Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 643-652

  Takei, Makoto ^a   Ando, Yosuke ^a   Saitoh, Wataru ^a   Tanimoto, Tomoe ^a   Kiyosawa, Naoki ^a   Manabe, Sunao ^a   Sanbuissho, Atsushi ^a   Okazaki, Osamu ^a   Iwabuchi, Haruo ^a   Yamoto, Takashi ^a   Adam, Klaus Peter ^b   Weiel, James E ^b   Ryals, John A ^b   Milburn, Michael V ^b   Guo, Lining ^b  

^a DAIICHI SANKYO CO   (Japan)

^b METABOLON INC   (United States)

Author keywords

Ethylene glycol monomethyl ether; Metabolomics; Mode of action

Indexed keywords

2 METHOXYETHANOL; BRANCHED CHAIN AMINO ACID; CARNITINE; CHOLINE; DIMETHYLGLYCINE; FLAVOPROTEIN; GLYCINE; SARCOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CATALYSIS; ENZYME INHIBITION; FATTY ACID OXIDATION; MALE; METABOLOMICS; MULTIPLE ACYL COA DEHYDROGENASE DEFICIENCY; NONHUMAN; OXIDATION; RAT; TESTIS INJURY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRON-TRANSFERRING FLAVOPROTEINS; ENZYME INHIBITORS; EPIDIDYMIS; ETHYLENE GLYCOLS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; METABOLOMICS; ORGAN SIZE; RATS; RATS, INBRED F344; SPERM COUNT; SPERMATOZOA; TESTIS;

MAMMALIA; RATTUS;

EID: 78549250742     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq211     Document Type: Article

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