Multimodal therapies for postoperative nausea and vomiting, and pain

British Journal of Anaesthesia

Volumn 107, Issue SUPPL. 1, 2011, Pages

  Chandrakantan, A ^a   Glass, P S A ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

nausea; pain; postoperative; vomiting

Indexed keywords

ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; APREPITANT; BUPIVACAINE; BUTYROPHENONE DERIVATIVE; CELECOXIB; CLONIDINE; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DEXMEDETOMIDINE; DEXTROMETHORPHAN; FENTANYL; GABAPENTIN; IBUPROFEN; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; KETAMINE; LORAZEPAM; MIDAZOLAM; MORPHINE; NEOSTIGMINE; NITROUS OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; ONDANSETRON; OPIATE; PROPOFOL; SEROTONIN ANTAGONIST; STEROID; TACHYKININ RECEPTOR ANTAGONIST; UNINDEXED DRUG;

ACUPUNCTURE ANALGESIA; ADD ON THERAPY; AMPUTATION; ANXIETY DISORDER; ARTICLE; BREAST SURGERY; CESAREAN SECTION; CHEMORECEPTOR; CHEMORECEPTOR TRIGGER ZONE; CHRONIC PAIN; CONFUSION; CONSTIPATION; CORONARY ARTERY BYPASS GRAFT; DIARRHEA; DISEASE COURSE; DISEASE SEVERITY; DIZZINESS; DROWSINESS; DRUG EFFICACY; DRUG POTENTIATION; DRUG TOLERANCE; DRUG WITHDRAWAL; EPIDURAL ANESTHESIA; EXTRAPYRAMIDAL SYMPTOM; GENERAL ANESTHESIA; GENETIC PREDISPOSITION; HEADACHE; HEALTH CARE COST; HEART ARRHYTHMIA; HERNIOPLASTY; HUMAN; HYPOTENSION; INFLAMMATION; INGUINAL HERNIA; INHALATION ANESTHESIA; INTRAVENOUS ANESTHESIA; MEDICAL HISTORY; META ANALYSIS (TOPIC); MOOD CHANGE; MOTION SICKNESS; MUCOSAL DRYNESS; NERVE BLOCK; NERVOUSNESS; NEURAXIAL ANALGESIA; OPERATION DURATION; PATHOPHYSIOLOGY; PERIPHERAL NERVE; POST DISCHARGE NAUSEA AND VOMITING; POSTOPERATIVE CARE; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PRURITUS; QT PROLONGATION; REGIONAL ANESTHESIA; RISK ASSESSMENT; RISK REDUCTION; SEX DIFFERENCE; SIDE EFFECT; SINGLE DRUG DOSE; SPINAL ANESTHESIA; SURGICAL PATIENT; TACHYCARDIA; THORACOTOMY; TRANSCUTANEOUS NERVE STIMULATION; UNSPECIFIED SIDE EFFECT; URINE RETENTION; WEAKNESS;

EID: 83455236278     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer358     Document Type: Article

References (148)

1. Macario A,Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg 1999; 89: 652-8 (Pubitemid 29409815)
2. Macario A,Weinger M, Truong P, Lee M. Which clinical anesthesia outcomes are both common and important to avoid? The perspective of a panel of expert anesthesiologists. Anesth Analg 1999; 88: 1085-91 (Pubitemid 29211545)
3. Apfel CC, Kranke P, Katz MH, et al. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth 2002; 88: 659-68 (Pubitemid 34498594)
4. Chen HL, Wong CS, Ho ST, Chang FL, Hsu CH, Wu CT. A lethal pulmonary embolism during percutaneous vertebroplasty. Anesth Analg 2002; 95: 1060-2, table of contents
5. Wu CL, Berenholtz SM, Pronovost PJ, Fleisher LA. Systematic review and analysis of postdischarge symptoms after outpatient surgery. Anesthesiology 2002; 96: 994-1003 (Pubitemid 34266696)
6. Visser K, Hassink EA, Bonsel GJ, Moen J, Kalkman CJ. Randomized controlled trial of total intravenous anesthesia with propofol versus inhalation anesthesia with isoflurane-nitrous oxide: postoperative nausea with vomiting and economic analysis. Anesthesiology 2001; 95: 616-26
7. Cohen MM, Duncan PG, DeBoer DP, Tweed WA. The postoperative interview: assessing risk factors for nausea and vomiting. Anesth Analg 1994; 78: 7-16 (Pubitemid 24012595)
8. Apfel CC, Laara E, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 1999; 91: 693-700 (Pubitemid 29418651)
9. Apfel CC, Korttila K, Abdalla M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004; 350: 2441-51
10. Lichtor JL, Glass PS. We're tired of waiting. Anesth Analg 2008; 107: 353-5
11. Gupta A, Wu CL, Elkassabany N, Krug CE, Parker SD, Fleisher LA. Does the routine prophylactic use of antiemetics affect the incidence of postdischarge nausea and vomiting following ambulatory surgery?: A systematic review of randomized controlled trials. Anesthesiology 2003; 99: 488-95 (Pubitemid 36909577)
12. Carroll NV, Miederhoff P, Cox FM, Hirsch JD. Postoperative nausea and vomiting after discharge from outpatient surgery centers. Anesth Analg 1995; 80: 903-9
13. White PF, Sacan O, Nuangchamnong N, Sun T, Eng MR. The relationship between patient risk factors and early versus late postoperative emetic symptoms. Anesth Analg 2008; 107: 459-63
14. Habib AS, Gan TJ. Combination therapy for postoperative nausea and vomiting - A more effective prophylaxis? Ambul Surg 2001; 9: 59-71 (Pubitemid 32651675)
15. Eberhart LH, Morin AM, Bothner U, Georgieff M. Droperidol and 5-HT3-receptor antagonists, alone or in combination, for prophylaxis of postoperative nausea and vomiting. A meta-analysis of randomised controlled trials. Acta Anaesthesiol Scand 2000; 44: 1252-7
16. Gan TJ, Meyer TA, Apfel CC, et al. Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2007; 105: 1615-28, table of contents (Pubitemid 350190555)
17. Bellville JW, Bross ID, Howland WS. Postoperative nausea and vomiting. IV. Factors related to postoperative nausea and vomiting. Anesthesiology 1960; 21: 186-93
18. Palazzo M, Evans R. Logistic regression analysis of fixed patient factors for postoperative sickness: a model for risk assessment. Br J Anaesth 1993; 70: 135-40 (Pubitemid 23042083)
19. Gan TJ. Risk factors for postoperative nausea and vomiting. Anesth Analg 2006; 102: 1884-98 (Pubitemid 43799873)
20. Sinclair DR, Chung F, Mezei G. Can postoperative nausea and vomiting be predicted? Anesthesiology 1999; 91: 109-18 (Pubitemid 29307343)
21. Janicki PK, Vealey R, Liu J, Escajeda J, Postula M, Welker K. Genome-wide association study using pooled DNA to identify candidate markers mediating susceptibility to postoperative nausea and vomiting. Anesthesiology 2011; 115: 54-64
22. Koivuranta M, Laara E, Snare L, Alahuhta S. A survey of postoperative nausea and vomiting. Anaesthesia 1997; 52: 443-9 (Pubitemid 27214151)
23. Tramer MR, Fuchs-Buder T. Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic review. Br J Anaesth 1999; 82: 379-86 (Pubitemid 29112540)
24. Sukhani R, Vazquez J, Pappas AL, Frey K, Aasen M, Slogoff S. Recovery after propofol with and without intraoperative fentanyl in patients undergoing ambulatory gynecologic laparoscopy. Anesth Analg 1996; 83: 975-81 (Pubitemid 26365408)
25. Moiniche S, Romsing J, Dahl JB, Tramer MR. Nonsteroidal antiinflammatory drugs and the risk of operative site bleeding after tonsillectomy: a quantitative systematic review. Anesth Analg 2003; 96: 68-77, table of contents (Pubitemid 36050041)
26. Polati E, Verlato G, Finco G, et al. Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. Anesth Analg 1997; 85: 395-9 (Pubitemid 27349153)
27. Gan TJ, Joshi GP, Viscusi E, et al. Preoperative parenteral parecoxib and follow-up oral valdecoxib reduce length of stay and improve quality of patient recovery after laparoscopic cholecystectomy surgery. Anesth Analg 2004; 98: 1665-73, table of contents (Pubitemid 38668912)
28. Roberts GW, Bekker TB, Carlsen HH, Moffatt CH, Slattery PJ, McClure AF. Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner. Anesth Analg 2005; 101: 1343-8 (Pubitemid 41531869)
29. Habib AS, White WD, Eubanks S, Pappas TN, Gan TJ. A randomized comparison of a multimodal management strategy versus combination antiemetics for the prevention of postoperative nausea and vomiting. Anesth Analg 2004; 99: 77-81 (Pubitemid 38808168)
30. Van den Bosch JE, Moons KG, Bonsel GJ, Kalkman CJ. Does measurement of preoperative anxiety have added value for predicting postoperative nausea and vomiting? Anesth Analg 2005; 100: 1525-32, table of contents
31. Eberhart LH, Geldner G, Kranke P, et al. The development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. Anesth Analg 2004; 99: 1630-7, table of contents (Pubitemid 39551894)
32. Honkavaara P. Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia. Br J Anaesth 1996; 76: 316-8 (Pubitemid 26043470)
33. Liu K, Hsu CC, Chia YY. The effect of dose of dexamethasone for antiemesis after major gynecological surgery. Anesth Analg 1999; 89: 1316-8 (Pubitemid 29521963)
34. Henzi I, Sonderegger J, Tramer MR. Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting. Can J Anaesth 2000; 47: 537-51
35. White PF. Prevention of postoperative nausea and vomiting - A multimodal solution to a persistent problem. N Engl J Med 2004; 350: 2511-2 (Pubitemid 38736549)
36. Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg 2008; 106: 1407-9, table of contents (Pubitemid 351571068)
37. Fujii Y, Itakura M. A prospective, randomized, double-blind, placebo-controlled study to assess the antiemetic effects of midazolam on postoperative nausea and vomiting in women undergoing laparoscopic gynecologic surgery. Clin Ther 2005; 32: 1633-7
38. Jung JS, Park JS, Kim SO, et al. Prophylactic antiemetic effect of midazolam after middle ear surgery. Otolaryngol Head Neck Surg 2007; 137: 753-6 (Pubitemid 47632931)
39. Gomez-Hernandez J, Orozco-Alatorre AL, Dominguez- Contreras M, et al. Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer. BMC Cancer 2010; 10: 692
40. Diemunsch P, Gan TJ, Philip BK, et al. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind phase III trial in patients undergoing open abdominal surgery. Br J Anaesth 2007; 99: 202-11 (Pubitemid 47260214)
41. Gan TJ, Apfel CC, Kovac A, et al. A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesth Analg 2007; 104: 1082-9, table of contents (Pubitemid 46649925)
42. Jensen K, Kehlet H, Lund CM. Post-operative recovery profile after laparoscopic cholecystectomy: a prospective, observational study of a multimodal anaesthetic regime. Acta Anaesthesiol Scand 2007; 51: 464-71 (Pubitemid 46425725)
43. Scuderi PE, James RL, Harris L, Mims GR III. Multimodal antiemetic management prevents early postoperative vomiting after outpatient laparoscopy. Anesth Analg 2000; 91: 1408-14
44. Yogendran S, Asokumar B, Cheng DC, Chung F. A prospective randomized double-blinded study of the effect of intravenous fluid therapy on adverse outcomes on outpatient surgery. Anesth Analg 1995; 80: 682-6
45. Chaudhary S, Sethi AK, Motiani P, Adatia C. Pre-operative intravenous fluid therapy with crystalloids or colloids on postoperative nausea & vomiting. Indian J Med Res 2008; 127: 577-81
46. Haentjens LL, Ghoundiwal D, Touhiri K, et al. Does infusion of colloid influence the occurrence of postoperative nausea and vomiting after elective surgery in women? Anesth Analg 2009; 108: 1788-93
47. Borgeat A, Ekatodramis G, Schenker CA. Postoperative nausea and vomiting in regional anesthesia: a review. Anesthesiology 2003; 98: 530-47 (Pubitemid 36592823)
48. Joo HS, Perks WJ. Sevoflurane versus propofol for anesthetic induction: a meta-analysis. Anesth Analg 2000; 91: 213-9 (Pubitemid 30437089)
49. Gan TJ, Glass PS, Howell ST, Canada AT, Grant AP, Ginsberg B. Determination of plasma concentrations of propofol associated with 50% reduction in postoperative nausea. Anesthesiology 1997; 87: 779-84 (Pubitemid 27456229)
50. Dershwitz M, Michalowski P, Chang Y, Rosow CE, Conlay LA. Postoperative nausea and vomiting after total intravenous anesthesia with propofol and remifentanil or alfentanil: how important is the opioid? J Clin Anesth 2002; 14: 275-8 (Pubitemid 34667245)
51. Shende D, Das K. Comparative effects of intravenous ketorolac and pethidine on perioperative analgesia and postoperative nausea and vomiting (PONV) for paediatric strabismus surgery. Acta Anaesthesiol Scand 1999; 43: 265-9 (Pubitemid 29109471)
52. Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 2005; 102: 1249-60 (Pubitemid 40745845)
53. Salman MA, Yucebas ME, Coskun F, Aypar U. Day-case laparoscopy: a comparison of prophylactic opioid, NSAID or local anesthesia for postoperative analgesia. Acta Anaesthesiol Scand 2000; 44: 536-42 (Pubitemid 30233016)
54. Camu F, Beecher T, Recker DP, Verburg KM. Valdecoxib, a COX-2- specific inhibitor, is an efficacious, opioid-sparing analgesic in patients undergoing hip arthroplasty. Am J Ther 2002; 9: 43-51
55. Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. Anesth Analg 2004; 99: 482-95, table of contents (Pubitemid 38970424)
56. Bell RF, Dahl JB, Moore RA, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev 2006; CD004603
57. Cheng CR, Sessler DI, Apfel CC. Does neostigmine administration produce a clinically important increase in postoperative nausea and vomiting? Anesth Analg 2005; 101: 1349-55 (Pubitemid 41531870)
58. Kranke P, Schuster F, Eberhart LH. Recent advances, trends and economic considerations in the risk assessment, prevention and treatment of postoperative nausea and vomiting. Expert Opin Pharmacother 2007; 8: 3217-35
59. McKenzie R, Uy NT, Riley TJ, Hamilton DL. Droperidol/ondansetron combination controls nausea and vomiting after tubal banding. Anesth Analg 1996; 83: 1218-22 (Pubitemid 26418807)
60. Riley TJ, McKenzie R, Trantisira BR, Hamilton DL. Droperidol- ondansetron combination versus droperidol alone for postoperative control of emesis after total abdominal hysterectomy. J Clin Anesth 1998; 10: 6-12 (Pubitemid 28115011)
61. Hache JJ, Vallejo MC, Waters JH, Williams BA. Aprepitant in a multimodal approach for prevention of postoperative nausea and vomiting in high-risk patients: is there such a thing as 'too many modalities'? ScientificWorldJournal 2009; 9: 291-9
62. Glass PS, White PF. Practice guidelines for the management of postoperative nausea and vomiting: past, present, and future. Anesth Analg 2007; 105: 1528-9 (Pubitemid 350190538)
63. Fan CF, Tanhui E, Joshi S, Trivedi S, Hong Y, Shevde K. Acupressure treatment for prevention of postoperative nausea and vomiting. Anesth Analg 1997; 84: 821-5 (Pubitemid 27147709)
64. Zarate E, Mingus M, White PF, et al. The use of transcutaneous acupoint electrical stimulation for preventing nausea and vomiting after laparoscopic surgery. Anesth Analg 2001; 92: 629-35 (Pubitemid 32185102)
65. Helmreich RJ, Shiao SY, Dune LS. Meta-analysis of acustimulation effects on nausea and vomiting in pregnant women. Explore (NY) 2006; 2: 412-21 (Pubitemid 44341146)
66. White PF, Issioui T, Hu J, et al. Comparative efficacy of acustimulation (ReliefBand) versus ondansetron (Zofran) in combination with droperidol for preventing nausea and vomiting. Anesthesiology 2002; 97: 1075-81 (Pubitemid 35265558)
67. Streitberger K, Diefenbacher M, Bauer A, et al. Acupuncture compared to placebo-acupuncture for postoperative nausea and vomiting prophylaxis: a randomised placebo-controlled patient and observer blind trial. Anaesthesia 2004; 59: 142-9 (Pubitemid 38190266)
68. Rawal N, Hylander J, Nydahl PA, Olofsson I, Gupta A. Survey of postoperative analgesia following ambulatory surgery. Acta Anaesthesiol Scand 1997; 41: 1017-22 (Pubitemid 27414744)
69. Rathmell JP, Wu CL, Sinatra RS, et al. Acute post-surgical pain management: a critical appraisal of current practice, December 2-4, 2005. Reg Anesth Pain Med 2006; 31(4 Suppl. 1): 1-42 (Pubitemid 44061639)
70. Beauregard L, Pomp A, Choiniere M. Severity and impact of pain after day-surgery. Can J Anaesth 1998; 45: 304-11 (Pubitemid 28255306)
71. Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology 2000; 93: 1123-33
72. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006; 367: 1618-25 (Pubitemid 43674227)
73. Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992; 77: 162-84
74. Chung F. Recovery pattern and home-readiness after ambulatory surgery. Anesth Analg 1995; 80: 896-902
75. Kehlet H, Dahl JB. The value of 'multimodal' or 'balanced analgesia' in postoperative pain treatment. Anesth Analg 1993; 77: 1048-56 (Pubitemid 23319808)
76. Eriksson H, Tenhunen A, Korttila K. Balanced analgesia improves recovery and outcome after outpatient tubal ligation. Acta Anaesthesiol Scand 1996; 40: 151-5 (Pubitemid 26063247)
77. Dahl JB, Kehlet H. Non-steroidal anti-inflammatory drugs: rationale for use in severe postoperative pain. Br J Anaesth 1991; 66: 703-12
78. Blackburn A, Stevens JD, Wheatley RG, Madej TH, Hunter D. Balanced analgesia with intravenous ketorolac and patientcontrolled morphine following lower abdominal surgery. J Clin Anesth 1995; 7: 103-8
79. Chan A, Dore CJ, Ramachandra V. Analgesia for day surgery. Evaluation of the effect of diclofenac given before or after surgery with or without bupivacaine infiltration. Anaesthesia 1996; 51: 592-5
80. Sutters KA, Levine JD, Dibble S, Savedra M, Miaskowski C. Analgesic efficacy and safety of single-dose intramuscular ketorolac for postoperative pain management in children following tonsillectomy. Pain 1995; 61: 145-53
81. Nikolajsen L, Sorensen HC, Jensen TS, Kehlet H. Chronic pain following Caesarean section. Acta Anaesthesiol Scand 2004; 48: 111-6 (Pubitemid 38058149)
82. Caumo W, Schmidt AP, Schneider CN, et al. Preoperative predictors of moderate to intense acute postoperative pain in patients undergoing abdominal surgery. Acta Anaesthesiol Scand 2002; 46: 1265-71 (Pubitemid 35341896)
83. Katz J, Poleshuck EL, Andrus CH, et al. Risk factors for acute pain and its persistence following breast cancer surgery. Pain 2005; 119: 16-25 (Pubitemid 41752961)
84. Caumo W, Hidalgo MP, Schmidt AP, et al. Effect of pre-operative anxiolysis on postoperative pain response in patients undergoing total abdominal hysterectomy. Anaesthesia 2002; 57: 740-6
85. Kain ZN, Sevarino FB, Rinder C, et al. Preoperative anxiolysis and postoperative recovery in women undergoing abdominal hysterectomy. Anesthesiology 2001; 94: 415-22 (Pubitemid 32198447)
86. Ciccozzi A, Marinangeli F, Colangeli A, et al. Anxiolysis and postoperative pain in patients undergoing spinal anesthesia for abdominal hysterectomy. Minerva Anestesiol 2007; 73: 387-93 (Pubitemid 47249575)
87. Bauer KP, Dom PM, Ramirez AM, O'Flaherty JE. Preoperative intravenous midazolam: benefits beyond anxiolysis. J Clin Anesth 2004; 16: 177-83 (Pubitemid 38813265)
88. Stamer UM, Stuber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol 2007; 20: 478-84 (Pubitemid 47415138)
89. Mitra S, Sinatra RS. Perioperative management of acute pain in the opioid-dependent patient. Anesthesiology 2004; 101: 212-27 (Pubitemid 38833284)
90. Kalkman CJ, Visser K, Moen J, Bonsel GJ, Grobbee DE, Moons KG. Preoperative prediction of severe postoperative pain. Pain 2003; 105: 415-23 (Pubitemid 37186904)
91. Rosaeg OP, Lui AC, Cicutti NJ, Bragg PR, Crossan ML, Krepski B. Peri-operative multimodal pain therapy for caesarean section: analgesia and fitness for discharge. Can J Anaesth 1997; 44: 803-9 (Pubitemid 27479112)
92. Fassoulaki A, Triga A, Melemeni A, Sarantopoulos C. Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg 2005; 101: 1427-32 (Pubitemid 41531883)
93. Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci 2009; 32: 1-32
94. Staud R, Craggs JG, Robinson ME, Perlstein WM, Price DD. Brain activity related to temporal summation of C-fiber evoked pain. Pain 2007; 129: 130-42 (Pubitemid 46551377)
95. Labrakakis C, Ferrini F, Koninck Y. Mechanisms of plasticity of inhibition in chronic pain conditions. In: Woodin MA, Maffei A, eds. Inhibitory Synaptic Plasticity. New York: Springer, 2011; 91-105
96. Dworkin RH, Backonja M, Rowbotham MC, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol 2003; 60: 1524-34 (Pubitemid 37443116)
97. Pogatzki-Zahn EM, Zahn PK. From preemptive to preventive analgesia. Curr Opin Anaesthesiol 2006; 19: 551-5 (Pubitemid 44386060)
98. Katz J, McCartney CJ. Current status of preemptive analgesia. Curr Opin Anaesthesiol 2002; 15: 435-41
99. Capdevila X, Barthelet Y, Biboulet P, Ryckwaert Y, Rubenovitch J, d'Athis F. Effects of perioperative analgesic technique on the surgical outcome and duration of rehabilitation after major knee surgery. Anesthesiology 1999; 91: 8-15 (Pubitemid 29307331)
100. Barratt SM, Smith RC, Kee AJ, Mather LE, Cousins MJ. Multimodal analgesia and intravenous nutrition preserves total body protein following major upper gastrointestinal surgery. Reg Anesth Pain Med 2002; 27: 15-22 (Pubitemid 34093275)
101. White PF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 2005; 101(5 Suppl.): S5-22
102. Oderda GM, Evans RS, Lloyd J, et al. Cost of opioid-related adverse drug events in surgical patients. J Pain Symptom Manage 2003; 25: 276-83 (Pubitemid 36287086)
103. Gupta K, Kshirsagar S, Chang L, et al. Morphine stimulates angiogenesis by activating proangiogenic and survivalpromoting signaling and promotes breast tumor growth. Cancer Res 2002; 62: 4491-8 (Pubitemid 34827313)
104. Singleton PA, Moss J. Effect of perioperative opioids on cancer recurrence: a hypothesis. Future Oncol 2010; 6: 1237-42
105. Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology 2008; 109: 180-7
106. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology 2006; 105: 660-4
107. Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 2005; 103: 1296-304 (Pubitemid 41692514)
108. Marret E, Flahault A, Samama CM, Bonnet F. Effects of postoperative, nonsteroidal, antiinflammatory drugs on bleeding risk after tonsillectomy: meta-analysis of randomized, controlled trials. Anesthesiology 2003; 98: 1497-502 (Pubitemid 36622488)
109. Romsing J, Moiniche S. A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain. Acta Anaesthesiol Scand 2004; 48: 525-46 (Pubitemid 38649583)
110. White PF, Kehlet H, Liu S. Perioperative analgesia: what do we still know? Anesth Analg 2009; 108: 1364-7
111. Nussmeier NA, Whelton AA, Brown MT, et al. Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery. Anesthesiology 2006; 104: 518-26
112. White PF, Tang J, Wender RH, et al. The effects of oral ibuprofen and celecoxib in preventing pain, improving recovery outcomes and patient satisfaction after ambulatory surgery. Anesth Analg 2010; 112: 323-9
113. Menigaux C, Guignard B, Fletcher D, Sessler DI, Dupont X, Chauvin M. Intraoperative small-dose ketamine enhances analgesia after outpatient knee arthroscopy. Anesth Analg 2001; 93: 606-12 (Pubitemid 32783283)
114. Lavand'homme P, De Kock M, Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. Anesthesiology 2005; 103: 813-20 (Pubitemid 41415530)
115. Chia YY, Liu K, Liu YC, Chang HC, Wong CS. Adding ketamine in a multimodal patient-controlled epidural regimen reduces postoperative pain and analgesic consumption. Anesth Analg 1998; 86: 1245-9 (Pubitemid 28249245)
116. Hocking G, Cousins MJ. Ketamine in chronic pain management: an evidence-based review. Anesth Analg 2003; 97: 1730-9 (Pubitemid 37475130)
117. Seib RK, Paul JE. Preoperative gabapentin for postoperative analgesia: a meta-analysis. Can J Anaesth 2006; 53: 461-9 (Pubitemid 44018359)
118. Kong VK, Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth 2007; 99: 775-86 (Pubitemid 351773386)
119. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 2002; 97: 560-4 (Pubitemid 34977313)
120. Clarke H, Pereira S, Kennedy D, et al. Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty. Acta Anaesthesiol Scand 2009; 53: 1073-83
121. Nikolajsen L, Finnerup NB, Kramp S, Vimtrup AS, Keller J, Jensen TS. A randomized study of the effects of gabapentin on postamputation pain. Anesthesiology 2006; 105: 1008-15 (Pubitemid 44655513)
122. Buvanendran A, Kroin JS, Della Valle CJ, Kari M, Moric M, Tuman KJ. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg 2010; 110: 199-207
123. Amr YM, Yousef AA. Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain 2010; 26: 381-5
124. Lin TF, Yeh YC, Lin FS, et al. Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia. Br J Anaesth 2009; 102: 117-22
125. Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg 2004; 98: 153-8, table of contents (Pubitemid 38029869)
126. Tufanogullari B, White PF, Peixoto MP, et al. Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables. Anesth Analg 2008; 106: 1741-8
127. Jeffs SA, Hall JE, Morris S. Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia. Br J Anaesth 2002; 89: 424-7 (Pubitemid 34993971)
128. Striebel WH, Koenigs DI, Kramer JA. Intravenous clonidine fails to reduce postoperative meperidine requirements. J Clin Anesth 1993; 5: 221-5 (Pubitemid 23171957)
129. Jahangiri M, Jayatunga AP, Bradley JW, Dark CH. Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine. Ann R Coll Surg Engl 1994; 76: 324-6 (Pubitemid 24268520)
130. Michaloliakou C, Chung F, Sharma S. Preoperative multimodal analgesia facilitates recovery after ambulatory laparoscopic cholecystectomy. Anesth Analg 1996; 82: 44-51 (Pubitemid 26017380)
131. Bisgaard T, Klarskov B, Kristiansen VB, et al. Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: a randomized, double-blinded, placebo-controlled study. Anesth Analg 1999; 89: 1017-24 (Pubitemid 29458484)
132. Klein SM, Nielsen KC, Greengrass RA, Warner DS, Martin A, Steele SM. Ambulatory discharge after long-acting peripheral nerve blockade: 2382 blocks with ropivacaine. Anesth Analg 2002; 94: 65-70, table of contents (Pubitemid 34038720)
133. Capdevila X, Pirat P, Bringuier S, et al. Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients. Anesthesiology 2005; 103: 1035-45 (Pubitemid 41552059)
134. McCartney CJ, Duggan E, Apatu E. Should we add clonidine to local anesthetic for peripheral nerve blockade? A qualitative systematic review of the literature. Reg Anesth Pain Med 2007; 32: 330-8 (Pubitemid 47285747)
135. Rodgers A, Walker N, Schug S, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. Br Med J 2000; 321: 1493
136. Brodner G, Van Aken H, Hertle L, et al. Multimodal perioperative management-combining thoracic epidural analgesia, forced mobilization, and oral nutrition-reduces hormonal and metabolic stress and improves convalescence after major urologic surgery. Anesth Analg 2001; 92: 1594-600 (Pubitemid 32493190)
137. Senturk M, Ozcan PE, Talu GK, et al. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg 2002; 94: 11-5, table of contents (Pubitemid 34038711)
138. Jensen MK, Andersen C. Can chronic poststernotomy pain after cardiac valve replacement be reduced using thoracic epidural analgesia? Acta Anaesthesiol Scand 2004; 48: 871-4 (Pubitemid 38993102)
139. Brandsborg B, Nikolajsen L, Hansen CT, Kehlet H, Jensen TS. Risk factors for chronic pain after hysterectomy: a nationwide questionnaire and database study. Anesthesiology 2007; 106: 1003-12 (Pubitemid 46684068)
140. Chan MT, Wan AC, Gin T, Leslie K, Myles PS. Chronic postsurgical pain after nitrous oxide anesthesia. Pain 2011; 152: 2514-20
141. Paech MJ, Pavy TJ, Orlikowski CE, Lim W, Evans SF. Postoperative epidural infusion: a randomized, double-blind, dose-finding trial of clonidine in combination with bupivacaine and fentanyl. Anesth Analg 1997; 84: 1323-8 (Pubitemid 27250479)
142. Wallet F, Clement HJ, Bouret C, et al. Effects of a continuous low-dose clonidine epidural regimen on pain, satisfaction and adverse events during labour: a randomized, double-blind, placebo-controlled trial. Eur J Anaesthesiol 2010; 27: 441-7
143. Curatolo M, Schnider TW, Petersen-Felix S, et al. A direct search procedure to optimize combinations of epidural bupivacaine, fentanyl, and clonidine for postoperative analgesia. Anesthesiology 2000; 92: 325-37 (Pubitemid 30078328)
144. Bjordal JM, Johnson MI, Ljunggreen AE. Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption. A meta-analysis with assessment of optimal treatment parameters for postoperative pain. Eur J Pain 2003; 7: 181-8 (Pubitemid 36330536)
145. Fountas KN, Kapsalaki EZ, Johnston KW, Smisson HF III, Vogel RL, Robinson JS Jr. Postoperative lumbar microdiscectomy pain. Minimalization by irrigation and cooling. Spine (Phila Pa 1976) 1999; 24: 1958-60 (Pubitemid 29449316)
146. Werner MU, Duun P, Kehlet H. Prediction of postoperative pain by preoperative nociceptive responses to heat stimulation. Anesthesiology 2004; 100: 115-9, discussion 115A (Pubitemid 38031662)
147. Maletic V, Raison CL. Neurobiology of depression, fibromyalgia and neuropathic pain. Front Biosc 2009; 14: 5291-338
148. Costigan M, Woolf CJ. Pain: molecular mechanisms. J Pain 2000; 1(Suppl. 1): 35-44