A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy

Anesthesiology

Volumn 97, Issue 3, 2002, Pages 560-564

  Dirks, Jesper ^a,b   Fredensborg, Birgitte B ^b   Christensen, Dennis ^b   Fomsgaard, Jonna S ^b   Flyger, Henrik ^b   Dahl, Jørgen B ^b  

^a Multidisciplinary Pain Center   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; GABAPENTIN; MORPHINE;

ADULT; AGED; ARTICLE; BODY MOVEMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENMARK; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG USE; FEMALE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MASTECTOMY; NAUSEA; OUTCOMES RESEARCH; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; VERTIGO; VISUAL ANALOG SCALE; VISUAL DISORDER;

ACETIC ACIDS; AGED; AMINES; ANALGESICS; ANALGESICS, OPIOID; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MASTECTOMY; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TREATMENT OUTCOME;

EID: 0036725365     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200209000-00007     Document Type: Article

References (27)

1. Gabapentin for the treatment of postherpetic neuralgia: A randomized controlled trial
2. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial
3. Gabapentin in postherpetic neuralgia: A randomised, double blind, placebo controlled study
4. A summary of mechanistic hypotheses of gabapentin pharmacology
5. Gabapentin in pain management
6. Gabapentin enhances the analgesic effect of morphine in healthy volunteers
7. Effects of gabapentin in acute inflammatory pain in humans
8. Gabapentin suppresses cutaneous hyperalgesia following heat/capsaicin sensitization
9. Preemptive analgesia-treating postoperative pain by preventing the establishment of central sensitization
10. The consort statement: Revised recommendations for improving the quality of reports of parallel-group randomized trials
11. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain
12. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat
13. Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia
14. Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
15. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat
16. Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain
17. Effect of remifentanil on pain and secondary hyperalgesia associated with the heat-capsaicin sensitization model in healthy volunteers
18. Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans
19. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain
20. Use and efficacy of low-dose ketamine in the management. Acute postoperative pain: A review of current techniques and outcomes
21. Effect of preoperative oral dextromethorphan on immediate and late postoperative pain and hyperalgesia after total abdominal hysterectomy
22. Preoperative oral dextromethorphan does not reduce pain or analgesic consumption in children after adeno-tonsillectomy
23. Pregabalin in patients with postoperative dental pain
24. Acute opioid tolerance: Intraoperative remifentanil increases postoperative pain and morphine requirement
25. NMDA and opioid receptors: Their interactions in antinociception, tolerance and neuroplasticity
26. No clinical evidence of acute opioid tolerance after remifentanil-based anaesthesia
27. Mechanism-based pain diagnosis: Issues for analgesic drug development