The effect of preoperative gabapentin on postoperative nausea and vomiting: A meta-analysis

Anesthesia and Analgesia

Volumn 122, Issue 4, 2016, Pages 976-985

  Grant, Michael C ^a   Lee, HeeWon ^a   Page, Andrew J ^a   Hobson, Deborah ^a   Wick, Elizabeth ^a   Wu, Christopher L ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; 4 AMINOBUTYRIC ACID; AMINE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

ANTIEMETIC ACTIVITY; ARTICLE; DIZZINESS; GENERAL ANESTHESIA; HEADACHE; HIGH RISK POPULATION; HUMAN; META ANALYSIS; NAUSEA; POSTOPERATIVE NAUSEA AND VOMITING; PREOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SOMNOLENCE; TREATMENT OUTCOME; VOMITING; XEROSTOMIA; PROCEDURES;

AMINES; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; HUMANS; POSTOPERATIVE NAUSEA AND VOMITING; PREOPERATIVE CARE; TREATMENT OUTCOME;

EID: 84961771237     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000001120     Document Type: Article

References (78)

1. Apfel CC, Läärä E, Koivuranta M, Greim CA, Roewer N, A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 1999 91 693 700
2. Watcha MF, White PF, Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992 77 162 84
3. Habib AS, Chen YT, Taguchi A, Hu XH, Gan TJ, Postoperative nausea and vomiting following inpatient surgeries in a teaching hospital: a retrospective database analysis. Curr Med Res Opin 2006 22 1093 9
4. Carroll NV, Miederhoff PA, Cox FM, Hirsch JD, Costs incurred by outpatient surgical centers in managing postoperative nausea and vomiting. J Clin Anesth 1994 6 364 9
5. Golembiewski J, Chernin E, Chopra T, Prevention and treatment of postoperative nausea and vomiting. Am J Health Syst Pharm 2005 62 1247 60
6. Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, Watcha M, Chung F, Angus S, Apfel CC, Bergese SD, Candiotti KA, Chan MT, Davis PJ, Hooper VD, Lagoo-Deenadayalan S, Myles P, Nezat G, Philip BK, Tramèr MR, Society for Ambulatory Anesthesia Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2014 118 85 113
7. Chandrakantan A, Glass PS, Multimodal therapies for postoperative nausea and vomiting, and pain. Br J Anaesth 2011 107 suppl 1 i27 40
8. Moore RA, Wiffen PJ, Derry S, Toelle T, Rise AS, Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev 2014 4
9. 2+ influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology 2002 42 229 36
10. Hurley RW, Cohen SP, Williams KA, Rowlingson AJ, Wu CL, The analgesic effects of perioperative gabapentin on postoperative pain: a meta-Analysis. Reg Anesth Pain Med 2006 31 237 47
11. Page AJ, Ejaz A, Spolverato G, Zavadsky T, Grant MC, Galante DJ, Wick EC, Weiss M, Makary MA, Wu CL, Pawlik TM, Enhanced recovery after surgery protocols for open hepatectomy-physiology, immunomodulation, and implementation. J Gastrointest Surg 2015 19 387 99
12. Geltzeiler CB, Rotramel A, Wilson C, Deng L, Whiteford MH, Frankhouse J, Prospective study of colorectal enhanced recovery after surgery in a community hospital. JAMA Surg 2014 149 955 61
13. Cruz FM, de Iracema Gomes Cubero D, Taranto P, Lerner T, Lera AT, da Costa Miranda M, da Cunha Vieira M, de Souza Fêde AB, Schindler F, Carrasco MM, de Afonseca SO, Pinczowski H, del Giglio A, Gabapentin for the prevention of chemotherapy-induced nausea and vomiting: a pilot study. Support Care Cancer 2012 20 601 6
14. Guttuso T Jr, Roscoe J, Griggs J, Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. Lancet 2003 361 1703 5
15. Guttuso T Jr, Robinson LK, Amankwah KS, Gabapentin use in hyperemesis gravidarum: a pilot study. Early Hum Dev 2010 86 65 6
16. Erol DD, The analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine for the treatment of postdural puncture headache. Adv Med Sci 2011 56 25 9
17. Pandey CK, Priye S, Ambesh SP, Singh S, Singh U, Singh PK, Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study. J Postgrad Med 2006 52 97 100
18. Achuthan S, Singh I, Varthya SB, Srinivasan A, Chakrabarti A, Hota D, Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: a quantitative analysis of evidence from randomized controlled clinical trials. Br J Anaesth 2015 114 588 97
19. Alayed N, Alghanaim N, Tan X, Tulandi T, Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-Analysis. Obstet Gynecol 2014 123 1221 9
20. Guttuso T Jr, Gabapentin's anti-nausea and anti-Emetic effects: a review. Exp Brain Res 2014 232 2535 9
21. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ, Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996 17 1 12
22. Mohammadi SS, Seyedi M, Effects of gabapentin on early postoperative pain, nausea and vomiting in laparoscopic surgery for assisted reproductive technologies. Pak J Biol Sci 2008 11 1878 80
23. Bashir F, Mohd K, Qazi S, Hashia AM, A randomized, double blind, placebo controlled study evaluating preventive role of gabapentin for PONV in patients undergoing laparoscopic cholecystectomy. JK Science 2009 11 190 3
24. Khademi S, Ghaffarpasand F, Heiran HR, Asefi A, Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. Med Princ Pract 2010 19 57 60
25. Ajori L, Nazari L, Mazloomfard MM, Amiri Z, Effects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: a double blind randomized clinical trial. Arch Gynecol Obstet 2012 285 677 82
26. Jahromi HE, Gholami M, Rezaei F, A randomized double-blinded placebo controlled study of four interventions for the prevention of postoperative nausea and vomiting in maxillofacial trauma surgery. J Craniofac Surg 2013 24 e623 7
27. Misra S, Parthasarathi G, Vilanilam GC, The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. J Neurosurg Anesthesiol 2013 25 386 91
28. Semira, Abbas S, Tandon VR, Bashir A, Kour K, A prospective, randomized, placebo-controlled trail comparing the effectiveness of gabapentin, ondansetron & dexamethasone in prevention of nausea & vomiting after laparoscopic cholecystectomy. JK Science 2013 15 117 21
29. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB, A randomized study of the effects of single-Dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 2002 97 560 4
30. Dierking G, Duedahl TH, Rasmussen ML, Fomsgaard JS, Møiniche S, Rømsing J, Dahl JB, Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. Acta Anaesthesiol Scand 2004 48 322 7
31. Gilron I, Orr E, Tu D, O'Neill JP, Zamora JE, Bell AC, A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-Evoked pain after abdominal hysterectomy. Pain 2005 113 191 200
32. Pandey CK, Priye S, Singh S, Singh U, Singh RB, Singh PK, Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can J Anaesth 2004 51 358 63
33. Rorarius MG, Mennander S, Suominen P, Rintala S, Puura A, Pirhonen R, Salmelin R, Haanpää M, Kujansuu E, Yli-Hankala A, Gabapentin for the prevention of postoperative pain after vaginal hysterectomy. Pain 2004 110 175 81
34. Turan A, Karamanlioʇlu B, Memiş D, Usar P, Pamukçu Z, Türe M, The analgesic effects of gabapentin after total abdominal hysterectomy. Anesth Analg 2004 98 1370 3
35. Turan A, Karamanlioʇlu B, Memiş D, Hamamcioglu MK, Tükenmez B, Pamukçu Z, Kurt I, Analgesic effects of gabapentin after spinal surgery. Anesthesiology 2004 100 935 8
36. Ménigaux C, Adam F, Guignard B, Sessler DI, Chauvin M, Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg 2005 100 1394 9
37. Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB, Singh U, Singh PK, Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol 2005 17 65 8
38. Radhakrishnan M, Bithal PK, Chaturvedi A, Effect of preemptive gabapentin on postoperative pain relief and morphine consumption following lumbar laminectomy and discectomy: a randomized, double-blinded, placebo-controlled study. J Neurosurg Anesthesiol 2005 17 125 8
39. Al-Mujadi H, A-Refai AR, Katzarov MG, Dehrab NA, Batra YK, Al-Qattan AR, Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Can J Anaesth 2006 53 268 73
40. Bartholdy J, Hilsted KL, Hjortsoe NC, Engbaek J, Dahl JB, Effect of gabapentin on morphine demand and pain after laparoscopic sterilization using Filshie clips. A double blind randomized clinical trial. BMC Anesthesiol 2006 6 12
41. Mikkelsen S, Hilsted KL, Andersen PJ, Hjortsø NC, Enggaard TP, Jørgensen DG, Hansen M, Henriksen J, Dahl JB, The effect of gabapentin on post-operative pain following tonsillectomy in adults. Acta Anaesthesiol Scand 2006 50 809 15
42. Turan A, White PF, Karamanlioglu B, Memis D, Tasdogan M, Pamukçu Z, Yavuz E, Gabapentin: an alternative to the cyclooxygenase-2 inhibitors for perioperative pain management. Anesth Analg 2006 102 175 81
43. Durmus M, Kadir But A, Saricicek V, Ilksen Toprak H, Ozcan Ersoy M, The post-operative analgesic effects of a combination of gabapentin and paracetamol in patients undergoing abdominal hysterectomy: a randomized clinical trial. Acta Anaesthesiol Scand 2007 51 299 304
44. Koç S, Memis D, Sut N, The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. Anesth Analg 2007 105 1137 42
45. Takmaz SA, Kaymak C, Pehlivan BS, Dikmen B, [Effect of preoperative 900 and 1200 mg single oral dose of gabapentin on postoperative pain relief and tramadol consumption in open cholecystectomy surgery]. Agri 2007 19 32 8
46. Ghafari MH, Akrami M, Nouralishahi B, Sadegh A, Preoperative gabapentin or clonidine decreases postoperative pain and morphine consumption after abdominal hysterectomy. Res J BiolSci 2009 4 458 63
47. Gilron I, Orr E, Tu D, Mercer CD, Bond D, A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-Evoked pain after ambulatory laparoscopic cholecystectomy. Anesth Analg 2009 108 623 30
48. Sekhavat L, Zare F, Mojibian M, The postoperative analgesic effects of low-Dose gabapentin in patients undergoing abdominal hysterectomy. S Afr J Obstet Gynecol 2009 15 37 40
49. Sen H, Sizlan A, Yanarates O, Emirkadi H, Ozkan S, Dagli G, Turan A, A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy. Anesth Analg 2009 109 1645 50
50. Bang SR, Yu SK, Kim TH, Can gabapentin help reduce postoperative pain in arthroscopic rotator cuff repair? A prospective, randomized, double-blind study. Arthroscopy 2010 26 S106 11
51. Menda F, Köner O, Sayin M, Ergenoʇlu M, Küçükaksu S, Aykaç B, Effects of single-Dose gabapentin on postoperative pain and morphine consumption after cardiac surgery. J Cardiothorac Vasc Anesth 2010 24 808 13
52. Srivastava U, Kumar A, Saxena S, Mishra AR, Saraswat N, Mishra S, Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized double-blind, placebo-controlled trial. Eur J Anaesthesiol 2010 27 331 5
53. Ghai A, Gupta M, Hooda S, Singla D, Wadhera R, A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy. Saudi J Anaesth 2011 5 252 7
54. Khan ZH, Rahimi M, Makarem J, Khan RH, Optimal dose of pre-incision/post-incision gabapentin for pain relief following lumbar laminectomy: a randomized study. Acta Anaesthesiol Scand 2011 55 306 12
55. Ozgencil E, Yalcin S, Tuna H, Yorukoglu D, Kecik Y, Perioperative administration of gabapentin 1,200 mg day-1 and pregabalin 300 mg day-1 for pain following lumbar laminectomy and discectomy: a randomised, double-blinded, placebo-controlled study. Singapore Med J 2011 52 883 9
56. Ucak A, Onan B, Sen H, Selcuk I, Turan A, Yilmaz AT, The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth 2011 25 824 9
57. Behdad S, Ayatollahi V, Bafghi AT, Tezerjani MD, Abrishamkar M, Effect of gabapentin on postoperative pain and operation complications: a randomized placebo controlled trial. West Indian Med J 2012 61 128 33
58. Deniz MN, Sertoz N, Erhan E, Ugur G, Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy. J Int Med Res 2012 40 2362 9
59. Frouzanfard F, Fazel MR, Abolhasani A, Fakharian E, Mousavi G, Moravveji A, Effects of gabapentin on pain and opioid consumption after abdominal hysterectomy. Pain Res Manag 2013 18 94 6
60. Kinney MA, Mantilla CB, Carns PE, Passe MA, Brown MJ, Hooten WM, Curry TB, Long TR, Wass CT, Wilson PR, Weingarten TN, Huntoon MA, Rho RH, Mauck WD, Pulido JN, Allen MS, Cassivi SD, Deschamps C, Nichols FC, Shen KR, Wigle DA, Hoehn SL, Alexander SL, Hanson AC, Schroeder DR, Preoperative gabapentin for acute post-Thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study. Pain Pract 2012 12 175 83
61. Rimaz S, Alavi CE, Sedighinejad A, Tolouie M, Kavoosi S, Koochakinejad L, Effect of gabapentin on morphine consumption and pain after surgical debridement of burn wounds: a double-blind randomized clinical trial study. Arch Trauma Res 2012 1 38 43
62. Siddiqui NT, Fischer H, Guerina L, Friedman Z, Effect of a preoperative gabapentin on postoperative analgesia in patients with inflammatory bowel disease following major bowel surgery: a randomized, placebo-controlled trial. Pain Pract 2014 14 132 9
63. Khurana G, Jindal P, Sharma JP, Bansal KK, Postoperative pain and long-Term functional outcome after administration of gabapentin and pregabalin in patients undergoing spinal surgery. Spine (Phila Pa 1976) 2014 39 E363 8
64. Kotsovolis G, Karakoulas K, Grosomanidis V, Tziris N, Comparison between the combination of gabapentin, ketamine, lornoxicam, and local ropivacaine and each of these drugs alone for pain after laparoscopic cholecystectomy: a randomized trial. Pain Pract 2015 15 355 63
65. VanMeter SA, Kavanagh ST, Warren S, Barrett RW, Dose response of Gabapentin enacarbil versus placebo in subjects with moderate-To-severe primary restless legs syndrome: an integrated analysis of three 12-week studies. CNS Drugs 2012 26 773 80
66. Chang CY, Challa CK, Shah J, Eloy JD, Gabapentin in acute postoperative pain management. Biomed Res Int 2014 2014 631756
67. 2+ channel alpha2delta subunit. J Neurosci 1997 17 6884 91
68. Stahl SM, Mechanism of action of alpha2delta ligands: voltage sensitive calcium channel (VSCC) modulators. J Clin Psychiatry 2004 65 1033 4
69. Maneuf YP, Hughes J, McKnight AT, Gabapentin inhibits the substance P-facilitated K(+)-Evoked release of [(3)H]glutamate from rat caudial trigeminal nucleus slices. Pain 2001 93 191 6
70. Fehrenbacher JC, Taylor CP, Vasko MR, Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. Pain 2003 105 133 41
71. Dias JM, de Brito TV, de Aguiar Magalhães D, da Silva Santos PW, Batista JA, do Nascimento Dias EG, de Barros Fernandes H, Damasceno SR, Silva RO, Aragão KS, Souza MH, Medeiros JV, Barbosa AL, Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute inflammation and oxidative stress in mice. Inflammation 2014 37 1826 36
72. Mayell A, Srinivasan I, Campbell F, Peliowski A, Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatr Anaesth 2014 24 1239 44
73. Tsai KC, Yang YL, Fan PC, Gabapentin for postoperative vomiting in children requiring posterior fossa tumor resection. Pediatr Neonatol 2015 56 351 4
74. Kazak Z, Meltem Mortimer N, Sekerci S, Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery. Eur Arch Otorhinolaryngol 2010 267 731 6
75. Clarke H, Pereira S, Kennedy D, Andrion J, Mitsakakis N, Gollish J, Katz J, Kay J, Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty. Acta Anaesthesiol Scand 2009 53 1073 83
76. Dauri M, Faria S, Gatti A, Celidonio L, Carpenedo R, Sabato AF, Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. Curr Drug Targets 2009 10 716 33
77. Wu CL, Berenholtz SM, Pronovost PJ, Fleisher LA, Systematic review and analysis of postdischarge symptoms after outpatient surgery. Anesthesiology 2002 96 994 1003
78. Heidari M, Honarmand A, Safavi M, Chitsazi M, Khalighinejad F, Geranisetron versus gabapentin in preventing postoperative nausea and vomiting after middle ear surgery in adults: a double-blinded randomized clinical trial study. Adv Biomed Res 2015 4 22