메뉴 건너뛰기




Volumn 8, Issue 10, 2013, Pages

Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2

Author keywords

[No Author keywords available]

Indexed keywords

FUMARIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRANSCRIPTION FACTOR NRF2; VASCULOTROPIN;

EID: 84884831484     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076670     Document Type: Article
Times cited : (41)

References (40)
  • 1
    • 79955985384 scopus 로고    scopus 로고
    • Fumarate esters as angiogenesis inhibitors: key to action in psoriasis?
    • 10.1038/jid.2011.45
    • Arbiser JL, (2011) Fumarate esters as angiogenesis inhibitors: key to action in psoriasis? J Invest Dermatol 131: 1189-1191. doi:10.1038/jid.2011.45. PubMed: 21566578.
    • (2011) J Invest Dermatol , vol.131 , pp. 1189-1191
    • Arbiser, J.L.1
  • 2
    • 84866423965 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
    • 10.1056/NEJMoa1114287
    • Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, et al. (2012) Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 367: 1098-1107. doi:10.1056/NEJMoa1114287. PubMed: 22992073.
    • (2012) N Engl J Med , vol.367 , pp. 1098-1107
    • Gold, R.1    Kappos, L.2    Arnold, D.L.3    Bar-Or, A.4    Giovannoni, G.5
  • 3
    • 84863426841 scopus 로고    scopus 로고
    • Effects of dimethyl fumarate on neuroprotection and immunomodulation
    • 10.1186/1742-2094-9-163
    • Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, et al. (2012) Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation 9: 163. doi:10.1186/1742-2094-9-163. PubMed: 22769044.
    • (2012) J Neuroinflammation , vol.9 , pp. 163
    • Albrecht, P.1    Bouchachia, I.2    Goebels, N.3    Henke, N.4    Hofstetter, H.H.5
  • 4
    • 84865009934 scopus 로고    scopus 로고
    • Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor kappa B (NF-kappaB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling
    • 10.1074/jbc.M112.383380
    • Peng H, Guerau-de-Arellano M, Mehta VB, Yang Y, Huss DJ, et al. (2012) Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor kappa B (NF-kappaB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem 287: 28017-28026. doi:10.1074/jbc.M112.383380. PubMed: 22733812.
    • (2012) J Biol Chem , vol.287 , pp. 28017-28026
    • Peng, H.1    Guerau-de-Arellano, M.2    Mehta, V.B.3    Yang, Y.4    Huss, D.J.5
  • 5
    • 79958153194 scopus 로고    scopus 로고
    • The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1
    • Lin SX, Lisi L, Dello Russo C, Polak PE, Sharp A, et al. (2011) The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1. ASN. New Eur 3.
    • (2011) ASN. New Eur , vol.3
    • Lin, S.X.1    Lisi, L.2    Dello Russo, C.3    Polak, P.E.4    Sharp, A.5
  • 6
    • 84863244462 scopus 로고    scopus 로고
    • Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway
    • 10.1016/j.cmet.2012.01.017
    • Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, et al. (2012) Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab 15: 361-371. doi:10.1016/j.cmet.2012.01.017. PubMed: 22405071.
    • (2012) Cell Metab , vol.15 , pp. 361-371
    • Ashrafian, H.1    Czibik, G.2    Bellahcene, M.3    Aksentijević, D.4    Smith, A.C.5
  • 7
    • 84867324847 scopus 로고    scopus 로고
    • Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling
    • 10.1371/journal.pone.0045870
    • Oh CJ, Kim JY, Choi YK, Kim HJ, Jeong JY, et al. (2012) Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling. PLOS ONE 7: e45870. doi:10.1371/journal.pone.0045870. PubMed: 23056222.
    • (2012) PLOS ONE , vol.7
    • Oh, C.J.1    Kim, J.Y.2    Choi, Y.K.3    Kim, H.J.4    Jeong, J.Y.5
  • 8
    • 84858648216 scopus 로고    scopus 로고
    • Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway
    • 10.1124/jpet.111.190132
    • Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, et al. (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther 341: 274-284. doi:10.1124/jpet.111.190132. PubMed: 22267202.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 274-284
    • Scannevin, R.H.1    Chollate, S.2    Jung, M.Y.3    Shackett, M.4    Patel, H.5
  • 9
    • 79952136166 scopus 로고    scopus 로고
    • Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
    • 10.1093/brain/awq386
    • Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, et al. (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134: 678-692. doi:10.1093/brain/awq386. PubMed: 21354971.
    • (2011) Brain , vol.134 , pp. 678-692
    • Linker, R.A.1    Lee, D.H.2    Ryan, S.3    van Dam, A.M.4    Conrad, R.5
  • 10
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • 17182618
    • Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, et al. (2007) Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem 282: 4524-4532. PubMed: 17182618.
    • (2007) J Biol Chem , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsilä, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5
  • 11
    • 77953319433 scopus 로고    scopus 로고
    • Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites
    • 10.1074/jbc.M110.101048
    • Serra-Pérez A, Planas AM, Núñez-O'Mara A, Berra E, García-Villoria J, et al. (2010) Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites. J Biol Chem 285: 18217-18224. doi:10.1074/jbc.M110.101048. PubMed: 20368331.
    • (2010) J Biol Chem , vol.285 , pp. 18217-18224
    • Serra-Pérez, A.1    Planas, A.M.2    Núñez-O'Mara, A.3    Berra, E.4    García-Villoria, J.5
  • 12
    • 80052607424 scopus 로고    scopus 로고
    • Overexpression of carbonic anhydrase and HIF-1alpha in Wilms tumours
    • 10.1186/1471-2407-11-390
    • Dungwa JV, Hunt LP, Ramani P, (2011) Overexpression of carbonic anhydrase and HIF-1alpha in Wilms tumours. BMC Cancer 11: 390. doi:10.1186/1471-2407-11-390. PubMed: 21910893.
    • (2011) BMC Cancer , vol.11 , pp. 390
    • Dungwa, J.V.1    Hunt, L.P.2    Ramani, P.3
  • 13
    • 84866601479 scopus 로고    scopus 로고
    • Regulation of metabolism by hypoxia-inducible factor 1
    • 10.1101/sqb.2011.76.010678
    • Semenza GL, (2011) Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harb Symp Quant Biol 76: 347-353. doi:10.1101/sqb.2011.76.010678. PubMed: 21785006.
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 347-353
    • Semenza, G.L.1
  • 14
    • 0041903805 scopus 로고    scopus 로고
    • VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    • 10.1038/ng1211
    • Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, et al. (2003) VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 34: 383-394. doi:10.1038/ng1211. PubMed: 12847526.
    • (2003) Nat Genet , vol.34 , pp. 383-394
    • Lambrechts, D.1    Storkebaum, E.2    Morimoto, M.3    Del-Favero, J.4    Desmet, F.5
  • 15
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • 10.1038/88842
    • Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, et al. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 28: 131-138. doi:10.1038/88842. PubMed: 11381259.
    • (2001) Nat Genet , vol.28 , pp. 131-138
    • Oosthuyse, B.1    Moons, L.2    Storkebaum, E.3    Beck, H.4    Nuyens, D.5
  • 16
    • 78650721472 scopus 로고    scopus 로고
    • Deregulation of the hypoxia inducible factor-1alpha pathway in monocytes from sporadic amyotrophic lateral sclerosis patients
    • 10.1016/j.neuroscience.2010.10.040
    • Moreau C, Gosset P, Kluza J, Brunaud-Danel V, Lassalle P, et al. (2011) Deregulation of the hypoxia inducible factor-1alpha pathway in monocytes from sporadic amyotrophic lateral sclerosis patients. Neuroscience 172: 110-117. doi:10.1016/j.neuroscience.2010.10.040. PubMed: 20977930.
    • (2011) Neuroscience , vol.172 , pp. 110-117
    • Moreau, C.1    Gosset, P.2    Kluza, J.3    Brunaud-Danel, V.4    Lassalle, P.5
  • 17
    • 2642526164 scopus 로고    scopus 로고
    • VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
    • 10.1038/nature02544
    • Azzouz M, Ralph GS, Storkebaum E, Walmsley LE, Mitrophanous KA, et al. (2004) VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429: 413-417. doi:10.1038/nature02544. PubMed: 15164063.
    • (2004) Nature , vol.429 , pp. 413-417
    • Azzouz, M.1    Ralph, G.S.2    Storkebaum, E.3    Walmsley, L.E.4    Mitrophanous, K.A.5
  • 18
    • 14044271973 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial growth factor in cancer
    • 10.1016/j.cytogfr.2005.01.005
    • Loureiro RM, D'Amore PA, (2005) Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev 16: 77-89. doi:10.1016/j.cytogfr.2005.01.005. PubMed: 15733833.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 77-89
    • Loureiro, R.M.1    D'Amore, P.A.2
  • 19
    • 75549083984 scopus 로고    scopus 로고
    • Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
    • 10.1038/sj.bjc.6605486
    • Chen J, Imanaka N, Griffin JD, (2010) Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer 102: 351-360. doi:10.1038/sj.bjc.6605486. PubMed: 20010940.
    • (2010) Br J Cancer , vol.102 , pp. 351-360
    • Chen, J.1    Imanaka, N.2    Griffin, J.D.3
  • 20
    • 40649089427 scopus 로고    scopus 로고
    • PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)
    • 10.1073/pnas.0706790105
    • Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS, (2008) PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A 105: 2622-2627. doi:10.1073/pnas.0706790105. PubMed: 18268343.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2622-2627
    • Emerling, B.M.1    Weinberg, F.2    Liu, J.L.3    Mak, T.W.4    Chandel, N.S.5
  • 21
    • 77955352128 scopus 로고    scopus 로고
    • Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy
    • 10.4161/auto.6.5.12189
    • Fan W, Tang Z, Chen D, Moughon D, Ding X, et al. (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6: 614-621. doi:10.4161/auto.6.5.12189. PubMed: 20495340.
    • (2010) Autophagy , vol.6 , pp. 614-621
    • Fan, W.1    Tang, Z.2    Chen, D.3    Moughon, D.4    Ding, X.5
  • 22
    • 0037377144 scopus 로고    scopus 로고
    • Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
    • 12453873
    • Alam J, Killeen E, Gong P, Naquin R, Hu B, et al. (2003) Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am J Physiol Renal Physiol 284: F743-F752. PubMed: 12453873.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Alam, J.1    Killeen, E.2    Gong, P.3    Naquin, R.4    Hu, B.5
  • 23
    • 0141649274 scopus 로고    scopus 로고
    • Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element
    • 10.1016/j.bbaexp.2003.08.006
    • Lee JM, Anderson PC, Padgitt JK, Hanson JM, Waters CM, et al. (2003) Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. Biochim Biophys Acta 1629: 92-101. doi:10.1016/j.bbaexp.2003.08.006. PubMed: 14522084.
    • (2003) Biochim Biophys Acta , vol.1629 , pp. 92-101
    • Lee, J.M.1    Anderson, P.C.2    Padgitt, J.K.3    Hanson, J.M.4    Waters, C.M.5
  • 24
    • 38849092688 scopus 로고    scopus 로고
    • Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells
    • 10.1158/0008-5472.CAN-07-2751
    • Suswam E, Li Y, Zhang X, Gillespie GY, Li X, et al. (2008) Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res 68: 674-682. doi:10.1158/0008-5472.CAN-07-2751. PubMed: 18245466.
    • (2008) Cancer Res , vol.68 , pp. 674-682
    • Suswam, E.1    Li, Y.2    Zhang, X.3    Gillespie, G.Y.4    Li, X.5
  • 25
    • 40949102111 scopus 로고    scopus 로고
    • Post-transcriptional control of cytokine production
    • 10.1038/ni1584
    • Anderson P, (2008) Post-transcriptional control of cytokine production. Nat Immunol 9: 353-359. doi:10.1038/ni1584. PubMed: 18349815.
    • (2008) Nat Immunol , vol.9 , pp. 353-359
    • Anderson, P.1
  • 26
    • 0035871942 scopus 로고    scopus 로고
    • Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells
    • 10.1016/S0006-2952(01)00564-0
    • Chun YS, Yeo EJ, Choi E, Teng CM, Bae JM, et al. (2001) Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem Pharmacol 61: 947-954. doi:10.1016/S0006-2952(01)00564-0. PubMed: 11286986.
    • (2001) Biochem Pharmacol , vol.61 , pp. 947-954
    • Chun, Y.S.1    Yeo, E.J.2    Choi, E.3    Teng, C.M.4    Bae, J.M.5
  • 27
    • 81155137317 scopus 로고    scopus 로고
    • Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke
    • 10.1371/journal.pone.0027798
    • Yan J, Zhou B, Taheri S, Shi H, (2011) Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. PLOS ONE 6: e27798. doi:10.1371/journal.pone.0027798. PubMed: 22110762.
    • (2011) PLOS ONE , vol.6
    • Yan, J.1    Zhou, B.2    Taheri, S.3    Shi, H.4
  • 28
    • 0037414180 scopus 로고    scopus 로고
    • YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1
    • 10.1093/jnci/95.7.516
    • Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, et al. (2003) YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95: 516-525. doi:10.1093/jnci/95.7.516. PubMed: 12671019.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 516-525
    • Yeo, E.J.1    Chun, Y.S.2    Cho, Y.S.3    Kim, J.4    Lee, J.C.5
  • 29
    • 34249982595 scopus 로고    scopus 로고
    • YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia
    • 10.1038/sj.onc.1210169
    • Sun HL, Liu YN, Huang YT, Pan SL, Huang DY, et al. (2007) YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia. Oncogene 26: 3941-3951. doi:10.1038/sj.onc.1210169. PubMed: 17213816.
    • (2007) Oncogene , vol.26 , pp. 3941-3951
    • Sun, H.L.1    Liu, Y.N.2    Huang, Y.T.3    Pan, S.L.4    Huang, D.Y.5
  • 30
    • 33846990665 scopus 로고    scopus 로고
    • A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent
    • 16773207
    • Kim HL, Yeo EJ, Chun YS, Park JW, (2006) A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent. Int J Oncol 29: 255-260. PubMed: 16773207.
    • (2006) Int J Oncol , vol.29 , pp. 255-260
    • Kim, H.L.1    Yeo, E.J.2    Chun, Y.S.3    Park, J.W.4
  • 31
    • 84882287457 scopus 로고    scopus 로고
    • Impaired Cytoplasmic-Nuclear Transport of Hypoxia-Inducible Factor-1alpha in Amyotrophic Lateral Sclerosis
    • Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, et al. (2013) Impaired Cytoplasmic-Nuclear Transport of Hypoxia-Inducible Factor-1alpha in Amyotrophic Lateral Sclerosis. Brain Pathol.
    • (2013) Brain Pathol
    • Nagara, Y.1    Tateishi, T.2    Yamasaki, R.3    Hayashi, S.4    Kawamura, M.5
  • 32
    • 77957062260 scopus 로고    scopus 로고
    • Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis
    • 10.1093/brain/awq179
    • Linker RA, Lee DH, Demir S, Wiese S, Kruse N, et al. (2010) Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 133: 2248-2263. doi:10.1093/brain/awq179. PubMed: 20826430.
    • (2010) Brain , vol.133 , pp. 2248-2263
    • Linker, R.A.1    Lee, D.H.2    Demir, S.3    Wiese, S.4    Kruse, N.5
  • 33
    • 79551626268 scopus 로고    scopus 로고
    • Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease
    • 10.1371/journal.pone.0016172
    • Ellrichmann G, Petrasch-Parwez E, Lee DH, Reick C, Arning L, et al. (2011) Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. PLOS ONE 6: e16172. doi:10.1371/journal.pone.0016172. PubMed: 21297955.
    • (2011) PLOS ONE , vol.6
    • Ellrichmann, G.1    Petrasch-Parwez, E.2    Lee, D.H.3    Reick, C.4    Arning, L.5
  • 34
    • 77649087440 scopus 로고    scopus 로고
    • Glycolysis: a bioenergetic or a survival pathway?
    • 10.1016/j.tibs.2009.10.006
    • Bolaños JP, Almeida A, Moncada S, (2010) Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci 35: 145-149. doi:10.1016/j.tibs.2009.10.006. PubMed: 20006513.
    • (2010) Trends Biochem Sci , vol.35 , pp. 145-149
    • Bolaños, J.P.1    Almeida, A.2    Moncada, S.3
  • 35
    • 77955361353 scopus 로고    scopus 로고
    • Effects of mitochondrial dysfunction on the immunological properties of microglia
    • 10.1186/1742-2094-7-45
    • Ferger AI, Campanelli L, Reimer V, Muth KN, Merdian I, et al. (2010) Effects of mitochondrial dysfunction on the immunological properties of microglia. J Neuroinflammation 7: 45. doi:10.1186/1742-2094-7-45. PubMed: 20701773.
    • (2010) J Neuroinflammation , vol.7 , pp. 45
    • Ferger, A.I.1    Campanelli, L.2    Reimer, V.3    Muth, K.N.4    Merdian, I.5
  • 36
    • 39749140405 scopus 로고    scopus 로고
    • HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    • 10.1038/nature06613
    • Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, et al. (2008) HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451: 1008-1012. doi:10.1038/nature06613. PubMed: 18288196.
    • (2008) Nature , vol.451 , pp. 1008-1012
    • Arany, Z.1    Foo, S.Y.2    Ma, Y.3    Ruas, J.L.4    Bommi-Reddy, A.5
  • 37
    • 39749188133 scopus 로고    scopus 로고
    • The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes
    • 10.1523/JNEUROSCI.5323-07.2008
    • Vangeison G, Carr D, Federoff HJ, Rempe DA, (2008) The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. J Neurosci 28: 1988-1993. doi:10.1523/JNEUROSCI.5323-07.2008. PubMed: 18287515.
    • (2008) J Neurosci , vol.28 , pp. 1988-1993
    • Vangeison, G.1    Carr, D.2    Federoff, H.J.3    Rempe, D.A.4
  • 38
    • 84863547119 scopus 로고    scopus 로고
    • Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
    • 10.1172/JCI60842
    • Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, et al. (2012) Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest 122: 2454-2468. doi:10.1172/JCI60842. PubMed: 22653056.
    • (2012) J Clin Invest , vol.122 , pp. 2454-2468
    • Argaw, A.T.1    Asp, L.2    Zhang, J.3    Navrazhina, K.4    Pham, T.5
  • 39
    • 16644382257 scopus 로고    scopus 로고
    • Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    • 10.1038/nn1360
    • Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, et al. (2005) Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 8: 85-92. doi:10.1038/nn1360. PubMed: 15568021.
    • (2005) Nat Neurosci , vol.8 , pp. 85-92
    • Storkebaum, E.1    Lambrechts, D.2    Dewerchin, M.3    Moreno-Murciano, M.P.4    Appelmans, S.5
  • 40
    • 32344449557 scopus 로고    scopus 로고
    • Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALS
    • 10.1136/jnnp.2005.070904
    • Moreau C, Devos D, Brunaud-Danel V, Defebvre L, Perez T, et al. (2006) Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALS. J Neurol Neurosurg, Psychiatry 77: 255-257. doi:10.1136/jnnp.2005.070904. PubMed: 16421133.
    • (2006) J Neurol Neurosurg, Psychiatry , vol.77 , pp. 255-257
    • Moreau, C.1    Devos, D.2    Brunaud-Danel, V.3    Defebvre, L.4    Perez, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.