메뉴 건너뛰기




Volumn 4, Issue 1, 2015, Pages

Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease

Author keywords

Aging; Daytime sleepiness; Fragmentation; Neurodegeneration; Sleep

Indexed keywords


EID: 84961289931     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/s40064-014-0777-6     Document Type: Article
Times cited : (38)

References (170)
  • 2
    • 36248996490 scopus 로고    scopus 로고
    • Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    • 10.1038/nature06310
    • Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L (2007) Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450:420–424, doi:10.1038/nature06310
    • (2007) Nature , vol.450 , pp. 420-424
    • Adamantidis, A.R.1    Zhang, F.2    Aravanis, A.M.3    Deisseroth, K.4    de Lecea, L.5
  • 3
    • 60049094872 scopus 로고    scopus 로고
    • Disrupted sleep and circadian patterns in frontotemporal dementia
    • 10.1111/j.1468-1331.2008.02414.x
    • Anderson KN, Hatfield C, Kipps C, Hastings M, Hodges JR (2009) Disrupted sleep and circadian patterns in frontotemporal dementia. Eur J Neurol 16:317–323, doi:10.1111/j.1468-1331.2008.02414.x
    • (2009) Eur J Neurol , vol.16 , pp. 317-323
    • Anderson, K.N.1    Hatfield, C.2    Kipps, C.3    Hastings, M.4    Hodges, J.R.5
  • 4
    • 0034122975 scopus 로고    scopus 로고
    • An altered histaminergic innervation of the substantia nigra in Parkinson’s disease
    • 10.1006/exnr.2000.7362
    • Anichtchik OV, Rinne JO, Kalimo H, Panula P (2000) An altered histaminergic innervation of the substantia nigra in Parkinson’s disease. Exp Neurol 163:20–30, doi:10.1006/exnr.2000.7362
    • (2000) Exp Neurol , vol.163 , pp. 20-30
    • Anichtchik, O.V.1    Rinne, J.O.2    Kalimo, H.3    Panula, P.4
  • 5
    • 71849087826 scopus 로고    scopus 로고
    • Sleepiness in Parkinson’s disease
    • 10.1016/S1353-8020(09)70792-8
    • Arnulf I, Leu-Semenescu S (2009) Sleepiness in Parkinson’s disease. Parkinsonism Relat Disord 15(Suppl 3):S101–S104, doi:10.1016/S1353-8020(09)70792-8
    • (2009) Parkinsonism Relat Disord , vol.15 , pp. S101-S104
    • Arnulf, I.1    Leu-Semenescu, S.2
  • 6
    • 36248990083 scopus 로고    scopus 로고
    • Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain
    • 10.1097/WNR.0b013e3282f262f6
    • Basheer R, Bauer A, Elmenhorst D, Ramesh V, McCarley RW (2007) Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain. Neuroreport 18:1895–1899, doi:10.1097/WNR.0b013e3282f262f6
    • (2007) Neuroreport , vol.18 , pp. 1895-1899
    • Basheer, R.1    Bauer, A.2    Elmenhorst, D.3    Ramesh, V.4    McCarley, R.W.5
  • 7
    • 77958579815 scopus 로고    scopus 로고
    • Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin
    • 10.1111/j.1365-2869.2010.00819.x
    • Bassetti CL, Baumann CR, Dauvilliers Y, Croyal M, Robert P, Schwartz JC (2010) Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin. J Sleep Res 19:620–623, doi:10.1111/j.1365-2869.2010.00819.x
    • (2010) J Sleep Res , vol.19 , pp. 620-623
    • Bassetti, C.L.1    Baumann, C.R.2    Dauvilliers, Y.3    Croyal, M.4    Robert, P.5    Schwartz, J.C.6
  • 8
    • 68149152781 scopus 로고    scopus 로고
    • Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia
    • 10.1212/WNL.0b013e3181ad53e7
    • Benarroch EE, Schmeichel AM, Dugger BN, Sandroni P, Parisi JE, Low PA (2009) Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia. Neurology 73:106–112, doi:10.1212/WNL.0b013e3181ad53e7
    • (2009) Neurology , vol.73 , pp. 106-112
    • Benarroch, E.E.1    Schmeichel, A.M.2    Dugger, B.N.3    Sandroni, P.4    Parisi, J.E.5    Low, P.A.6
  • 9
    • 23844553762 scopus 로고    scopus 로고
    • Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression
    • 10.1210/jc.2005-0035
    • Bixler EO, Vgontzas AN, Lin H-M, Calhoun SL, Vela-Bueno A, Kales A (2005) Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab 90:4510–4515, doi:10.1210/jc.2005-0035
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4510-4515
    • Bixler, E.O.1    Vgontzas, A.N.2    Lin, H.-M.3    Calhoun, S.L.4    Vela-Bueno, A.5    Kales, A.6
  • 10
    • 0027529620 scopus 로고
    • Sleep in normal aging and dementia
    • Bliwise DL (1993) Sleep in normal aging and dementia. Sleep 16:40–81
    • (1993) Sleep , vol.16 , pp. 40-81
    • Bliwise, D.L.1
  • 11
    • 84899019792 scopus 로고    scopus 로고
    • Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis
    • 10.1001/jamaneurol.2013.5847
    • Bloom GS (2014) Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71:505–508, doi:10.1001/jamaneurol.2013.5847
    • (2014) JAMA Neurol , vol.71 , pp. 505-508
    • Bloom, G.S.1
  • 13
    • 84896696502 scopus 로고    scopus 로고
    • Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson’s disease
    • 10.1371/journal.pone.0081233
    • Bolitho SJ, Naismith SL, Salahuddin P, Terpening Z, Grunstein RR, Lewis SJ (2013) Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson’s disease. PLoS One 8:e81233, doi:10.1371/journal.pone.0081233
    • (2013) PLoS One , vol.8 , pp. e81233
    • Bolitho, S.J.1    Naismith, S.L.2    Salahuddin, P.3    Terpening, Z.4    Grunstein, R.R.5    Lewis, S.J.6
  • 15
    • 24744460262 scopus 로고    scopus 로고
    • Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment
    • 10.1111/j.1365-2869.2005.00462.x
    • Bonanni E, Maestri M, Tognoni G, Fabbrini M, Nucciarone B, Manca ML, Gori S, Iudice A, Murri L (2005) Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment. J Sleep Res 14:311–317, doi:10.1111/j.1365-2869.2005.00462.x
    • (2005) J Sleep Res , vol.14 , pp. 311-317
    • Bonanni, E.1    Maestri, M.2    Tognoni, G.3    Fabbrini, M.4    Nucciarone, B.5    Manca, M.L.6    Gori, S.7    Iudice, A.8    Murri, L.9
  • 16
    • 0028213511 scopus 로고
    • Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital
    • Bouras C, Hof PR, Giannakopoulos P, Michel JP, Morrison JH (1994) Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb Cortex 4:138–50
    • (1994) Cereb Cortex , vol.4 , pp. 138-150
    • Bouras, C.1    Hof, P.R.2    Giannakopoulos, P.3    Michel, J.P.4    Morrison, J.H.5
  • 18
    • 5444255434 scopus 로고    scopus 로고
    • Stages in the development of Parkinson’s disease-related pathology
    • 10.1007/s00441-004-0956-9
    • Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res 318:121–134, doi:10.1007/s00441-004-0956-9
    • (2004) Cell Tissue Res , vol.318 , pp. 121-134
    • Braak, H.1    Ghebremedhin, E.2    Rüb, U.3    Bratzke, H.4    Del Tredici, K.5
  • 19
    • 80054904670 scopus 로고    scopus 로고
    • Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years
    • 10.1097/NEN.0b013e318232a379
    • Braak H, Thal DR, Ghebremedhin E, Del Tredici K (2011) Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960–969, doi:10.1097/NEN.0b013e318232a379
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 960-969
    • Braak, H.1    Thal, D.R.2    Ghebremedhin, E.3    Del Tredici, K.4
  • 20
    • 78650800249 scopus 로고    scopus 로고
    • Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer’s disease
    • 10.1124/jpet.110.166876
    • Brioni JD, Esbenshade TA, Garrison TR, Bitner SR, Cowart MD (2011) Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer’s disease. J Pharmacol Exp Ther 336:38–46, doi:10.1124/jpet.110.166876
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 38-46
    • Brioni, J.D.1    Esbenshade, T.A.2    Garrison, T.R.3    Bitner, S.R.4    Cowart, M.D.5
  • 21
    • 84866544628 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in aging and age-related diseases
    • 10.3389/fphys.2012.00263
    • Brown MK, Naidoo N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3:263, doi:10.3389/fphys.2012.00263
    • (2012) Front Physiol , vol.3 , pp. 263
    • Brown, M.K.1    Naidoo, N.2
  • 22
    • 76949086562 scopus 로고    scopus 로고
    • Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice
    • 10.1016/j.neulet.2010.01.048
    • Brownell SE, Conti B (2010) Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice. Neurosci Lett 472:29–32, doi:10.1016/j.neulet.2010.01.048
    • (2010) Neurosci Lett , vol.472 , pp. 29-32
    • Brownell, S.E.1    Conti, B.2
  • 23
    • 79960121463 scopus 로고    scopus 로고
    • Differential degeneration of the locus coeruleus in dementia subtypes
    • Brunnström H, Friberg N, Lindberg E, Englund E (2011) Differential degeneration of the locus coeruleus in dementia subtypes. Clin Neuropathol 30:104–10
    • (2011) Clin Neuropathol , vol.30 , pp. 104-110
    • Brunnström, H.1    Friberg, N.2    Lindberg, E.3    Englund, E.4
  • 24
    • 57749095477 scopus 로고    scopus 로고
    • A critical evaluation of the Braak staging scheme for Parkinson’s disease
    • 10.1002/ana.21541
    • Burke RE, Dauer WT, Vonsattel JPG (2008) A critical evaluation of the Braak staging scheme for Parkinson’s disease. Ann Neurol 64:485–491, doi:10.1002/ana.21541
    • (2008) Ann Neurol , vol.64 , pp. 485-491
    • Burke, R.E.1    Dauer, W.T.2    Vonsattel, J.P.G.3
  • 27
    • 0033862484 scopus 로고    scopus 로고
    • Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer’s disease prospectively assessed for behavioural changes
    • 10.1046/j.1365-2990.2000.00254.x
    • Chen CPL-H, Eastwood SL, Hope T, McDonald B, Francis PT, Esiri MM (2000) Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer’s disease prospectively assessed for behavioural changes. Neuropathol Appl Neurobiol 26:347–355, doi:10.1046/j.1365-2990.2000.00254.x
    • (2000) Neuropathol Appl Neurobiol , vol.26 , pp. 347-355
    • Chen, C.P.L.-H.1    Eastwood, S.L.2    Hope, T.3    McDonald, B.4    Francis, P.T.5    Esiri, M.M.6
  • 29
    • 84927622092 scopus 로고    scopus 로고
    • Sleep measures expressing “functional uncertainty” in elderlies’ sleep
    • 10.1159/000358083
    • Conte F, Arzilli C, Errico BM, Giganti F, Iovino D, Ficca G (2014) Sleep measures expressing “functional uncertainty” in elderlies’ sleep. Gerontology 60:448–457, doi:10.1159/000358083
    • (2014) Gerontology , vol.60 , pp. 448-457
    • Conte, F.1    Arzilli, C.2    Errico, B.M.3    Giganti, F.4    Iovino, D.5    Ficca, G.6
  • 30
    • 43149110353 scopus 로고    scopus 로고
    • Sleep disturbances in patients with parkinsonism
    • 10.1038/ncpneuro0775
    • De Cock VC, Vidailhet M, Arnulf I (2008) Sleep disturbances in patients with parkinsonism. Nat Clin Pract Neurol 4:254–266, doi:10.1038/ncpneuro0775
    • (2008) Nat Clin Pract Neurol , vol.4 , pp. 254-266
    • De Cock, V.C.1    Vidailhet, M.2    Arnulf, I.3
  • 31
    • 84895531538 scopus 로고    scopus 로고
    • Hypocretin (orexin) regulation of sleep-to-wake transitions
    • 10.3389/fphar.2014.00016
    • De Lecea L, Huerta R (2014) Hypocretin (orexin) regulation of sleep-to-wake transitions. Front Pharmacol 5:16, doi:10.3389/fphar.2014.00016
    • (2014) Front Pharmacol , vol.5 , pp. 16
    • De Lecea, L.1    Huerta, R.2
  • 34
    • 34249319761 scopus 로고    scopus 로고
    • Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque
    • 10.1016/j.neurobiolaging.2006.05.025
    • Downs JL, Dunn MR, Borok E, Shanabrough M, Horvath TL, Kohama SG, Urbanski HF (2007) Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque. Neurobiol Aging 28:1286–1295, doi:10.1016/j.neurobiolaging.2006.05.025
    • (2007) Neurobiol Aging , vol.28 , pp. 1286-1295
    • Downs, J.L.1    Dunn, M.R.2    Borok, E.3    Shanabrough, M.4    Horvath, T.L.5    Kohama, S.G.6    Urbanski, H.F.7
  • 35
    • 0035887990 scopus 로고    scopus 로고
    • Histamine function in brain disorders
    • 10.1016/S0166-4328(01)00215-7
    • Fernandez-Novoa L (2001) Histamine function in brain disorders. Behav Brain Res 124:213–233, doi:10.1016/S0166-4328(01)00215-7
    • (2001) Behav Brain Res , vol.124 , pp. 213-233
    • Fernandez-Novoa, L.1
  • 36
    • 34447323906 scopus 로고    scopus 로고
    • Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the national sleep foundation “2003 Sleep in America” Poll
    • 10.1097/01.JGP.0000249385.50101.67
    • Foley DJ, Vitiello MV, Bliwise DL, Ancoli-Israel S, Monjan AA, Walsh JK (2007) Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the national sleep foundation “2003 Sleep in America” Poll. Am J Geriatr psychiatry 15:344–350, doi:10.1097/01.JGP.0000249385.50101.67
    • (2007) Am J Geriatr psychiatry , vol.15 , pp. 344-350
    • Foley, D.J.1    Vitiello, M.V.2    Bliwise, D.L.3    Ancoli-Israel, S.4    Monjan, A.A.5    Walsh, J.K.6
  • 39
    • 0030748440 scopus 로고    scopus 로고
    • Effects of sleep deprivation on serotonergic neuronal activity in the dorsal raphe nucleus of the freely moving cat
    • 10.1016/S0893-133X(97)00025-0
    • Gardner JP, Fornal CA, Jacobs BL (1997) Effects of sleep deprivation on serotonergic neuronal activity in the dorsal raphe nucleus of the freely moving cat. Neuropsychopharmacology 17:72–81, doi:10.1016/S0893-133X(97)00025-0
    • (1997) Neuropsychopharmacology , vol.17 , pp. 72-81
    • Gardner, J.P.1    Fornal, C.A.2    Jacobs, B.L.3
  • 40
    • 84901590669 scopus 로고    scopus 로고
    • Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder
    • 10.1016/j.sleep.2013.12.021
    • Gong Y, Xiong K-P, Mao C-J, Shen Y, Hu WD, Huang JY, Han F, Chen R, Liu CF (2014) Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Med 15:647–653, doi:10.1016/j.sleep.2013.12.021
    • (2014) Sleep Med , vol.15 , pp. 647-653
    • Gong, Y.1    Xiong, K.-P.2    Mao, C.-J.3    Shen, Y.4    Hu, W.D.5    Huang, J.Y.6    Han, F.7    Chen, R.8    Liu, C.F.9
  • 41
    • 33750017772 scopus 로고    scopus 로고
    • Circadian regulation of arousal: role of the noradrenergic locus coeruleus system and light exposure
    • González MMC, Aston-Jones G (2006) Circadian regulation of arousal: role of the noradrenergic locus coeruleus system and light exposure. Sleep 29:1327–1336
    • (2006) Sleep , vol.29 , pp. 1327-1336
    • González, M.M.C.1    Aston-Jones, G.2
  • 42
    • 84904425796 scopus 로고    scopus 로고
    • Sleep in older adults: normative changes, sleep disorders, and treatment options
    • 10.1016/j.cger.2014.04.007
    • Gooneratne NS, Vitiello MV (2014) Sleep in older adults: normative changes, sleep disorders, and treatment options. Clin Geriatr Med 30:591–627, doi:10.1016/j.cger.2014.04.007
    • (2014) Clin Geriatr Med , vol.30 , pp. 591-627
    • Gooneratne, N.S.1    Vitiello, M.V.2
  • 43
    • 84889653958 scopus 로고    scopus 로고
    • The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia?
    • 10.1016/j.neubiorev.2013.09.003
    • Gratwicke J, Kahan J, Zrinzo L, Hariz M, Limousin P, Foltynie T, Jahanshahi M (2013) The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia? Neurosci Biobehav Rev 37:2676–2688, doi:10.1016/j.neubiorev.2013.09.003
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 2676-2688
    • Gratwicke, J.1    Kahan, J.2    Zrinzo, L.3    Hariz, M.4    Limousin, P.5    Foltynie, T.6    Jahanshahi, M.7
  • 44
    • 17644392788 scopus 로고    scopus 로고
    • The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation
    • 10.1523/JNEUROSCI.0666-05.2005
    • Grivel J, Cvetkovic V, Bayer L, Machard D, Tobler I, Mühlethaler M, Serafin M (2005) The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation. J Neurosci 25:4127–4130, doi:10.1523/JNEUROSCI.0666-05.2005
    • (2005) J Neurosci , vol.25 , pp. 4127-4130
    • Grivel, J.1    Cvetkovic, V.2    Bayer, L.3    Machard, D.4    Tobler, I.5    Mühlethaler, M.6    Serafin, M.7
  • 45
    • 77954427486 scopus 로고    scopus 로고
    • Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer’s disease
    • 10.1093/cercor/bhp232
    • Grothe M, Zaborszky L, Atienza M, Gil-Neciga E, Rodriguez-Romero R, Teipel SJ, Amunts K, Suarez-Gonzalez A, Cantero JL (2010) Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer’s disease. Cereb Cortex 20:1685–1695, doi:10.1093/cercor/bhp232
    • (2010) Cereb Cortex , vol.20 , pp. 1685-1695
    • Grothe, M.1    Zaborszky, L.2    Atienza, M.3    Gil-Neciga, E.4    Rodriguez-Romero, R.5    Teipel, S.J.6    Amunts, K.7    Suarez-Gonzalez, A.8    Cantero, J.L.9
  • 46
    • 84859492616 scopus 로고    scopus 로고
    • Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer’s disease
    • 10.1016/j.biopsych.2011.06.019
    • Grothe M, Heinsen H, Teipel SJ (2012) Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer’s disease. Biol Psychiatry 71:805–813, doi:10.1016/j.biopsych.2011.06.019
    • (2012) Biol Psychiatry , vol.71 , pp. 805-813
    • Grothe, M.1    Heinsen, H.2    Teipel, S.J.3
  • 47
    • 84914688045 scopus 로고    scopus 로고
    • Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer’s disease dementia
    • Grothe MJ, Schuster C, Bauer F, Heinsen H, Prudlo J, Teipel SJ. (2014) Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer’s disease dementia. J Neurol 1–10. doi:10.1007/s00415-014-7439-z
    • (2014) J Neurol , pp. 1-10
    • Grothe, M.J.1    Schuster, C.2    Bauer, F.3    Heinsen, H.4    Prudlo, J.5    Teipel, S.J.6
  • 48
    • 33846583006 scopus 로고    scopus 로고
    • Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer’s disease
    • 10.1016/j.neurobiolaging.2006.02.007
    • Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM (2007) Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer’s disease. Neurobiol Aging 28:327–335, doi:10.1016/j.neurobiolaging.2006.02.007
    • (2007) Neurobiol Aging , vol.28 , pp. 327-335
    • Grudzien, A.1    Shaw, P.2    Weintraub, S.3    Bigio, E.4    Mash, D.C.5    Mesulam, M.M.6
  • 50
    • 0025099780 scopus 로고
    • Loss of brainstem serotonin- and substance P-containing neurons in Parkinson’s disease
    • Halliday GM, Blumbergs PC, Cotton RG, Blessing WW, Geffen LB (1990) Loss of brainstem serotonin- and substance P-containing neurons in Parkinson’s disease. Brain Res 510:104–107
    • (1990) Brain Res , vol.510 , pp. 104-107
    • Halliday, G.M.1    Blumbergs, P.C.2    Cotton, R.G.3    Blessing, W.W.4    Geffen, L.B.5
  • 51
    • 84890091449 scopus 로고    scopus 로고
    • The role of s-nitrosylation and s-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration
    • 10.1155/2013/797914
    • Halloran M, Parakh S, Atkin JD (2013) The role of s-nitrosylation and s-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration. Int J Cell Biol 2013:797914, doi:10.1155/2013/797914
    • (2013) Int J Cell Biol , vol.2013 , pp. 797914
    • Halloran, M.1    Parakh, S.2    Atkin, J.D.3
  • 52
    • 78649674046 scopus 로고    scopus 로고
    • Modes and models of forebrain cholinergic neuromodulation of cognition
    • 10.1038/npp.2010.104
    • Hasselmo ME, Sarter M (2011) Modes and models of forebrain cholinergic neuromodulation of cognition. Neuropsychopharmacology 36:52–73, doi:10.1038/npp.2010.104
    • (2011) Neuropsychopharmacology , vol.36 , pp. 52-73
    • Hasselmo, M.E.1    Sarter, M.2
  • 57
    • 0028907136 scopus 로고
    • Image analyser-assisted morphometry of the locus coeruleus in Alzheimer’s disease, Parkinson's disease and amyotrophic lateral sclerosis
    • Hoogendijk WJ, Pool CW, Troost D, van Zwieten E, Swaab DF (1995) Image analyser-assisted morphometry of the locus coeruleus in Alzheimer’s disease, Parkinson's disease and amyotrophic lateral sclerosis. Brain 118(Pt 1):131–143
    • (1995) Brain , vol.118 , pp. 131-143
    • Hoogendijk, W.J.1    Pool, C.W.2    Troost, D.3    van Zwieten, E.4    Swaab, D.F.5
  • 59
    • 0033669132 scopus 로고    scopus 로고
    • Age-related loss of the AMPA receptor subunits GluR2/3 in the human nucleus basalis of Meynert
    • 10.1006/exnr.2000.7544
    • Ikonomovic MD, Nocera R, Mizukami K, Armstrong DM (2000) Age-related loss of the AMPA receptor subunits GluR2/3 in the human nucleus basalis of Meynert. Exp Neurol 166:363–375, doi:10.1006/exnr.2000.7544
    • (2000) Exp Neurol , vol.166 , pp. 363-375
    • Ikonomovic, M.D.1    Nocera, R.2    Mizukami, K.3    Armstrong, D.M.4
  • 60
    • 0032841093 scopus 로고    scopus 로고
    • Neuropathological changes in the nucleus basalis correlate with clinical measures of dementia
    • Iraizoz I, Guijarro JL, Gonzalo LM, de Lacalle S (1999) Neuropathological changes in the nucleus basalis correlate with clinical measures of dementia. Acta Neuropathol 98:186–196
    • (1999) Acta Neuropathol , vol.98 , pp. 186-196
    • Iraizoz, I.1    Guijarro, J.L.2    Gonzalo, L.M.3    de Lacalle, S.4
  • 62
    • 0142011167 scopus 로고    scopus 로고
    • Estrogen receptors and metabolic activity in the human tuberomamillary nucleus: changes in relation to sex, aging and Alzheimer’s disease
    • 10.1016/S0006-8993(03)03347-X
    • Ishunina TA, van Heerikhuize JJ, Ravid R, Swaab DF (2003) Estrogen receptors and metabolic activity in the human tuberomamillary nucleus: changes in relation to sex, aging and Alzheimer’s disease. Brain Res 988:84–96, doi:10.1016/S0006-8993(03)03347-X
    • (2003) Brain Res , vol.988 , pp. 84-96
    • Ishunina, T.A.1    van Heerikhuize, J.J.2    Ravid, R.3    Swaab, D.F.4
  • 63
    • 0031025580 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: occurrence of Bunina bodies in the locus ceruleus pigmented neurons
    • Iwanaga K, Wakabayashi K, Honma Y, Takahashi H (1997) Amyotrophic lateral sclerosis: occurrence of Bunina bodies in the locus ceruleus pigmented neurons. Clin Neuropathol 16:23–6
    • (1997) Clin Neuropathol , vol.16 , pp. 23-26
    • Iwanaga, K.1    Wakabayashi, K.2    Honma, Y.3    Takahashi, H.4
  • 65
    • 77957742617 scopus 로고    scopus 로고
    • Sleep deprivation triggers inducible nitric oxide-dependent nitric oxide production in wake-active basal forebrain neurons
    • 10.1523/JNEUROSCI.0014-10.2010
    • Kalinchuk AV, McCarley RW, Porkka-Heiskanen T, Basheer R (2010) Sleep deprivation triggers inducible nitric oxide-dependent nitric oxide production in wake-active basal forebrain neurons. J Neurosci 30:13254–13264, doi:10.1523/JNEUROSCI.0014-10.2010
    • (2010) J Neurosci , vol.30 , pp. 13254-13264
    • Kalinchuk, A.V.1    McCarley, R.W.2    Porkka-Heiskanen, T.3    Basheer, R.4
  • 67
    • 84903275882 scopus 로고    scopus 로고
    • Frontotemporal lobar degeneration: a clinical approach
    • 10.1055/s-0034-1381735
    • Karageorgiou E, Miller BL (2014) Frontotemporal lobar degeneration: a clinical approach. Semin Neurol 34:189–201, doi:10.1055/s-0034-1381735
    • (2014) Semin Neurol , vol.34 , pp. 189-201
    • Karageorgiou, E.1    Miller, B.L.2
  • 68
    • 79952006976 scopus 로고    scopus 로고
    • Age-related loss of orexin/hypocretin neurons
    • 10.1016/j.neuroscience.2011.01.031
    • Kessler BA, Stanley EM, Frederick-Duus D, Fadel J (2011) Age-related loss of orexin/hypocretin neurons. Neuroscience 178:82–88, doi:10.1016/j.neuroscience.2011.01.031
    • (2011) Neuroscience , vol.178 , pp. 82-88
    • Kessler, B.A.1    Stanley, E.M.2    Frederick-Duus, D.3    Fadel, J.4
  • 69
    • 84883266617 scopus 로고    scopus 로고
    • Sleep allostasis in chronic sleep restriction: the role of the norepinephrine system
    • 10.1016/j.brainres.2013.07.048
    • Kim Y, Chen L, McCarley RW, Strecker RE (2013) Sleep allostasis in chronic sleep restriction: the role of the norepinephrine system. Brain Res 1531:9–16, doi:10.1016/j.brainres.2013.07.048
    • (2013) Brain Res , vol.1531 , pp. 9-16
    • Kim, Y.1    Chen, L.2    McCarley, R.W.3    Strecker, R.E.4
  • 70
    • 48049088111 scopus 로고    scopus 로고
    • Age-related reduction in the maximal capacity for sleep–implications for insomnia
    • 10.1016/j.cub.2008.06.047
    • Klerman EB, Dijk D-J (2008) Age-related reduction in the maximal capacity for sleep–implications for insomnia. Curr Biol 18:1118–1123, doi:10.1016/j.cub.2008.06.047
    • (2008) Curr Biol , vol.18 , pp. 1118-1123
    • Klerman, E.B.1    Dijk, D.-J.2
  • 72
    • 73749084700 scopus 로고    scopus 로고
    • Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson’s disease
    • 10.1016/j.neuroimage.2009.11.035
    • Kumakura Y, Danielsen EH, Gjedde A, Vernaleken I, Buchholz HG, Heinz A, Gründer G, Bartenstein P, Cumming P (2010) Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson’s disease. Neuroimage 49:2933–2939, doi:10.1016/j.neuroimage.2009.11.035
    • (2010) Neuroimage , vol.49 , pp. 2933-2939
    • Kumakura, Y.1    Danielsen, E.H.2    Gjedde, A.3    Vernaleken, I.4    Buchholz, H.G.5    Heinz, A.6    Gründer, G.7    Bartenstein, P.8    Cumming, P.9
  • 73
    • 18744402189 scopus 로고    scopus 로고
    • Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer’s disease
    • 10.1007/s00213-004-2077-2
    • Lai MK, Tsang SW, Alder JT, Keene J, Hope T, Esiri MM, Francis PT, Chen CP (2005) Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer’s disease. Psychopharmacology (Berl) 179:673–677, doi:10.1007/s00213-004-2077-2
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 673-677
    • Lai, M.K.1    Tsang, S.W.2    Alder, J.T.3    Keene, J.4    Hope, T.5    Esiri, M.M.6    Francis, P.T.7    Chen, C.P.8
  • 75
    • 36349021288 scopus 로고    scopus 로고
    • Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects
    • 10.1111/j.1365-2869.2007.00613.x
    • Lemoine P, Nir T, Laudon M, Zisapel N (2007) Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res 16:372–380, doi:10.1111/j.1365-2869.2007.00613.x
    • (2007) J Sleep Res , vol.16 , pp. 372-380
    • Lemoine, P.1    Nir, T.2    Laudon, M.3    Zisapel, N.4
  • 78
    • 84879656270 scopus 로고    scopus 로고
    • Sleep fragmentation and the risk of incident Alzheimer’s disease and cognitive decline in older persons
    • 10.5665/sleep.2802
    • Lim ASP, Kowgier M, Yu L, Buchman AS, Bennett DA (2013a) Sleep fragmentation and the risk of incident Alzheimer’s disease and cognitive decline in older persons. Sleep 36:1027–1032, doi:10.5665/sleep.2802
    • (2013) Sleep , vol.36 , pp. 1027-1032
    • Lim, A.S.P.1    Kowgier, M.2    Yu, L.3    Buchman, A.S.4    Bennett, D.A.5
  • 79
    • 84890413875 scopus 로고    scopus 로고
    • Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep
    • 10.1001/jamaneurol.2013.4215
    • Lim ASP, Yu L, Kowgier M, Schneider JA, Buchman AS, Bennett DA (2013b) Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep. JAMA Neurol 70:1544–1551, doi:10.1001/jamaneurol.2013.4215
    • (2013) JAMA Neurol , vol.70 , pp. 1544-1551
    • Lim, A.S.P.1    Yu, L.2    Kowgier, M.3    Schneider, J.A.4    Buchman, A.S.5    Bennett, D.A.6
  • 80
    • 84881243057 scopus 로고    scopus 로고
    • The contribution of dopamine in REM sleep regulation, Sleep Med Rev:
    • Lima MMS (2013) Sleep disturbances in Parkinson’s disease: The contribution of dopamine in REM sleep regulation. Sleep Med Rev. doi:10.1016/j.smrv.2012.10.006
    • (2013) Sleep disturbances in Parkinson’s disease
    • Lima, M.M.S.1
  • 81
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the Hypocretin (Orexin) receptor 2 gene
    • 10.1016/S0092-8674(00)81965-0
    • Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the Hypocretin (Orexin) receptor 2 gene. Cell 98:365–376, doi:10.1016/S0092-8674(00)81965-0
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3    Kadotani, H.4    Rogers, W.5    Lin, X.6    Qiu, X.7    de Jong, P.J.8    Nishino, S.9    Mignot, E.10
  • 82
    • 84859826913 scopus 로고    scopus 로고
    • Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis
    • 10.1111/j.1468-1331.2011.03637.x
    • Lo Coco D, La Bella V (2012) Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis. Eur J Neurol 19:760–763, doi:10.1111/j.1468-1331.2011.03637.x
    • (2012) Eur J Neurol , vol.19 , pp. 760-763
    • Lo Coco, D.1    La Bella, V.2
  • 84
    • 30644460902 scopus 로고    scopus 로고
    • Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter
    • 10.1523/JNEUROSCI.2244-05.2006
    • Lu J, Jhou TC, Saper CB (2006) Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. J Neurosci 26:193–202, doi:10.1523/JNEUROSCI.2244-05.2006
    • (2006) J Neurosci , vol.26 , pp. 193-202
    • Lu, J.1    Jhou, T.C.2    Saper, C.B.3
  • 85
    • 84874601219 scopus 로고    scopus 로고
    • Melatonin prolonged release: in the treatment of insomnia in patients aged ≥55 years
    • 10.1007/s40266-012-0018-z
    • Lyseng-Williamson KA (2012) Melatonin prolonged release: in the treatment of insomnia in patients aged ≥55 years. Drugs Aging 29:911–923, doi:10.1007/s40266-012-0018-z
    • (2012) Drugs Aging , vol.29 , pp. 911-923
    • Lyseng-Williamson, K.A.1
  • 87
    • 0032785340 scopus 로고    scopus 로고
    • Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep
    • Manfridi A, Brambilla D, Mancia M (1999) Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep. Am J Physiol 277:R1488–R1492
    • (1999) Am J Physiol , vol.277 , pp. R1488-R1492
    • Manfridi, A.1    Brambilla, D.2    Mancia, M.3
  • 88
    • 0021228324 scopus 로고
    • Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age
    • 10.1016/0006-8993(84)91397-0
    • Marcusson JO, Morgan DG, Winblad B, Finch CE (1984) Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age. Brain Res 311:51–56, doi:10.1016/0006-8993(84)91397-0
    • (1984) Brain Res , vol.311 , pp. 51-56
    • Marcusson, J.O.1    Morgan, D.G.2    Winblad, B.3    Finch, C.E.4
  • 89
    • 84908292589 scopus 로고    scopus 로고
    • GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice
    • 10.1016/j.neuroscience.2014.09.063
    • Matsuki T, Takasu M, Hirose Y, Murakoshi N, Sinton CM, Motoike T, Yanagisawa M (2014) GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice. Neuroscience 284C:217–224, doi:10.1016/j.neuroscience.2014.09.063
    • (2014) Neuroscience , vol.284C , pp. 217-224
    • Matsuki, T.1    Takasu, M.2    Hirose, Y.3    Murakoshi, N.4    Sinton, C.M.5    Motoike, T.6    Yanagisawa, M.7
  • 90
    • 78751532908 scopus 로고    scopus 로고
    • An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions
    • 10.1111/j.1440-1789.2010.01129.x
    • Matsuoka T, Fujii N, Kondo A, Iwaki A, Hokonohara T, Honda H, Sasaki K, Suzuki SO, Iwaki T (2011) An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions. Neuropathology 31:71–76, doi:10.1111/j.1440-1789.2010.01129.x
    • (2011) Neuropathology , vol.31 , pp. 71-76
    • Matsuoka, T.1    Fujii, N.2    Kondo, A.3    Iwaki, A.4    Hokonohara, T.5    Honda, H.6    Sasaki, K.7    Suzuki, S.O.8    Iwaki, T.9
  • 91
    • 77949915629 scopus 로고    scopus 로고
    • Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study
    • 10.1016/j.sleep.2009.07.018
    • Merlino G, Piani A, Gigli GL, Cancelli I, Rinaldi A, Baroselli A, Serafini A, Zanchettin B, Valente M (2010) Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study. Sleep Med 11:372–377, doi:10.1016/j.sleep.2009.07.018
    • (2010) Sleep Med , vol.11 , pp. 372-377
    • Merlino, G.1    Piani, A.2    Gigli, G.L.3    Cancelli, I.4    Rinaldi, A.5    Baroselli, A.6    Serafini, A.7    Zanchettin, B.8    Valente, M.9
  • 92
    • 2542511697 scopus 로고    scopus 로고
    • Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum
    • 10.1002/ana.20100
    • Mesulam M, Shaw P, Mash D, Weintraub S (2004) Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol 55:815–828, doi:10.1002/ana.20100
    • (2004) Ann Neurol , vol.55 , pp. 815-828
    • Mesulam, M.1    Shaw, P.2    Mash, D.3    Weintraub, S.4
  • 93
    • 84884154016 scopus 로고    scopus 로고
    • Poor sleep quality impairs cognitive performance in older adults
    • 10.1111/jsr.12054
    • Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N (2013) Poor sleep quality impairs cognitive performance in older adults. J Sleep Res 22:535–541, doi:10.1111/jsr.12054
    • (2013) J Sleep Res , vol.22 , pp. 535-541
    • Miyata, S.1    Noda, A.2    Iwamoto, K.3    Kawano, N.4    Okuda, M.5    Ozaki, N.6
  • 94
    • 0018366299 scopus 로고
    • Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases
    • Monaco F, Fumero S, Mondino A, Mutani R (1979) Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases. J Neurol Neurosurg Psychiatry 42:640–641
    • (1979) J Neurol Neurosurg Psychiatry , vol.42 , pp. 640-641
    • Monaco, F.1    Fumero, S.2    Mondino, A.3    Mutani, R.4
  • 95
    • 79958212802 scopus 로고    scopus 로고
    • Serotonin control of sleep-wake behavior
    • 10.1016/j.smrv.2010.11.003
    • Monti JM (2011) Serotonin control of sleep-wake behavior. Sleep Med Rev 15:269–281, doi:10.1016/j.smrv.2010.11.003
    • (2011) Sleep Med Rev , vol.15 , pp. 269-281
    • Monti, J.M.1
  • 97
    • 0027992407 scopus 로고
    • Absolute number and size of pigmented locus coeruleus neurons in young and aged individuals
    • 10.1016/0891-0618(94)90028-0
    • Mouton PR, Pakkenberg B, Gundersen HJG, Price DL (1994) Absolute number and size of pigmented locus coeruleus neurons in young and aged individuals. J Chem Neuroanat 7:185–190, doi:10.1016/0891-0618(94)90028-0
    • (1994) J Chem Neuroanat , vol.7 , pp. 185-190
    • Mouton, P.R.1    Pakkenberg, B.2    Gundersen, H.J.G.3    Price, D.L.4
  • 98
    • 79960317871 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in wake-active neurons progresses with aging
    • 10.1111/j.1474-9726.2011.00699.x
    • Naidoo N, Zhu J, Zhu Y, Fenik P, Lian J, Galante R, Veasey S (2011) Endoplasmic reticulum stress in wake-active neurons progresses with aging. Aging Cell 10:640–649, doi:10.1111/j.1474-9726.2011.00699.x
    • (2011) Aging Cell , vol.10 , pp. 640-649
    • Naidoo, N.1    Zhu, J.2    Zhu, Y.3    Fenik, P.4    Lian, J.5    Galante, R.6    Veasey, S.7
  • 99
    • 0027161586 scopus 로고
    • Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer’s disease
    • Nakamura S, Takemura M, Ohnishi K, Suenaga T, Nishimura M, Akiguchi I, Kimura J, Kimura T (1993) Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer’s disease. Neurosci Lett 151:196–199
    • (1993) Neurosci Lett , vol.151 , pp. 196-199
    • Nakamura, S.1    Takemura, M.2    Ohnishi, K.3    Suenaga, T.4    Nishimura, M.5    Akiguchi, I.6    Kimura, J.7    Kimura, T.8
  • 100
    • 0026501037 scopus 로고
    • Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia
    • 10.1002/jnr.490310115
    • Nordberg A, Alafuzoff I, Winblad B (1992) Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia. J Neurosci Res 31:103–111, doi:10.1002/jnr.490310115
    • (1992) J Neurosci Res , vol.31 , pp. 103-111
    • Nordberg, A.1    Alafuzoff, I.2    Winblad, B.3
  • 101
    • 84880813336 scopus 로고    scopus 로고
    • Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase
    • 10.1523/JNEUROSCI.0595-13.2013
    • Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H (2013) Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase. J Neurosci 33:12557–12568, doi:10.1523/JNEUROSCI.0595-13.2013
    • (2013) J Neurosci , vol.33 , pp. 12557-12568
    • Obukuro, K.1    Nobunaga, M.2    Takigawa, M.3    Morioka, H.4    Hisatsune, A.5    Isohama, Y.6    Shimokawa, H.7    Tsutsui, M.8    Katsuki, H.9
  • 102
    • 14644409106 scopus 로고    scopus 로고
    • Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan
    • Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27:1255–1273
    • (2004) Sleep , vol.27 , pp. 1255-1273
    • Ohayon, M.M.1    Carskadon, M.A.2    Guilleminault, C.3    Vitiello, M.V.4
  • 103
    • 0030846138 scopus 로고    scopus 로고
    • Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging
    • 10.1016/S0197-4580(97)00034-1
    • Ohm TG, Busch C, Bohl J (1997) Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging. Neurobiol Aging 18:393–399, doi:10.1016/S0197-4580(97)00034-1
    • (1997) Neurobiol Aging , vol.18 , pp. 393-399
    • Ohm, T.G.1    Busch, C.2    Bohl, J.3
  • 104
    • 68149169022 scopus 로고    scopus 로고
    • Brainstem Alzheimer’s-like pathology in the triple transgenic mouse model of Alzheimer's disease
    • 10.1016/j.nbd.2009.06.004
    • Overk CR, Kelley CM, Mufson EJ (2009) Brainstem Alzheimer’s-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis 35:415–425, doi:10.1016/j.nbd.2009.06.004
    • (2009) Neurobiol Dis , vol.35 , pp. 415-425
    • Overk, C.R.1    Kelley, C.M.2    Mufson, E.J.3
  • 105
    • 19044361911 scopus 로고    scopus 로고
    • An essay on the shaking palsy
    • 10.1176/appi.neuropsych.14.2.223
    • Parkinson J (2002) An essay on the shaking palsy. J Neuropsychiatr 14:223–236, doi:10.1176/appi.neuropsych.14.2.223
    • (2002) J Neuropsychiatr , vol.14 , pp. 223-236
    • Parkinson, J.1
  • 106
    • 0033848471 scopus 로고    scopus 로고
    • Selective pathological changes of the periaqueductal gray matter in Alzheimer’s disease
    • Parvizi J, Van Hoesen GW, Damasio A (2000) Selective pathological changes of the periaqueductal gray matter in Alzheimer’s disease. Ann Neurol 48:344–353
    • (2000) Ann Neurol , vol.48 , pp. 344-353
    • Parvizi, J.1    Van Hoesen, G.W.2    Damasio, A.3
  • 107
    • 0031734352 scopus 로고    scopus 로고
    • Hourly profiles of sleep and wakefulness in severely versus mild-moderately demented nursing home patients
    • Pat-Horenczyk R, Klauber MR, Shochat T, Ancoli-Israel S (1998) Hourly profiles of sleep and wakefulness in severely versus mild-moderately demented nursing home patients. Aging (Milano) 10:308–315
    • (1998) Aging (Milano) , vol.10 , pp. 308-315
    • Pat-Horenczyk, R.1    Klauber, M.R.2    Shochat, T.3    Ancoli-Israel, S.4
  • 110
    • 79955727519 scopus 로고    scopus 로고
    • The cholinergic system, EEG and sleep
    • 10.1016/j.bbr.2011.01.017
    • Platt B, Riedel G (2011) The cholinergic system, EEG and sleep. Behav Brain Res 221:499–504, doi:10.1016/j.bbr.2011.01.017
    • (2011) Behav Brain Res , vol.221 , pp. 499-504
    • Platt, B.1    Riedel, G.2
  • 111
    • 84859496019 scopus 로고    scopus 로고
    • Serotonin neuron loss and nonmotor symptoms continue in Parkinson’s patients treated with dopamine grafts
    • 10.1126/scitranslmed.3003391
    • Politis M, Wu K, Loane C, Quinn NP, Brooks DJ, Oertel WH, Björklund A, Lindvall O, Piccini P (2012) Serotonin neuron loss and nonmotor symptoms continue in Parkinson’s patients treated with dopamine grafts. Sci Transl Med 4:128ra41, doi:10.1126/scitranslmed.3003391
    • (2012) Sci Transl Med , vol.4 , pp. 128ra41
    • Politis, M.1    Wu, K.2    Loane, C.3    Quinn, N.P.4    Brooks, D.J.5    Oertel, W.H.6    Björklund, A.7    Lindvall, O.8    Piccini, P.9
  • 112
    • 0024098817 scopus 로고
    • Elevated levels of histamine metabolites in cerebrospinal fluid of aging, healthy humans
    • Prell GD, Khandelwal JK, Burns RS, LeWitt PA, Green JP (1988) Elevated levels of histamine metabolites in cerebrospinal fluid of aging, healthy humans. Compr Gerontol A 2:114–119
    • (1988) Compr Gerontol A , vol.2 , pp. 114-119
    • Prell, G.D.1    Khandelwal, J.K.2    Burns, R.S.3    LeWitt, P.A.4    Green, J.P.5
  • 113
    • 77958056066 scopus 로고    scopus 로고
    • Cytomorphometric changes in the dorsal raphe neurons after rapid eye movement sleep deprivation are mediated by noradrenalin in rats
    • 10.1186/1744-9081-6-62
    • Ranjan A, Biswas S, Mallick BN (2010) Cytomorphometric changes in the dorsal raphe neurons after rapid eye movement sleep deprivation are mediated by noradrenalin in rats. Behav Brain Funct 6:62, doi:10.1186/1744-9081-6-62
    • (2010) Behav Brain Funct , vol.6 , pp. 62
    • Ranjan, A.1    Biswas, S.2    Mallick, B.N.3
  • 115
    • 84866565986 scopus 로고    scopus 로고
    • The serotonergic system in ageing and Alzheimer’s disease
    • 10.1016/j.pneurobio.2012.06.010
    • Rodríguez JJ, Noristani HN, Verkhratsky A (2012) The serotonergic system in ageing and Alzheimer’s disease. Prog Neurobiol 99:15–41, doi:10.1016/j.pneurobio.2012.06.010
    • (2012) Prog Neurobiol , vol.99 , pp. 15-41
    • Rodríguez, J.J.1    Noristani, H.N.2    Verkhratsky, A.3
  • 117
    • 0021961337 scopus 로고
    • The nucleus basalis of Meynert in neurological disease: a quantitative morphological study
    • 10.1002/ana.410170210
    • Rogers JD, Brogan D, Mirra SS (1985) The nucleus basalis of Meynert in neurological disease: a quantitative morphological study. Ann Neurol 17:163–170, doi:10.1002/ana.410170210
    • (1985) Ann Neurol , vol.17 , pp. 163-170
    • Rogers, J.D.1    Brogan, D.2    Mirra, S.S.3
  • 119
    • 77949408590 scopus 로고    scopus 로고
    • Ameliorating amyotrophic lateral sclerosis
    • 10.1056/NEJMcibr0912229
    • Rowland LP (2010) Ameliorating amyotrophic lateral sclerosis. N Engl J Med 362:953–954, doi:10.1056/NEJMcibr0912229
    • (2010) N Engl J Med , vol.362 , pp. 953-954
    • Rowland, L.P.1
  • 120
    • 53249088144 scopus 로고    scopus 로고
    • Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation
    • 10.2174/157015908785777229
    • Samuels ER, Szabadi E (2008) Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation. Curr Neuropharmacol 6:235–253, doi:10.2174/157015908785777229
    • (2008) Curr Neuropharmacol , vol.6 , pp. 235-253
    • Samuels, E.R.1    Szabadi, E.2
  • 122
    • 33746603602 scopus 로고    scopus 로고
    • Serotonergic mechanisms in amyotrophic lateral sclerosis
    • 10.1080/00207450600754087
    • Sandyk R (2006) Serotonergic mechanisms in amyotrophic lateral sclerosis. Int J Neurosci 116:775–826, doi:10.1080/00207450600754087
    • (2006) Int J Neurosci , vol.116 , pp. 775-826
    • Sandyk, R.1
  • 123
    • 84901348083 scopus 로고    scopus 로고
    • Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
    • 10.3389/fnagi.2014.00082
    • Sawiak SJ, Picq J-L, Dhenain M (2014) Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate. Front Aging Neurosci 6:82, doi:10.3389/fnagi.2014.00082
    • (2014) Front Aging Neurosci , vol.6 , pp. 82
    • Sawiak, S.J.1    Picq, J.-L.2    Dhenain, M.3
  • 124
    • 84881553335 scopus 로고    scopus 로고
    • Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
    • 10.1016/j.sleep.2012.10.009
    • Schenck CH, Boeve BF, Mahowald MW (2013) Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 14:744–748, doi:10.1016/j.sleep.2012.10.009
    • (2013) Sleep Med , vol.14 , pp. 744-748
    • Schenck, C.H.1    Boeve, B.F.2    Mahowald, M.W.3
  • 125
    • 79955727727 scopus 로고    scopus 로고
    • The cholinergic system in aging and neuronal degeneration
    • 10.1016/j.bbr.2010.11.058
    • Schliebs R, Arendt T (2011) The cholinergic system in aging and neuronal degeneration. Behav Brain Res 221:555–563, doi:10.1016/j.bbr.2010.11.058
    • (2011) Behav Brain Res , vol.221 , pp. 555-563
    • Schliebs, R.1    Arendt, T.2
  • 126
    • 84866002362 scopus 로고    scopus 로고
    • Age-related changes in sleep and circadian rhythms: impact on cognitive performance and underlying neuroanatomical networks
    • 10.3389/fneur.2012.00118
    • Schmidt C, Peigneux P, Cajochen C (2012) Age-related changes in sleep and circadian rhythms: impact on cognitive performance and underlying neuroanatomical networks. Front Neurol 3:118, doi:10.3389/fneur.2012.00118
    • (2012) Front Neurol , vol.3 , pp. 118
    • Schmidt, C.1    Peigneux, P.2    Cajochen, C.3
  • 128
    • 84866004789 scopus 로고    scopus 로고
    • Selective rapid eye movement sleep deprivation affects cell size and number in kitten locus coeruleus
    • 10.3389/fneur.2012.00069
    • Shaffery JP, Allard JS, Manaye KF, Roffwarg HP (2012) Selective rapid eye movement sleep deprivation affects cell size and number in kitten locus coeruleus. Front Neurol 3:69, doi:10.3389/fneur.2012.00069
    • (2012) Front Neurol , vol.3 , pp. 69
    • Shaffery, J.P.1    Allard, J.S.2    Manaye, K.F.3    Roffwarg, H.P.4
  • 129
    • 84865606992 scopus 로고    scopus 로고
    • Alterations in the histaminergic system in Alzheimer’s disease: a postmortem study
    • 10.1016/j.neurobiolaging.2011.12.026
    • Shan L, Bossers K, Unmehopa U, Bao AM, Swaab DF (2012a) Alterations in the histaminergic system in Alzheimer’s disease: a postmortem study. Neurobiol Aging 33:2585–2598, doi:10.1016/j.neurobiolaging.2011.12.026
    • (2012) Neurobiol Aging , vol.33 , pp. 2585-2598
    • Shan, L.1    Bossers, K.2    Unmehopa, U.3    Bao, A.M.4    Swaab, D.F.5
  • 130
    • 84861184163 scopus 로고    scopus 로고
    • Neuronal histamine production remains unaltered in Parkinson’s disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus
    • 10.1016/j.neurobiolaging.2011.01.004
    • Shan L, Liu C-Q, Balesar R, Hofman MA, Bao AM, Swaab DF (2012b) Neuronal histamine production remains unaltered in Parkinson’s disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus. Neurobiol Aging 33:1343–1344, doi:10.1016/j.neurobiolaging.2011.01.004
    • (2012) Neurobiol Aging , vol.33 , pp. 1343-1344
    • Shan, L.1    Liu, C.-Q.2    Balesar, R.3    Hofman, M.A.4    Bao, A.M.5    Swaab, D.F.6
  • 131
    • 84879029748 scopus 로고    scopus 로고
    • Neuronal histaminergic system in aging and age-related neurodegenerative disorders
    • 10.1016/j.exger.2012.08.002
    • Shan L, Swaab DF, Bao A-M (2013) Neuronal histaminergic system in aging and age-related neurodegenerative disorders. Exp Gerontol 48:603–607, doi:10.1016/j.exger.2012.08.002
    • (2013) Exp Gerontol , vol.48 , pp. 603-607
    • Shan, L.1    Swaab, D.F.2    Bao, A.-M.3
  • 133
    • 0037865199 scopus 로고    scopus 로고
    • Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons
    • 10.1016/S0304-3940(03)00463-4
    • Shirokawa T, Ishida Y, Isobe K (2003) Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons. Neurosci Lett 344:212–214, doi:10.1016/S0304-3940(03)00463-4
    • (2003) Neurosci Lett , vol.344 , pp. 212-214
    • Shirokawa, T.1    Ishida, Y.2    Isobe, K.3
  • 134
    • 0033599781 scopus 로고    scopus 로고
    • Tyrosine hydroxylase mRNA is increased in old age and norepinephrine uptake transporter mRNA is decreased in middle age in locus coeruleus of Brown-Norway rats
    • Shores MM, White SS, Veith RC, Szot P (1999) Tyrosine hydroxylase mRNA is increased in old age and norepinephrine uptake transporter mRNA is decreased in middle age in locus coeruleus of Brown-Norway rats. Brain Res 826:143–147
    • (1999) Brain Res , vol.826 , pp. 143-147
    • Shores, M.M.1    White, S.S.2    Veith, R.C.3    Szot, P.4
  • 135
    • 84872238370 scopus 로고    scopus 로고
    • Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study
    • 10.1371/journal.pone.0053814
    • Sims RE, Wu HHT, Dale N (2013) Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study. PLoS One 8:e53814, doi:10.1371/journal.pone.0053814
    • (2013) PLoS One , vol.8 , pp. e53814
    • Sims, R.E.1    Wu, H.H.T.2    Dale, N.3
  • 136
    • 78650170744 scopus 로고    scopus 로고
    • Selective noradrenergic vulnerability in α-synuclein transgenic mice
    • 10.1016/j.neurobiolaging.2008.11.010
    • Sotiriou E, Vassilatis DK, Vila M, Stefanis L (2010) Selective noradrenergic vulnerability in α-synuclein transgenic mice. Neurobiol Aging 31:2103–2114, doi:10.1016/j.neurobiolaging.2008.11.010
    • (2010) Neurobiol Aging , vol.31 , pp. 2103-2114
    • Sotiriou, E.1    Vassilatis, D.K.2    Vila, M.3    Stefanis, L.4
  • 137
    • 84857685282 scopus 로고    scopus 로고
    • Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system
    • 10.1002/syn.21533
    • Stanley EM, Fadel J (2012) Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system. Synapse 66:445–452, doi:10.1002/syn.21533
    • (2012) Synapse , vol.66 , pp. 445-452
    • Stanley, E.M.1    Fadel, J.2
  • 138
    • 0344873126 scopus 로고    scopus 로고
    • Acetylcholine systems and rhythmic activities during the waking–sleep cycle
    • 10.1016/S0079-6123(03)45013-9
    • Steriade M (2004) Acetylcholine systems and rhythmic activities during the waking–sleep cycle. Prog Brain Res 145:179–196, doi:10.1016/S0079-6123(03)45013-9
    • (2004) Prog Brain Res , vol.145 , pp. 179-196
    • Steriade, M.1
  • 139
    • 77955273862 scopus 로고    scopus 로고
    • Locus coeruleus neuronal activity during the sleep-waking cycle in mice
    • 10.1016/j.neuroscience.2010.06.009
    • Takahashi K, Kayama Y, Lin JS, Sakai K (2010) Locus coeruleus neuronal activity during the sleep-waking cycle in mice. Neuroscience 169:1115–1126, doi:10.1016/j.neuroscience.2010.06.009
    • (2010) Neuroscience , vol.169 , pp. 1115-1126
    • Takahashi, K.1    Kayama, Y.2    Lin, J.S.3    Sakai, K.4
  • 141
    • 34250897889 scopus 로고    scopus 로고
    • Hypocretin (orexin) cell loss in Parkinson’s disease
    • 10.1093/brain/awm097
    • Thannickal TC, Lai Y-Y, Siegel JM (2007) Hypocretin (orexin) cell loss in Parkinson’s disease. Brain 130:1586–1595, doi:10.1093/brain/awm097
    • (2007) Brain , vol.130 , pp. 1586-1595
    • Thannickal, T.C.1    Lai, Y.-Y.2    Siegel, J.M.3
  • 142
    • 0026740163 scopus 로고
    • Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia
    • 10.1016/0304-3940(92)90322-X
    • Tohgi H, Abe T, Takahashi S, Kimura M, Takahashi J, Kikuchi T (1992) Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neurosci Lett 141:9–12, doi:10.1016/0304-3940(92)90322-X
    • (1992) Neurosci Lett , vol.141 , pp. 9-12
    • Tohgi, H.1    Abe, T.2    Takahashi, S.3    Kimura, M.4    Takahashi, J.5    Kikuchi, T.6
  • 143
    • 0027162932 scopus 로고
    • Concentrations of serotonin and its related substances in the cerebrospinal fluid of Parkinsonian patients and their relations to the severity of symptoms
    • 10.1016/0304-3940(93)90111-W
    • Tohgi H, Abe T, Takahashi S, Takahashi J, Hamato H (1993) Concentrations of serotonin and its related substances in the cerebrospinal fluid of Parkinsonian patients and their relations to the severity of symptoms. Neurosci Lett 150:71–74, doi:10.1016/0304-3940(93)90111-W
    • (1993) Neurosci Lett , vol.150 , pp. 71-74
    • Tohgi, H.1    Abe, T.2    Takahashi, S.3    Takahashi, J.4    Hamato, H.5
  • 144
    • 79960663747 scopus 로고    scopus 로고
    • Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
    • 10.1523/JNEUROSCI.0784-11.2011
    • Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, Yamanaka A (2011) Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci 31:10529–10539, doi:10.1523/JNEUROSCI.0784-11.2011
    • (2011) J Neurosci , vol.31 , pp. 10529-10539
    • Tsunematsu, T.1    Kilduff, T.S.2    Boyden, E.S.3    Takahashi, S.4    Tominaga, M.5    Yamanaka, A.6
  • 146
    • 84874413042 scopus 로고    scopus 로고
    • The missing link between long-term stimulation of nicotinic receptors and the increases of acetylcholine release and vasodilation in the cerebral cortex of aged rats
    • 10.1007/s12576-012-0239-2
    • Uchida S, Hotta H, Misawa H, Kawashima K (2013) The missing link between long-term stimulation of nicotinic receptors and the increases of acetylcholine release and vasodilation in the cerebral cortex of aged rats. J Physiol Sci 63:95–101, doi:10.1007/s12576-012-0239-2
    • (2013) J Physiol Sci , vol.63 , pp. 95-101
    • Uchida, S.1    Hotta, H.2    Misawa, H.3    Kawashima, K.4
  • 147
    • 33745315287 scopus 로고    scopus 로고
    • S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    • 10.1038/nature04782
    • Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA (2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441:513–517, doi:10.1038/nature04782
    • (2006) Nature , vol.441 , pp. 513-517
    • Uehara, T.1    Nakamura, T.2    Yao, D.3    Shi, Z.Q.4    Gu, Z.5    Ma, Y.6    Masliah, E.7    Nomura, Y.8    Lipton, S.A.9
  • 149
    • 0023798706 scopus 로고
    • Aberrant morphology of serotonergic fibers in the forebrain of the aged rat
    • 10.1016/0304-3940(88)90638-6
    • Van Luijtelaar MGPA, Steinbusch HWM, Tonnaer JADM (1988) Aberrant morphology of serotonergic fibers in the forebrain of the aged rat. Neurosci Lett 95:93–96, doi:10.1016/0304-3940(88)90638-6
    • (1988) Neurosci Lett , vol.95 , pp. 93-96
    • Van Luijtelaar, M.G.P.A.1    Steinbusch, H.W.M.2    Tonnaer, J.A.D.M.3
  • 150
    • 0026603327 scopus 로고
    • Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study
    • 10.1016/0197-4580(92)90032-S
    • Van Luijtelaar MGPA, Tonnaer JADM, Steinbusch HWM (1992) Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study. Neurobiol Aging 13:201–215, doi:10.1016/0197-4580(92)90032-S
    • (1992) Neurobiol Aging , vol.13 , pp. 201-215
    • Van Luijtelaar, M.G.P.A.1    Tonnaer, J.A.D.M.2    Steinbusch, H.W.M.3
  • 151
    • 84937366896 scopus 로고
    • Sleep in Alzheimer’s disease and the sundown syndrome
    • discussion 93–4
    • Vitiello MV, Bliwise DL, Prinz PN (1992) Sleep in Alzheimer’s disease and the sundown syndrome. Neurology 42:83–93, discussion 93–4
    • (1992) Neurology , vol.42 , pp. 83-93
    • Vitiello, M.V.1    Bliwise, D.L.2    Prinz, P.N.3
  • 153
    • 84902963042 scopus 로고    scopus 로고
    • Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial
    • 10.2147/CIA.S65625
    • Wade AG, Farmer M, Harari G, Fund N, Laudon M, Nir T, Frydman-Marom A, Zisapel N (2014) Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clin Interv Aging 9:947–961, doi:10.2147/CIA.S65625
    • (2014) Clin Interv Aging , vol.9 , pp. 947-961
    • Wade, A.G.1    Farmer, M.2    Harari, G.3    Fund, N.4    Laudon, M.5    Nir, T.6    Frydman-Marom, A.7    Zisapel, N.8
  • 155
    • 84887485291 scopus 로고    scopus 로고
    • Optimizing sleep in older adults: treating insomnia
    • 10.1016/j.maturitas.2013.05.007
    • Wennberg AM, Canham SL, Smith MT, Spira AP (2013) Optimizing sleep in older adults: treating insomnia. Maturitas 76:247–252, doi:10.1016/j.maturitas.2013.05.007
    • (2013) Maturitas , vol.76 , pp. 247-252
    • Wennberg, A.M.1    Canham, S.L.2    Smith, M.T.3    Spira, A.P.4
  • 156
    • 84858136734 scopus 로고    scopus 로고
    • Altered CSF orexin and α-synuclein levels in dementia patients
    • 10.3233/JAD-2012-111655
    • Wennström M, Londos E, Minthon L, Nielsen HM (2012) Altered CSF orexin and α-synuclein levels in dementia patients. J Alzheimers Dis 29:125–132, doi:10.3233/JAD-2012-111655
    • (2012) J Alzheimers Dis , vol.29 , pp. 125-132
    • Wennström, M.1    Londos, E.2    Minthon, L.3    Nielsen, H.M.4
  • 157
  • 158
    • 84889576311 scopus 로고    scopus 로고
    • Association of basal forebrain volumes and cognition in normal aging
    • 10.1016/j.neuropsychologia.2013.11.002
    • Wolf D, Grothe M, Fischer FU, Heinsen H, Kilimann I, Teipel S, Fellgiebel A (2014) Association of basal forebrain volumes and cognition in normal aging. Neuropsychologia 53:54–63, doi:10.1016/j.neuropsychologia.2013.11.002
    • (2014) Neuropsychologia , vol.53 , pp. 54-63
    • Wolf, D.1    Grothe, M.2    Fischer, F.U.3    Heinsen, H.4    Kilimann, I.5    Teipel, S.6    Fellgiebel, A.7
  • 160
    • 79951592621 scopus 로고    scopus 로고
    • Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats
    • Xu A, Sakurai E, Kuramasu A, Zhang J, Li J, Okamura N, Zhang D, Yoshikawa T, Watanabe T, Yanai K (2010) Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats. J Pharmacol Sci 114:444–453
    • (2010) J Pharmacol Sci , vol.114 , pp. 444-453
    • Xu, A.1    Sakurai, E.2    Kuramasu, A.3    Zhang, J.4    Li, J.5    Okamura, N.6    Zhang, D.7    Yoshikawa, T.8    Watanabe, T.9    Yanai, K.10
  • 162
    • 0035108489 scopus 로고    scopus 로고
    • Frontotemporal dementia: evidence for impairment of ascending serotoninergic but not noradrenergic innervation. Immunocytochemical and quantitative study using a graph method
    • Yang Y, Schmitt HP (2001) Frontotemporal dementia: evidence for impairment of ascending serotoninergic but not noradrenergic innervation. Immunocytochemical and quantitative study using a graph method. Acta Neuropathol 101:256–270
    • (2001) Acta Neuropathol , vol.101 , pp. 256-270
    • Yang, Y.1    Schmitt, H.P.2
  • 163
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • Zarow C, Lyness SA, Mortimer JA, Chui HC (2003) Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol 60:337–341
    • (2003) Arch Neurol , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4
  • 164
    • 84901357991 scopus 로고    scopus 로고
    • Outcomes of Alzheimer’s disease therapy with acetylcholinesterase inhibitors and memantine
    • 10.1517/14740338.2014.914168
    • Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J, Kuca K (2014) Outcomes of Alzheimer’s disease therapy with acetylcholinesterase inhibitors and memantine. Expert Opin Drug Saf 13:759–774, doi:10.1517/14740338.2014.914168
    • (2014) Expert Opin Drug Saf , vol.13 , pp. 759-774
    • Zemek, F.1    Drtinova, L.2    Nepovimova, E.3    Sepsova, V.4    Korabecny, J.5    Klimes, J.6    Kuca, K.7
  • 165
    • 25444437443 scopus 로고    scopus 로고
    • NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea
    • 10.1164/rccm.200504-581OC
    • Zhan G, Serrano F, Fenik P, Hsu R, Kong L, Pratico D, Klann E, Veasey SC (2005) NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Am J Respir Crit Care Med 172:921–929, doi:10.1164/rccm.200504-581OC
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 921-929
    • Zhan, G.1    Serrano, F.2    Fenik, P.3    Hsu, R.4    Kong, L.5    Pratico, D.6    Klann, E.7    Veasey, S.C.8
  • 166
    • 0037032094 scopus 로고    scopus 로고
    • Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli
    • 10.1016/S0006-8993(02)02947-5
    • Zhang Y-Q, Mei J, Lü S-G, Zhao Z-Q (2002) Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli. Brain Res 948:47–55, doi:10.1016/S0006-8993(02)02947-5
    • (2002) Brain Res , vol.948 , pp. 47-55
    • Zhang, Y.-Q.1    Mei, J.2    Lü, S.-G.3    Zhao, Z.-Q.4
  • 167
    • 27944437469 scopus 로고    scopus 로고
    • Age-related changes of hypocretin in basal forebrain of guinea pig
    • 10.1016/j.peptides.2005.05.003
    • Zhang J-H, Sampogna S, Morales FR, Chase MH (2005) Age-related changes of hypocretin in basal forebrain of guinea pig. Peptides 26:2590–2596, doi:10.1016/j.peptides.2005.05.003
    • (2005) Peptides , vol.26 , pp. 2590-2596
    • Zhang, J.-H.1    Sampogna, S.2    Morales, F.R.3    Chase, M.H.4
  • 169
    • 23244458905 scopus 로고    scopus 로고
    • Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats
    • 10.1111/j.1471-4159.2005.03245.x
    • Zhu M-Y, Wang W-P, Iyo AH, Ordway GA, Kim KS (2005) Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats. J Neurochem 94:828–838, doi:10.1111/j.1471-4159.2005.03245.x
    • (2005) J Neurochem , vol.94 , pp. 828-838
    • Zhu, M.-Y.1    Wang, W.-P.2    Iyo, A.H.3    Ordway, G.A.4    Kim, K.S.5
  • 170
    • 34548642885 scopus 로고    scopus 로고
    • Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model
    • 10.1523/JNEUROSCI.0857-07.2007
    • Zhu Y, Fenik P, Zhan G, Mazza E, Kelz M, Aston-Jones G, Veasey SC (2007) Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. J Neurosci 27:10060–10071, doi:10.1523/JNEUROSCI.0857-07.2007
    • (2007) J Neurosci , vol.27 , pp. 10060-10071
    • Zhu, Y.1    Fenik, P.2    Zhan, G.3    Mazza, E.4    Kelz, M.5    Aston-Jones, G.6    Veasey, S.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.