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Volumn 14, Issue , 2016, Pages 97-105

Sharpening Precision Medicine by a Thorough Interrogation of Metabolic Individuality

Author keywords

Diagnostics; Genome Wide Association Study; Inborn Errors of Metabolism; Mass Spectrometry; Metabolomics; Precision Medicine; Untargeted Analysis

Indexed keywords

BIOMOLECULES; CHROMOSOMES; DRUG PRODUCTS; HEALTH; MASS SPECTROMETRY; MEDICINE; METABOLISM; METABOLITES; PLASMA DIAGNOSTICS;

EID: 84961721005     PISSN: None     EISSN: 20010370     Source Type: Journal    
DOI: 10.1016/j.csbj.2016.01.001     Document Type: Review
Times cited : (35)

References (68)
  • 3
    • 84871391969 scopus 로고    scopus 로고
    • Promise of personalized omics to precision medicine
    • R. Chen, and M. Snyder Promise of personalized omics to precision medicine Wiley Interdiscip Rev Syst Biol Med 5 2013 73 82
    • (2013) Wiley Interdiscip Rev Syst Biol Med , vol.5 , pp. 73-82
    • Chen, R.1    Snyder, M.2
  • 4
    • 84864806354 scopus 로고    scopus 로고
    • Quantifying your body: A how-to guide from a systems biology perspective
    • L. Smarr Quantifying your body: a how-to guide from a systems biology perspective Biotechnol J 7 2012 980 991
    • (2012) Biotechnol J , vol.7 , pp. 980-991
    • Smarr, L.1
  • 5
    • 84864818817 scopus 로고    scopus 로고
    • Revolutionizing medicine in the 21st century through systems approaches
    • L. Hood, R. Balling, and C. Auffray Revolutionizing medicine in the 21st century through systems approaches Biotechnol J 7 2012 992 1001
    • (2012) Biotechnol J , vol.7 , pp. 992-1001
    • Hood, L.1    Balling, R.2    Auffray, C.3
  • 6
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • R. Chen, G.I. Mias, J. Li-Pook-Than, L. Jiang, H.Y. Lam, and et al. Personal omics profiling reveals dynamic molecular and medical phenotypes Cell 148 2012 1293 1307
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1    Mias, G.I.2    Li-Pook-Than, J.3    Jiang, L.4    Lam, H.Y.5
  • 7
    • 84897136781 scopus 로고    scopus 로고
    • Individualized medicine from prewomb to tomb
    • E.J. Topol Individualized medicine from prewomb to tomb Cell 157 2014 241 253
    • (2014) Cell , vol.157 , pp. 241-253
    • Topol, E.J.1
  • 8
    • 84884905922 scopus 로고    scopus 로고
    • Where genotype is not predictive of phenotype: Towards an understanding of the molecular basis of reduced penetrance in human inherited disease
    • D.N. Cooper, M. Krawczak, C. Polychronakos, C. Tyler-Smith, and H. Kehrer-Sawatzki Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease Hum Genet 132 2013 1077 1130
    • (2013) Hum Genet , vol.132 , pp. 1077-1130
    • Cooper, D.N.1    Krawczak, M.2    Polychronakos, C.3    Tyler-Smith, C.4    Kehrer-Sawatzki, H.5
  • 9
    • 84902440699 scopus 로고    scopus 로고
    • Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster
    • L.K. Reed, K. Lee, Z. Zhang, L. Rashid, A. Poe, and et al. Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster Genetics 197 2014 781 793
    • (2014) Genetics , vol.197 , pp. 781-793
    • Reed, L.K.1    Lee, K.2    Zhang, Z.3    Rashid, L.4    Poe, A.5
  • 10
    • 84942898373 scopus 로고    scopus 로고
    • Greenlandic Inuit show genetic signatures of diet and climate adaptation
    • M. Fumagalli, I. Moltke, N. Grarup, F. Racimo, P. Bjerregaard, and et al. Greenlandic Inuit show genetic signatures of diet and climate adaptation Science 349 2015 1343 1347
    • (2015) Science , vol.349 , pp. 1343-1347
    • Fumagalli, M.1    Moltke, I.2    Grarup, N.3    Racimo, F.4    Bjerregaard, P.5
  • 11
    • 84896769549 scopus 로고    scopus 로고
    • Clinical interpretation and implications of whole-genome sequencing
    • F.E. Dewey, M.E. Grove, C. Pan, B.A. Goldstein, J.A. Bernstein, and et al. Clinical interpretation and implications of whole-genome sequencing JAMA 311 2014 1035 1045
    • (2014) JAMA , vol.311 , pp. 1035-1045
    • Dewey, F.E.1    Grove, M.E.2    Pan, C.3    Goldstein, B.A.4    Bernstein, J.A.5
  • 12
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • An integrated encyclopedia of DNA elements in the human genome Nature 489 2012 57 74
    • (2012) Nature , vol.489 , pp. 57-74
  • 13
    • 84896797913 scopus 로고    scopus 로고
    • Clinical application of whole-genome sequencing: Proceed with care
    • W.G. Feero Clinical application of whole-genome sequencing: proceed with care JAMA 311 2014 1017 1019
    • (2014) JAMA , vol.311 , pp. 1017-1019
    • Feero, W.G.1
  • 14
    • 84872156123 scopus 로고    scopus 로고
    • Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
    • B.W. Parks, E. Nam, E. Org, E. Kostem, F. Norheim, and et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice Cell Metab 17 2013 141 152
    • (2013) Cell Metab , vol.17 , pp. 141-152
    • Parks, B.W.1    Nam, E.2    Org, E.3    Kostem, E.4    Norheim, F.5
  • 15
    • 84894075861 scopus 로고    scopus 로고
    • Understanding the apothecaries within: The necessity of a systematic approach for defining the chemical output of the human microbiome
    • K. Beebe, B. Sampey, S.M. Watkins, M. Milburn, and A.D. Eckhart Understanding the apothecaries within: the necessity of a systematic approach for defining the chemical output of the human microbiome Clin Transl Sci 7 2014 74 81
    • (2014) Clin Transl Sci , vol.7 , pp. 74-81
    • Beebe, K.1    Sampey, B.2    Watkins, S.M.3    Milburn, M.4    Eckhart, A.D.5
  • 16
    • 84897139220 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheritance: Myths and mechanisms
    • E. Heard, and R.A. Martienssen Transgenerational epigenetic inheritance: myths and mechanisms Cell 157 2014 95 109
    • (2014) Cell , vol.157 , pp. 95-109
    • Heard, E.1    Martienssen, R.A.2
  • 17
    • 84902523677 scopus 로고    scopus 로고
    • The emergent role of metabolic phenotyping in dynamic patient stratification
    • J.C. Lindon, and J.K. Nicholson The emergent role of metabolic phenotyping in dynamic patient stratification Expert Opin Drug Metab Toxicol 10 2014 915 919
    • (2014) Expert Opin Drug Metab Toxicol , vol.10 , pp. 915-919
    • Lindon, J.C.1    Nicholson, J.K.2
  • 18
    • 33750719994 scopus 로고    scopus 로고
    • Global systems biology, personalized medicine and molecular epidemiology
    • J.K. Nicholson Global systems biology, personalized medicine and molecular epidemiology Mol Syst Biol 2 2006 52
    • (2006) Mol Syst Biol , vol.2 , pp. 52
    • Nicholson, J.K.1
  • 19
    • 80052398214 scopus 로고    scopus 로고
    • Human metabolic individuality in biomedical and pharmaceutical research
    • K. Suhre, S.Y. Shin, A.K. Petersen, R.P. Mohney, D. Meredith, and et al. Human metabolic individuality in biomedical and pharmaceutical research Nature 477 2011 54 60
    • (2011) Nature , vol.477 , pp. 54-60
    • Suhre, K.1    Shin, S.Y.2    Petersen, A.K.3    Mohney, R.P.4    Meredith, D.5
  • 21
    • 84946780102 scopus 로고    scopus 로고
    • Improved drug therapy: Triangulating phenomics with genomics and metabolomics
    • A.A. Monte, C. Brocker, D.W. Nebert, F.J. Gonzalez, D.C. Thompson, and et al. Improved drug therapy: triangulating phenomics with genomics and metabolomics Hum Genomics 8 2014 16
    • (2014) Hum Genomics , vol.8 , pp. 16
    • Monte, A.A.1    Brocker, C.2    Nebert, D.W.3    Gonzalez, F.J.4    Thompson, D.C.5
  • 22
    • 84940545374 scopus 로고    scopus 로고
    • Metabolomic signatures for drug response phenotypes: Pharmacometabolomics enables precision medicine
    • R. Kaddurah-Daouk, and R. Weinshilboum Metabolomic signatures for drug response phenotypes: pharmacometabolomics enables precision medicine Clin Pharmacol Ther 98 2015 71 75
    • (2015) Clin Pharmacol Ther , vol.98 , pp. 71-75
    • Kaddurah-Daouk, R.1    Weinshilboum, R.2
  • 23
    • 84865804312 scopus 로고    scopus 로고
    • Metabolome 2.0: Quantitative genetics and network biology of metabolic phenotypes
    • M.E. Dumas Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes Mol Biosyst 8 2012 2494 2502
    • (2012) Mol Biosyst , vol.8 , pp. 2494-2502
    • Dumas, M.E.1
  • 24
    • 67650581630 scopus 로고    scopus 로고
    • The conservation and evolutionary modularity of metabolism
    • J.M. Peregrin-Alvarez, C. Sanford, and J. Parkinson The conservation and evolutionary modularity of metabolism Genome Biol 10 2009 R63
    • (2009) Genome Biol , vol.10 , pp. R63
    • Peregrin-Alvarez, J.M.1    Sanford, C.2    Parkinson, J.3
  • 25
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: What do metabolic outliers teach us?
    • R.J. DeBerardinis, and C.B. Thompson Cellular metabolism and disease: what do metabolic outliers teach us? Cell 148 2012 1132 1144
    • (2012) Cell , vol.148 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 26
    • 84886812954 scopus 로고    scopus 로고
    • The nexus of chromatin regulation and intermediary metabolism
    • P. Gut, and E. Verdin The nexus of chromatin regulation and intermediary metabolism Nature 502 2013 489 498
    • (2013) Nature , vol.502 , pp. 489-498
    • Gut, P.1    Verdin, E.2
  • 27
    • 84875755814 scopus 로고    scopus 로고
    • Influence of metabolism on epigenetics and disease
    • W.G. Kaelin Jr., and S.L. McKnight Influence of metabolism on epigenetics and disease Cell 153 2013 56 69
    • (2013) Cell , vol.153 , pp. 56-69
    • Kaelin, W.G.1    McKnight, S.L.2
  • 30
    • 0344931892 scopus 로고    scopus 로고
    • Relationship among genotype, biochemical phenotype, and cognitive performance in females with phenylalanine hydroxylase deficiency: Report from the Maternal Phenylketonuria Collaborative Study
    • F. Guttler, C. Azen, P. Guldberg, A. Romstad, W.B. Hanley, and et al. Relationship among genotype, biochemical phenotype, and cognitive performance in females with phenylalanine hydroxylase deficiency: report from the Maternal Phenylketonuria Collaborative Study Pediatrics 104 1999 258 262
    • (1999) Pediatrics , vol.104 , pp. 258-262
    • Guttler, F.1    Azen, C.2    Guldberg, P.3    Romstad, A.4    Hanley, W.B.5
  • 32
    • 42349100173 scopus 로고    scopus 로고
    • The chemical genomic portrait of yeast: Uncovering a phenotype for all genes
    • M.E. Hillenmeyer, E. Fung, J. Wildenhain, S.E. Pierce, S. Hoon, and et al. The chemical genomic portrait of yeast: uncovering a phenotype for all genes Science 320 2008 362 365
    • (2008) Science , vol.320 , pp. 362-365
    • Hillenmeyer, M.E.1    Fung, E.2    Wildenhain, J.3    Pierce, S.E.4    Hoon, S.5
  • 33
    • 84959365779 scopus 로고    scopus 로고
    • Elevations of C14:1 and C14:2 plasma acylcarnitines in fasted children: A diagnostic dilemma
    • L.C. Burrage, M.J. Miller, L.J. Wong, A.D. Kennedy, V.R. Sutton, and Q. Sun Elevations of C14:1 and C14:2 plasma acylcarnitines in fasted children: A diagnostic dilemma J. Pedatr. 169 2016 208 213
    • (2016) J. Pedatr. , vol.169 , pp. 208-213
    • Burrage, L.C.1    Miller, M.J.2    Wong, L.J.3    Kennedy, A.D.4    Sutton, V.R.5    Sun, Q.6
  • 34
    • 77956293821 scopus 로고    scopus 로고
    • Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population
    • W.E. Gall, K. Beebe, K.A. Lawton, K.P. Adam, M.W. Mitchell, and et al. Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population PLoS One 5 2010 e10883
    • (2010) PLoS One , vol.5
    • Gall, W.E.1    Beebe, K.2    Lawton, K.A.3    Adam, K.P.4    Mitchell, M.W.5
  • 35
    • 84899913633 scopus 로고    scopus 로고
    • Uremic solutes and risk of end-stage renal disease in type 2 diabetes: Metabolomic study
    • M.A. Niewczas, T.L. Sirich, A.V. Mathew, J. Skupien, R.P. Mohney, and et al. Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study Kidney Int 2014
    • (2014) Kidney Int
    • Niewczas, M.A.1    Sirich, T.L.2    Mathew, A.V.3    Skupien, J.4    Mohney, R.P.5
  • 37
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, and et al. Metabolite profiles and the risk of developing diabetes Nat Med 17 2011 448 453
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3    Cheng, S.4    Rhee, E.P.5
  • 38
    • 78549250742 scopus 로고    scopus 로고
    • Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family
    • M. Takei, Y. Ando, W. Saitoh, T. Tanimoto, N. Kiyosawa, and et al. Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family Toxicol Sci 118 2010 643 652
    • (2010) Toxicol Sci , vol.118 , pp. 643-652
    • Takei, M.1    Ando, Y.2    Saitoh, W.3    Tanimoto, T.4    Kiyosawa, N.5
  • 39
    • 40549135974 scopus 로고    scopus 로고
    • The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
    • T. Morimoto, Y. Sunagawa, T. Kawamura, T. Takaya, H. Wada, and et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats J Clin Invest 118 2008 868 878
    • (2008) J Clin Invest , vol.118 , pp. 868-878
    • Morimoto, T.1    Sunagawa, Y.2    Kawamura, T.3    Takaya, T.4    Wada, H.5
  • 40
    • 58349094740 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation
    • K.C. Choi, M.G. Jung, Y.H. Lee, J.C. Yoon, S.H. Kwon, and et al. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation Cancer Res 69 2009 583 592
    • (2009) Cancer Res , vol.69 , pp. 583-592
    • Choi, K.C.1    Jung, M.G.2    Lee, Y.H.3    Yoon, J.C.4    Kwon, S.H.5
  • 41
    • 33746504112 scopus 로고    scopus 로고
    • Common genetic polymorphisms affect the human requirement for the nutrient choline
    • K.A. da Costa, O.G. Kozyreva, J. Song, J.A. Galanko, L.M. Fischer, and et al. Common genetic polymorphisms affect the human requirement for the nutrient choline FASEB J 20 2006 1336 1344
    • (2006) FASEB J , vol.20 , pp. 1336-1344
    • Da Costa, K.A.1    Kozyreva, O.G.2    Song, J.3    Galanko, J.A.4    Fischer, L.M.5
  • 42
    • 77349097033 scopus 로고    scopus 로고
    • Gut check: Testing a role for the intestinal microbiome in human obesity
    • J.S. Flier, and J.J. Mekalanos Gut check: testing a role for the intestinal microbiome in human obesity Sci Transl Med 1 2009 [6 ps7]
    • (2009) Sci Transl Med , vol.1 , pp. 6ps7
    • Flier, J.S.1    Mekalanos, J.J.2
  • 43
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • E.Y. Hsiao, S.W. McBride, S. Hsien, G. Sharon, E.R. Hyde, and et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders Cell 155 2013 1451 1463
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3    Sharon, G.4    Hyde, E.R.5
  • 44
    • 84892894991 scopus 로고    scopus 로고
    • Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
    • C.M. Theriot, M.J. Koenigsknecht, PEC Jr., G.E. Hatton, A.M. Nelson, and et al. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection Nat Commun 2014 5
    • (2014) Nat Commun , pp. 5
    • Theriot, C.M.1    Koenigsknecht, M.J.2    C, P.E.3    Hatton, G.E.4    Nelson, A.M.5
  • 45
    • 84919687733 scopus 로고    scopus 로고
    • Diet and feeding pattern affect the diurnal dynamics of the gut microbiome
    • A. Zarrinpar, A. Chaix, S. Yooseph, and S. Panda Diet and feeding pattern affect the diurnal dynamics of the gut microbiome Cell Metab 20 2014 1006 1017
    • (2014) Cell Metab , vol.20 , pp. 1006-1017
    • Zarrinpar, A.1    Chaix, A.2    Yooseph, S.3    Panda, S.4
  • 47
    • 84955722457 scopus 로고    scopus 로고
    • Association of synergistetes and cyclodipeptides with periodontitis
    • J. Marchesan Association of synergistetes and cyclodipeptides with periodontitis J Dent Res 2015
    • (2015) J Dent Res
    • Marchesan, J.1
  • 48
    • 84927131694 scopus 로고    scopus 로고
    • Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
    • J.M. Yano, K. Yu, G.P. Donaldson, G.G. Shastri, P. Ann, and et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis Cell 161 2015 264 276
    • (2015) Cell , vol.161 , pp. 264-276
    • Yano, J.M.1    Yu, K.2    Donaldson, G.P.3    Shastri, G.G.4    Ann, P.5
  • 49
    • 84942874856 scopus 로고    scopus 로고
    • Early infancy microbial and metabolic alterations affect risk of childhood asthma
    • M.C. Arrieta, L.T. Stiemsma, P.A. Dimitriu, L. Thorson, S. Russell, and et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma Sci Transl Med 7 2015 [307ra152]
    • (2015) Sci Transl Med , vol.7 , pp. 307ra152
    • Arrieta, M.C.1    Stiemsma, L.T.2    Dimitriu, P.A.3    Thorson, L.4    Russell, S.5
  • 50
    • 84904561365 scopus 로고    scopus 로고
    • Starvation-induced transgenerational inheritance of small RNAs in C. elegans
    • O. Rechavi, L. Houri-Ze'evi, S. Anava, W.S. Goh, S.Y. Kerk, and et al. Starvation-induced transgenerational inheritance of small RNAs in C. elegans Cell 158 2014 277 287
    • (2014) Cell , vol.158 , pp. 277-287
    • Rechavi, O.1    Houri-Ze'evi, L.2    Anava, S.3    Goh, W.S.4    Kerk, S.Y.5
  • 51
    • 84872136401 scopus 로고    scopus 로고
    • Physiology. When metabolism and epigenetics converge
    • P. Sassone-Corsi Physiology. When metabolism and epigenetics converge Science 339 2013 148 150
    • (2013) Science , vol.339 , pp. 148-150
    • Sassone-Corsi, P.1
  • 52
    • 83255184978 scopus 로고    scopus 로고
    • Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans
    • O. Rechavi, G. Minevich, and O. Hobert Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans Cell 147 2011 1248 1256
    • (2011) Cell , vol.147 , pp. 1248-1256
    • Rechavi, O.1    Minevich, G.2    Hobert, O.3
  • 53
    • 84922789990 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms and pathways
    • A. Efeyan, W.C. Comb, and D.M. Sabatini Nutrient-sensing mechanisms and pathways Nature 517 2015 302 310
    • (2015) Nature , vol.517 , pp. 302-310
    • Efeyan, A.1    Comb, W.C.2    Sabatini, D.M.3
  • 54
    • 84872160110 scopus 로고    scopus 로고
    • Influence of threonine metabolism on S-adenosylmethionine and histone methylation
    • N. Shyh-Chang, J.W. Locasale, C.A. Lyssiotis, Y. Zheng, R.Y. Teo, and et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation Science 339 2013 222 226
    • (2013) Science , vol.339 , pp. 222-226
    • Shyh-Chang, N.1    Locasale, J.W.2    Lyssiotis, C.A.3    Zheng, Y.4    Teo, R.Y.5
  • 55
    • 84872166360 scopus 로고    scopus 로고
    • Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor
    • T. Shimazu, M.D. Hirschey, J. Newman, W. He, K. Shirakawa, and et al. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor Science 339 2013 211 214
    • (2013) Science , vol.339 , pp. 211-214
    • Shimazu, T.1    Hirschey, M.D.2    Newman, J.3    He, W.4    Shirakawa, K.5
  • 56
    • 84876575039 scopus 로고    scopus 로고
    • Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance
    • E. Ferrannini, A. Natali, S. Camastra, M. Nannipieri, A. Mari, and et al. Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance Diabetes J 62 2012 1730 1737
    • (2012) Diabetes J , vol.62 , pp. 1730-1737
    • Ferrannini, E.1    Natali, A.2    Camastra, S.3    Nannipieri, M.4    Mari, A.5
  • 58
    • 79960839794 scopus 로고    scopus 로고
    • Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists
    • J.R. Zgoda-Pols, S. Chowdhury, M. Wirth, M.V. Milburn, D.C. Alexander, and et al. Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists Toxicol Appl Pharmacol 255 2011 48 56
    • (2011) Toxicol Appl Pharmacol , vol.255 , pp. 48-56
    • Zgoda-Pols, J.R.1    Chowdhury, S.2    Wirth, M.3    Milburn, M.V.4    Alexander, D.C.5
  • 59
    • 84862509819 scopus 로고    scopus 로고
    • Metabolic disturbances associated with systemic lupus erythematosus
    • T. Wu, C. Xie, J. Han, Y. Ye, J. Weiel, and et al. Metabolic disturbances associated with systemic lupus erythematosus PLoS One 7 2012 e37210
    • (2012) PLoS One , vol.7
    • Wu, T.1    Xie, C.2    Han, J.3    Ye, Y.4    Weiel, J.5
  • 60
    • 84858796367 scopus 로고    scopus 로고
    • A two-way street: Reciprocal regulation of metabolism and signalling
    • K.E. Wellen, and C.B. Thompson A two-way street: reciprocal regulation of metabolism and signalling Nat Rev Mol Cell Biol 13 2012 270 276
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 270-276
    • Wellen, K.E.1    Thompson, C.B.2
  • 61
    • 84867431174 scopus 로고    scopus 로고
    • Rethinking the regulation of cellular metabolism
    • C.B. Thompson Rethinking the regulation of cellular metabolism Cold Spring Harb Symp Quant Biol 76 2011 23 29
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 23-29
    • Thompson, C.B.1
  • 62
    • 78649692853 scopus 로고    scopus 로고
    • On getting there from here
    • S.L. McKnight On getting there from here Science 330 2010 1338 1339
    • (2010) Science , vol.330 , pp. 1338-1339
    • McKnight, S.L.1
  • 63
    • 84937560990 scopus 로고    scopus 로고
    • Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate
    • C. Menni, D. Graham, G. Kastenmuller, N.H. Alharbi, S.M. Alsanosi, and et al. Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate Hypertension 66 2015 422 429
    • (2015) Hypertension , vol.66 , pp. 422-429
    • Menni, C.1    Graham, D.2    Kastenmuller, G.3    Alharbi, N.H.4    Alsanosi, S.M.5
  • 64
    • 84961728135 scopus 로고    scopus 로고
    • A next generation multiscale view of inborn errors of metabolism
    • C.A. Argmann, S.M. Houten, J. Zhu, and E.E. Schadt A next generation multiscale view of inborn errors of metabolism Cell Metab 2015
    • (2015) Cell Metab
    • Argmann, C.A.1    Houten, S.M.2    Zhu, J.3    Schadt, E.E.4
  • 65
    • 84930180113 scopus 로고    scopus 로고
    • Aromatic l-amino acid decarboxylase deficiency diagnosed by clinical metabolomic profiling of plasma
    • P.S. Atwal, T.R. Donti, A.L. Cardon, C.A. Bacino, Q. Sun, and et al. Aromatic l-amino acid decarboxylase deficiency diagnosed by clinical metabolomic profiling of plasma Mol Genet Metab 115 2015 91 94
    • (2015) Mol Genet Metab , vol.115 , pp. 91-94
    • Atwal, P.S.1    Donti, T.R.2    Cardon, A.L.3    Bacino, C.A.4    Sun, Q.5
  • 66
    • 84898473918 scopus 로고    scopus 로고
    • Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders
    • L. Wang, M.A. Conlon, C.T. Christophersen, M.J. Sorich, and M.T. Angley Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders Biomark Med 8 2014 331 344
    • (2014) Biomark Med , vol.8 , pp. 331-344
    • Wang, L.1    Conlon, M.A.2    Christophersen, C.T.3    Sorich, M.J.4    Angley, M.T.5
  • 67
    • 84939123366 scopus 로고    scopus 로고
    • Association between rs12045440 polymorphism in the CAPZB intron and serum TSH concentrations in Chinese thyroid tumor patients
    • S. Feng, S. Lin, J. Zou, Y. Wang, Q. Ji, and et al. Association between rs12045440 polymorphism in the CAPZB intron and serum TSH concentrations in Chinese thyroid tumor patients Int J Endocrinol 2015 2015 250542
    • (2015) Int J Endocrinol , vol.2015 , pp. 250542
    • Feng, S.1    Lin, S.2    Zou, J.3    Wang, Y.4    Ji, Q.5
  • 68
    • 84961759821 scopus 로고    scopus 로고
    • Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human
    • X. Lin, D. Wang, L. Wen, S. Zhou, Y. Hu, and et al. Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human J Sports Med Phys Fitness 2015
    • (2015) J Sports Med Phys Fitness
    • Lin, X.1    Wang, D.2    Wen, L.3    Zhou, S.4    Hu, Y.5


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