메뉴 건너뛰기




Volumn 123, Issue 4, 2015, Pages 331-336

Cadmium and proliferation in human uterine leiomyoma cells: Evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL) CHROMONE; 4 (3 CHLOROANILINO) 6, 7 DIMETHOXYQUINAZOLINE; CADMIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

EID: 84961289184     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1408234     Document Type: Article
Times cited : (29)

References (50)
  • 1
    • 70450004394 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry, accessed 10 October 2014
    • Agency for Toxic Substances and Disease Registry. 2012. Toxicological Profile for Cadmium. Available: http://www.atsdr.cdc.gov/toxprofiles/tp5.pdf [accessed 10 October 2014].
    • (2012) Toxicological Profile for Cadmium
  • 2
    • 84860133214 scopus 로고    scopus 로고
    • Cadmium- induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice
    • Ali I, Damdimopoulou P, Stenius U, Adamsson A, Mäkelä SI, Åkesson A, et al. 2012. Cadmium- induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice. Toxicol Sci 127:66–75.
    • (2012) Toxicol Sci , vol.127 , pp. 66-75
    • Ali, I.1    Damdimopoulou, P.2    Stenius, U.3    Adamsson, A.4    Mäkelä, S.I.5    Åkesson, A.6
  • 3
    • 77957926129 scopus 로고    scopus 로고
    • Estrogen-like effects of cadmium in vivo do not appear to be mediated via the classical estrogen receptor transcriptional pathway
    • Ali I, Penttinen-Damdimopoulou PE, Mäkelä SI, Berglund M, Stenius U, Åkesson A, et al. 2010. Estrogen-like effects of cadmium in vivo do not appear to be mediated via the classical estrogen receptor transcriptional pathway. Environ Health Perspect 118:1389–1394; doi:10.1289/ehp.1001967.
    • (2010) Environ Health Perspect , vol.118 , pp. 1389-1394
    • Ali, I.1    Penttinen-Damdimopoulou, P.E.2    Mäkelä, S.I.3    Berglund, M.4    Stenius, U.5    Åkesson, A.6
  • 5
    • 0036278606 scopus 로고    scopus 로고
    • Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: Molecular and phenotypic characteristics
    • Carney SA, Tahara H, Swartz CD, Risinger JI, He H, Moore AB, et al. 2002. Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics. Lab Invest 82:719–728.
    • (2002) Lab Invest , vol.82 , pp. 719-728
    • Carney, S.A.1    Tahara, H.2    Swartz, C.D.3    Risinger, J.I.4    He, H.5    Moore, A.B.6
  • 6
    • 84876837765 scopus 로고    scopus 로고
    • Roles of EGFR, PI3K, AKT, and mTOR in heavy metal-induced cancer
    • Carpenter RL, Jiang BH. 2013. Roles of EGFR, PI3K, AKT, and mTOR in heavy metal-induced cancer. Curr Cancer Drug Targets 13:252–266.
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 252-266
    • Carpenter, R.L.1    Jiang, B.H.2
  • 7
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. 2008. EGFR antagonists in cancer treatment. N Engl J Med 358:1160–1174.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 8
    • 80054712751 scopus 로고    scopus 로고
    • Growth factors and myometrium: Biological effects in uterine fibroid and possible clinical implications
    • Ciarmela P, Islam MS, Reis FM, Gray PC, Bloise E, Petraglia F, et al. 2011. Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications. Hum Reprod Update 17:772–790.
    • (2011) Hum Reprod Update , vol.17 , pp. 772-790
    • Ciarmela, P.1    Islam, M.S.2    Reis, F.M.3    Gray, P.C.4    Bloise, E.5    Petraglia, F.6
  • 9
    • 33645730357 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in estrogen receptor α-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor α-negative human breast tumors
    • Creighton CJ, Hilger AM, Murthy S, Rae JM, Chinnaiyan AM, El-Ashry D. 2006. Activation of mitogen-activated protein kinase in estrogen receptor α-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor α-negative human breast tumors. Cancer Res 66:3903–3911.
    • (2006) Cancer Res , vol.66 , pp. 3903-3911
    • Creighton, C.J.1    Hilger, A.M.2    Murthy, S.3    Rae, J.M.4    Chinnaiyan, A.M.5    El-Ashry, D.6
  • 10
    • 34248583886 scopus 로고    scopus 로고
    • Map kinase signalling pathways in cancer
    • Dhillon AS, Hagan S, Rath O, Kolch W. 2007. Map kinase signalling pathways in cancer. Oncogene 26:3279–3290.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 11
    • 47649110244 scopus 로고    scopus 로고
    • A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and prolifera tion in uterine leiomyoma cells
    • Di X, Yu L, Moore AB, Castro L, Zheng X, Hermon T, et al. 2008. A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and prolifera tion in uterine leiomyoma cells. Hum Reprod 23:1873–1883.
    • (2008) Hum Reprod , vol.23 , pp. 1873-1883
    • Di, X.1    Yu, L.2    Moore, A.B.3    Castro, L.4    Zheng, X.5    Hermon, T.6
  • 12
    • 84867607130 scopus 로고    scopus 로고
    • An essential role of p27 downregula-tion in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells
    • Gao X, Yu L, Castro L, Tucker CJ, Moore AB, Xiao H, et al. 2012. An essential role of p27 downregula-tion in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells. Am J Physiol Endocrinol Metab 303:E1025–E1035.
    • (2012) Am J Physiol Endocrinol Metab , vol.303 , pp. E1025-E1035
    • Gao, X.1    Yu, L.2    Castro, L.3    Tucker, C.J.4    Moore, A.B.5    Xiao, H.6
  • 14
    • 2142714539 scopus 로고    scopus 로고
    • Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction
    • Henson MC, Chedrese PJ. 2004. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 229:383–392.
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 383-392
    • Henson, M.C.1    Chedrese, P.J.2
  • 15
    • 77955570074 scopus 로고    scopus 로고
    • Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestine
    • Höfer N, Diel P, Wittsiepe J, Wilhelm M, Kluxen FM, Degen GH. 2010. Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestine. Arch Toxicol 84:541–552.
    • (2010) Arch Toxicol , vol.84 , pp. 541-552
    • Höfer, N.1    Diel, P.2    Wittsiepe, J.3    Wilhelm, M.4    Kluxen, F.M.5    Degen, G.H.6
  • 16
    • 84856322881 scopus 로고    scopus 로고
    • Cadmium and cadmium compounds
    • International Agency for Research on Cancer, accessed 10 October 2014
    • International Agency for Research on Cancer. 2012. Cadmium and cadmium compounds. IARC Monogr Eval Carcinog Risk Hum 100C:121–145.Available: http://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-8.pdf [accessed 10 October 2014].
    • (2012) IARC Monogr Eval Carcinog Risk Hum , vol.100 , pp. 121-145
  • 17
    • 77953477695 scopus 로고    scopus 로고
    • E-screen and vitellogenin assay for the detec-tion of the estrogenic activity of alkylphenols and trace elements
    • Isidori M, Cangiano M, Palermo FA, Parrella A. 2010. E-screen and vitellogenin assay for the detec-tion of the estrogenic activity of alkylphenols and trace elements. Comp Biochem Physiol C Toxicol Pharmacol 152:51–56.
    • (2010) Comp Biochem Physiol C Toxicol Pharmacol , vol.152 , pp. 51-56
    • Isidori, M.1    Cangiano, M.2    Palermo, F.A.3    Parrella, A.4
  • 18
    • 40749109376 scopus 로고    scopus 로고
    • The asso-ciation between heavy metals, endometriosis and uterine myomas among premenopausal women: National Health and Nutrition Examination Survey 1999–2002
    • Jackson LW, Zullo MD, Goldberg JM. 2008. The asso-ciation between heavy metals, endometriosis and uterine myomas among premenopausal women: National Health and Nutrition Examination Survey 1999–2002. Hum Reprod 23:679–687.
    • (2008) Hum Reprod , vol.23 , pp. 679-687
    • Jackson, L.W.1    Zullo, M.D.2    Goldberg, J.M.3
  • 19
    • 77955859670 scopus 로고    scopus 로고
    • Expression profiling of protein tyrosine kinases and their ligand activators in leiomyoma uteri
    • Jiang Y, Suo G, Sadarangani A, Cowan B, Wang JY. 2010. Expression profiling of protein tyrosine kinases and their ligand activators in leiomyoma uteri. Syst Biol Reprod Med 56:318–326.
    • (2010) Syst Biol Reprod Med , vol.56 , pp. 318-326
    • Jiang, Y.1    Suo, G.2    Sadarangani, A.3    Cowan, B.4    Wang, J.Y.5
  • 20
    • 84555187316 scopus 로고    scopus 로고
    • Cadmium increases HIF-1 and VEGF expres-sion through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells
    • Jing Y, Liu LZ, Jiang Y, Zhu Y, Guo NL, Barnett J, et al. 2012. Cadmium increases HIF-1 and VEGF expres-sion through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. Toxicol Sci 125:10–19.
    • (2012) Toxicol Sci , vol.125 , pp. 10-19
    • Jing, Y.1    Liu, L.Z.2    Jiang, Y.3    Zhu, Y.4    Guo, N.L.5    Barnett, J.6
  • 21
    • 0041888476 scopus 로고    scopus 로고
    • Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    • Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, et al. 2003. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 9:1081–1084.
    • (2003) Nat Med , vol.9 , pp. 1081-1084
    • Johnson, M.D.1    Kenney, N.2    Stoica, A.3    Hilakivi-Clarke, L.4    Singh, B.5    Chepko, G.6
  • 22
    • 84858189561 scopus 로고    scopus 로고
    • Dietary cadmium exposure and risk of post-menopausal breast cancer: A population-based prospective cohort study
    • Julin B, Wolk A, Bergkvist L, Bottai M, Åkesson A. 2012. Dietary cadmium exposure and risk of post-menopausal breast cancer: a population-based prospective cohort study. Cancer Res 72:1459–1466.
    • (2012) Cancer Res , vol.72 , pp. 1459-1466
    • Julin, B.1    Wolk, A.2    Bergkvist, L.3    Bottai, M.4    Åkesson, A.5
  • 23
    • 84856706368 scopus 로고    scopus 로고
    • Maternal cadmium exposure during pregnancy and size at birth: A prospective cohort study
    • Kippler M, Tofail F, Gardner R, Rahman A, Hamadani JD, Bottai M, et al. 2012. Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study. Environ Health Perspect 120:284–289; doi:10.1289/ehp.1103711.
    • (2012) Environ Health Perspect , vol.120 , pp. 284-289
    • Kippler, M.1    Tofail, F.2    Gardner, R.3    Rahman, A.4    Hamadani, J.D.5    Bottai, M.6
  • 24
    • 84862866031 scopus 로고    scopus 로고
    • Cadmium modulates expression of aryl hydrocarbon receptor-associated genes in rat uterus by interaction with the estrogen receptor
    • Kluxen FM, Höfer N, Kretzschmar G, Degen GH, Diel P. 2012. Cadmium modulates expression of aryl hydrocarbon receptor-associated genes in rat uterus by interaction with the estrogen receptor. Arch Toxicol 86:591–601.
    • (2012) Arch Toxicol , vol.86 , pp. 591-601
    • Kluxen, F.M.1    Höfer, N.2    Kretzschmar, G.3    Degen, G.H.4    Diel, P.5
  • 25
    • 30344469923 scopus 로고    scopus 로고
    • Serum cadmium levels in pancreatic cancer patients from the East Nile Delta region of Egypt
    • Kriegel AM, Soliman AS, Zhang Q, El-Ghawalby N, Ezzat F, Soultan A, et al. 2006. Serum cadmium levels in pancreatic cancer patients from the East Nile Delta region of Egypt. Environ Health Perspect 114:113–119; doi:10.1289/ehp.8035.
    • (2006) Environ Health Perspect , vol.114 , pp. 113-119
    • Kriegel, A.M.1    Soliman, A.S.2    Zhang, Q.3    El-Ghawalby, N.4    Ezzat, F.5    Soultan, A.6
  • 26
    • 79957827152 scopus 로고    scopus 로고
    • EGFR upregulates inflammatory and proliferative responses in human lung adenocarcinoma cell line (A549), induced by lower dose of cadmium chloride
    • Kundu S, Sengupta S, Bhattacharyya A. 2011. EGFR upregulates inflammatory and proliferative responses in human lung adenocarcinoma cell line (A549), induced by lower dose of cadmium chloride. Inhal Toxicol 23:339–348.
    • (2011) Inhal Toxicol , vol.23 , pp. 339-348
    • Kundu, S.1    Sengupta, S.2    Bhattacharyya, A.3
  • 27
    • 84879495316 scopus 로고    scopus 로고
    • A bi-faceted role of estrogen receptor β in breast cancer
    • Leygue E, Murphy LC. 2013. A bi-faceted role of estrogen receptor β in breast cancer. Endocr Relat Cancer 20:R127–R139.
    • (2013) Endocr Relat Cancer , vol.20 , pp. R127-R139
    • Leygue, E.1    Murphy, L.C.2
  • 28
    • 0033868842 scopus 로고    scopus 로고
    • The effect of cadmium on oogenesis in Xenopus laevis
    • Lienesch LA, Dumont JN, Bantle JA. 2000. The effect of cadmium on oogenesis in Xenopus laevis. Chemosphere 41:1651–1658.
    • (2000) Chemosphere , vol.41 , pp. 1651-1658
    • Lienesch, L.A.1    Dumont, J.N.2    Bantle, J.A.3
  • 29
    • 42049108836 scopus 로고    scopus 로고
    • Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium
    • Liu Z, Yu X, Shaikh ZA. 2008. Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicol Appl Pharmacol 228:286–294.
    • (2008) Toxicol Appl Pharmacol , vol.228 , pp. 286-294
    • Liu, Z.1    Yu, X.2    Shaikh, Z.A.3
  • 31
    • 34248575149 scopus 로고    scopus 로고
    • Integrating signals from RTKs to ERK/MAPK
    • McKay MM, Morrison DK. 2007. Integrating signals from RTKs to ERK/MAPK. Oncogene 26:3113–3121.
    • (2007) Oncogene , vol.26 , pp. 3113-3121
    • McKay, M.M.1    Morrison, D.K.2
  • 32
    • 33847685611 scopus 로고    scopus 로고
    • Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells
    • Nampoothiri LP, Agarwal A, Gupta S. 2007. Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells. Arch Toxicol 81:145–150.
    • (2007) Arch Toxicol , vol.81 , pp. 145-150
    • Nampoothiri, L.P.1    Agarwal, A.2    Gupta, S.3
  • 33
    • 29544452425 scopus 로고    scopus 로고
    • Tissue levels of cadmium and trace elements in patients with myoma and uterine cancer
    • Nasiadek M, Krawczyk T, Sapota A. 2005. Tissue levels of cadmium and trace elements in patients with myoma and uterine cancer. Hum Exp Toxicol 24:623–630.
    • (2005) Hum Exp Toxicol , vol.24 , pp. 623-630
    • Nasiadek, M.1    Krawczyk, T.2    Sapota, A.3
  • 35
    • 84961294124 scopus 로고    scopus 로고
    • 2009–2010 Data Documentation, Codebook, and Frequencies
    • NHANES, National Health and Nutrition Examination Survey, accessed 10 October 2014
    • NHANES (National Health and Nutrition Examination Survey). 2011. 2009–2010 Data Documentation, Codebook, and Frequencies. Blood Cadmium, Lead, and Total Mercury (PbCd_F). Available: http://www.cdc.gov/nchs/nhanes/nhanes2009-2010/pbcd_f.htm [accessed 10 October 2014].
    • (2011) Blood Cadmium, Lead, and Total Mercury (Pbcd_F)
  • 36
  • 37
    • 15544379599 scopus 로고    scopus 로고
    • Estrogen-receptor biology: Continuing progress and therapeutic implications
    • Osborne CK, Schiff R. 2005. Estrogen-receptor biology: continuing progress and therapeutic implications. J Clin Oncol 23:1616–1622.
    • (2005) J Clin Oncol , vol.23 , pp. 1616-1622
    • Osborne, C.K.1    Schiff, R.2
  • 38
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Corre-lation with clinical response to gefitinib therapy
    • Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. 2004. EGFR mutations in lung cancer: corre-lation with clinical response to gefitinib therapy. Science 304:1497–1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 39
    • 79961090796 scopus 로고    scopus 로고
    • Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women
    • Pollack AZ, Schisterman EF, Goldman LR, Mumford SL, Albert PS, Jones RL, et al. 2011. Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. Environ Health Perspect 119:1156–1161; doi:10.1289/ehp.1003284.
    • (2011) Environ Health Perspect , vol.119 , pp. 1156-1161
    • Pollack, A.Z.1    Schisterman, E.F.2    Goldman, L.R.3    Mumford, S.L.4    Albert, P.S.5    Jones, R.L.6
  • 40
    • 84930485164 scopus 로고    scopus 로고
    • Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells
    • Qu W, Tokar EJ, Kim AJ, Bell MW, Waalkes MP. 2012. Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells. Environ Health Perspect 120:1265–1271; doi:10.1289/ehp.1205082.
    • (2012) Environ Health Perspect , vol.120 , pp. 1265-1271
    • Qu, W.1    Tokar, E.J.2    Kim, A.J.3    Bell, M.W.4    Waalkes, M.P.5
  • 41
    • 0031763790 scopus 로고    scopus 로고
    • Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma
    • Shimomura Y, Matsuo H, Samoto T, Maruo T. 1998. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab 83:2192–2198.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2192-2198
    • Shimomura, Y.1    Matsuo, H.2    Samoto, T.3    Maruo, T.4
  • 42
    • 77954852834 scopus 로고    scopus 로고
    • Cadmium promotes breast cancer cell prolif-eration by potentiating the interaction between ERα and c-Jun
    • Siewit CL, Gengler B, Vegas E, Puckett R, Louie MC. 2010. Cadmium promotes breast cancer cell prolif-eration by potentiating the interaction between ERα and c-Jun. Mol Endocrinol 24:981–992.
    • (2010) Mol Endocrinol , vol.24 , pp. 981-992
    • Siewit, C.L.1    Gengler, B.2    Vegas, E.3    Puckett, R.4    Louie, M.C.5
  • 44
    • 0037406464 scopus 로고    scopus 로고
    • Cadmium, lung and prostate cancer: A systematic review of recent epidemiological data
    • Verougstraete V, Lison D, Hotz P. 2003. Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data. J Toxicol Environ Health B Crit Rev 6:227–255.
    • (2003) J Toxicol Environ Health B Crit Rev , vol.6 , pp. 227-255
    • Verougstraete, V.1    Lison, D.2    Hotz, P.3
  • 45
    • 4444304724 scopus 로고    scopus 로고
    • Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists
    • Wilson VS, Bobseine K, Gray LE Jr. 2004. Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists. Toxicol Sci 81:69–77.
    • (2004) Toxicol Sci , vol.81 , pp. 69-77
    • Wilson, V.S.1    Bobseine, K.2    Gray, L.E.3
  • 46
    • 21644441223 scopus 로고    scopus 로고
    • Cadmium down-regulates human OGG1 through suppression of Sp1 activity
    • Youn CK, Kim SH, Lee DY, Song SH, Chang IY, Hyun JW, et al. 2005. Cadmium down-regulates human OGG1 through suppression of Sp1 activity. J Biol Chem 280:25185–25195.
    • (2005) J Biol Chem , vol.280 , pp. 25185-25195
    • Youn, C.K.1    Kim, S.H.2    Lee, D.Y.3    Song, S.H.4    Chang, I.Y.5    Hyun, J.W.6
  • 47
    • 77951517877 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma
    • Yu L, Moore AB, Dixon D. 2010. Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. Semin Reprod Med 28(3):250–259.
    • (2010) Semin Reprod Med , vol.28 , Issue.3 , pp. 250-259
    • Yu, L.1    Moore, A.B.2    Dixon, D.3
  • 48
    • 44649107576 scopus 로고    scopus 로고
    • Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway acti-vation in human uterine leiomyomas
    • Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, et al. 2008. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway acti-vation in human uterine leiomyomas. Mol Med 14:264–275.
    • (2008) Mol Med , vol.14 , pp. 264-275
    • Yu, L.1    Saile, K.2    Swartz, C.D.3    He, H.4    Zheng, X.5    Kissling, G.E.6
  • 49
    • 58149280227 scopus 로고    scopus 로고
    • Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells
    • Zang Y, Odwin-Dacosta S, Yager JD. 2009. Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells. Toxicol Lett 184:134–138.
    • (2009) Toxicol Lett , vol.184 , pp. 134-138
    • Zang, Y.1    Odwin-Dacosta, S.2    Yager, J.D.3
  • 50
    • 77955537607 scopus 로고    scopus 로고
    • Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure
    • Zhang M, He Z, Wen L, Wu J, Yuan L, Lu Y, et al. 2010. Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure. Reprod Biol Endocrinol 8:97; doi:10.1186/1477-7827-8-97.
    • (2010) Reprod Biol Endocrinol , vol.8 , pp. 97
    • Zhang, M.1    He, Z.2    Wen, L.3    Wu, J.4    Yuan, L.5    Lu, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.