메뉴 건너뛰기




Volumn 7, Issue 1, 2014, Pages 74-81

Understanding the apothecaries within: The necessity of a systematic approach for defining the chemical output of the human microbiome

Author keywords

Colon; Metabolism; Metabolomics; Microbiome; Small intestine

Indexed keywords

COLON; METABOLISM; METABOLOMICS; MICROBIOME; SMALL INTESTINE;

EID: 84894075861     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/cts.12131     Document Type: Review
Times cited : (12)

References (81)
  • 2
    • 47349131536 scopus 로고    scopus 로고
    • Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells: adhesion properties, competition against enteropathogens and modulation of IL-8 production
    • Candela M, Perna F, Carnevali P, Vitali B, Ciati R, Gionchetti P, Rizzello F, Campieri M, Brigidi P. Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells: adhesion properties, competition against enteropathogens and modulation of IL-8 production. Int J Food Microbiol. 2008; 125: 286-292.
    • (2008) Int J Food Microbiol. , vol.125 , pp. 286-292
    • Candela, M.1    Perna, F.2    Carnevali, P.3    Vitali, B.4    Ciati, R.5    Gionchetti, P.6    Rizzello, F.7    Campieri, M.8    Brigidi, P.9
  • 5
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012; 336: 1268-1273.
    • (2012) Science. , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 6
    • 84873728735 scopus 로고    scopus 로고
    • Developing a metagenomic view of xenobiotic metabolism
    • Haiser HJ, Turnbaugh PJ. Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013; 69: 21-31.
    • (2013) Pharmacol Res , vol.69 , pp. 21-31
    • Haiser, H.J.1    Turnbaugh, P.J.2
  • 7
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444: 1022-1023.
    • (2006) Nature. , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 9
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 2011; 474: 298-306.
    • (2011) Nature. , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 18
    • 84877026861 scopus 로고    scopus 로고
    • Disruption of the gut microbiome as a risk factor for microbial infections
    • Khosravi A, Mazmanian SK. Disruption of the gut microbiome as a risk factor for microbial infections. Curr Opin Microbiol. 2013; 16: 221-227.
    • (2013) Curr Opin Microbiol , vol.16 , pp. 221-227
    • Khosravi, A.1    Mazmanian, S.K.2
  • 20
    • 84872535919 scopus 로고    scopus 로고
    • Xenobiotics shape the physiology and gene expression of the active human gut microbiome
    • Maurice CF, Haiser HJ, Turnbaugh PJ. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell. 2013; 152: 39-50.
    • (2013) Cell. , vol.152 , pp. 39-50
    • Maurice, C.F.1    Haiser, H.J.2    Turnbaugh, P.J.3
  • 21
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature. 2012; 489: 242-249.
    • (2012) Nature. , vol.489 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 22
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: an integrative view
    • Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012; 148: 1258-1270.
    • (2012) Cell. , vol.148 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3    Knight, R.4
  • 23
    • 79952712983 scopus 로고    scopus 로고
    • Gut microbiome-host interactions in health and disease
    • Kinross JM, Darzi AW, Nicholson JK. Gut microbiome-host interactions in health and disease. Genome Med. 2011; 3: 14.
    • (2011) Genome Med , vol.3 , pp. 14
    • Kinross, J.M.1    Darzi, A.W.2    Nicholson, J.K.3
  • 28
    • 53149089114 scopus 로고    scopus 로고
    • Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells
    • Kim YS, Kim JJ, Cho KH, Jung WS, Moon SK, Park EK, Kim DH. Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. J Microbiol Biotechnol. 2008; 18: 1109-1114.
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 1109-1114
    • Kim, Y.S.1    Kim, J.J.2    Cho, K.H.3    Jung, W.S.4    Moon, S.K.5    Park, E.K.6    Kim, D.H.7
  • 31
    • 62649114601 scopus 로고    scopus 로고
    • A fatty acid messenger is responsible for inducing dispersion in microbial biofilms
    • Davies DG, Marques CN. A fatty acid messenger is responsible for inducing dispersion in microbial biofilms. J Bacteriol. 2009; 191: 1393-1403.
    • (2009) J Bacteriol , vol.191 , pp. 1393-1403
    • Davies, D.G.1    Marques, C.N.2
  • 32
    • 60849098765 scopus 로고    scopus 로고
    • Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp
    • Oh DC, Scott JJ, Currie CR, Clardy J. Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Org Lett. 2009; 11: 633-636.
    • (2009) Org Lett , vol.11 , pp. 633-636
    • Oh, D.C.1    Scott, J.J.2    Currie, C.R.3    Clardy, J.4
  • 33
    • 33750075448 scopus 로고    scopus 로고
    • Midgut bacteria required for Bacillus thuringiensis insecticidal activity
    • Broderick NA, Raffa KF, Handelsman J. Midgut bacteria required for Bacillus thuringiensis insecticidal activity. Proc Natl Acad Sci USA. 2006; 103: 15196-15199.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15196-15199
    • Broderick, N.A.1    Raffa, K.F.2    Handelsman, J.3
  • 35
    • 63749103609 scopus 로고    scopus 로고
    • New developments in microbial interspecies signaling
    • Shank EA, Kolter R. New developments in microbial interspecies signaling. Curr Opin Microbiol. 2009; 12: 205-214.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 205-214
    • Shank, E.A.1    Kolter, R.2
  • 36
    • 43049109929 scopus 로고    scopus 로고
    • Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans
    • McAlester G, O'Gara F, Morrissey JP. Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. J Med Microbiol. 2008; 57: 563-569.
    • (2008) J Med Microbiol , vol.57 , pp. 563-569
    • McAlester, G.1    O'Gara, F.2    Morrissey, J.P.3
  • 37
    • 70349542895 scopus 로고    scopus 로고
    • Interspecies chemical communication in bacterial development
    • Straight PD, Kolter R. Interspecies chemical communication in bacterial development. Annu Rev Microbiol. 2009; 63: 99-118.
    • (2009) Annu Rev Microbiol , vol.63 , pp. 99-118
    • Straight, P.D.1    Kolter, R.2
  • 38
    • 27144544090 scopus 로고    scopus 로고
    • NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine
    • Karatan E, Duncan TR, Watnick PI. NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine. J Bacteriol. 2005; 187: 7434-7443.
    • (2005) J Bacteriol , vol.187 , pp. 7434-7443
    • Karatan, E.1    Duncan, T.R.2    Watnick, P.I.3
  • 40
    • 2442612988 scopus 로고    scopus 로고
    • Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa
    • Lepine F, Milot S, Deziel E, He J, Rahme LG. Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa. J Am Soc Mass Spectrom. 2004; 15: 862-869.
    • (2004) J Am Soc Mass Spectrom , vol.15 , pp. 862-869
    • Lepine, F.1    Milot, S.2    Deziel, E.3    He, J.4    Rahme, L.G.5
  • 41
    • 63749104134 scopus 로고    scopus 로고
    • Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules
    • Williams P, Camara M. Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules. Curr Opin Microbiol. 2009; 12: 182-191.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 182-191
    • Williams, P.1    Camara, M.2
  • 43
    • 63749127958 scopus 로고    scopus 로고
    • Inter-kingdom signaling: chemical language between bacteria and host
    • Pacheco AR, Sperandio V. Inter-kingdom signaling: chemical language between bacteria and host. Curr Opin Microbiol. 2009; 12: 192-198.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 192-198
    • Pacheco, A.R.1    Sperandio, V.2
  • 44
    • 77349097033 scopus 로고    scopus 로고
    • Gut check: testing a role for the intestinal microbiome in human obesity
    • Flier JS, Mekalanos JJ. Gut check: testing a role for the intestinal microbiome in human obesity. Sci Transl Med. 2009; 1: 6ps7.
    • (2009) Sci Transl Med , vol.1
    • Flier, J.S.1    Mekalanos, J.J.2
  • 45
    • 75349107399 scopus 로고    scopus 로고
    • Quorum sensing in natural environments: emerging views from microbial mats
    • Decho AW, Norman RS, Visscher PT. Quorum sensing in natural environments: emerging views from microbial mats. Trends Microbiol. 2010; 18: 73-80.
    • (2010) Trends Microbiol , vol.18 , pp. 73-80
    • Decho, A.W.1    Norman, R.S.2    Visscher, P.T.3
  • 46
    • 33646032683 scopus 로고    scopus 로고
    • Bacterially speaking
    • Bassler BL, Losick R. Bacterially speaking. Cell. 2006; 125: 237-246.
    • (2006) Cell. , vol.125 , pp. 237-246
    • Bassler, B.L.1    Losick, R.2
  • 48
    • 0344931892 scopus 로고    scopus 로고
    • Relationship among genotype, biochemical phenotype, and cognitive performance in females with phenylalanine hydroxylase deficiency: report from the Maternal Phenylketonuria Collaborative Study
    • de la
    • Guttler F, Azen C, Guldberg P, Romstad A, Hanley WB, Levy HL, Matalon R, Rouse BM, Trefz F, de la Cruz F, et al. Relationship among genotype, biochemical phenotype, and cognitive performance in females with phenylalanine hydroxylase deficiency: report from the Maternal Phenylketonuria Collaborative Study. Pediatrics. 1999; 104: 258-262.
    • (1999) Pediatrics. , vol.104 , pp. 258-262
    • Guttler, F.1    Azen, C.2    Guldberg, P.3    Romstad, A.4    Hanley, W.B.5    Levy, H.L.6    Matalon, R.7    Rouse, B.M.8    Trefz, F.9    Cruz, F.10
  • 53
    • 0034707908 scopus 로고    scopus 로고
    • Exploitation of gut bacteria in the locust
    • Dillon RJ, Vennard CT, Charnley AK. Exploitation of gut bacteria in the locust. Nature. 2000; 403: 851.
    • (2000) Nature. , vol.403 , pp. 851
    • Dillon, R.J.1    Vennard, C.T.2    Charnley, A.K.3
  • 55
    • 84897965358 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Jun 26 [Epub ahead of print].
    • Shin NR, Lee JC, Lee HY, Kim MS, Whon TW, Lee MS, Bae JW. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2013. Jun 26 [Epub ahead of print].
    • (2013) Gut.
    • Shin, N.R.1    Lee, J.C.2    Lee, H.Y.3    Kim, M.S.4    Whon, T.W.5    Lee, M.S.6    Bae, J.W.7
  • 58
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011; 332: 974-977.
    • (2011) Science. , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6    Mazmanian, S.K.7
  • 66
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA. 2009; 106: 14728-14733.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 67
    • 84878886096 scopus 로고    scopus 로고
    • The human microbiome is a source of therapeutic drug targets
    • Wallace BD, Redinbo MR. The human microbiome is a source of therapeutic drug targets. Curr Opin Chem Biol. 2013; 17: 379-384.
    • (2013) Curr Opin Chem Biol , vol.17 , pp. 379-384
    • Wallace, B.D.1    Redinbo, M.R.2
  • 68
    • 17844404232 scopus 로고    scopus 로고
    • Gut microorganisms, mammalian metabolism and personalized health care
    • Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol. 2005; 3: 431-438.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 431-438
    • Nicholson, J.K.1    Holmes, E.2    Wilson, I.D.3
  • 69
    • 67650595188 scopus 로고    scopus 로고
    • The role of gut microbiota in drug response
    • Wilson ID, Nicholson JK. The role of gut microbiota in drug response. Curr Pharm Des. 2009; 15: 1519-1523.
    • (2009) Curr Pharm Des , vol.15 , pp. 1519-1523
    • Wilson, I.D.1    Nicholson, J.K.2
  • 70
    • 79960839794 scopus 로고    scopus 로고
    • Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists
    • Zgoda-Pols JR, Chowdhury S, Wirth M, Milburn MV, Alexander DC, Alton KB. Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists. Toxicol Appl Pharmacol. 2011; 255: 48-56.
    • (2011) Toxicol Appl Pharmacol , vol.255 , pp. 48-56
    • Zgoda-Pols, J.R.1    Chowdhury, S.2    Wirth, M.3    Milburn, M.V.4    Alexander, D.C.5    Alton, K.B.6
  • 71
    • 84880439384 scopus 로고    scopus 로고
    • Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
    • Haiser HJ, Gootenberg DB, Chatman K, Sirasani G, Balskus EP, Turnbaugh PJ. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science. 2013; 341: 295-298.
    • (2013) Science. , vol.341 , pp. 295-298
    • Haiser, H.J.1    Gootenberg, D.B.2    Chatman, K.3    Sirasani, G.4    Balskus, E.P.5    Turnbaugh, P.J.6
  • 73
    • 69949110703 scopus 로고    scopus 로고
    • Therapeutic implications of manipulating and mining the microbiota
    • Shanahan F. Therapeutic implications of manipulating and mining the microbiota. J Physiol. 2009; 587: 4175-4179.
    • (2009) J Physiol. , vol.587 , pp. 4175-4179
    • Shanahan, F.1
  • 74
    • 38849190556 scopus 로고    scopus 로고
    • Gut microbiota: a potential new territory for drug targeting
    • Jia W, Li H, Zhao L, Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov. 2008; 7: 123-129.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 123-129
    • Jia, W.1    Li, H.2    Zhao, L.3    Nicholson, J.K.4
  • 75
    • 78649702566 scopus 로고    scopus 로고
    • Organization of GC/MS and LC/MS metabolomics data into chemical libraries
    • Dehaven CD, Evans AM, Dai H, Lawton KA. Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminform. 2010; 2: 9.
    • (2010) J Cheminform , vol.2 , pp. 9
    • Dehaven, C.D.1    Evans, A.M.2    Dai, H.3    Lawton, K.A.4
  • 76
    • 79851507789 scopus 로고    scopus 로고
    • Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes
    • Yang JY, Karr JR, Watrous JD, Dorrestein PC. Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes. Curr Opin Chem Biol. 2011; 15: 79-87.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 79-87
    • Yang, J.Y.1    Karr, J.R.2    Watrous, J.D.3    Dorrestein, P.C.4
  • 77
    • 53349117682 scopus 로고    scopus 로고
    • Metabolomics: biochemistry's new look
    • Blow N. Metabolomics: biochemistry's new look. Nature. 2008; 455: 697-700.
    • (2008) Nature. , vol.455 , pp. 697-700
    • Blow, N.1
  • 79
    • 84862213123 scopus 로고    scopus 로고
    • Metabolomics as a key integrator for "omic" advancement of personalized medicine and future therapies
    • Eckhart AD, Beebe K, Milburn M. Metabolomics as a key integrator for "omic" advancement of personalized medicine and future therapies. Clin Transl Sci. 2012; 5: 285-288.
    • (2012) Clin Transl Sci , vol.5 , pp. 285-288
    • Eckhart, A.D.1    Beebe, K.2    Milburn, M.3
  • 81
    • 84884189510 scopus 로고    scopus 로고
    • Microbiome research goes without a home
    • Mole B. Microbiome research goes without a home. Nature. 2013; 500: 16-17.
    • (2013) Nature. , vol.500 , pp. 16-17
    • Mole, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.