Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: A randomized, double-blind, placebo-controlled study

Journal of Neurosurgical Anesthesiology

Volumn 17, Issue 2, 2005, Pages 65-68

  Pandey, Chandra Kant ^a   Navkar, Deepa Vishwas ^a   Giri, Pramod Janardan ^a   Raza, Mehdi ^a   Behari, Sanjay ^a   Singh, R B ^a   Singh, Uttam ^a   Singh, Prabhat Kumar ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Diskectomy; Gabapentin; Optimal dose; Preemptive analgesia

Indexed keywords

ATROPINE; FENTANYL; GABAPENTIN; LIDOCAINE; LORAZEPAM; NEOSTIGMINE; NITROUS OXIDE; OXYGEN; PLACEBO; PROPOFOL; VECURONIUM;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; ATAXIA; CLINICAL TRIAL; CONCENTRATION LOSS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG UTILIZATION; EVALUATION; FEMALE; HEADACHE; HUMAN; INTERVERTEBRAL DISKECTOMY; LUMBAR DISK; MAJOR CLINICAL STUDY; MALE; NAUSEA; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SCORING SYSTEM; SOMNOLENCE; VERTIGO; VISUAL ANALOG SCALE; VOMITING;

ADULT; AMINES; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS; ANALGESICS, OPIOID; BODY WEIGHT; CYCLOHEXANECARBOXYLIC ACIDS; DISKECTOMY; DOUBLE-BLIND METHOD; FEMALE; FENTANYL; GAMMA-AMINOBUTYRIC ACID; HUMANS; LUMBAR VERTEBRAE; MALE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POSTOPERATIVE NAUSEA AND VOMITING;

EID: 18044389511     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ana.0000151407.62650.51     Document Type: Article

References (16)

1. Dirks J, Fredensborg BB, Christensen D, et al. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology. 2002;97:560-564.
2. Mao J, Chen LL. Gabapentin in pain management. Anesth Analg. 2000; 91:680-687.
3. Field MJ, Holloman EF, McCleary S, et al. Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain. J Pharmacol Exp Ther. 1997;282:1242-1246.
4. Dirks J, Petersen KL, Rowbotham MC, et al. Gabapentin suppresses cutaneous hyperalgesia following heat/capsaicin sensitization. Anesthesiology. 2002;97:102-106.
5. Petersen KL, Jones B, Segredo V, et al. Effect of ramifentanil on pain and secondary hyperalgesia associated with the heat-capsaicin sensitization model in healthy volunteers. Anesthesiology. 2001;94:15-20.
6. Goa KL, Sorkin EM. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993;46:409-427.
7. Taylor CP, Gee NS, Su TZ, et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 1998;29:233-249.
8. 2δ subunits of calcium channel. J Biol Chem. 1996;271:5768-5776.
9. Fassoulaki A, Patris K, Sarantopoulos C, et al. The analgesic effect of gabapentin and mexilentine after breast surgery for cancer. Anesth Analg. 2002;95:985-991.
10. Rorarius MG, Mennander S, Suominen P, et al. Gabapentin for the prevention of postoperative pain after vaginal hysterectomy. Pain. 2004;110:175-181.
11. Dierking G, Duedahl TH, Rasmussen ML, et al. Effect of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. Acta Anaesthesiol Scand. 2004;48:322-327.
12. Turan A, Memis D, Karamanhoglu B, et al. The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesth Analg. 2004;99:375-378.
13. Turan A, Karamanhoglu B, Memis D, et al. The analgesic effects of gabapentin after total abdominal hysterectomy. Anesth Analg. 2004;98:1370-1373.
14. Turan A, Karamanhoglu B, Memis D, et al. Analgesic effects of gabapentin after spinal surgery. Anesthesiology. 2004;100:935-938.
15. Pandey CK, Priye S, Singh S, et al. Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can J Anesth. 2004;51:358-363.
16. Eckhardt K, Ammon S, Hofmann U, et al. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg. 2000;91:185-191.