Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestine

Archives of Toxicology

Volumn 84, Issue 7, 2010, Pages 541-552

  Höfer, Nicola ^a,b   Diel, Patrick ^a   Wittsiepe, Jürgen ^c   Wilhelm, Michael ^c   Kluxen, Felix M ^a,b   Degen, Gisela H ^b  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Cadmium; Endocrine disruption; Estrogenic activity; Route of exposure; Small intestine

Indexed keywords

CADMIUM CHLORIDE; CYCLINE; DRINKING WATER; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYLESTRADIOL; METALLOPROTEIN; METALLOTHIONEIN I; PROTEIN PS2; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ESTROGEN ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; HORMONE ACTION; IMMUNOHISTOCHEMISTRY; KIDNEY; LONG TERM EXPOSURE; MOLECULAR MECHANICS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; RECEPTOR DOWN REGULATION; SMALL INTESTINE; TISSUE LEVEL; WISTAR RAT;

ANIMALS; CADMIUM; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; ESTRONE; ETHINYL ESTRADIOL; FEMALE; INJECTIONS, INTRAPERITONEAL; INTESTINES; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RNA, MESSENGER; UTERUS;

RATTUS; RATTUS NORVEGICUS;

EID: 77955570074     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0524-x     Document Type: Article

References (66)

1. Alonso-González C, González A, Mazarrasa O, Güezmes A, Sánchez-Mateos S, Martínez-Campa C, Cos S, Sánchez- Barceló EJ, Mediavilla MD (2007) Melatonin prevents the estrogenic effects of subchronic administration of cadmium on mice mammary glands. J Pineal Res 42:403-410
2. Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P (2004) Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer 11(3):537-551
3. Bernard A (2008) Cadmium & its adverse effects on human health. Indian J Med Res 128(4):557-564
4. Blazka ME, Shaikh ZA (1991) Sex differences in hepatic and renal cadmium accumulation and metallothionein induction. Role of estradiol. Biochem Pharmacol 41(5):775-780
5. Brown AM, Jeltsch JM, Roberts M, Chambon P (1984) Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci USA 81(20):6344-6348
6. Byrne C, Divekar SD, Storchan GB, Parodi DA, Martin MB (2009) Cadmium - a metallohormone? Toxicol Appl Pharmacol 238(3):266-271
7. Chan HM, Cherian MG (1992) Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicology 72(3):281-290
8. Chan HM, Satoh M, Zalups RK, Cherian MG (1992) Exogenous metallothionein and renal toxicity of cadmium and mercury in rats. oxicology 76(1):15-26
9. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162(1):156-159
10. Couse JF, Korach KS (2004) Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205(1-2):55-63
11. Coyle P, Philcox JC, Carey LC, Rofe AM (2002) Metallothionein: the multipurpose protein. Cell Mol Life Sci 59:627-647
12. Deroo BJ, Korach KS (2006) Estrogen receptors and human disease. J Clin Invest 116(3):561-570
13. DFG (2004) Cadmium und seine anorganischen Verbindungen. Arbeitsmedizinisch-toxikologische Begründungen von MAKWerten, 39. Lieferung. Wiley, Weinheim
14. Diel P (2002) Tissue-specific estrogenic response and molecular mechanisms. Toxicol Lett 127(1-3):217-224
15. Diel P, Laudenbach-Leschowsky U, Friedel A, Voss A, Roussel J (2005) Pulsed estradiol exposure has a limited ability to induce uterine proliferation in ovariectomised female Wistar rats. Mol Cell Endocrinol 230(1-2):7-15
16. EFSA (2009) Scientific opinion of the panel on contaminants in the food chain on a request from the European commission on cadmium in food. EFSA J 980:1-139
17. Elsenhans B, Kolb K, Schumann K, Forth W (1994) The longitudinal distribution of cadmium, zinc, copper, iron, and metallothionein in the small-intestinal mucosa of rats after administration of cadmium chloride. Biol Trace Elem Res 41(1-2):31-46
18. Enmark E, Gustafsson JA (1999) Oestrogen receptors - an overview. J Intern Med 246(2):133-138
19. Foley EF, Jazaeri AA, Shupnik MA, Jazaeri O, Rice LW (2000) Selective loss of estrogen receptor beta in malignant human colon. Cancer Res 60(2):245-248
20. Fritzemeier KH, Hertrampf T, Diel P (2008) Alpha estratriene dervatives as ER-beta selective ligands for the prevention of intestinal cancer. European Patent No. 08160239.3-2123
21. Ghoshal K, Jacob ST (2001) Regulation of metallothionein gene expression. Prog Nucleic Acid Res Mol Biol 66:357-384
22. Gilad LA, Schwartz B (2007) Association of estrogen receptor beta with plasma-membrane caveola components: implication in control of vitamin D receptor. J Mol Endocrinol 38(6):603-618
23. Gilad LA, Bresler T, Gnainsky J, Smirnoff P, Schwartz B (2005) Regulation of vitamin D receptor expression via estrogeninduced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol 185(3):577-592
24. Gilad LA, Tirosh O, Schwartz B (2006) Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells. J Endocrinol 191(2):387-398
25. Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A, Groneberg DA (2006) The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol 1:22
26. Grody WW, Schrader WT, O'Malley BW (1982) Activation, transformation, and subunit structure of steroid hormone receptors. Endocr Rev 3(2):141-163
27. Gustafsson JA (2000) Novel aspects of estrogen action. J Soc Gynecol Investig 7(1 Suppl):S8-S9
28. Gustafsson JA (2003) What pharmacologists can learn from recent advances in estrogen signalling. Trends Pharmacol Sci 24(9):479-485
29. Harnish DC (2006) Estrogen receptor ligands in the control of pathogenic inflammation. Curr Opin Investig Drugs 7(11):997-1001
30. Harnish DC, Albert LM, Leathurby Y, Eckert AM, Ciarletta A, Kasaian M, Keith JC Jr (2004) Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 286(1):G118-G125
31. Harris HA (2007) Estrogen receptor-beta: recent lessons from in vivo studies. Mol Endocrinol 21(1):1-13
32. Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, Miller CP, Kharode YP, Marzolf J, Komm BS, Winneker RC, Frail DE, Henderson RA, Zhu Y, Keith JC Jr (2003) Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology 144(10):4241-4249
33. Höfer N, Diel P, Wittsiepe J, Wilhelm M, Degen GH (2009) Doseand route-dependent hormonal activity of the metalloestrogen cadmium in the rat uterus. Toxicol Lett 191(2-3):123-131
34. IPCS INCHEM (2007) International Chemical Safety Card (ICSC) of Cadmium (PIM 089). The International Programme on Chemical Safety (IPCS)
35. Jin T, Lu J, Nordberg M (1998) Toxicokinetics and biochemistry of cadmium with special emphasis on the role of metallothionein. Neurotoxicology 19(4-5):529-535
36. Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB (2003) Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 9(8):1081-1084
37. Klaassen CD, Liu J, Choudhuri S (1999) Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 39:267-294
38. Konstantinopoulos PA, Kominea A, Vandoros G, Sykiotis GP, Andricopoulos P, Varakis I, Sotiropoulou-Bonikou G, Papavassiliou AG (2003) Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur J Cancer 39(9):1251-1258
39. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93(12):5925-5930
40. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138(3):863-870 (Pubitemid 27089735)
41. Liel Y, Shany S, Smirnoff P, Schwartz B (1999) Estrogen increases 1,25-dihydroxyvitamin D receptors expression and bioresponse in the rat duodenal mucosa. Endocrinology 140(1):280-285
42. Liu Z, Yu X, Shaikh ZA (2008) Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicol Appl Pharmacol 228(3):286-294
43. Marchbank T, Westley BR, May FE, Calnan DP, Playford RJ (1998) Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects. J Pathol 185(2):153-158
44. Martineti V, Picariello L, Tognarini I, Carbonell Sala S, Gozzini A, Azzari C, Mavilia C, Tanini A, Falchetti A, Fiorelli G, Tonelli F, Brandi ML (2005) ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components. Endocr Relat Cancer 12(2):455-469
45. Murphy MS (1998) Growth factors and the gastrointestinal tract. Nutrition 14(10):771-774
46. Nie SN, Sun HC, Wu XH, Qian XM (2004) Cyclooxygenase 2, pS2, inducible nitric oxide synthase and transforming growth factor alpha in gastric adaptation to stress. World J Gastroenterol 10(23):3537-3541
47. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA (2001) Mechanisms of estrogen action. Physiol Rev 81(4):1535-1565
48. Nordberg M (1998) Metallothioneins: historical review and state of knowledge. Talanta 46:243-254
49. Nordberg GF (2009) Historical perspectives on cadmium toxicology. Toxicol Appl Pharmacol 238(3):192-200
50. Pettersson K, Gustafsson JA (2001) Role of estrogen receptor beta in estrogen action. Annu Rev Physiol 63:165-192
51. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29(9):e45
52. Pillet S, D'Elia M, Bernier J, Bouquegneau JM, Fournier M, Cyr DG (2006) Immunomodulatory effects of estradiol and cadmium in adult female rats. Toxicol Sci 92(2):423-432
53. Prins GS, Korach KS (2008) The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids 73(3):233-244
54. Ribieras S, Tomasetto C, Rio MC (1998) The pS2/TFF1 trefoil factor, from basic research to clinical applications. Biochim Biophys Acta 1378(1):F61-F77
55. Rivera-Gonzalez R, Petersen DN, Tkalcevic G, Thompson DD, Brown TA (1998) Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen. J Steroid Biochem Mol Biol 64(1-2):13-24
56. Sato M, Kondoh M (2002) Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med 196(1):9-22
57. Schwartz B, Smirnoff P, Shany S, Liel Y (2000) Estrogen controls expression and bioresponse of 1,25-dihydroxyvitamin D receptors in the rat colon. Mol Cell Biochem 203(1-2):87-93
58. Seibel J, Molzberger AF, Hertrampf T, Laudenbach-Leschowski U, Degen GH, Diel P (2008) In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis. Arch Toxicol 82(12):941-950
59. Singh S, Poulsom R, Hanby AM, Rogers LA, Wright NA, Sheppard MC, Langman MJ (1998) Expression of oestrogen receptor and oestrogen-inducible genes pS2 and ERD5 in large bowel mucosa and cancer. J Pathol 184(2):153-160
60. Stoica A, Katzenellenbogen BS, Martin MB (2000) Activation of estrogen receptor-alpha by the heavy metal cadmium. Mol Endocrinol 14(4):545-553
61. Takiguchi M, Yoshihara S (2006) New aspects of cadmium as endocrine disruptor. Environ Sci 13(2):107-116
62. Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, Panayappan L, Chatterjee M (2007) Metallothionein: an overview. World J Gastroenterol 13(7):993-996
63. Wada-Hiraike O, Imamov O, Hiraike H, Hultenby K, Schwend T, Omoto Y, Warner M, Gustafsson JA (2006a) (2006a) Role of estrogen receptor beta in colonic epithelium. Proc Natl Acad Sci USA 103(8):2959-2964
64. Wada-Hiraike O, Warner M, Gustafsson JA (2006b) New developments in oestrogen signalling in colonic epithelium. Biochem Soc Trans Dec 34(Pt 6):1114-1116
65. Young PC, Cleary RE, Ragan WD (1977) Effect of metal ions on the binding of 17beta-estradiol to human endometrial cytosol. Fertil Steril 28(4):459-463
66. Zhang W, Yang J, Wang J, Xia P, Xu Y, Jia H, Chen Y (2007) Comparative studies on the increase of uterine weight and related mechanisms of cadmium and p-nonylphenol. Toxiocology 241(1-2):84-91