Age-related loss of orexin/hypocretin neurons

Neuroscience

Volumn 178, Issue , 2011, Pages 82-88

  Kessler, B A ^a   Stanley, E M ^a   Frederick Duus, D ^a   Fadel, J ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Energy balance; Hypocretin; Hypothalamus; Melanin concentrating hormone; Orexin

Indexed keywords

OREXIN;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LOSS; COGNITION; CONTROLLED STUDY; DIENCEPHALON; HOMEOSTASIS; HYPOTHALAMUS; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AGING; ANIMALS; ANTIGENS, NUCLEAR; CELL COUNT; HYPOTHALAMIC AREA, LATERAL; HYPOTHALAMIC HORMONES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANINS; MODELS, ANIMAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; PITUITARY HORMONES; RATS; RATS, INBRED BN; RATS, INBRED F344; RATS, INBRED STRAINS;

EID: 79952006976     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.01.031     Document Type: Article

References (65)

1. Arrigoni E., Mochizuki T., Scammell T.E. Activation of the basal forebrain by the orexin/hypocretin neurones. Acta Physiol (Oxf) 2010, 198:223-235.
2. Beal M.F. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?. Ann Neurol 1992, 31:119-130.
3. Bittencourt J.C., Elias C.F. Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers. Brain Res 1998, 805:1-19.
4. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.L., Vale W., Sawchenko P.E. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 1992, 319:218-245.
5. Black B.J., McMahan C.A., Masoro E.J., Ikeno Y., Katz M.S. Senescent terminal weight loss in the male F344 rat. Am J Physiol Regul Integr Comp Physiol 2003, 284:R336-R342.
6. Boschen K.E., Fadel J.R., Burk J.A. Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats. Psychopharmacology (Berl) 2009, 206:205-213.
7. Broberger C., De Lecea L., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 1998, 402:460-474.
8. + channels mediate inhibition of orexin neurons by glucose. Neuron 2006, 50:711-722.
9. Burdakov D., Luckman S.M., Verkhratsky A. Glucose-sensing neurons of the hypothalamus. Philos Trans R Soc Lond B Biol Sci 2005, 360:2227-2235.
10. Cai X.J., Widdowson P.S., Harrold J., Wilson S., Buckingham R.E., Arch J.R., Tadayyon M., Clapham J.C., Wilding J., Williams G. Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 1999, 48:2132-2137.
11. Casatti C.A., Elias C.F., Sita L.V., Frigo L., Furlani V.C., Bauer J.A., Bittencourt J.C. Distribution of melanin-concentrating hormone neurons projecting to the medial mammillary nucleus. Neuroscience 2002, 115:899-915.
12. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999, 98:437-451.
13. Cruz-Muros I., Afonso-Oramas D., Abreu P., Barroso-Chinea P., Rodriguez M., Gonzalez M.C., Hernandez T.G. Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments. Exp Neurol 2007, 204:147-161.
14. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998, 95:322-327.
15. de Lecea L., Sutcliffe J.G., Fabre V. Hypocretins/orexins as integrators of physiological information: lessons from mutant animals. Neuropeptides 2002, 36:85-95.
16. Desarnaud F., Murillo-Rodriguez E., Lin L., Xu M., Gerashchenko D., Shiromani S.N., Nishino S., Mignot E., Shiromani P.J. The diurnal rhythm of hypocretin in young and old F344 rats. Sleep 2004, 27:851-856.
17. Downs J.L., Dunn M.R., Borok E., Shanabrough M., Horvath T.L., Kohama S.G., Urbanski H.F. Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque. Neurobiol Aging 2007, 28:1286-1295.
18. Eggermann E., Bayer L., Serafin M., Saint-Mleux B., Bernheim L., Machard D., Jones B.E., Muhlethaler M. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J Neurosci 2003, 23:1557-1562.
19. Elias C.F., Bittencourt J.C. Study of the origins of melanin-concentrating hormone and neuropeptide EI immunoreactive projections to the periaqueductal gray matter. Brain Res 1997, 755:255-271.
20. Espana R.A., Baldo B.A., Kelley A.E., Berridge C.W. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience 2001, 106:699-715.
21. Fadel J., Bubser M., Deutch A.Y. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J Neurosci 2002, 22:6742-6746.
22. Fadel J., Burk J.A. Orexin/hypocretin modulation of the basal forebrain cholinergic system: role in attention. Brain Res 2010, 1314:112-123.
23. Fadel J., Frederick-Duus D. Orexin/hypocretin modulation of the basal forebrain cholinergic system: insights from in vivo microdialysis studies. Pharmacol Biochem Behav 2008, 90:156-162.
24. Fadel J., Pasumarthi R., Reznikov L.R. Stimulation of cortical acetylcholine release by orexin A. Neuroscience 2005, 130:541-547.
25. Frederick-Duus D., Guyton M.F., Fadel J. Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience 2007, 149:499-507.
26. Goldman G., Coleman P.D. Neuron numbers in locus coeruleus do not change with age in Fisher 344 rat. Neurobiol Aging 1981, 2:33-36.
27. Hahn J.D. Comparison of melanin-concentrating hormone and hypocretin/orexin peptide expression patterns in a current parceling scheme of the lateral hypothalamic zone. Neurosci Lett 2010, 468:12-17.
28. Hakansson M., de Lecea L., Sutcliffe J.G., Yanagisawa M., Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J Neuroendocrinol 1999, 11:653-663.
29. Hanriot L., Camargo N., Courau A.C., Leger L., Luppi P.H., Peyron C. Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats. J Comp Neurol 2007, 505:147-157.
30. Harris G.C., Aston-Jones G. Arousal and reward: a dichotomy in orexin function. Trends Neurosci 2006, 29:571-577.
31. Harrison T.A., Chen C.T., Dun N.J., Chang J.K. Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla. Neurosci Lett 1999, 273:17-20.
32. Kappeler L., Gourdji D., Zizzari P., Bluet-Pajot M.T., Epelbaum J. Age-associated changes in hypothalamic and pituitary neuroendocrine gene expression in the rat. J Neuroendocrinol 2003, 15:592-601.
33. Katsuki H., Akaike A. Excitotoxic degeneration of hypothalamic orexin neurons in slice culture. Neurobiol Dis 2004, 15:61-69.
34. Kilduff T.S., de Lecea L. Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems. J Comp Neurol 2001, 435:1-5.
35. Kilduff T.S., Peyron C. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci 2000, 23:359-365.
36. Kotz C.M., Mullett M.A., Wang C. Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation. Am J Physiol Regul Integr Comp Physiol 2005, 289:R359-R366.
37. Lambe E.K., Olausson P., Horst N.K., Taylor J.R., Aghajanian G.K. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. J Neurosci 2005, 25:5225-5229.
38. Li Y., Gao X.B., Sakurai T., van den Pol A.N. Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 2002, 36:1169-1181.
39. Lipman R.D., Chrisp C.E., Hazzard D.G., Bronson R.T. Pathologic characterization of brown Norway, brown Norway x Fischer 344, and Fischer 344 x brown Norway rats with relation to age. J Gerontol A Biol Sci Med Sci 1996, 51:B54-B59.
40. Matsumura T., Nakayama M., Nomura A., Naito A., Kamahara K., Kadono K., Inoue M., Homma T., Sekizawa K. Age-related changes in plasma orexin-A concentrations. Exp Gerontol 2002, 37:1127.
41. Mattson M.P. Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 2008, 1144:97-112.
42. Michinaga S., Hisatsune A., Isohama Y., Katsuki H. Inhibition of neural activity depletes orexin from rat hypothalamic slice culture. J Neurosci Res 2010, 88:214-221.
43. Mochizuki T., Crocker A., McCormack S., Yanagisawa M., Sakurai T., Scammell T.E. Behavioral state instability in orexin knock-out mice. J Neurosci 2004, 24:6291-6300.
44. Naumann A., Bellebaum C., Daum I. Cognitive deficits in narcolepsy. J Sleep Res 2006, 15:329-338.
45. Nishino S., Ripley B., Overeem S., Lammers G.J., Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
46. Obukuro K., Takigawa M., Hisatsune A., Isohama Y., Katsuki H. Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats. Neuroscience 2010, 170:298-307.
47. Peyron C., Sapin E., Leger L., Luppi P.H., Fort P. Role of the melanin-concentrating hormone neuropeptide in sleep regulation. Peptides 2009, 30:2052-2059.
48. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998, 18:9996-10015.
49. Pissios P. Animals models of MCH function and what they can tell us about its role in energy balance. Peptides 2009, 30:2040-2044.
50. Porkka-Heiskanen T., Alanko L., Kalinchuk A., Heiskanen S., Stenberg D. The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain. Neurobiol Aging 2004, 25:231-238.
51. Rieger M., Mayer G., Gauggel S. Attention deficits in patients with narcolepsy. Sleep 2003, 26:36-43.
52. Sakurai T. Orexins and orexin receptors: implication in feeding behavior. Regul Pept 1999, 85:25-30.
53. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
54. Sanchez H.L., Silva L.B., Portiansky E.L., Herenu C.B., Goya R.G., Zuccolilli G.O. Dopaminergic mesencephalic systems and behavioral performance in very old rats. Neuroscience 2008, 154:1598-1606.
55. Sawai N., Ueta Y., Nakazato M., Ozawa H. Developmental and aging change of orexin-A and -B immunoreactive neurons in the male rat hypothalamus. Neurosci Lett 2010, 468:51-55.
56. Sturrock R.R., Rao K.A. A quantitative histological study of neuronal loss from the locus coeruleus of ageing mice. Neuropathol Appl Neurobiol 1985, 11:55-60.
57. Swanson L.W., Sanchez-Watts G., Watts A.G. Comparison of melanin-concentrating hormone and hypocretin/orexin mRNA expression patterns in a new parceling scheme of the lateral hypothalamic zone. Neurosci Lett 2005, 387:80-84.
58. Sweet D.C., Levine A.S., Billington C.J., Kotz C.M. Feeding response to central orexins. Brain Res 1999, 821:535-538.
59. Takano S., Kanai S., Hosoya H., Ohta M., Uematsu H., Miyasaka K. Orexin-A does not stimulate food intake in old rats. Am J Physiol Gastrointest Liver Physiol 2004, 287:G1182-G1187.
60. Terao A., Apte-Deshpande A., Morairty S., Freund Y.R., Kilduff T.S. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 2002, 332:190-194.
61. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., Siegel J.M. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000, 27:469-474.
62. Wolden-Hanson T. Mechanisms of the anorexia of aging in the Brown Norway rat. Physiol Behav 2006, 88:267-276.
63. Wolkove N., Elkholy O., Baltzan M., Palayew M. Sleep and aging: 1. Sleep disorders commonly found in older people. CMAJ 2007, 176:1299-1304.
64. Zeitzer J.M., Nishino S., Mignot E. The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. Trends Pharmacol Sci 2006, 27:368-374.
65. Zhang J.H., Sampogna S., Morales F.R., Chase M.H. Age-related changes in hypocretin (orexin) immunoreactivity in the cat brainstem. Brain Res 2002, 930:206-211.