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Volumn 38, Issue 7, 2012, Pages 911-918

Cannabinoids: A new hope for breast cancer therapy?

Author keywords

Cannabinoids; G protein coupled receptors; Preclinical studies

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ANANDAMIDE; BEVACIZUMAB; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CHEMOKINE RECEPTOR CXCR4; DRONABINOL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FLUOROURACIL; GEMCITABINE; LAPATINIB; NABILONE; NABIXIMOLS; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PACLITAXEL; PROGESTERONE RECEPTOR; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; TEMOZOLOMIDE; TRASTUZUMAB;

EID: 84865417165     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2012.06.005     Document Type: Review
Times cited : (98)

References (75)
  • 1
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Gaoni Y., Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964, 86:1646-1647.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 2
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P., Batkai S., Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006, 58:389-462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 3
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda L.A., Lolait S.J., Brownstein M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990, 346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3
  • 4
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane W.A., Hanus L., Breuer A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258:1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 5
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R., Ben-Shabat S., Hanus L., et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995, 50:83-90.
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3
  • 6
    • 0028970517 scopus 로고
    • 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain
    • Sugiura T., Kondo S., Sukagawa A., et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 1995, 215:89-97.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 89-97
    • Sugiura, T.1    Kondo, S.2    Sukagawa, A.3
  • 7
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993, 365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 8
    • 78650120798 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB
    • Pertwee R.G., Howlett A.C., Abood M.E., et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB. Pharmacol Rev 2010, 62:588-631.
    • (2010) Pharmacol Rev , vol.62 , pp. 588-631
    • Pertwee, R.G.1    Howlett, A.C.2    Abood, M.E.3
  • 9
    • 50349086035 scopus 로고    scopus 로고
    • Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis
    • Machado Rocha F.C., Stefano S.C., De Cassia Haiek R., et al. Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis. Eur J Cancer Care (Engl) 2008, 17:431-443.
    • (2008) Eur J Cancer Care (Engl) , vol.17 , pp. 431-443
    • Machado Rocha, F.C.1    Stefano, S.C.2    De Cassia Haiek, R.3
  • 13
    • 80053426842 scopus 로고    scopus 로고
    • Targeted therapies for breast cancer
    • Higgins M.J., Baselga J. Targeted therapies for breast cancer. J Clin Invest 2011, 121:3797-3803.
    • (2011) J Clin Invest , vol.121 , pp. 3797-3803
    • Higgins, M.J.1    Baselga, J.2
  • 14
    • 80053562371 scopus 로고    scopus 로고
    • Development of subtype-selective oestrogen receptor-based therapeutics
    • Nilsson S., Koehler K.F., Gustafsson J.A. Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discov 2011, 10:778-792.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 778-792
    • Nilsson, S.1    Koehler, K.F.2    Gustafsson, J.A.3
  • 15
    • 0032493378 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
    • De Petrocellis L., Melck D., Palmisano A., et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci U S A 1998, 95:8375-8380.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8375-8380
    • De Petrocellis, L.1    Melck, D.2    Palmisano, A.3
  • 16
    • 0033405883 scopus 로고    scopus 로고
    • Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells
    • Melck D., Rueda D., Galve-Roperh I., et al. Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. FEBS Lett 1999, 463:235-240.
    • (1999) FEBS Lett , vol.463 , pp. 235-240
    • Melck, D.1    Rueda, D.2    Galve-Roperh, I.3
  • 17
    • 0034465259 scopus 로고    scopus 로고
    • Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
    • Melck D., De Petrocellis L., Orlando P., et al. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 2000, 141:118-126.
    • (2000) Endocrinology , vol.141 , pp. 118-126
    • Melck, D.1    De Petrocellis, L.2    Orlando, P.3
  • 18
    • 50649112355 scopus 로고    scopus 로고
    • JunD is involved in the antiproliferative effect of Delta(9)-tetrahydrocannabinol on human breast cancer cells
    • Caffarel M.M., Moreno-Bueno G., Cerutti C., et al. JunD is involved in the antiproliferative effect of Delta(9)-tetrahydrocannabinol on human breast cancer cells. Oncogene 2008, 27:5033-5044.
    • (2008) Oncogene , vol.27 , pp. 5033-5044
    • Caffarel, M.M.1    Moreno-Bueno, G.2    Cerutti, C.3
  • 19
    • 33746125474 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
    • Caffarel M.M., Sarrio D., Palacios J., et al. Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 2006, 66:6615-6621.
    • (2006) Cancer Res , vol.66 , pp. 6615-6621
    • Caffarel, M.M.1    Sarrio, D.2    Palacios, J.3
  • 20
    • 80052532033 scopus 로고    scopus 로고
    • Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion
    • Nasser M.W., Qamri Z., Deol Y.S., et al. Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. PLoS One 2011, 6:e23901.
    • (2011) PLoS One , vol.6
    • Nasser, M.W.1    Qamri, Z.2    Deol, Y.S.3
  • 21
    • 80052094283 scopus 로고    scopus 로고
    • Homeostatic chemokine receptors and organ-specific metastasis
    • Zlotnik A., Burkhardt A.M., Homey B. Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol 2011, 11:597-606.
    • (2011) Nat Rev Immunol , vol.11 , pp. 597-606
    • Zlotnik, A.1    Burkhardt, A.M.2    Homey, B.3
  • 22
    • 34547676475 scopus 로고    scopus 로고
    • ErbB receptors: from oncogenes to targeted cancer therapies
    • Zhang H., Berezov A., Wang Q., et al. ErbB receptors: from oncogenes to targeted cancer therapies. J Clin Invest 2007, 117:2051-2058.
    • (2007) J Clin Invest , vol.117 , pp. 2051-2058
    • Zhang, H.1    Berezov, A.2    Wang, Q.3
  • 23
    • 77954789824 scopus 로고    scopus 로고
    • Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
    • Caffarel M.M., Andradas C., Mira E., et al. Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol Cancer 2010, 9:196.
    • (2010) Mol Cancer , vol.9 , pp. 196
    • Caffarel, M.M.1    Andradas, C.2    Mira, E.3
  • 24
    • 34247499539 scopus 로고    scopus 로고
    • Insights from transgenic mouse models of ERBB2-induced breast cancer
    • Ursini-Siegel J., Schade B., Cardiff R.D., et al. Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer 2007, 7:389-397.
    • (2007) Nat Rev Cancer , vol.7 , pp. 389-397
    • Ursini-Siegel, J.1    Schade, B.2    Cardiff, R.D.3
  • 25
    • 65449146377 scopus 로고    scopus 로고
    • Emerging strategies for exploiting cannabinoid receptor agonists as medicines
    • Pertwee R.G. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 2009, 156:397-411.
    • (2009) Br J Pharmacol , vol.156 , pp. 397-411
    • Pertwee, R.G.1
  • 26
    • 33750507764 scopus 로고    scopus 로고
    • Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells
    • Laezza C., Pisanti S., Crescenzi E., et al. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. FEBS Lett 2006, 580:6076-6082.
    • (2006) FEBS Lett , vol.580 , pp. 6076-6082
    • Laezza, C.1    Pisanti, S.2    Crescenzi, E.3
  • 27
    • 33747624175 scopus 로고    scopus 로고
    • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    • Ligresti A., Moriello A.S., Starowicz K., et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006, 318:1375-1387.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1375-1387
    • Ligresti, A.1    Moriello, A.S.2    Starowicz, K.3
  • 28
    • 36749015683 scopus 로고    scopus 로고
    • Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
    • McAllister S.D., Christian R.T., Horowitz M.P., et al. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther 2007, 6:2921-2927.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2921-2927
    • McAllister, S.D.1    Christian, R.T.2    Horowitz, M.P.3
  • 29
    • 79960835512 scopus 로고    scopus 로고
    • Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
    • McAllister S.D., Murase R., Christian R.T., et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat 2011.
    • (2011) Breast Cancer Res Treat
    • McAllister, S.D.1    Murase, R.2    Christian, R.T.3
  • 30
    • 70949091684 scopus 로고    scopus 로고
    • Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
    • Qamri Z., Preet A., Nasser M.W., et al. Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Mol Cancer Ther 2009, 8:3117-3129.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3117-3129
    • Qamri, Z.1    Preet, A.2    Nasser, M.W.3
  • 31
    • 79960115996 scopus 로고    scopus 로고
    • Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
    • Shrivastava A., Kuzontkoski P.M., Groopman J.E., et al. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 2011, 10:1161-1172.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1161-1172
    • Shrivastava, A.1    Kuzontkoski, P.M.2    Groopman, J.E.3
  • 32
    • 29144447456 scopus 로고    scopus 로고
    • Anandamide inhibits adhesion and migration of breast cancer cells
    • Grimaldi C., Pisanti S., Laezza C., et al. Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res 2006, 312:363-373.
    • (2006) Exp Cell Res , vol.312 , pp. 363-373
    • Grimaldi, C.1    Pisanti, S.2    Laezza, C.3
  • 33
    • 58249101216 scopus 로고    scopus 로고
    • The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway
    • Laezza C., Pisanti S., Malfitano A.M., et al. The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. Endocr Relat Cancer 2008, 15:965-974.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 965-974
    • Laezza, C.1    Pisanti, S.2    Malfitano, A.M.3
  • 34
    • 84855184409 scopus 로고    scopus 로고
    • Impact of cyclooxygenase-2 in breast cancer
    • Hoellen F., Kelling K., Dittmer C., et al. Impact of cyclooxygenase-2 in breast cancer. Anticancer Res 2011, 31:4359-4367.
    • (2011) Anticancer Res , vol.31 , pp. 4359-4367
    • Hoellen, F.1    Kelling, K.2    Dittmer, C.3
  • 35
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: biochemistry and biology
    • Jaffe A.B., Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005, 21:247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 36
    • 68549122708 scopus 로고    scopus 로고
    • Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
    • Narumiya S., Tanji M., Ishizaki T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 2009, 28:65-76.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 65-76
    • Narumiya, S.1    Tanji, M.2    Ishizaki, T.3
  • 37
    • 68549126922 scopus 로고    scopus 로고
    • The cytoskeleton and cancer
    • Hall A. The cytoskeleton and cancer. Cancer Metastasis Rev 2009, 28:5-14.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 5-14
    • Hall, A.1
  • 38
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    • Izzo A.A., Borrelli F., Capasso R., et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009, 30:515-527.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3
  • 40
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T., Hanus L., De Petrocellis L., et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 2001, 134:845-852.
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3
  • 41
    • 66449115318 scopus 로고    scopus 로고
    • Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    • Salazar M., Carracedo A., Salanueva I.J., et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009.
    • (2009) J Clin Invest
    • Salazar, M.1    Carracedo, A.2    Salanueva, I.J.3
  • 42
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • Carracedo A., Gironella M., Lorente M., et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006, 66:6748-6755.
    • (2006) Cancer Res , vol.66 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3
  • 43
    • 79958809001 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    • Vara D., Salazar M., Olea-Herrero N., et al. Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ 2011, 18:1099-1111.
    • (2011) Cell Death Differ , vol.18 , pp. 1099-1111
    • Vara, D.1    Salazar, M.2    Olea-Herrero, N.3
  • 44
    • 67651183775 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
    • Oesch S., Walter D., Wachtel M., et al. Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma. Mol Cancer Ther 2009, 8:1838-1845.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1838-1845
    • Oesch, S.1    Walter, D.2    Wachtel, M.3
  • 45
    • 33751198532 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win, 55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    • Gustafsson K., Christensson B., Sander B., et al. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win, 55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol Pharmacol 2006, 70:1612-1620.
    • (2006) Mol Pharmacol , vol.70 , pp. 1612-1620
    • Gustafsson, K.1    Christensson, B.2    Sander, B.3
  • 46
    • 33748492117 scopus 로고    scopus 로고
    • The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
    • Massi P., Vaccani A., Bianchessi S., et al. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 2006, 63:2057-2066.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2057-2066
    • Massi, P.1    Vaccani, A.2    Bianchessi, S.3
  • 47
    • 33747592582 scopus 로고    scopus 로고
    • Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression
    • McKallip R.J., Jia W., Schlomer J., et al. Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol Pharmacol 2006, 70:897-908.
    • (2006) Mol Pharmacol , vol.70 , pp. 897-908
    • McKallip, R.J.1    Jia, W.2    Schlomer, J.3
  • 48
    • 14844362003 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    • McKallip R.J., Nagarkatti M., Nagarkatti P.S. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 2005, 174:3281-3289.
    • (2005) J Immunol , vol.174 , pp. 3281-3289
    • McKallip, R.J.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 49
    • 0034235808 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway
    • Zhu L.X., Sharma S., Stolina M., et al. Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunol 2000, 165:373-380.
    • (2000) J Immunol , vol.165 , pp. 373-380
    • Zhu, L.X.1    Sharma, S.2    Stolina, M.3
  • 50
    • 0642273057 scopus 로고    scopus 로고
    • Methanandamide increases COX-2 expression and tumor growth in murine lung cancer
    • Gardner B., Zhu L.X., Sharma S., et al. Methanandamide increases COX-2 expression and tumor growth in murine lung cancer. FASEB J 2003, 17:2157-2159.
    • (2003) FASEB J , vol.17 , pp. 2157-2159
    • Gardner, B.1    Zhu, L.X.2    Sharma, S.3
  • 51
    • 33845627660 scopus 로고    scopus 로고
    • Cannabinoid receptors as novel targets for the treatment of melanoma
    • Blazquez C., Carracedo A., Barrado L., et al. Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 2006, 20:2633-2635.
    • (2006) FASEB J , vol.20 , pp. 2633-2635
    • Blazquez, C.1    Carracedo, A.2    Barrado, L.3
  • 52
    • 26844566936 scopus 로고    scopus 로고
    • Toxicity and carcinogenicity of delta 9-tetrahydrocannabinol in Fischer rats and B6C3F1 mice
    • Chan P.C., Sills R.C., Braun A.G., et al. Toxicity and carcinogenicity of delta 9-tetrahydrocannabinol in Fischer rats and B6C3F1 mice. Fundam Appl Toxicol 1996, 30:109-117.
    • (1996) Fundam Appl Toxicol , vol.30 , pp. 109-117
    • Chan, P.C.1    Sills, R.C.2    Braun, A.G.3
  • 53
    • 63149189746 scopus 로고    scopus 로고
    • Modulation of Delta9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase
    • Takeda S., Yamamoto I., Watanabe K. Modulation of Delta9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase. Toxicology 2009, 259:25-32.
    • (2009) Toxicology , vol.259 , pp. 25-32
    • Takeda, S.1    Yamamoto, I.2    Watanabe, K.3
  • 54
    • 39249083222 scopus 로고    scopus 로고
    • Delta(9)-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling
    • Takeda S., Yamaori S., Motoya E., et al. Delta(9)-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling. Toxicology 2008, 245:141-146.
    • (2008) Toxicology , vol.245 , pp. 141-146
    • Takeda, S.1    Yamaori, S.2    Motoya, E.3
  • 56
    • 38049025796 scopus 로고    scopus 로고
    • Expression of cannabinoid receptors and neurotrophins in human gliomas
    • Calatozzolo C., Salmaggi A., Pollo B., et al. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurol Sci 2007, 28:304-310.
    • (2007) Neurol Sci , vol.28 , pp. 304-310
    • Calatozzolo, C.1    Salmaggi, A.2    Pollo, B.3
  • 57
    • 33846921353 scopus 로고    scopus 로고
    • Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors
    • Ellert-Miklaszewska A., Grajkowska W., Gabrusiewicz K., et al. Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors. Brain Res 2007, 1137:161-169.
    • (2007) Brain Res , vol.1137 , pp. 161-169
    • Ellert-Miklaszewska, A.1    Grajkowska, W.2    Gabrusiewicz, K.3
  • 58
    • 0035422139 scopus 로고    scopus 로고
    • Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    • Sanchez C., de Ceballos M.L., Gomez del Pulgar T., et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 2001, 61:5784-5789.
    • (2001) Cancer Res , vol.61 , pp. 5784-5789
    • Sanchez, C.1    de Ceballos, M.L.2    Gomez del Pulgar, T.3
  • 59
    • 78650812262 scopus 로고    scopus 로고
    • Tumour Cannabinoid CB(1) receptor and phosphorylated epidermal growth factor receptor expression are additive prognostic markers for prostate cancer
    • Fowler C.J., Hammarsten P., Bergh A. Tumour Cannabinoid CB(1) receptor and phosphorylated epidermal growth factor receptor expression are additive prognostic markers for prostate cancer. PLoS One 2010, 5:e15205.
    • (2010) PLoS One , vol.5
    • Fowler, C.J.1    Hammarsten, P.2    Bergh, A.3
  • 60
    • 80052069061 scopus 로고    scopus 로고
    • High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer
    • Gustafsson S.B., Palmqvist R., Henriksson M.L., et al. High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer. PLoS One 2011, 6:e23003.
    • (2011) PLoS One , vol.6
    • Gustafsson, S.B.1    Palmqvist, R.2    Henriksson, M.L.3
  • 61
    • 45549095987 scopus 로고    scopus 로고
    • The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
    • Zheng D., Bode A.M., Zhao Q., et al. The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 2008, 68:3992-3998.
    • (2008) Cancer Res , vol.68 , pp. 3992-3998
    • Zheng, D.1    Bode, A.M.2    Zhao, Q.3
  • 62
    • 51049102995 scopus 로고    scopus 로고
    • Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    • Wang D., Wang H., Ning W., et al. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 2008, 68:6468-6476.
    • (2008) Cancer Res , vol.68 , pp. 6468-6476
    • Wang, D.1    Wang, H.2    Ning, W.3
  • 63
    • 33645763253 scopus 로고    scopus 로고
    • The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    • Carracedo A., Lorente M., Egia A., et al. The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 2006, 9:301-312.
    • (2006) Cancer Cell , vol.9 , pp. 301-312
    • Carracedo, A.1    Lorente, M.2    Egia, A.3
  • 64
    • 17344380844 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
    • Galve-Roperh I., Sanchez C., Cortes M.L., et al. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000, 6:313-319.
    • (2000) Nat Med , vol.6 , pp. 313-319
    • Galve-Roperh, I.1    Sanchez, C.2    Cortes, M.L.3
  • 65
    • 0037253496 scopus 로고    scopus 로고
    • Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    • Casanova M.L., Blazquez C., Martinez-Palacio J., et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003, 111:43-50.
    • (2003) J Clin Invest , vol.111 , pp. 43-50
    • Casanova, M.L.1    Blazquez, C.2    Martinez-Palacio, J.3
  • 66
    • 34548498839 scopus 로고    scopus 로고
    • The toxicology of cannabis and cannabis prohibition
    • Grotenhermen F. The toxicology of cannabis and cannabis prohibition. Chem Biodivers 2007, 4:1744-1769.
    • (2007) Chem Biodivers , vol.4 , pp. 1744-1769
    • Grotenhermen, F.1
  • 67
    • 84860660570 scopus 로고    scopus 로고
    • Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial
    • Portenoy R.K., Ganae-Motan E.D., Allende S., et al. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. J Pain 2012.
    • (2012) J Pain
    • Portenoy, R.K.1    Ganae-Motan, E.D.2    Allende, S.3
  • 68
    • 77953796878 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis
    • Wade D.T., Collin C., Stott C., et al. Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Mult Scler 2010, 16:707-714.
    • (2010) Mult Scler , vol.16 , pp. 707-714
    • Wade, D.T.1    Collin, C.2    Stott, C.3
  • 69
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: potential anticancer agents
    • Guzman M. Cannabinoids: potential anticancer agents. Nat Rev Cancer 2003, 3:745-755.
    • (2003) Nat Rev Cancer , vol.3 , pp. 745-755
    • Guzman, M.1
  • 70
    • 80051985532 scopus 로고    scopus 로고
    • Abuse potential and psychoactive effects of delta-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine
    • Robson P. Abuse potential and psychoactive effects of delta-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine. Expert Opin Drug Saf 2011, 10:675-685.
    • (2011) Expert Opin Drug Saf , vol.10 , pp. 675-685
    • Robson, P.1
  • 71
    • 78751527443 scopus 로고    scopus 로고
    • A combined preclinical therapy of cannabinoids and temozolomide against glioma
    • Torres S., Lorente M., Rodriguez-Fornes F., et al. A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 2011, 10:90-103.
    • (2011) Mol Cancer Ther , vol.10 , pp. 90-103
    • Torres, S.1    Lorente, M.2    Rodriguez-Fornes, F.3
  • 72
    • 79959956124 scopus 로고    scopus 로고
    • Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
    • Donadelli M., Dando I., Zaniboni T., et al. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis 2011, 2:e152.
    • (2011) Cell Death Dis , vol.2
    • Donadelli, M.1    Dando, I.2    Zaniboni, T.3
  • 73
    • 67349195495 scopus 로고    scopus 로고
    • Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines
    • Miyato H., Kitayama J., Yamashita H., et al. Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. J Surg Res 2009, 155:40-47.
    • (2009) J Surg Res , vol.155 , pp. 40-47
    • Miyato, H.1    Kitayama, J.2    Yamashita, H.3
  • 74
    • 58849113520 scopus 로고    scopus 로고
    • Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil
    • Gustafsson S.B., Lindgren T., Jonsson M., et al. Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil. Cancer Chemother Pharmacol 2009, 63:691-701.
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 691-701
    • Gustafsson, S.B.1    Lindgren, T.2    Jonsson, M.3
  • 75
    • 73949139182 scopus 로고    scopus 로고
    • Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
    • Marcu J.P., Christian R.T., Lau D., et al. Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther 2010, 9:180-189.
    • (2010) Mol Cancer Ther , vol.9 , pp. 180-189
    • Marcu, J.P.1    Christian, R.T.2    Lau, D.3


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