-
1
-
-
33947489961
-
Isolation, structure and partial synthesis of an active constituent of hashish
-
Gaoni Y, Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964;86:1646-7.
-
(1964)
J am Chem Soc
, vol.86
, pp. 1646-1647
-
-
Gaoni, Y.1
Mechoulam, R.2
-
2
-
-
38349158960
-
The diverse cb1 and cb2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
-
Pertwee RG. The diverse cb1 and cb2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 2008;153:199-215.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 199-215
-
-
Pertwee, R.G.1
-
3
-
-
0027078685
-
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
-
Devane WA, Hanus L, Breuer A, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992;258:1946-9.
-
(1992)
Science
, vol.258
, pp. 1946-1949
-
-
Devane, W.A.1
Hanus, L.2
Breuer, A.3
-
4
-
-
0029012014
-
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
-
Mechoulam R, Ben-Shabat S, Hanus L, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995;50:83-90.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 83-90
-
-
Mechoulam, R.1
Ben-Shabat, S.2
Hanus, L.3
-
5
-
-
0028970517
-
2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
-
Sugiura T, Kondo S, Sukagawa A, et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 1995;215:89-97.
-
(1995)
Biochem Biophys Res Commun
, vol.215
, pp. 89-97
-
-
Sugiura, T.1
Kondo, S.2
Sukagawa, A.3
-
6
-
-
78650120798
-
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond cb1 and cb2
-
Pertwee RG, Howlett AC, Abood ME, et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond cb1 and cb2. Pharmacol Rev 2010;62:588-631.
-
(2010)
Pharmacol Rev
, vol.62
, pp. 588-631
-
-
Pertwee, R.G.1
Howlett, A.C.2
Abood, M.E.3
-
7
-
-
0025325535
-
Structure of a cannabinoid receptor and functional expression of the cloned cdna
-
Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cdna. Nature 1990;346:561-4.
-
(1990)
Nature
, vol.346
, pp. 561-564
-
-
Matsuda, L.A.1
Lolait, S.J.2
Brownstein, M.J.3
Young, A.C.4
Bonner, T.I.5
-
8
-
-
0027515373
-
Molecular characterization of a peripheral receptor for cannabinoids
-
Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365:61-5.
-
(1993)
Nature
, vol.365
, pp. 61-65
-
-
Munro, S.1
Thomas, K.L.2
Abu-Shaar, M.3
-
9
-
-
33845959991
-
Cannabinoid cb2 receptor: A new target for controlling neural cell survival?
-
Fernandez-Ruiz J, Romero J, Velasco G, Tolon R, Ramos J, Guzman M. Cannabinoid cb2 receptor: a new target for controlling neural cell survival? Trends Pharmacol Sci 2007;28:39-45.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 39-45
-
-
Fernandez-Ruiz, J.1
Romero, J.2
Velasco, G.3
Tolon, R.4
Ramos, J.5
Guzman, M.6
-
10
-
-
77952623444
-
Cb2: A cannabinoid receptor with an identity crisis
-
Atwood BK, Mackie K. cb2: a cannabinoid receptor with an identity crisis. Br J Pharmacol 2010;160:467-79.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 467-479
-
-
Atwood, B.K.1
Mackie, K.2
-
11
-
-
33745929641
-
A pilot clinical study of delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
-
Guzman M, Duarte MJ, Blazquez C, et al. A pilot clinical study of delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer 2006;95:197-203.
-
(2006)
Br J Cancer
, vol.95
, pp. 197-203
-
-
Guzman, M.1
Duarte, M.J.2
Blazquez, C.3
-
12
-
-
39049104489
-
Cannabinoids for cancer treatment: Progress and promise
-
Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H. Cannabinoids for cancer treatment: progress and promise. Cancer Res 2008;68:339-42.
-
(2008)
Cancer Res
, vol.68
, pp. 339-342
-
-
Sarfaraz, S.1
Adhami, V.M.2
Syed, D.N.3
Afaq, F.4
Mukhtar, H.5
-
13
-
-
51349141952
-
Endocannabinoid signaling as a synaptic circuit breaker in neurological disease
-
Katona I, Freund TF. Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nat Med 2008;14:923-30.
-
(2008)
Nat Med
, vol.14
, pp. 923-930
-
-
Katona, I.1
Freund, T.F.2
-
14
-
-
33748703859
-
The endocannabinoid system as an emerging target of pharmacotherapy
-
Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006;58:389-462.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 389-462
-
-
Pacher, P.1
Batkai, S.2
Kunos, G.3
-
15
-
-
65449146377
-
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
-
Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 2009;156:397-411.
-
(2009)
Br J Pharmacol
, vol.156
, pp. 397-411
-
-
Pertwee, R.G.1
-
16
-
-
0142166330
-
Cannabinoids: Potential anticancer agents
-
Guzman M. Cannabinoids: potential anticancer agents. Nat Rev Cancer 2003;3:745-55.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 745-755
-
-
Guzman, M.1
-
17
-
-
84861530762
-
Towards the use of cannabinoids as antitumour agents
-
Velasco G, Sanchez C, Guzman M. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 2012;12:436-44.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 436-444
-
-
Velasco, G.1
Sanchez, C.2
Guzman, M.3
-
18
-
-
77952532122
-
The expression level of cb1 and cb2 receptors determines their efficacy at inducing apoptosis in astrocytomas
-
Cudaback E, Marrs W, Moeller T, Stella N. The expression level of cb1 and cb2 receptors determines their efficacy at inducing apoptosis in astrocytomas. PloS One 2010;5:e8702.
-
(2010)
Plos One
, vol.5
-
-
Cudaback, E.1
Marrs, W.2
Moeller, T.3
Stella, N.4
-
19
-
-
1542510624
-
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (Tace/adam17)-mediated transactivation of the epidermal growth factor receptor
-
Hart S, Fischer OM, Ullrich A. Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (tace/adam17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res 2004;64:1943-50.
-
(2004)
Cancer Res
, vol.64
, pp. 1943-1950
-
-
Hart, S.1
Fischer, O.M.2
Ullrich, A.3
-
20
-
-
14844362003
-
Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
-
McKallip RJ, Nagarkatti M, Nagarkatti PS. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 2005;174:3281-9.
-
(2005)
J Immunol
, vol.174
, pp. 3281-3289
-
-
McKallip, R.J.1
Nagarkatti, M.2
Nagarkatti, P.S.3
-
21
-
-
0034235808
-
Delta-9-tetrahydrocannabinol inhibits antitumour immunity by a cb2 receptormediated, cytokine-dependent pathway
-
Zhu LX, Sharma S, Stolina M, et al. Delta-9-tetrahydrocannabinol inhibits antitumour immunity by a cb2 receptormediated, cytokine-dependent pathway. J Immunol 2000;165:373-80.
-
(2000)
J Immunol
, vol.165
, pp. 373-380
-
-
Zhu, L.X.1
Sharma, S.2
Stolina, M.3
-
22
-
-
79951590481
-
Update on the endocannabinoid system as an anticancer target
-
Malfitano AM, Ciaglia E, Gangemi G, Gazzerro P, Laezza C, Bifulco M. Update on the endocannabinoid system as an anticancer target. Expert Opin Ther Targets 2011;15:297-308.
-
(2011)
Expert Opin Ther Targets
, vol.15
, pp. 297-308
-
-
Malfitano, A.M.1
Ciaglia, E.2
Gangemi, G.3
Gazzerro, P.4
Laezza, C.5
Bifulco, M.6
-
23
-
-
0035422139
-
Inhibition of glioma growth in vivo by selective activation of the cb2 cannabinoid receptor
-
Sanchez C, de Ceballos ML, Gomez del Pulgar T, et al. Inhibition of glioma growth in vivo by selective activation of the cb2 cannabinoid receptor. Cancer Res 2001;61:5784-9.
-
(2001)
Cancer Res
, vol.61
, pp. 5784-5789
-
-
Sanchez, C.1
De Ceballos, M.L.2
Gomez Del Pulgar, T.3
-
24
-
-
33746125474
-
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
-
Caffarel MM, Sarrio D, Palacios J, Guzman M, Sanchez C. Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 2006;66:6615-21.
-
(2006)
Cancer Res
, vol.66
, pp. 6615-6621
-
-
Caffarel, M.M.1
Sarrio, D.2
Palacios, J.3
Guzman, M.4
Sanchez, C.5
-
25
-
-
73149109062
-
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
-
Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 2010;140:49-61.
-
(2010)
Cell
, vol.140
, pp. 49-61
-
-
Nomura, D.K.1
Long, J.Z.2
Niessen, S.3
Hoover, H.S.4
Ng, S.W.5
Cravatt, B.F.6
-
26
-
-
77957906635
-
Fatty acid amide hydrolase in prostate cancer: Association with disease severity and outcome, cb1 receptor expression and regulation by il-4
-
Thors L, Bergh A, Persson E, et al. Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, cb1 receptor expression and regulation by il-4. PLoS One 2010;5:e12275.
-
(2010)
Plos One
, vol.5
-
-
Thors, L.1
Bergh, A.2
Persson, E.3
-
27
-
-
45549095987
-
The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
-
Zheng D, Bode AM, Zhao Q, et al. The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 2008;68:3992-8.
-
(2008)
Cancer Res
, vol.68
, pp. 3992-3998
-
-
Zheng, D.1
Bode, A.M.2
Zhao, Q.3
-
28
-
-
0036141517
-
Leukemic predisposition of pSca-1/Cb2 transgenic mice
-
Joosten M, Valk PJ, Jorda MA, et al. Leukemic predisposition of pSca-1/Cb2 transgenic mice. Exp Hematol 2002;30:142-9.
-
(2002)
Exp Hematol
, vol.30
, pp. 142-149
-
-
Joosten, M.1
Valk, P.J.2
Jorda, M.A.3
-
29
-
-
84930689586
-
Role of cannabinoid receptor cb2 in her2 pro-oncogenic signaling in breast cancer
-
Perez-Gomez E, Andradas C, Blasco-Benito S, et al. Role of cannabinoid receptor cb2 in her2 pro-oncogenic signaling in breast cancer. J Natl Cancer Inst 2015;107:djv077.
-
(2015)
J Natl Cancer Inst
, vol.107
-
-
Perez-Gomez, E.1
Radas, C.2
Blasco-Benito, S.3
-
30
-
-
51049102995
-
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
-
Wang D, Wang H, Ning W, Backlund MG, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 2008;68:6468-76.
-
(2008)
Cancer Res
, vol.68
, pp. 6468-6476
-
-
Wang, D.1
Wang, H.2
Ning, W.3
Backlund, M.G.4
Dey, S.K.5
Dubois, R.N.6
-
31
-
-
38149055682
-
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
-
Izzo AA, Aviello G, Petrosino S, et al. Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. J Mol Med (Berl) 2008;86:89-98.
-
(2008)
J Mol Med (Berl)
, vol.86
, pp. 89-98
-
-
Izzo, A.A.1
Aviello, G.2
Petrosino, S.3
-
32
-
-
4143086166
-
Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas
-
Blazquez C, Gonzalez-Feria L, Alvarez L, Haro A, Casanova ML, Guzman M. Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 2004;64:5617-23.
-
(2004)
Cancer Res
, vol.64
, pp. 5617-5623
-
-
Blazquez, C.1
Gonzalez-Feria, L.2
Alvarez, L.3
Haro, A.4
Casanova, M.L.5
Guzman, M.6
-
33
-
-
17344380844
-
Antitumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
-
Galve-Roperh I, Sanchez C, Cortes ML, Gómez del Pulgar T, Izquierdo M, Guzman M. Antitumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000;6:313-19.
-
(2000)
Nat Med
, vol.6
, pp. 313-319
-
-
Galve-Roperh, I.1
Sanchez, C.2
Cortes, M.L.3
Gómez Del Pulgar, T.4
Izquierdo, M.5
Guzman, M.6
-
34
-
-
0036534724
-
De novo-synthesized ceramide is involved in cannabinoidinduced apoptosis
-
Gomez del Pulgar T, Velasco G, Sanchez C, Haro A, Guzman M. De novo-synthesized ceramide is involved in cannabinoidinduced apoptosis. Biochem J 2002;363:183-8.
-
(2002)
Biochem J
, vol.363
, pp. 183-188
-
-
Gomez Del Pulgar, T.1
Velasco, G.2
Sanchez, C.3
Haro, A.4
Guzman, M.5
-
35
-
-
33645763253
-
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
-
Carracedo A, Lorente M, Egia A, et al. The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 2006;9:301-12.
-
(2006)
Cancer Cell
, vol.9
, pp. 301-312
-
-
Carracedo, A.1
Lorente, M.2
Egia, A.3
-
36
-
-
0035951881
-
Human p8 is a hmg-i/y-like protein with dna binding activity enhanced by phosphorylation
-
Encinar JA, Mallo GV, Mizyrycki C, et al. Human p8 is a hmg-i/y-like protein with dna binding activity enhanced by phosphorylation. J Biol Chem 2001;276:2742-51.
-
(2001)
J Biol Chem
, vol.276
, pp. 2742-2751
-
-
Encinar, J.A.1
Mallo, G.V.2
Mizyrycki, C.3
-
37
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of er stress in human glioma cells
-
Salazar M, Carracedo A, Salanueva IJ, et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of er stress in human glioma cells. J Clin Invest 2009;119:1359-72.
-
(2009)
J Clin Invest
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
Carracedo, A.2
Salanueva, I.J.3
-
38
-
-
0038242819
-
Trb3: A tribbles homolog that inhibits Akt/pkb activation by insulin in liver
-
Du K, Herzig S, Kulkarni RN, Montminy M. trb3: a tribbles homolog that inhibits Akt/pkb activation by insulin in liver. Science 2003;300:1574-7.
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkarni, R.N.3
Montminy, M.4
-
40
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008;451:1069-75.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
41
-
-
67549142261
-
Life and death partners: Apoptosis, autophagy and the cross-talk between them
-
Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 2009;16:966-75.
-
(2009)
Cell Death Differ
, vol.16
, pp. 966-975
-
-
Eisenberg-Lerner, A.1
Bialik, S.2
Simon, H.U.3
Kimchi, A.4
-
42
-
-
84926252071
-
Autophagy in malignant transformation and cancer progression
-
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, et al. Autophagy in malignant transformation and cancer progression. EMBO J 2015;34:856-80.
-
(2015)
EMBO J
, vol.34
, pp. 856-880
-
-
Galluzzi, L.1
Pietrocola, F.2
Bravo-San Pedro, J.M.3
-
43
-
-
79958809001
-
Antitumoral action of cannabinoids on hepatocellular carcinoma: Role of ampk-dependent activation of autophagy
-
Vara D, Salazar M, Olea-Herrero N, Guzman M, Velasco G, Diaz-Laviada I. Antitumoral action of cannabinoids on hepatocellular carcinoma: role of ampk-dependent activation of autophagy. Cell Death Differ 2011;18:1099-111.
-
(2011)
Cell Death Differ
, vol.18
, pp. 1099-1111
-
-
Vara, D.1
Salazar, M.2
Olea-Herrero, N.3
Guzman, M.4
Velasco, G.5
Diaz-Laviada, I.6
-
44
-
-
84938096558
-
Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death
-
Armstrong JL, Hill DS, McKee CS, et al. Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death. J Invest Dermatol 2015;135:1629-37.
-
(2015)
J Invest Dermatol
, vol.135
, pp. 1629-1637
-
-
Armstrong, J.L.1
Hill, D.S.2
McKee, C.S.3
-
45
-
-
4644226099
-
Cannabinoids down-regulate pi3k/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein
-
Ellert-Miklaszewska A, Kaminska B, Konarska L. Cannabinoids down-regulate pi3k/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal 2005;17:25-37.
-
(2005)
Cell Signal
, vol.17
, pp. 25-37
-
-
Ellert-Miklaszewska, A.1
Kaminska, B.2
Konarska, L.3
-
46
-
-
33845627660
-
Cannabinoid receptors as novel targets for the treatment of melanoma
-
Blazquez C, Carracedo A, Barrado L, et al. Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 2006;20:2633-5.
-
(2006)
FASEB J
, vol.20
, pp. 2633-2635
-
-
Blazquez, C.1
Carracedo, A.2
Barrado, L.3
-
47
-
-
50649112355
-
JunD is involved in the antiproliferative effect of delta9-tetrahydrocannabinol on human breast cancer cells
-
Caffarel MM, Moreno-Bueno G, Cerutti C, et al. JunD is involved in the antiproliferative effect of delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene 2008;27:5033-44.
-
(2008)
Oncogene
, vol.27
, pp. 5033-5044
-
-
Caffarel, M.M.1
Moreno-Bueno, G.2
Cerutti, C.3
-
48
-
-
33746138649
-
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
-
Carracedo A, Gironella M, Lorente M, et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006;66:6748-55.
-
(2006)
Cancer Res
, vol.66
, pp. 6748-6755
-
-
Carracedo, A.1
Gironella, M.2
Lorente, M.3
-
49
-
-
84885187757
-
The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
-
Salazar M, Lorente M, Garcia-Taboada E, et al. The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochim Biophys Acta 2013;1831:1573-8.
-
(2013)
Biochim Biophys Acta
, vol.1831
, pp. 1573-1578
-
-
Salazar, M.1
Lorente, M.2
Garcia-Taboada, E.3
-
50
-
-
84865417165
-
Cannabinoids: A new hope for breast cancer therapy?
-
Caffarel MM, Andradas C, Perez-Gomez E, Guzman M, Sanchez C. Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev 2012;38:911-18.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 911-918
-
-
Caffarel, M.M.1
Radas, C.2
Perez-Gomez, E.3
Guzman, M.4
Sanchez, C.5
-
51
-
-
33845973763
-
Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of erk1/2 leading to G1 cell cycle arrest
-
Sarfaraz S, Afaq F, Adhami VM, Malik A, Mukhtar H. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of erk1/2 leading to G1 cell cycle arrest. J Biol Chem 2006;281:39480-91.
-
(2006)
J Biol Chem
, vol.281
, pp. 39480-39491
-
-
Sarfaraz, S.1
Afaq, F.2
Adhami, V.M.3
Malik, A.4
Mukhtar, H.5
-
52
-
-
79960336157
-
The endocannabinoid system and cancer: Therapeut ic implicat ion
-
Guindon J, Hohmann AG. The endocannabinoid system and cancer: therapeut ic implicat ion. Br J Pharmacol 2011;163:1447-63.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 1447-1463
-
-
Guindon, J.1
Hohmann, A.G.2
-
53
-
-
52949118833
-
Mechanisms of control of neuron survival by the endocannabinoid system
-
Galve-Roperh I, Aguado T, Palazuelos J, Guzman M. Mechanisms of control of neuron survival by the endocannabinoid system. Curr Pharm Des 2008;14:2279-88.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 2279-2288
-
-
Galve-Roperh, I.1
Aguado, T.2
Palazuelos, J.3
Guzman, M.4
-
54
-
-
0037253496
-
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
-
Casanova ML, Blazquez C, Martinez-Palacio J, et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003;111:43-50.
-
(2003)
J Clin Invest
, vol.111
, pp. 43-50
-
-
Casanova, M.L.1
Blazquez, C.2
Martinez-Palacio, J.3
-
55
-
-
26844566936
-
Toxicity and carcinogenicity of delta 9-tetrahydrocannabinol in Fischer rats and B6C3F1 mice
-
Chan PC, Sills RC, Braun AG, Haseman JK, Bucher JR. Toxicity and carcinogenicity of delta 9-tetrahydrocannabinol in Fischer rats and B6C3F1 mice. Fundam Appl Toxicol 1996;30:109-17.
-
(1996)
Fundam Appl Toxicol
, vol.30
, pp. 109-117
-
-
Chan, P.C.1
Sills, R.C.2
Braun, A.G.3
Haseman, J.K.4
Bucher, J.R.5
-
56
-
-
79955865808
-
Stimulation of the midkine/ alk axis renders glioma cells resistant to cannabinoid antitumoral action
-
Lorente M, Torres S, Salazar M, et al. Stimulation of the midkine/ alk axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ 2011;18:959-73.
-
(2011)
Cell Death Differ
, vol.18
, pp. 959-973
-
-
Lorente, M.1
Torres, S.2
Salazar, M.3
-
57
-
-
33747624175
-
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
-
Ligresti A, Moriello AS, Starowicz K, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006;318:1375-87.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 1375-1387
-
-
Ligresti, A.1
Moriello, A.S.2
Starowicz, K.3
-
58
-
-
38449109178
-
5-Lipoxygenase and anandamide hydrolase (Faah) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
-
Massi P, Valenti M, Vaccani A, et al. 5-Lipoxygenase and anandamide hydrolase (faah) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008;104:1091-100.
-
(2008)
J Neurochem
, vol.104
, pp. 1091-1100
-
-
Massi, P.1
Valenti, M.2
Vaccani, A.3
-
59
-
-
79960115996
-
Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
-
Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 2011;10:1161-72.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1161-1172
-
-
Shrivastava, A.1
Kuzontkoski, P.M.2
Groopman, J.E.3
Prasad, A.4
-
60
-
-
84872128254
-
Triggering of the trpv2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
-
Nabissi M, Morelli MB, Santoni M, Santoni G. Triggering of the trpv2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 2012;34:48-57.
-
(2012)
Carcinogenesis
, vol.34
, pp. 48-57
-
-
Nabissi, M.1
Morelli, M.B.2
Santoni, M.3
Santoni, G.4
-
61
-
-
0037365941
-
Inhibition of tumor angiogenesis by cannabinoids
-
Blazquez C, Casanova ML, Planas A, et al. Inhibition of tumor angiogenesis by cannabinoids. FASEB J 2003;17:529-31.
-
(2003)
FASEB J
, vol.17
, pp. 529-531
-
-
Blazquez, C.1
Casanova, M.L.2
Planas, A.3
-
62
-
-
0141594998
-
Inhibitory effects of cannabinoid cb1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis
-
Portella G, Laezza C, Laccetti P, De Petrocellis L, Di Marzo V, Bifulco M. Inhibitory effects of cannabinoid cb1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 2003;17:1771-3.
-
(2003)
FASEB J
, vol.17
, pp. 1771-1773
-
-
Portella, G.1
Laezza, C.2
Laccetti, P.3
De Petrocellis, L.4
Di Marzo, V.5
Bifulco, M.6
-
63
-
-
34147215056
-
Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
-
Pisanti S, Borselli C, Oliviero O, Laezza C, Gazzerro P, Bifulco M. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. J Cell Physiol 2007;211:495-503.
-
(2007)
J Cell Physiol
, vol.211
, pp. 495-503
-
-
Pisanti, S.1
Borselli, C.2
Oliviero, O.3
Laezza, C.4
Gazzerro, P.5
Bifulco, M.6
-
64
-
-
40949083594
-
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
-
Blazquez C, Salazar M, Carracedo A, et al. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 2008;68:1945-52.
-
(2008)
Cancer Res
, vol.68
, pp. 1945-1952
-
-
Blazquez, C.1
Salazar, M.2
Carracedo, A.3
-
65
-
-
29144447456
-
Anandamide inhibits adhesion and migration of breast cancer cells
-
Grimaldi C, Pisanti S, Laezza C, et al. Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res 2006;312:363-73.
-
(2006)
Exp Cell Res
, vol.312
, pp. 363-373
-
-
Grimaldi, C.1
Pisanti, S.2
Laezza, C.3
-
66
-
-
70949091684
-
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
-
Qamri Z, Preet A, Nasser MW, et al. Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Mol Cancer Ther 2009;8:3117-29.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 3117-3129
-
-
Qamri, Z.1
Preet, A.2
Nasser, M.W.3
-
67
-
-
38049143945
-
Delta9-tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
-
Preet A, Ganju RK, Groopman JE. Delta9-tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 2008;27:339-46.
-
(2008)
Oncogene
, vol.27
, pp. 339-346
-
-
Preet, A.1
Ganju, R.K.2
Groopman, J.E.3
-
68
-
-
38049185265
-
Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1
-
Ramer R, Hinz B. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 2008;100:59-69.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 59-69
-
-
Ramer, R.1
Hinz, B.2
-
69
-
-
79960835512
-
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
-
McAllister SD, Murase R, Christian RT, et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat 2011;129:37-47.
-
(2011)
Breast Cancer Res Treat
, vol.129
, pp. 37-47
-
-
McAllister, S.D.1
Murase, R.2
Christian, R.T.3
-
70
-
-
84874840668
-
Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
-
Soroceanu L, Murase R, Limbad C, et al. Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target. Cancer Res 2012;73:1559-69.
-
(2012)
Cancer Res
, vol.73
, pp. 1559-1569
-
-
Soroceanu, L.1
Murase, R.2
Limbad, C.3
-
71
-
-
60549114334
-
Cb1 and cb2 cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (Thc)-induced T helper cell shift following immune activation by Legionella pneumophila infection
-
Newton CA, Chou PJ, Perkins I, Klein TW. cb1 and cb2 cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (thc)-induced T helper cell shift following immune activation by Legionella pneumophila infection. J Neuroimmune Pharmacol 2009;4:92-102.
-
(2009)
J Neuroimmune Pharmacol
, vol.4
, pp. 92-102
-
-
Newton, C.A.1
Chou, P.J.2
Perkins, I.3
Klein, T.W.4
-
72
-
-
33749014963
-
Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection
-
Lu T, Newton C, Perkins I, Friedman H, Klein TW. Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. J Pharmacol Exp Ther 2006;319:269-76.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 269-276
-
-
Lu, T.1
Newton, C.2
Perkins, I.3
Friedman, H.4
Klein, T.W.5
-
73
-
-
17144400758
-
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
-
Steffens S, Veillard NR, Arnaud C, et al. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 2005;434:782-6. [Erratum in: Nature 2005;435:528]
-
(2005)
Nature
, vol.434
, pp. 782-786
-
-
Steffens, S.1
Veillard, N.R.2
Arnaud, C.3
-
74
-
-
78649605467
-
Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
-
Hegde VL, Nagarkatti M, Nagarkatti PS. Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties. Eur J Immunol 2010;40:3358-71.
-
(2010)
Eur J Immunol
, vol.40
, pp. 3358-3371
-
-
Hegde, V.L.1
Nagarkatti, M.2
Nagarkatti, P.S.3
-
75
-
-
65549122582
-
Cannabinoids, endocannabinoids, and related analogs in inflammation
-
Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. AAPS J 2009;11:109-19.
-
(2009)
AAPS J
, vol.11
, pp. 109-119
-
-
Burstein, S.H.1
Zurier, R.B.2
-
76
-
-
79952279722
-
Cannabis-derived substances in cancer therapy—an emerging anti-inflammatory role for the cannabinoids
-
Liu WM, Fowler DW, Dalgleish AG. Cannabis-derived substances in cancer therapy—an emerging anti-inflammatory role for the cannabinoids. Curr Clin Pharmacol 2010;5:281-7.
-
(2010)
Curr Clin Pharmacol
, vol.5
, pp. 281-287
-
-
Liu, W.M.1
Fowler, D.W.2
Dalgleish, A.G.3
-
77
-
-
23744517089
-
Identification of midkine as a mediator for intercellular transfer of drug resistance
-
Mirkin BL, Clark S, Zheng X, et al. Identification of midkine as a mediator for intercellular transfer of drug resistance. Oncogene 2005;24:4965-74.
-
(2005)
Oncogene
, vol.24
, pp. 4965-4974
-
-
Mirkin, B.L.1
Clark, S.2
Zheng, X.3
-
78
-
-
34250204188
-
The midkine family in cancer, inflammation and neural development
-
Kadomatsu K. The midkine family in cancer, inflammation and neural development. Nagoya J Med Sci 2005;67:71-82.
-
(2005)
Nagoya J Med Sci
, vol.67
, pp. 71-82
-
-
Kadomatsu, K.1
-
79
-
-
66949152073
-
Anaplastic lymphoma kinase: Signalling in development and disease
-
Palmer RH, Vernersson E, Grabbe C, Hallberg B. Anaplastic lymphoma kinase: signalling in development and disease. Biochem J 2009;420:345-61.
-
(2009)
Biochem J
, vol.420
, pp. 345-361
-
-
Palmer, R.H.1
Vernersson, E.2
Grabbe, C.3
Hallberg, B.4
-
80
-
-
17444402489
-
Adjuvant chemotherapy in the treatment of high grade gliomas
-
Lonardi S, Tosoni A, Brandes AA. Adjuvant chemotherapy in the treatment of high grade gliomas. Cancer Treat Rev 2005;31:79-89.
-
(2005)
Cancer Treat Rev
, vol.31
, pp. 79-89
-
-
Lonardi, S.1
Tosoni, A.2
Brandes, A.A.3
-
81
-
-
33750719122
-
Therapeutic options for recurrent high-grade glioma in adult patients: Recent advances
-
Nieder C, Adam M, Molls M, Grosu AL. Therapeutic options for recurrent high-grade glioma in adult patients: recent advances. Crit Rev Oncol Hematol 2006;60:181-93.
-
(2006)
Crit Rev Oncol Hematol
, vol.60
, pp. 181-193
-
-
Nieder, C.1
Adam, M.2
Molls, M.3
Grosu, A.L.4
-
82
-
-
70350449411
-
Advances in the genetics of glioblastoma: Are we reaching critical mass?
-
Purow B, Schiff D. Advances in the genetics of glioblastoma: are we reaching critical mass? Nat Rev Neurol 2009;5:419-26.
-
(2009)
Nat Rev Neurol
, vol.5
, pp. 419-426
-
-
Purow, B.1
Schiff, D.2
-
83
-
-
70349088987
-
Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis
-
Lorente M, Carracedo A, Torres S, et al. Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. Glia 2009;57:1374-85.
-
(2009)
Glia
, vol.57
, pp. 1374-1385
-
-
Lorente, M.1
Carracedo, A.2
Torres, S.3
-
84
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-96.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den Bent, M.J.3
-
85
-
-
78751527443
-
A combined preclinical therapy of cannabinoids and temozolomide against glioma
-
Torres S, Lorente M, Rodriguez-Fornes F, et al. A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 2011;10:90-103.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 90-103
-
-
Torres, S.1
Lorente, M.2
Rodriguez-Fornes, F.3
-
86
-
-
77957364747
-
Translating cancer research into targeted therapeutics
-
de Bono JS, Ashworth A. Translating cancer research into targeted therapeutics. Nature 2010;467:543-9.
-
(2010)
Nature
, vol.467
, pp. 543-549
-
-
De Bono, J.S.1
Ashworth, A.2
-
87
-
-
79955755025
-
Targeting oncogenic alk: A promising strategy for cancer treatment
-
Grande E, Bolos MV, Arriola E. Targeting oncogenic alk: a promising strategy for cancer treatment. Mol Cancer Ther 2011;10:569-79.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 569-579
-
-
Grande, E.1
Bolos, M.V.2
Arriola, E.3
-
88
-
-
79959956124
-
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ros-mediated mechanism
-
Donadelli M, Dando I, Zaniboni T, et al. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ros-mediated mechanism. Cell Death Dis 2011;2:e152.
-
(2011)
Cell Death Dis
, vol.2
-
-
Donadelli, M.1
Dando, I.2
Zaniboni, T.3
-
89
-
-
67349195495
-
Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines
-
Miyato H, Kitayama J, Yamashita H, et al. Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. J Surg Res 2009;155:40-7.
-
(2009)
J Surg Res
, vol.155
, pp. 40-47
-
-
Miyato, H.1
Kitayama, J.2
Yamashita, H.3
-
90
-
-
58849113520
-
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: Synergism with 5-fluorouracil
-
Gustafsson SB, Lindgren T, Jonsson M, Jacobsson SO. Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil. Cancer Chemother Pharmacol 2009;63:691-701.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 691-701
-
-
Gustafsson, S.B.1
Lindgren, T.2
Jonsson, M.3
Jacobsson, S.O.4
-
91
-
-
33748492117
-
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
-
Massi P, Vaccani A, Bianchessi S, Costa B, Macchi P, Parolaro D. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 2006;63:2057-66.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2057-2066
-
-
Massi, P.1
Vaccani, A.2
Bianchessi, S.3
Costa, B.4
Macchi, P.5
Parolaro, D.6
-
92
-
-
36749015683
-
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
-
McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther 2007;6:2921-7.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2921-2927
-
-
McAllister, S.D.1
Christian, R.T.2
Horowitz, M.P.3
Garcia, A.4
Desprez, P.Y.5
-
93
-
-
73949139182
-
Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
-
Marcu JP, Christian RT, Lau D, et al. Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther 2010;9:180-9.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 180-189
-
-
Marcu, J.P.1
Christian, R.T.2
Lau, D.3
-
94
-
-
84917737275
-
The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model
-
Scott KA, Dalgleish AG, Liu WM. The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. Mol Cancer Ther 2014;13:2955-67.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2955-2967
-
-
Scott, K.A.1
Dalgleish, A.G.2
Liu, W.M.3
-
95
-
-
0035651034
-
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
-
Bifulco M, Laezza C, Portella G, et al. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J 2001;15:2745-7.
-
(2001)
FASEB J
, vol.15
, pp. 2745-2747
-
-
Bifulco, M.1
Laezza, C.2
Portella, G.3
-
96
-
-
0042972716
-
Possible endocannabinoid control of colorectal cancer growth
-
Ligresti A, Bisogno T, Matias I, et al. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 2003;125:677-87.
-
(2003)
Gastroenterology
, vol.125
, pp. 677-687
-
-
Ligresti, A.1
Bisogno, T.2
Matias, I.3
|