Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists

Toxicology and Applied Pharmacology

Volumn 255, Issue 1, 2011, Pages 48-56

  Zgoda Pols, Joanna R ^a   Chowdhury, Swapan ^a   Wirth, Mark ^a   Milburn, Michael V ^b   Alexander, Danny C ^b   Alton, Kevin B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b METABOLON INC   (United States)

Author keywords

3 indoxyl sulfate; Acute kidney injury; Central nervous system; Metabolomics; Mice; Nicotinic acid agonist

Indexed keywords

BIOLOGICAL MARKER; CREATININE; INDICAN; NICOTINIC ACID DERIVATIVE; SCH 900424; SCH 900765; UNCLASSIFIED DRUG; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NEPHROTOXICITY; NONHUMAN; QUANTITATIVE ANALYSIS; URINARY EXCRETION;

ACUTE KIDNEY INJURY; ANIMALS; BIOLOGICAL MARKERS; BRAIN; INDICAN; KIDNEY; MALE; METABOLOMICS; MICE; NICOTINIC AGONISTS; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT;

ANIMALIA; MURINAE; MUS;

EID: 79960839794     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.05.015     Document Type: Article

References (31)

1. Boudonck K.J., Mitchell M.W., Nemet L., Keresztes L., Nyska A., Shinar D., Rosenstock M. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol. Pathol. 2009, 37:280-292.
2. Buse J.B., Freeman J.L., Edelman S.V., Jovanovic L., McGill J.B. Serum 1,5-anhydroglucitol (GlycoMark): a short-term glycemic marker. Diabetes Technol. Ther. 2003, 5:355-363.
3. Casella G., Berger R.L. Statistical Inference 2002, Duxbury, Pacific Grove, CA. second ed.
4. Deguchi T., Kouno Y., Terasaki T., Takadate A., Otagiri M. Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats. Pharm. Res. 2005, 22:619-627.
5. 2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. Kidney Int. 2003, 63:1764-1775.
6. Enomoto A., Takeda M., Tojo A., Sekine T., Cha S.H., Khamdang S., Takayama F., Aoyama I., Nakamura S., Endou H., Niwa T. Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J. Am. Soc. Nephrol. 2002, 13:1711-1720.
7. Evans A.M., Dehaven C.D., Barrett T., Mitchell M., Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal. Chem. 2009, 6656-6667.
8. Gartland K.P., Bonner F.W., Nicholson J.K. Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. 1989, 35:242-250.
9. Harper H.A., Doolan P.D. The renal aminoacidurias. Clin. Chem. 1963, 9:19-26.
10. Hoffman D., Fuchs T.C., Henzler T., Matheis K.A., Herget T., Dekant W., Hewitt P., Mally A. Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity. Toxicology 2010, 277:49-58.
11. Iwata K., Watanabe H., Morisaki T., Matsuzaki T., Ohmura T., Hamada A., Saito H. Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure. Pharm. Res. 2007, 24:662-671.
12. Kirkland J.L., Vargas E., Lye M. Indican excretion in the elderly. Postgrad. Med. J. 1983, 59:717-719.
13. Kusuhara H., Sekine T., Utsunomiya-Tate N., Tsuda M., Kojima R., Cha S.H., Sugiyama Y., Kanai Y., Endou H. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 1999, 274:13675-13680.
14. Lawton K.A., Berger A., Mitchell M., Milgram K.E., Evans A.M., Guo L., Hanson R.W., Kalhan S.C., Ryals J.A., Milburn M.V. Analysis of the adult human plasma metabolome. Pharmacogenomics 2008, 9:383-397.
15. Martinez A.W., Recht N.S., Hostetter T.H., Meyer T.W. Removal of P-cresol sulfate by hemodialysis. J. Am. Soc. Nephrol. 2005, 16:3430-3436.
16. Motojima M., Hosokawa A., Yamato H., Muraki T., Yoshioka T. Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. Br. J. Pharmacol. 2002, 135:555-563.
17. Niwa T., Takeda N., Tatematsu A., Maeda K. Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography. Clin. Chem. 1988, 34:2264-2267.
18. Ohta T., Masutomi N., Tsutsui N., Sakairi T., Mitchell M., Milburn M.V., Ryals J.A., Beebe K.D., Guo L. Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. Toxicol. Pathol. 2009, 37:521-535.
19. Ohtsuki S., Asaba H., Takanaga H., Deguchi T., Hosoya K., Otagiri M., Terasaki T. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J. Neurochem. 2002, 83:57-66.
20. Portilla D., Li S., Nagothu K.K., Megyesi J., Kaissling B., Schnackenberg L., Safirstein R.L., Beger R.D. Metabolomic study of cisplatin-induced nephrotoxicity. Kidney Int. 2006, 69:2194-2204.
21. Schoots A.C., De Vries P.M., Thiemann R., Hazejager W.A., Visser S.L., Oe P.L. Biochemical and neurophysiological parameters in hemodialyzed patients with chronic renal failure. Clin. Chim. Acta 1989, 185:91-107.
22. Silbernagl S. The renal handling of amino acids and oligopeptides. Physiol. Rev. 1988, 68:911-1007.
23. Sweet D.H. Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol. Appl. Pharmacol. 2005, 204:198-215.
24. Tizianello A., De Ferrari G., Garibotto G., Gurreri G., Robaudo C. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J. Clin. Invest. 1980, 65:1162-1173.
25. Togashi Y., Sakaguchi Y., Miyamoto M., Miyamoto Y. Urinary cystatin C as a biomarker for acute kidney injury and its immunohistochemical localization in kidney in the CDDP-treated rats. Exp. Toxic. Pathol. 2011, 10.1016/j.etp. 2011.01.018.
26. Vaidya V.S., Ramirez V., Ichimura T., Bobadilla N.A., Bonventre J.V. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am. J. Physiol. Renal Physiol. 2006, 290:F517-F529.
27. van de Poll M.C., Soeters P.B., Deutz N.E., Fearon K.C., Dejong C.H. Renal metabolism of amino acids: its role in interorgan amino acid exchange. Am. J. Clin. Nutr. 2004, 79:185-197.
28. Vanholder R., De Smet R., Lameire N. Protein-bound uremic solutes: the forgotten toxins. Kidney Int. Suppl. 2001, 78:S266-S270.
29. Vanholder R., De Smet R., Glorieux G., Argiles A., Baurmeister U., Brunet P., Clark W., Cohen G., De Deyn P.P., Deppisch R., Descamps-Latscha B., Henle T., Jorres A., Lemke H.D., Massy Z.A., Passlick-Deetjen J., Rodriguez M., Stegmayr B., Stenvinkel P., Tetta C., Wanner C., Zidek W. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003, 63:1934-1943.
30. Wang G., Korfmacher W.A. Development of a biomarker assay for 3-indoxyl sulfate in mouse plasma and brain by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:2061-2069.
31. Zgoda-Pols J.R., Srnka A., Chowdhruy S., Alton K.B. Investigative renal toxicity study in mice using MS-based metabolomics. The 57th American Society for Mass Spectrometry Conference, Philadelphia, PA 2009.