Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

Journal of Cell Science

Volumn 127, Issue 6, 2014, Pages 1263-1278

  Scotter, Emma L ^a   Vance, Caroline ^a   Nishimura, Agnes L ^a   Lee, Youn Bok ^a   Chen, Han Jou ^a   Urwin, Hazel ^a   Sardone, Valentina ^a,b   Mitchell, Jacqueline C ^a   Rogelj, Boris ^a,c   Rubinsztein, David C ^d   Shaw, Christopher E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PAVIA   (Italy)

^c JO EF STEFAN INSTITUTE   (Slovenia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Aggrephagy; ALS; Autophagy; Proteasome; TDP 43; UPS

Indexed keywords

PROTEASOME; TAR DNA BINDING PROTEIN; UBIQUITIN PROTEASOME; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; PROTEIN AGGREGATE; PROTEIN TDP-43;

ARTICLE; AUTOPHAGY; CELL CULTURE; GENETIC TRANSFECTION; HUMAN; MAMMAL CELL; PLASMID; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN METABOLISM; TDP 43 PROTEINOPATHY; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE; UBIQUITINATION;

AUTOPHAGY; CELL LINE, TUMOR; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN AGGREGATES; PROTEOLYSIS; TDP-43 PROTEINOPATHIES; UBIQUITINATION;

EID: 84903362511     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.140087     Document Type: Article

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