Effect of preemptive gabapentin on postoperative pain relief and morphine consumption following lumbar laminectomy and discectomy: A randomized, double-blinded, placebo-controlled study

Journal of Neurosurgical Anesthesiology

Volumn 17, Issue 3, 2005, Pages 125-128

  Radhakrishnan, M ^a   Bithal, Parmod K ^a,b   Chaturvedi, Arvind ^a  

^a Neurosciences Centre   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Gabapentin; Lumbar laminectomy; Morphine; Patient controlled analgesia pump; Postoperative pain

Indexed keywords

ADRENALIN; ATROPINE; FENTANYL; GABAPENTIN; GLYCOPYRRONIUM BROMIDE; ISOFLURANE; LIDOCAINE; MORPHINE; NEOSTIGMINE; NITROUS OXIDE; PLACEBO; ROCURONIUM; THIOPENTAL; VECURONIUM;

ADULT; ARTICLE; BOLUS INJECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; GENERAL ANESTHESIA; HEADACHE; HUMAN; INFUSION PUMP; INTERVERTEBRAL DISKECTOMY; LAMINECTOMY; MAJOR CLINICAL STUDY; MALE; NAUSEA; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PERIOD; PREMEDICATION; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RESPIRATION DEPRESSION; SOMNOLENCE; URINE RETENTION; VERBAL RATING SCALE; VOMITING; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; AMINES; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS; ANALGESICS, OPIOID; CYCLOHEXANECARBOXYLIC ACIDS; DISKECTOMY; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; LAMINECTOMY; MALE; MIDDLE AGED; MORPHINE; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES;

EID: 22844452220     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ana.0000167147.90544.ab     Document Type: Article

References (19)

1. Gee NS, Brown JP, Dissanayake VU, et al. The novel anticonvulsant drug, gabapentin, binds to the alpha 2-delta subunit of a calcium channel. J Biol Chem. 1996;271:5768-5776.
2. Mathews EA, Dikenson AH. Combination of gabapentin and morphine mediates enhanced inhibitory effects on dorsal horn neuronal responses in rat model of neuropathy. Anesthesiology. 2002;96:633-640.
3. B agonists and gabapentin on mechanical hyperalgesia in models of neuropathic pain inflammatory pain in the rat. Pain. 2001;90:217-226.
4. Dirks J, Fredensborg BB, Christensen D, et al. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology. 2002;97:560-564.
5. Gress AK, Francis S, Sharpe P, et al. Analgesic effect of gabapentin premedication in laparoscopic cholecystectomy: A randomized double-blind placebo controlled trial. Br J Anaesth. 2001;87:174P.
6. Dierking G, Duedahl TH, Rasmussen ML, et al. Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy. A randomized, double blind trial. Acta Anaesthesiol Scand. 2004;48:322-327.
7. Turan A, Karamanlioglu B, Mustafa KH, et al. Analgesic effects of gabapentin after spinal surgery. Anesthesiology. 2004;100:935-938.
8. Gutton KG, Martin DJ, Pinnock RD. Gabapentin inhibits high threshold calcium channel currents in cultured rat dorsal root ganglion. Br J Pharmacol. 2002;135:257-265.
9. Goa KL, Sorkin EM. Gabapentin: A review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993;46:409-427.
10. Dirks J, Moiniche S, Hilsted KL, et al. Mechanisms of postoperative pain. Clinical indications for a contribution of central neuronal sensitization. Anesthesiology. 2002;97:1591-1596.
11. Field MJ, Holloman EF, Mc Cleary S, et al. Evaluation of gabapentin and S-(+)-3-isobutyl GABA in a rat model of postoperative pain. J Pharmacol Exp Ther. 1997;282:1242-1246.
12. Field MJ, Oles RJ, Lewis AS, et al. Gabapentin and S-(+)-3- isobutylgaba represent a novel class of selective antihyperalgesic agents. J Pharmacol. 1997;121:1513-1522.
13. Welty DF, Schielke GP, Vartanian MG, et al. Gabapentin anticonvulsant action in erativerats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate. Epilepsy Res. 1993;6:175-181.
14. Eckhardt K, Ammon S, Hofman U, et al. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg. 2000;91:185-191.
15. Mads U Wemer, Perkins FM, Holte K. Effects of gabapentin in acute inflammatory pain in humans. Reg Anesth Pain Med. 2001;26:322-328.
16. Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: Intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology. 2000;93:409-417.
17. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response. Anesthesiology. 2000;93:858-875.
18. Bjune K, Stubhaug A, Dodgson MS, et al. Additive analgesic effect of codeine and paracetamol can be detected in strong, but not moderate, pain after caesarean section. Baseline pain-intensity is a determinant of assay-sensitivity in a postoperative analgesic trial. Acta Anaesthesiol Scand. 1996;40:399-407.
19. Kawamata M, Watanabe H, Nishikawa K. Different mechanisms of development and maintenance of experimental incision induced hyperalgesia in human skin. Anesthesiology. 2002;97:550-559.