메뉴 건너뛰기




Volumn 4, Issue 128, 2012, Pages

Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; FLUORODEOXYGLUCOSE F 18; LEVODOPA; NORADRENALIN; RACLOPRIDE; SEROTONIN;

EID: 84859496019     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003391     Document Type: Article
Times cited : (109)

References (61)
  • 1
    • 32544432029 scopus 로고    scopus 로고
    • National Institute for Clinical Excellence, Nonmotor symptoms of Parkinson's disease: Diagnosis and management
    • K. R. Chaudhuri, D. G. Healy, A. H. Schapira; National Institute for Clinical Excellence, Nonmotor symptoms of Parkinson's disease: Diagnosis and management. Lancet Neurol. 5, 235-245 (2006).
    • (2006) Lancet Neurol. , vol.5 , pp. 235-245
    • Chaudhuri, K.R.1    Healy, D.G.2    Schapira, A.H.3
  • 3
    • 79953276342 scopus 로고    scopus 로고
    • NMSS Validation Group, the impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease
    • P. Martinez-Martin, C. Rodriguez-Blazquez, M. M. Kurtis, K. R. Chaudhuri; NMSS Validation Group, The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease. Mov. Disord. 26, 399-406 (2011).
    • (2011) Mov. Disord. , vol.26 , pp. 399-406
    • Martinez-Martin, P.1    Rodriguez-Blazquez, C.2    Kurtis, M.M.3    Chaudhuri, K.R.4
  • 4
    • 77957262214 scopus 로고    scopus 로고
    • Clinical review of treatment options for select nonmotor symptoms of Parkinson's disease
    • L. D. Wood, J. J. Neumiller, S. M. Setter, E. K. Dobbins, Clinical review of treatment options for select nonmotor symptoms of Parkinson's disease. Am. J. Geriatr. Pharmacother. 8, 294-315 (2010).
    • (2010) Am. J. Geriatr. Pharmacother. , vol.8 , pp. 294-315
    • Wood, L.D.1    Neumiller, J.J.2    Setter, S.M.3    Dobbins, E.K.4
  • 5
    • 21844473567 scopus 로고    scopus 로고
    • Cell therapy in Parkinson's disease
    • O. Lindvall, A. Björklund, Cell therapy in Parkinson's disease. NeuroRx 1, 382-393 (2004).
    • (2004) NeuroRx , vol.1 , pp. 382-393
    • Lindvall, O.1    Björklund, A.2
  • 7
    • 78649534741 scopus 로고    scopus 로고
    • Dyskinesias after neural transplantation in Parkinson's disease: What do we know and what is next?
    • M. Politis, Dyskinesias after neural transplantation in Parkinson's disease: What do we know and what is next? BMC Med. 8, 80 (2010).
    • (2010) BMC Med. , vol.8 , pp. 80
    • Politis, M.1
  • 10
    • 0037208682 scopus 로고    scopus 로고
    • Biochemistry of Parkinson's disease: Is a brain serotonergic deficiency a characteristic of idiopathic Parkinson's disease?
    • S. J. Kish, Biochemistry of Parkinson's disease: Is a brain serotonergic deficiency a characteristic of idiopathic Parkinson's disease? Adv. Neurol. 91, 39-49 (2003).
    • (2003) Adv. Neurol. , vol.91 , pp. 39-49
    • Kish, S.J.1
  • 13
    • 78651295081 scopus 로고    scopus 로고
    • Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: Possible link to serotonin deficits and non-motor symptoms in Parkinson's disease
    • D. M. Kuhn, C. E. Sykes, T. J. Geddes, K. L. Jaunarajs, C. Bishop, Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: Possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. J. Neurochem. 116, 426-437 (2011).
    • (2011) J. Neurochem. , vol.116 , pp. 426-437
    • Kuhn, D.M.1    Sykes, C.E.2    Geddes, T.J.3    Jaunarajs, K.L.4    Bishop, C.5
  • 16
    • 78049460075 scopus 로고    scopus 로고
    • Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction
    • N. Pavese, V. Metta, S. K. Bose, K. R. Chaudhuri, D. J. Brooks, Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction. Brain 133, 3434-3443 (2010).
    • (2010) Brain , vol.133 , pp. 3434-3443
    • Pavese, N.1    Metta, V.2    Bose, S.K.3    Chaudhuri, K.R.4    Brooks, D.J.5
  • 17
    • 78650030521 scopus 로고    scopus 로고
    • Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures
    • M. Politis, K. Wu, C. Loane, F. E. Turkheimer, S. Molloy, D. J. Brooks, P. Piccini, Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures. Neurology 75, 1920-1927 (2010).
    • (2010) Neurology , vol.75 , pp. 1920-1927
    • Politis, M.1    Wu, K.2    Loane, C.3    Turkheimer, F.E.4    Molloy, S.5    Brooks, D.J.6    Piccini, P.7
  • 18
    • 79960250055 scopus 로고    scopus 로고
    • Serotonergic mediated body mass index changes in Parkinson's disease
    • M. Politis, C. Loane, K. Wu, D. J. Brooks, P. Piccini, Serotonergic mediated body mass index changes in Parkinson's disease. Neurobiol. Dis. 43, 609-615 (2011).
    • (2011) Neurobiol. Dis. , vol.43 , pp. 609-615
    • Politis, M.1    Loane, C.2    Wu, K.3    Brooks, D.J.4    Piccini, P.5
  • 21
    • 0033693186 scopus 로고    scopus 로고
    • The validity of the Beck Depression Inventory as a screening and diagnostic instrument for depression in patients with Parkinson's disease
    • A. F. Leentjens, F. R. Verhey, G. J. Luijckx, J. Troost, The validity of the Beck Depression Inventory as a screening and diagnostic instrument for depression in patients with Parkinson's disease. Mov. Disord. 15, 1221-1224 (2000).
    • (2000) Mov. Disord. , vol.15 , pp. 1221-1224
    • Leentjens, A.F.1    Verhey, F.R.2    Luijckx, G.J.3    Troost, J.4
  • 22
    • 33747409022 scopus 로고    scopus 로고
    • Recognizing depression in patients with Parkinson's disease: Accuracy and specificity of two depression rating scale
    • C. D. Silberman, J. Laks, C. F. Capitão, C. S. Rodrigues, I. Moreira, E. Engelhardt, Recognizing depression in patients with Parkinson's disease: Accuracy and specificity of two depression rating scale. Arq. Neuropsiquiatr. 64, 407-411 (2006).
    • (2006) Arq. Neuropsiquiatr. , vol.64 , pp. 407-411
    • Silberman, C.D.1    Laks, J.2    Capitão, C.F.3    Rodrigues, C.S.4    Moreira, I.5    Engelhardt, E.6
  • 27
    • 0142134118 scopus 로고    scopus 로고
    • Monoamine neuron innervation of the normal human brain: An 18F-DOPA PET study
    • R. Y. Moore, A. L. Whone, S. McGowan, D. J. Brooks, Monoamine neuron innervation of the normal human brain: An 18F-DOPA PET study. Brain Res. 982, 137-145 (2003).
    • (2003) Brain Res. , vol.982 , pp. 137-145
    • Moore, R.Y.1    Whone, A.L.2    McGowan, S.3    Brooks, D.J.4
  • 28
    • 0019464864 scopus 로고
    • Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
    • H. W. Steinbusch, Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6, 557-618 (1981).
    • (1981) Neuroscience , vol.6 , pp. 557-618
    • Steinbusch, H.W.1
  • 29
    • 0024431682 scopus 로고
    • Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression
    • V. Chan-Palay, E. Asan, Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression. J. Comp. Neurol. 287, 373-392 (1989).
    • (1989) J. Comp. Neurol. , vol.287 , pp. 373-392
    • Chan-Palay, V.1    Asan, E.2
  • 31
    • 0036392590 scopus 로고    scopus 로고
    • Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
    • H. Braak, K. Del Tredici, H. Bratzke, J. Hamm-Clement, D. Sandmann-Keil, U. Rüb, Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J. Neurol. 249 (Suppl. 3), 1-5 (2002).
    • (2002) J. Neurol. , vol.249 , Issue.SUPPL. 3 , pp. 1-5
    • Braak, H.1    Del Tredici, K.2    Bratzke, H.3    Hamm-Clement, J.4    Sandmann-Keil, D.5    Rüb, U.6
  • 33
    • 0020630532 scopus 로고
    • Noradrenaline and 5-hydroxytryptamine modulation of brain dopamine function: Implications for the treatment of Parkinson's disease
    • P. Jenner, M. Sheehy, C. D. Marsden, Noradrenaline and 5-hydroxytryptamine modulation of brain dopamine function: Implications for the treatment of Parkinson's disease. Br. J. Clin. Pharmacol. 15 (Suppl. 2), 277S-289S (1983).
    • (1983) Br. J. Clin. Pharmacol. , vol.15 , Issue.SUPPL. 2
    • Jenner, P.1    Sheehy, M.2    Marsden, C.D.3
  • 34
    • 0026046072 scopus 로고
    • Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease
    • P. Gaspar, C. Duyckaerts, C. Alvarez, F. Javoy-Agid, B. Berger, Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease. Ann. Neurol. 30, 365-374 (1991).
    • (1991) Ann. Neurol. , vol.30 , pp. 365-374
    • Gaspar, P.1    Duyckaerts, C.2    Alvarez, C.3    Javoy-Agid, F.4    Berger, B.5
  • 35
    • 0018890580 scopus 로고
    • Dorsal raphe cells with collateral projections to the caudate-putamen and substantia nigra: A fluorescent retrograde double labeling study in the rat
    • D. van der Kooy, T. Hattori, Dorsal raphe cells with collateral projections to the caudate-putamen and substantia nigra: A fluorescent retrograde double labeling study in the rat. Brain Res. 186, 1-7 (1980).
    • (1980) Brain Res. , vol.186 , pp. 1-7
    • Van Der Kooy, D.1    Hattori, T.2
  • 36
    • 0025050481 scopus 로고
    • Immunohistochemical study of the serotoninergic innervation of the basal ganglia in the squirrel monkey
    • B. Lavoie, A. Parent, Immunohistochemical study of the serotoninergic innervation of the basal ganglia in the squirrel monkey. J. Comp. Neurol. 299, 1-16 (1990).
    • (1990) J. Comp. Neurol. , vol.299 , pp. 1-16
    • Lavoie, B.1    Parent, A.2
  • 39
    • 0026076047 scopus 로고
    • The neuropathologic basis of different clinical subgroups of Parkinson's disease
    • W. Paulus, K. Jellinger, The neuropathologic basis of different clinical subgroups of Parkinson's disease. J. Neuropathol. Exp. Neurol. 50, 743-755 (1991).
    • (1991) J. Neuropathol. Exp. Neurol. , vol.50 , pp. 743-755
    • Paulus, W.1    Jellinger, K.2
  • 40
    • 43649106356 scopus 로고    scopus 로고
    • Invited Article: Nervous system pathology in sporadic Parkinson disease
    • H. Braak, K. Del Tredici, Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 70, 1916-1925 (2008).
    • (2008) Neurology , vol.70 , pp. 1916-1925
    • Braak, H.1    Del Tredici, K.2
  • 41
    • 77955844658 scopus 로고    scopus 로고
    • Staging of serotonergic dysfunction in Parkinson's disease: An in vivo 11C-DASB PET study
    • M. Politis, K. Wu, C. Loane, L. Kiferle, S. Molloy, D. J. Brooks, P. Piccini, Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study. Neurobiol. Dis. 40, 216-221 (2010).
    • (2010) Neurobiol. Dis. , vol.40 , pp. 216-221
    • Politis, M.1    Wu, K.2    Loane, C.3    Kiferle, L.4    Molloy, S.5    Brooks, D.J.6    Piccini, P.7
  • 42
    • 69549126673 scopus 로고    scopus 로고
    • Serotonin and Parkinson's disease: On movement, mood, and madness
    • S. H. Fox, R. Chuang, J. M. Brotchie, Serotonin and Parkinson's disease: On movement, mood, and madness. Mov. Disord. 24, 1255-1266 (2009).
    • (2009) Mov. Disord. , vol.24 , pp. 1255-1266
    • Fox, S.H.1    Chuang, R.2    Brotchie, J.M.3
  • 43
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases
    • A. J. Hughes, S. E. Daniel, L. Kilford, A. J. Lees, Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55, 181-184 (1992).
    • (1992) J. Neurol. Neurosurg. Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 46
    • 0030637930 scopus 로고    scopus 로고
    • A critical review of the current status and possible developments in brain transplantation
    • S. Rehncrona, A critical review of the current status and possible developments in brain transplantation. Adv. Tech. Stand. Neurosurg. 23, 3-46 (1997).
    • (1997) Adv. Tech. Stand. Neurosurg. , vol.23 , pp. 3-46
    • Rehncrona, S.1
  • 51
    • 0020956774 scopus 로고
    • Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
    • C. S. Patlak, R. G. Blasberg, J. D. Fenstermacher, Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3, 1-7 (1983).
    • (1983) J. Cereb. Blood Flow Metab. , vol.3 , pp. 1-7
    • Patlak, C.S.1    Blasberg, R.G.2    Fenstermacher, J.D.3
  • 56
    • 0031279782 scopus 로고    scopus 로고
    • Parametric imaging of ligand-receptor binding in PET using a simplified reference region model
    • R. N. Gunn, A. A. Lammertsma, S. P. Hume, V. J. Cunningham, Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 6, 279-287 (1997).
    • (1997) Neuroimage , vol.6 , pp. 279-287
    • Gunn, R.N.1    Lammertsma, A.A.2    Hume, S.P.3    Cunningham, V.J.4
  • 57
    • 13844317450 scopus 로고    scopus 로고
    • Regional distribution of serotonin transporter protein in postmortem human brain: Is the cerebellum a SERT-free brain region?
    • S. J. Kish, Y. Furukawa, L. J. Chang, J. Tong, N. Ginovart, A. Wilson, S. Houle, J. H. Meyer, Regional distribution of serotonin transporter protein in postmortem human brain: Is the cerebellum a SERT-free brain region? Nucl. Med. Biol. 32, 123-128 (2005).
    • (2005) Nucl. Med. Biol. , vol.32 , pp. 123-128
    • Kish, S.J.1    Furukawa, Y.2    Chang, L.J.3    Tong, J.4    Ginovart, N.5    Wilson, A.6    Houle, S.7    Meyer, J.H.8
  • 60
    • 0035200087 scopus 로고    scopus 로고
    • Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter: Modeling strategies
    • N. Ginovart, A. A. Wilson, J. H. Meyer, D. Hussey, S. Houle, Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter: Modeling strategies. J. Cereb. Blood Flow Metab. 21, 1342-1353 (2001).
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 1342-1353
    • Ginovart, N.1    Wilson, A.A.2    Meyer, J.H.3    Hussey, D.4    Houle, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.