Dexamethasone treatment and prognostic factors in community-acquired bacterial meningitis: A Danish retrospective population-based cohort study

Scandinavian Journal of Infectious Diseases

Volumn 46, Issue 6, 2014, Pages 418-425

  Bodilsen, Jacob ^a   Dalager Pedersen, Michael ^a   Schønheyder, Henrik Carl ^a   Nielsen, Henrik ^a  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Bacterial meningitis; Dexamethasone; Dutch Meningitis Risk Score; Epidemiology; Risk score

Indexed keywords

DEXAMETHASONE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT;

ADULT; AGED; ARTICLE; BACTERIAL MENINGITIS; COHORT ANALYSIS; COMMUNITY ACQUIRED BACTERIAL MENINGITIS; COMMUNITY ACQUIRED INFECTION; COMORBIDITY; CONTROLLED STUDY; DUTCH MENINGITIS RISK SCORE; FEMALE; GLASGOW OUTCOME SCALE; HEARING IMPAIRMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; SCORING SYSTEM; TACHYCARDIA; COMMUNITY-ACQUIRED INFECTIONS; DENMARK; MENINGITIS, BACTERIAL; MICROBIOLOGY; MIDDLE AGED;

ADULT; AGED; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; COHORT STUDIES; COMMUNITY-ACQUIRED INFECTIONS; DENMARK; DEXAMETHASONE; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MENINGITIS, BACTERIAL; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84900841675     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2014.887223     Document Type: Article

References (34)

1. Harboe ZB, Valentiner-Branth P, Benfield TL, Christensen JJ, Andersen PH, Howitz M, et al. Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. Vaccine 2010; 28 : 2642-7.
2. Miller E, Salisbury D, Ramsay M. Planning, registration, and implementation of an immunisation campaign against meningococcal serogroup C disease in the UK: a success story. Vaccine 2001; 20(Suppl 1) : S58-67.
3. Snape M, Pollard A. Meningococcal polysaccharide-protein conjugate vaccines. Lancet Infect Dis 2005; 5 : 21-30.
4. Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev 2010; 23 : 467-92.
5. Gossger N, Snape MD, Yu LM, Finn A, Bona G, Esposito S, et al. Immunogenicity and tolerability of recombinant serogroup B meningococcal vaccine administered with or without routine infant vaccinations according to different immunization schedules: a randomized controlled trial. JAMA 2012; 307 : 573-82.
6. McIntyre PB, O'Brien KL, Greenwood B, van de Beek D. Effect of vaccines on bacterial meningitis worldwide. Lancet 2012; 380 : 1703-11.
7. Stephens D, Chang Q, Tzeng YL. Meningococcal disease: changes in epidemiology and prevention. Clin Epidemiol 2012; 4 : 237-45.
8. Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004; 39 : 1267-84.
9. Brouwer M, Heckenberg SG, de Gans J, Spanjaard L, Reitsma JB, van de Beek D. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. Neurology 2010; 75 : 1533-9.
10. Scheld WM, Dacey RG, Winn HR, Welsh JE, Jane JA, Sande MA. Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis. Alterations with penicillin and methylprednisolone. J Clin Invest 1980; 66 : 243-53.
11. Täuber MG, Khayam-Bashi H, Sande MA. Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis. J Infect Dis 1985; 151 : 528-34.
12. de Gans J, van de Beek D; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators. Dexamethasone in adults with bacterial meningitis. N Engl J Med 2002; 347 : 1549-56.
13. Nguyen TH, Tran TH, Thwaites G, Ly VC, Dinh XS, Ho Dang TN, et al. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 2007; 357 : 2431-40.
14. Scarborough M, Gordon SB, Whitty CJ, French N, Njalale Y, Chitani A, et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med 2007; 357 : 2441-50.
15. Heckenberg SG, Brouwer MC, van der Ende A, van de Beek D. Adjunctive dexamethasone in adults with meningococcal meningitis. Neurology 2012; 79 : 1563-9.
16. Peltola H, Roine I, Fernández J, Zavala I, Ayala SG, Mata AG, et al. Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2007; 45 : 1277-86.
17. Molyneux EM, Walsh AL, Forsyth H, Tembo M, Mwenechanya J, Kayira K, et al. Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet 2002; 360 : 211-8.
18. Leib S, Heimgartner C, Bifrare YD, Loeffler JM, Täauber MG. Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats. Pediatr Res 2003; 54 : 353-7.
19. Weisfelt M, Hoogman M, van de Beek D, de Gans J, Dreschler WA, Schmand BA. Dexamethasone and long-term outcome in adults with bacterial meningitis. Ann Neurol 2006; 60 : 456-68.
20. Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. A risk score for unfavorable outcome in adults with bacterial meningitis. Ann Neurol 2008; 63 : 90-7.
21. Schut ES, Brouwer MC, Scarborough M, Mai NT, Thwaites GE, Farrar JJ, et al. Validation of a Dutch risk score predicting poor outcome in adults with bacterial meningitis in Vietnam and Malawi. PLoS One 2012; 7 : e34311.
22. StatBank Denmark [Internet]. statbank.dk. Statistics Denmark; 2013. Available at: http://statbank.dk/statbank5a/default.asp?w = 1920 (accessed December 2013).
23. Møller KK, Pedersen SS, Skinhøj PP. [Dexamethasone to adults with acute bacterial meningitis]. Ugeskr Laeg 2003; 165 : 243-4.
24. Guidelines og retningslinier-Dansk Selskab for Infektionsmedicin [Internet]. infmed.dk. Danish Society for Infectious Diseases; 2013. Available at: http://www.infmed. dk/guidelines (accessed November 2013).
25. McMillan DA, Lin CY, Aronin SI, Quagliarello VJ. Community-acquired bacterial meningitis in adults: categorization of causes and timing of death. Clin Infect Dis 2001; 33 : 969-75.
26. Spanos A, Harrell FE, Durack D T. Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations. JAMA 1989; 262 : 2700-7.
27. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes J M. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988 ;16: 128-40.
28. Teasdale GM, Pettigrew LE, Wilson JT, Murray G, Jennett B. Analyzing outcome of treatment of severe head injury: a review and update on advancing the use of the Glasgow Outcome Scale. J Neurotrauma 1998; 15 : 587-97.
29. Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004; 159 : 702-6.
30. Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS, et al. Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med 1993; 328 : 21-8.
31. Schuchat A, Robinson K, Wenger JD, Harrison LH, Farley M, Reingold AL, et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N Engl J Med 1997; 337 : 970-6.
32. Swartz MN. Bacterial meningitis-a view of the past 90 years. N Engl J Med 2004; 351 : 1826-8.
33. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351 : 1849-59.
34. Heckenberg SG, de Gans J, Brouwer MC, Weisfelt M, Piet JR, Spanjaard L, et al. Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis. Medicine (Baltimore) 2008; 87 : 185-92.