Child 1989 143 : 1051 1055. (Pubitemid 19218195)
11. Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004 39 : 1267 1284. (Pubitemid 39458512)
12. Nguyen TH, Tran TH, Thwaites G, et al. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 2007 357 : 2431 2440. (Pubitemid 350272782)
13. Scarborough M, Gordon SB, Whitty CJ, et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med 2007 357 : 2441 2450. (Pubitemid 350272783)
14. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996 17 : 1 12. (Pubitemid 26120810)
15. Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 1998 352 : 609 613. (Pubitemid 28380142)
16. United Nations Human Development Index 2008. http://hdr.undp.org/en/ media/HDI-2008-EN-Tables.pdf (accessed on 23/03/2009).
17. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997 315 : 629 634. (Pubitemid 27387172)
18. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959 22 : 719 748.
19. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986 7 : 177 188. (Pubitemid 17189972)
20. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Eng J Med 2002 347 : 1549 1556. (Pubitemid 35315835)
21. Gijwani D, Kumhar MR, Singh VB, et al. Dexamethasone therapy for bacterial meningitis in adults: a double blind placebo control study. Neurol India 2002 50 : 63 67. (Pubitemid 34441091)
22. Thomas R, Le Tulzo Y, Bouget J, et al. Trial of dexamethasone treatment for severe bacterial meningitis in adults. Intensive Care Med 1999 25 : 475 480. (Pubitemid 29240443)
23. Bhaumik S, Behari M. Role of dexamethasone as adjunctive therapy in acute bacterial meningitis in adults. Neurol India 1998 46 : 225 228. (Pubitemid 29143305)
24. Gupta A, Singh NK. Dexamethasone in adults with bacterial meningitis. J Assoc Phys India 1996 44 : 90 92. (Pubitemid 126470432)
25. Girgis NI, Farid Z, Mikhail IA, Farrag I, Sultan Y, Kilpatrick ME. Dexamethasone treatment for bacterial meningitis in children and adults. Pediatr Infect Dis J 1989 8 : 848 851. (Pubitemid 20018839)
26. Bademosi O, Osuntokun BO. Prednisolone in the treatment of pneumococcal meningitis. Trop Geog Med 1979 31 : 53 56. (Pubitemid 9204361)
27. Bennett IL, Finland M, Hamburger M, Kass EH, Lepper M, Waisbren BA. The effectiveness of hydrocortisone in the management of severe infections. JAMA 1963 183 : 462 465.
28. Gilks CF, Ojoo SA, Ojoo JC, et al. Invasive pneumococcal disease in a cohort of predominantly HIV-1 infected female sex-workers in Nairobi, Kenya. Lancet 1996 347 : 718 723. (Pubitemid 26085646)
29. Almirante B, Saballs M, Ribera E, et al. Favorable prognosis of purulent meningitis in patients infected with human immunodeficiency virus. Clin Infect Dis 1998 27 : 176 180. (Pubitemid 28334438)
30. King SM, Law B, Langley JM, et al. Dexamethasone therapy for bacterial meningitis: Better never than late? Can J Infect Dis 1994 5 : 210 215. (Pubitemid 24352717)
31. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004 351 : 1849 1859. (Pubitemid 39426320)
32. Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol 2006 5 : 123 129. (Pubitemid 43107848)
33. Greenlee JE, Carroll KC. Cerebrospinal fluid in CNS infections. In : Scheld WM, Whitley RJ, Durack DT, eds. Infections of the Central Nervous System, 2nd edn. Philadelphia : Lippincott-Raven, 1997 : 899 922.
34. Gray LD, Fedorko DP. Laboratory diagnosis of bacterial meningitis. Clin Microbiol Rev 1992 5 : 130 145.
35. Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes: 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore) 1998 77 : 313 336. (Pubitemid 28449833)
36. Chapin-Robertson K, Dahlberg SE, Edberg SC. Clinical and laboratory analyses of cytospin-prepared Gram stains for recovery and diagnosis of bacteria from sterile body fluids. J Clin Microbiol 1992 30 : 377 380.
37. La Scolea LJ Jr., Dryja D. Quantitation of bacteria in cerebrospinal fluid and blood of children with meningitis and its diagnostic significance. J Clin Microbiol 1984 19 : 187 190. (Pubitemid 14183575)
38. van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N Engl J Med 2006 354 : 44 53. (Pubitemid 43048950)
39. Fitch MT, van de Beek D. Emergency diagnosis and treatment of adult meningitis. Lancet Infect Dis 2007 7 : 191 200. (Pubitemid 46274516)
40. Heyderman RS, Lambert HP, O'Sullivan I, Stuart JM, Taylor BL, Wall RA. Early management of suspected bacterial meningitis and meningococcal septicaemia in adults. J Infect 2003 46 : 75 77. (Pubitemid 36221652)
41. Durant ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis in adults - a review of 493 episodes. N Engl J Med 1994 328 : 21 28.
42. Sorensen HT, Mller-Petersen J, Bygum Krarup H, Pedersen H, Hansen H, Hamburger H. Early treatment of meningococcal disease. BMJ 1992 305 : 774.
43. Sorensen HT, Steffensen FH, Schonheyder HC, Nielsen GL, Olsen J. Clinical management of meningococcal disease. Prospective international registration may be needed. BMJ 1998 316 : 1016 1017.
44. Cartwright K, Strang J, Gossain S, Begg N. Early treatment of meningococcal disease. BMJ 1992 305 : 774.
45. Wang RI, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine - reporting of subgroup analyses in clinical trials. N Engl J Med 2007 357 : 2189 2194. (Pubitemid 350146117)
46. Lagakos SW. The challenge of subgroup analyses - reporting without distorting. N Engl J Med 2006 355 : 533.
47. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004 329 : 480 489. (Pubitemid 39158891)
48. Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-Analysis: The effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 2004 141 : 47 56. (Pubitemid 38857338)
49. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008 358 : 111 124.